Nano-Structures & Nano-Objects最新文献

{"title":"Metamaterials for electromagnetic wave manipulation: Advancements and future prospects","authors":"Md. Aminul Islam ,&nbsp;Md. Jahid Hasan ,&nbsp;Md. Shakil Chowdhury ,&nbsp;Jubaraz Ghosh ,&nbsp;Md Hosne Mobarak","doi":"10.1016/j.nanoso.2024.101424","DOIUrl":"10.1016/j.nanoso.2024.101424","url":null,"abstract":"<div><div>Metamaterials, with their unique ability to alter electromagnetic waves, have ushered in a new era of scientific and technological advancements. By exerting precise control over the behaviour of waves, these materials provide revolutionary applications, such as improved imaging, sensing, and communication systems. By utilizing sophisticated production processes such as nanofabrication methods and additive manufacturing, scientists can create metamaterials with exceptional accuracy at the nanoscale. This enables the practical application of these materials in various industries. Nevertheless, despite their excellent capacity, metamaterials encounter substantial obstacles, such as scalability concerns, intricate fabrication processes, and material degradation. However, current research endeavors, especially in interdisciplinary domains, present hopeful resolutions to surmount these obstacles, facilitating groundbreaking progress in domains like 5G technology, telecommunications, and medical imaging. This review study provides a complete analysis of recent accomplishments, problems, and probable future directions in metamaterial research. It offers insights into how nanotechnology addresses challenges and influences the field of electromagnetic manipulation.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101424"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143100762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined viscous dissipation and joule heating effects on chemically radiative MHD micropolar flow with heat source and convective boundary conditions","authors":"Jayaramireddy Konda ,&nbsp;M.Narendranadh Reddy ,&nbsp;Charankumar Ganteda ,&nbsp;Rajyalakshmi Kottapalli ,&nbsp;Y. Adinarayana ,&nbsp;Vediyappan Govindan ,&nbsp;Haewon Byeon ,&nbsp;Busayamas Pimpunchat","doi":"10.1016/j.nanoso.2025.101434","DOIUrl":"10.1016/j.nanoso.2025.101434","url":null,"abstract":"<div><div>The proposed study presents a comprehensive investigation of the combined effects of viscous dissipation and Joule heating on chemically reactive magnetohydrodynamic (MHD) micropolar fluid flow over a nonlinear stretching sheet, incorporating the influences of radiative heat transfer, heat source, and convective boundary conditions. The current study investigates the flow of a type of fluid called micropolar fluid in a stretched 2D space. This fluid is viscous, and the flow is influenced by convective boundary conditions. Mathematical equations are derived considering factors such as heat, friction, electrical effects, chemical reactions, and radiation heat transfer. The fluid can conduct electricity when exposed to an external magnetic field. The complex partial differential equations governing the boundary layer flow are simplified into ordinary differential equations using a technique known as similarity transformation. The problem is solved using the Runge-Kutta-Fehlberg method with a shooting technique. Graphs are generated to analyze how physical factors influence temperature and concentration profiles. The skin friction coefficient, local Nusselt number, and local Sherwood number are calculated and studied. In this study, we compare our results with those of other research and find good agreement.