Drug Discovery Today: Disease Models最新文献_第7页

Experimental models of cortical multiple sclerosis pathology 皮质多发性硬化病理实验模型

Drug Discovery Today: Disease Models Pub Date : 2017-12-01 DOI: 10.1016/j.ddmod.2018.09.002

Maarten E. Witte, Jack van Horssen

引用次数: 0

Large animal models to test mechanical circulatory support devices 大型动物模型测试机械循环支持装置

Drug Discovery Today: Disease Models Pub Date : 2017-06-01 DOI: 10.1016/j.ddmod.2018.06.003

Takuma Miyamoto , Jamshid H. Karimov , Andrew Xanthopoulos , Randall C. Starling , Kiyotaka Fukamachi

引用次数: 1

Models for evaluating the immune response to naturally derived biomaterials 评估对天然生物材料免疫反应的模型

Drug Discovery Today: Disease Models Pub Date : 2017-06-01 DOI: 10.1016/j.ddmod.2018.07.001

Jenna L. Dziki , Stephen F. Badylak

引用次数: 1

Editorial to “Evaluating biomaterials and implanted devices” “评估生物材料和植入装置”社论

Drug Discovery Today: Disease Models Pub Date : 2017-06-01 DOI: 10.1016/j.ddmod.2018.09.001

Roberto Gaetani, Karen L. Christman

引用次数: 0

Animal models of cardiovascular disease as test beds of bioengineered vascular grafts 心血管疾病动物模型作为生物工程血管移植的实验平台

Drug Discovery Today: Disease Models Pub Date : 2017-06-01 DOI: 10.1016/j.ddmod.2018.05.001

Sindhu Row , Daniel D. Swartz , Stelios T. Andreadis

{"title":"Animal models of cardiovascular disease as test beds of bioengineered vascular grafts","authors":"Sindhu Row , Daniel D. Swartz , Stelios T. Andreadis","doi":"10.1016/j.ddmod.2018.05.001","DOIUrl":"10.1016/j.ddmod.2018.05.001","url":null,"abstract":"<div>The last two decades have seen many advances in regenerative medicine, including the development of tissue engineered vessels (TEVs) for replacement of damaged or diseased arteries or veins. Biomaterials from natural sources, as well as synthetic polymeric materials have been employed in engineering vascular grafts. Recently, cell-free grafts have become available, opening new possibilities for the next generation, off-the-shelf products. These TEVs are first tested in small or large animal models, which are usually young and healthy. However, the majority of patients in need of vascular grafts are elderly and suffer from comorbidities that may complicate their response to the implants. Therefore, it is important to evaluate TEVs in animal models of vascular disease in order to increase their predictive value and learn how the disease microenvironment may affect the patency and remodeling of vascular grafts. Small animals with various disease phenotypes are readily utilizable due to the availability of transgenic or gene knockout technologies and can be used to address mechanistic questions related to vascular grafting. On the other hand, large animal models with similar anatomy, hematology and thrombotic responses to humans have been utilized in a preclinical setting. We propose that large animal models with certain pathologies or age range may provide more clinically relevant platforms for testing TEVs and facilitate the clinical translation of tissue engineering technologies by increasing the likelihood of success in clinical trials.</div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2018.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36787761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

In vitro and in vivo models for assessing the host response to biomaterials 用于评估宿主对生物材料反应的体外和体内模型

Drug Discovery Today: Disease Models Pub Date : 2017-06-01 DOI: 10.1016/j.ddmod.2018.04.002

Leila S. Saleh , Stephanie J. Bryant

{"title":"In vitro and in vivo models for assessing the host response to biomaterials","authors":"Leila S. Saleh , Stephanie J. Bryant","doi":"10.1016/j.ddmod.2018.04.002","DOIUrl":"10.1016/j.ddmod.2018.04.002","url":null,"abstract":"<div>The foreign body response (FBR) occurs ubiquitously to essentially all non-biological materials that are implanted into higher organisms. The FBR is characterized by inflammation followed by fibrosis and is mediated largely by macrophages. While many current medical devices tolerate the FBR, the FBR is responsible for many asceptic device failures and is hindering advancements of new devices that rely on device-host communication to function. To this end, in vitro and in vivo models are critical to studying how a biomaterial, via its chemistry and properties, affect the FBR. This short review highlights the main in vitro and in vivo models that are used to study the FBR. In vitro models that capture macrophage interrogation of a biomaterial and evaluation of macrophage attachment, polarization and fusion are described. In vivo models using rodents, which provide a relatively simple model of the complex FBR process, and human-relevant nonhuman primate models are described. Collectively, the combination of in vitro and in vivo models will help advance our fundmental understanding of the FBR and enable new biomaterials to be developed that can effectively modulate the FBR to achieve a desire device-host outcome.</div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2018.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36719692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Animal models for heart valve research and development 心脏瓣膜动物模型的研究与开发

Drug Discovery Today: Disease Models Pub Date : 2017-06-01 DOI: 10.1016/j.ddmod.2018.04.001

Arash Kheradvar , Ramin Zareian , Shimako Kawauchi , Richard L. Goodwin , Sandra Rugonyi

{"title":"Animal models for heart valve research and development","authors":"Arash Kheradvar , Ramin Zareian , Shimako Kawauchi , Richard L. Goodwin , Sandra Rugonyi","doi":"10.1016/j.ddmod.2018.04.001","DOIUrl":"10.1016/j.ddmod.2018.04.001","url":null,"abstract":"<div>Valvular heart disease is the third-most common cause of heart problems in the United States. Malfunction of the valves can be acquired or congenital and each may lead either to stenosis or regurgitation, or even both in some cases. Heart valve disease is a progressive disease, which is irreversible and may be fatal if left untreated. Medications cannot currently prevent valvular calcification or help repair damaged valves, as valve tissue is unable to regenerate spontaneously. Thus, heart valve replacement/repair is the only current available treatment. Heart valve research and development is currently focused on two parallel paths; first, research that aims to understand the underlying mechanisms for heart valve disease to emerge with an ultimate goal to devise medical treatment; and second, efforts to develop repair and replacement options for a diseased valve. Studies that focus on developmental malformation, including genetic and epigenetic causes, usually employ small animal models that are easy to access for in vivo imaging that minimally disturbs their environment during early stages of development. Alternatively, studies that aim to develop novel devices for replacement and repair of diseased valves often employ large animals whose heart size and anatomy closely replicate human’s. This paper aims to briefly review the current state-of-the-art animal models, and justification to use an animal model for a particular heart valve related project.</div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2018.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36852880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Humanized mouse model for evaluating biocompatibility and human immune cell interactions to biomaterials 评价生物材料的生物相容性和人免疫细胞相互作用的人源化小鼠模型

Drug Discovery Today: Disease Models Pub Date : 2017-06-01 DOI: 10.1016/j.ddmod.2018.06.002

Raymond M. Wang , Jingjin He , Yang Xu , Karen L. Christman

引用次数: 6

Animal models of vascular stenting 血管支架植入术动物模型

Drug Discovery Today: Disease Models Pub Date : 2017-06-01 DOI: 10.1016/j.ddmod.2018.06.001

Laura E. Leigh Perkins

引用次数: 3

An Opinion on non-human primates testing in Europe 对欧洲非人类灵长类动物试验的意见

Drug Discovery Today: Disease Models Pub Date : 2017-03-01 DOI: 10.1016/j.ddmod.2017.09.001

Michelle M. Epstein , Theo Vermeire

引用次数: 3