Humanized mouse model for evaluating biocompatibility and human immune cell interactions to biomaterials

Q3 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Disease Models Pub Date : 2017-06-01 DOI:10.1016/j.ddmod.2018.06.002

Raymond M. Wang , Jingjin He , Yang Xu , Karen L. Christman

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引用次数: 6

Abstract

Immune system humanized mice provide unique platforms for improving preclinical evaluation of the human immune response to novel biomaterial therapies. Wild-type animals and human immune cell in vitro cultures provide limited representation of the human immune response, leading to unexpected responses to therapies in human patients. Introducing human tissue, cells, and genes into immunodeficient mice have advanced these animal models to reconstitute multiple lineages of functional and maturely differentiated human immune cell populations. Safe implantation and remodeling responses promoting stable tissue resolutions are critical parameters coordinated by the immune response, which should be evaluated for new biomaterial therapeutics. This review discusses the development of immune system humanized mice, and highlights demonstrated use in biomaterial and related human immune response studies.

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评价生物材料的生物相容性和人免疫细胞相互作用的人源化小鼠模型

免疫系统人源化小鼠为改进人类对新型生物材料疗法的免疫反应的临床前评估提供了独特的平台。野生型动物和体外培养的人类免疫细胞对人类免疫反应的代表有限，导致人类患者对治疗产生意想不到的反应。将人类组织、细胞和基因导入免疫缺陷小鼠中，可以促进这些动物模型的发展，以重建多种功能性和成熟分化的人类免疫细胞群。安全的植入和重塑反应促进稳定的组织分辨率是免疫反应协调的关键参数，应该对新的生物材料治疗进行评估。本文综述了免疫系统人源化小鼠的研究进展，重点介绍了其在生物材料和相关人类免疫反应研究中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.