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101434"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effect of AgNPs and gentamicin: Inhibition of multi-drug resistance bacterial biofilm formation and down-regulated fim H gene","authors":"Tabarak M. Mahmood ,&nbsp;Kareem H. Jawad ,&nbsp;Majid S. Jabir","doi":"10.1016/j.nanoso.2025.101437","DOIUrl":"10.1016/j.nanoso.2025.101437","url":null,"abstract":"<div><div>Antibiotic resistance poses a significant public health concern, particularly in treating urinary tract infections (UTIs) caused by multi-drug resistant (MDR) Gram-negative bacteria. This study presents a novel approach to enhance the antibacterial activity of Gentamicin (Gent) against <em>Proteus mirabilis</em> and <em>Klebsiella pneumoniae</em> through the innovative creation of a silver nanoparticles (AgNPs) nanocomposite, termed Gent@AgNPs, using an environmentally friendly pulsed laser ablation technique. The morphology, size, and elemental composition of the silver nanoparticles (AgNPs) were examined using several analytical techniques, including (ZP.DLS, SEM, UV–vis spectroscopy, FT-IR, XRD, and TEM). The results confirmed that the hetero nanocomposite, consisting of silver nanoparticles and gentamicin, exhibited greater antimicrobial activity compared to gentamicin alone against two types of bacteria <em>P</em>. <em>mirabilis</em> and <em>K. pneumonia</em>. The mixture of silver nanoparticles with gentamicin was produced to enhance the drug delivery method to inhibit the growth of <em>K. pneumonia</em> and <em>P. mirabilis</em>, and also prevent the formation of bacterial biofilms on foley catheters. The smartly hybrid nanocomposite displayed an improvement, suggesting that in the future its potential as a viable therapeutic strategy against <em>P. mirabilis</em> and <em>K. pneumonia</em>. Additionally, it could be a promising approach to avoid the growth of bacterial biofilm formation during urinary tract infections (UTIs).</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101437"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural-morphological and adsorption properties of hollow balls of oxidized graphene obtained by auto-combustion of saccharose","authors":"Ivan Mironyuk ,&nbsp;Jean-Claude Grivel ,&nbsp;Hanna Vasylyeva ,&nbsp;Elif Coşkun ,&nbsp;Igor Mykytyn ,&nbsp;Volodymyr Mandzyuk","doi":"10.1016/j.nanoso.2025.101462","DOIUrl":"10.1016/j.nanoso.2025.101462","url":null,"abstract":"<div><div>In this work, the atomic structure and morphology of the carbon material obtained by self-combustion of the composite mixture of saccharose (52 <em>wt.</em>, %), potassium nitrate (44 <em>wt.</em>, %), and sulfur (4 <em>wt.</em>, %) were investigated. The proposed mechanisms for sample formation are as follows. Hollow balls of oxidized graphene are created due to the action of pyrolysis gases (vapor H₂O, CO₂). Further carbonization of the bubble shells leads to the formation of hollow carbon particles with a diameter of (10−100) nm and (300–3500) nm. Individual carbon atoms in graphene are oxidized to groups <img>C-OH, -СООН, and –ОСООН during auto combustion. Another oxidation pathway of carbon atoms is carried out with the participation of KNO₃. The N^5 + cations of this compound are converted into N₂ molecules by electrons captured from carbon atoms. Carbon atoms, oxidized in this way, transform into the =C²⁺ cations and attach O^2- anions. The obtained material was investigated using XRD, FTIR, XPS, Raman, and TG/DTG/DTA analysis. Also, the surface area and porous size distribution were measured using low-temperature N₂ adsorption/desorption isotherm. The oxidized state of carbon atoms in the graphene structure performs its new valuable properties, such as adsorption properties. The oxidized graphene can bind halogen anions in an aqueous medium. The kinetics of adsorption of iodine anions from the KI solution, equilibrium adsorption, and dependence of adsorption on pH were experimentally studied. The Elovic and diffusion kinetic models, Lagergren's models based on pseudo-first and pseudo-second-order equations, and the Langmuir-Hinshelwood kinetic model were applied to the obtained results. Equilibrium adsorption was analyzed using the theories of Langmuir, Freundlich, and Henry. The supposed mechanism is related to forming adsorption centers =C²⁺O^2-. The number of adsorption centers was quantified for the first time. It was found that the surface of oxidized graphene with an area of 10 nm² contains ∼ 24 groups = C²⁺O^2-, which can exchange O^2- anions, for example, for halogen anions. Hollow balls of carbon adsorbent can adsorb 618 mg∙g⁻¹ iodine anions from the aqueous solutions, which is a unique result since most carbon adsorbents and MOFs adsorb only molecular iodine.