A review of dry eye disease therapies: exploring the qualities of varenicline solution nasal spray

IF 0.9 Q4 OPHTHALMOLOGY

Expert Review of Ophthalmology Pub Date : 2023-01-02 DOI:10.1080/17469899.2023.2173173

S. Bhargava, Ranjani Panda, Asma M. Azam, J. Sheppard

引用次数: 0

Abstract

ABSTRACT Introduction Dry eye disease is a prevalent, multifactorial disease characterized by loss of tear film homeostasis. A myriad of ocular therapeutics is commercially available and in development for personalized management of dry eyes. Recently, Varenicline solution nasal spray (VNS) received approval from the US Food and Drug Administration for the treatment of dry eyes. Areas covered This review explores the current mainstay treatments for dry eyes and the role of VNS in addressing unmet needs in the treatment of dry eye disease. A PubMed and MEDLINE keyword search on Tyrvaya and Varenicline nasal solution spray was performed as a part of the inclusion criteria. Varenicline solution nasal spray has been shown to be well tolerated and demonstrated to provide clinically significant improvement in patients with dry eyes Expert opinion Treatment of dry eye disease with VNS may be most beneficial in patients with limited upper-body mobility, dexterity issues, tremors, and glaucoma.

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干眼病治疗综述:探讨伐尼克兰鼻喷雾剂的质量

摘要简介干眼病是一种常见的多因素疾病，其特征是泪膜稳态丧失。市面上有无数的眼部治疗方法，正在开发中，用于个性化管理干眼症。最近，Varenicline溶液鼻喷雾剂（VNS）获得了美国食品和药物管理局的批准，用于治疗干眼症。本综述探讨了目前干眼症的主要治疗方法，以及VNS在解决干眼症治疗中未满足的需求方面的作用。作为纳入标准的一部分，对Tyrvaya和Varenicline鼻喷雾剂进行了PubMed和MEDLINE关键词搜索。Varenicline溶液鼻喷雾剂已被证明具有良好的耐受性，并被证明可在干眼症患者中提供临床显著改善。专家意见VNS治疗干眼症可能对上半身活动受限、灵活性问题、震颤和青光眼患者最有益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Ophthalmology Health Professions-Optometry

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The worldwide problem of visual impairment is set to increase, as we are seeing increased longevity in developed countries. This will produce a crisis in vision care unless concerted action is taken. The substantial value that ophthalmic interventions confer to patients with eye diseases has led to intense research efforts in this area in recent years, with corresponding improvements in treatment, ophthalmic instrumentation and surgical techniques. As a result, the future for ophthalmology holds great promise as further exciting and innovative developments unfold.