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101462"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced hydrogen evolution activity and magnetic/electrodynamic properties of Fe/Bi co-doped nano CoNiV spinel oxides","authors":"Refah S. Alkhaldi ,&nbsp;Munirah A. Almessiere ,&nbsp;A. Hossan ,&nbsp;A. Baykal ,&nbsp;S. Caliskan ,&nbsp;Ram H. Kadam ,&nbsp;Y. Slimani ,&nbsp;Mohammed A. Gondal ,&nbsp;E. Cevik ,&nbsp;Sagar E. Shirsath","doi":"10.1016/j.nanoso.2025.101457","DOIUrl":"10.1016/j.nanoso.2025.101457","url":null,"abstract":"<div><div>In this study, Fe/Bi co-doped CoNiV nano spinel oxides (Co_0.5Ni_0.5Fe_xBi_xV_2–2xO₄ (x ≤ 0.040) NSOs) were synthesized through a hydrothermal approach. Employing M-H curves at 300 K (Room temperature, RT) and 10 K, magnetic properties of Fe/Bi doped CoNiV (x ≤ 0.040) NSOs are examined. It is observed that they possess paramagnetic and superparamagnetic nature at RT and 10 K, respectively. Substitution of V atoms with Fe/Bi yields fluctuations of magnetic parameters (with a maximum at x = 0.030) with growing doping content at 10 K. The accompanying saturation magnetization (Ms) at 10 K is estimated through the Langevin function, giving rise to the highest (lowest) M_s value at x = 0.030 (0.000, undoped NSOs). Our findings demonstrate that magnetic characteristics of Fe/Bi doped CoNiV (x ≤ 0.040) NSOs can be adjusted by controlling Fe/Bi dopants. The electrocatalyst Fe/Bi doped CoNiV (x = 0.04)@CS nanoelectrocatalyst demonstrated notable performance in the HER, with an overpotential of 271 mV, a Tafel slope of 131.07 mV/dec, and remarkable stability up to 20 h using chronopotentiometry methods. The surface and electrochemical analyses demonstrated that the sample, which underwent dual doping with 4.0 % Fe⁺³ and 4.0 % Bi⁺³ concentrations, had enhanced performance in the HER. Additionally, electromagnetic studies revealed superior EMI shielding effectiveness (SET), with the x = 0.03 composition achieving ∼30 dB over a broad frequency range. These results establish Fe/Bi doping as an effective strategy to tailor structural, magnetic, electrochemical, and EMI shielding properties, highlighting its multifunctional potential.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101457"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of copper nanowires and facile fabrication of nanostructured conductors with high transparency in 400–2500 nm spectral range","authors":"Pavel V. Arsenov ,&nbsp;Konstantin S. Pilyushenko ,&nbsp;Polina S. Mikhailova ,&nbsp;Mikhail A. Atlanov ,&nbsp;Maksim A. Popov ,&nbsp;Nikolay P. Simonenko ,&nbsp;Tatiana L. Simonenko ,&nbsp;Ivan S. Vlasov ,&nbsp;Ivan A. Volkov","doi":"10.1016/j.nanoso.2024.101429","DOIUrl":"10.1016/j.nanoso.2024.101429","url":null,"abstract":"<div><div>We studied the effect of parameters of a hydrothermal synthesis of copper nanowires on their dimensional characteristics. A robust protocol for the synthesis and isolation of copper nanowires with an average diameter of about 60 nm and a length of about 90 μm was developed. The final dispersion enriched with target nanowires purified from low-volatile oleylamine involved in the synthesis was used to fabricate transparent conductive films by spin coating. To increase the conductivity of the films, the rapid and efficient technique of removing the native oxide shell of nanowires utilizing the solution of formic acid in isopropyl alcohol was proposed. The fabricated transparent conductors have record-breaking characteristics: light transmittance of about 93 % (at a wavelength of 550 nm) with the sheet resistance of about 34 Ohm/sq. An important point is that the transmittance of the films with sheet resistance down to 30 Ohm/sq. exceeds 90 % in the wide spectral range (400–2500 nm), thus opening up great opportunities for applications of such nanomaterials in optoelectronics.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101429"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143100760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface functionalisation of crosslinked polyvinyl alcohol/ cellulose nanofiber biocompatible composite membrane using plasma","authors":"Sreedevi Thulaseedharakurup ,&nbsp;Neethu Ninan ,&nbsp;Bidhari Pidhatika ,&nbsp;Andrew Hayles ,&nbsp;Markos Negash Alemie ,&nbsp;Krasimir Vasilev ,&nbsp;Jyotishkumar Parameswaranpillai ,&nbsp;Poornima Vijayan P","doi":"10.1016/j.nanoso.2025.101461","DOIUrl":"10.1016/j.nanoso.2025.101461","url":null,"abstract":"<div><div>The emergence of antibiotic-resistant bacterial strains has posed a great threat to global health; so, the progress of novel antibacterial strategies has become an urgent necessity. In this regard, functionalized polymer membranes play their role as versatile candidates by interacting with a wide range of molecules. However, poor mechanical properties often limit their clinical applications. The current research focused on the preparation of boric acid (BA) crosslinked PVA composite membranes with cellulose nanofiber (CNF). Herein, BA acts as an antibacterial agent against bacterial infection and together with CNF provides mechanical integrity to the composite membrane. Furthermore, these membranes were subjected to surface functionalization with plasma polymerization, a technique that controlled not only their swelling behaviour but also improved their antibacterial properties. The composite membranes were then subjected to an antibacterial performance test against <em>Staphylococcus aureus</em> and <em>Pseudomonas aeruginosa</em>, which showed remarkable bactericidal activity. The cytocompatibility was done by cell viability assays and fluorescent staining, confirming the nontoxic nature and biocompatibility of the membranes with macrophages. Besides, contact angle measurements showed favourable hydrophilicity (44 ± 1.4 °) to promote cell adhesion, and tensile testing showed optimal mechanical properties at 2.5 phr cellulose nanofiber and 8 phr BA content. The antibacterial activity, mechanical robustness, and cytocompatibility shown by plasma coated PVA-BA-CNF membrane, make them ideal candidates for biomedical applications. It has great potential to act as an antibacterial platform in mitigating bacterial infection, enhancing bioactivity and offering flexible solutions to address antibiotic resistance challenges in clinical settings.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101461"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical study of thermal performance of silica-aerogel/paraffin nanostructure in the presence of CuO nanoparticles: A molecular dynamics approach","authors":"Ali B.M. Ali ,&nbsp;Rasha Abed Hussein ,&nbsp;Shahram Babadoust ,&nbsp;Narinderjit Singh Sawaran Singh ,&nbsp;Soheil Salahshour ,&nbsp;Sh. Baghaei","doi":"10.1016/j.nanoso.2025.101435","DOIUrl":"10.1016/j.nanoso.2025.101435","url":null,"abstract":"<div><div>The rise in air pollution and fuel costs increased the use of various renewable energy options. Currently, scientists face a significant challenge. Finding methods to store energy that can be easily converted is crucial. There is growing interest in using phase change materials for thermal energy storage systems. This interest stems from their ability to conserve energy and reduce air pollution. Silica aerogel effectively maintains the temperature of items over long periods. Phase change materials, recognized for storing thermal energy, are now favored for preserving both hot and cold temperatures. This study aimed to use computer simulations to understand the behavior of silica aerogel/PCM and CuO nanoparticles in a cube. The results show that the nanostructure can achieve a velocity of 0.0086 Å/fs and had a thermal conductivity of 1.85 W/m·K. These findings may have practical applications in heating and cooling systems, energy storage, and the aerospace industry.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101435"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of MWCNTs for successive polymeric and nano modification of a Nigerian bitumen, optimization using response surface methodology","authors":"Salawudeen Taofeeq Olalekan ,&nbsp;Arinkoola Akeem Olatunde ,&nbsp;Salam Kazeem kolapo ,&nbsp;Jimoh Monsurat Omolola ,&nbsp;Ogunkunle Samuel Akinlolu ,&nbsp;Akinrinsa Samuel Damilare ,&nbsp;Olufayo Augustina Olukemi ,&nbsp;Ayanshola Ayanniyi Mufutau ,&nbsp;Ogunleye Oladipupo Olaosebikan ,&nbsp;Abdulkareem Ambali Saka","doi":"10.1016/j.nanoso.2025.101444","DOIUrl":"10.1016/j.nanoso.2025.101444","url":null,"abstract":"<div><div>Polyethylene (PE) is attractive as a bitumen modifier for several reasons, the most important of which is cost. However, polymeric bitumen is highly sensitive to PE dosages and suffers thermal degradation. To develop a tougher, more ductile crack-resistant binder, a ternary mixture was formulated using PE-modified binder and Multi-Wall Carbon Nanotubes (MWCNTs). The conventional properties of PE-modified bitumen were optimized using a mixture design and Response Surface Methodology (RSM). MWCNTs (0.1 – 0.3 wt%), mixing time (20 – 40 min) and speed (1000 – 15000 rpm) were considered for ternary modification at 140 °C. The softening and penetration points as well as ductility were used to determine the best mix. MWCNT was synthesized using a carbon vapour deposition method and characterized using Transmission Electron Microscopy (TEM), which indicates cylindrical-shaped CNT with numerous walls; Thermogravimetric Analysis (TGA) indicates crystalline graphitic carbon with a weight loss of 25.96 %; X-ray Diffraction (XRD), which indicates graphene-like layers of tube walls at 2θ values of 25.89° and 44.53°. Brunauer-Emmett Teller (BET) shows surface area, pore size and pore volume of 0.62 m²/g, 15.91 nm and 0.00362 cm³/g, respectively. The developed models for the modified bitumen are predictive (R² greater than or equals to 0.94). The optimum mix design for polymeric bitumen was 4.07 wt% PE, and 95.83 wt% bitumen and 0.1 wt% MWCNT, 1500 rpm mixing speed and 37.7 min for the ternary bitumen. The relatively small absolute relative error between experimental and simulation indicated the reliability of the final models with a combined desirability of 0.77 – 0.87.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101444"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palladium nanoparticles: Potential for receptor-mediated chemotherapeutic drug delivery to cervical cancer cells","authors":"Lorenzo Lance David,&nbsp;Moganavelli Singh","doi":"10.1016/j.nanoso.2024.101428","DOIUrl":"10.1016/j.nanoso.2024.101428","url":null,"abstract":"<div><div>Novel therapeutic strategies are needed to mitigate the hurdles faced by traditional cancer therapy that involves surgery, chemotherapy, and radiotherapy. The advent of nanomedicine has led to the production of an array of nanomaterials for therapeutic delivery. Nanoparticles (NPs) are potential anticancer delivery systems due to their favorable physical and chemical characteristics. Palladium NPs (PdNPs) are easy to synthesize, stable, have low cytotoxicity and good biocompatibility, and can be modified for use in biomedicine. PdNPs were synthesized chemically and modified with the biopolymer chitosan and the targeting ligand transferrin (Tf). This was used to encapsulate the anticancer drugs doxorubicin (DOX) and 5-fluorouracil (5-FU) individually and as a dual-drug formulation. PdNPs were spherical, small (98.9 nm), and had good colloidal stability (zeta potential = −22.3 mV). High drug encapsulation efficiency (&gt;70 %) was noted for both drugs, with a sustained release profile for the Tf-modified PdNPs at low pH for both drug formulations over 72 h. These PdNPs were targeted to a cervical cancer cell model (HeLa) that highly expresses the Tf receptor. Cytotoxicity was assessed on the human embryonic kidney (HEK293), breast adenocarcinoma (MCF-7), and HeLa cell lines. The anticancer activity confirmed the targeting specificity of the Tf-containing nanocomplexes to the HeLa cells, with good cell viability in the non-cancer (HEK293) cells. Tf-targeted nanocomplexes containing the dual-drug generated better anticancer activity than their non-targeted counterparts, confirming their potential as targeted therapeutic delivery vehicles that warrant further investigation.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101428"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143100763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}