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Drug Discovery Today: Disease Models最新文献

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A review of animal models used to evaluate potential allergenicity of genetically modified organisms (GMOs) 用于评估转基因生物潜在致敏性的动物模型综述
Drug Discovery Today: Disease Models Pub Date : 2015-12-01 DOI: 10.1016/j.ddmod.2016.11.001
Nathan Marsteller , Katrine L. Bøgh , Richard E. Goodman , Michelle M. Epstein
{"title":"A review of animal models used to evaluate potential allergenicity of genetically modified organisms (GMOs)","authors":"Nathan Marsteller ,&nbsp;Katrine L. Bøgh ,&nbsp;Richard E. Goodman ,&nbsp;Michelle M. Epstein","doi":"10.1016/j.ddmod.2016.11.001","DOIUrl":"10.1016/j.ddmod.2016.11.001","url":null,"abstract":"<div><p><span><span>Food safety regulators request prediction of allergenicity for newly expressed proteins in genetically modified (GM) crops and in novel foods. Some have suggested using </span>animal models<span> to assess potential allergenicity. A variety of animal models have been used in research to evaluate sensitisation or elicitation of allergic responses. However, protocols for sensitisation and challenge, animal species and strains, diets and other environmental factors differ widely. We present a comprehensive review of published, peer-reviewed experimental animal models used for the evaluation of allergenicity of </span></span>genetically modified organisms (GMOs).</p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":"17 ","pages":"Pages 81-88"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2016.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76469179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Epithelial models to study food allergen-induced barrier disruption and immune activation 研究食物过敏原诱导的屏障破坏和免疫激活的上皮模型
Drug Discovery Today: Disease Models Pub Date : 2015-12-01 DOI: 10.1016/j.ddmod.2016.09.002
Marija Gavrovic-Jankulovic , Linette E.M. Willemsen
{"title":"Epithelial models to study food allergen-induced barrier disruption and immune activation","authors":"Marija Gavrovic-Jankulovic ,&nbsp;Linette E.M. Willemsen","doi":"10.1016/j.ddmod.2016.09.002","DOIUrl":"10.1016/j.ddmod.2016.09.002","url":null,"abstract":"<div><p>Changes in lifestyle, diet and environmental factors in westernized countries correspond with the rise in non-communicable diseases affecting metabolic and immune disorders, such as allergies. Therefore the mechanisms by which environmental factors and allergens are capable of elicitating allergic sensitization need to be further unraveled. <em>In vitro</em><span> models using human epithelial cells, with or without immune cells<span><span>, are needed to achieve this purpose. Epithelial cells cover mucosal surfaces and provide a barrier between the external and internal environment. In mucosal tissues such as the respiratory and gastro-intestinal tract, epithelial cells not only contribute to barrier integrity but also actively regulate dendritic cell function and adaptive immune responses and can support tolerance induction or allergic sensitization. Certain allergens contain protease activity which may facilitate them to cross the barrier, others are transported via </span>transcytosis. In addition, certain allergens may provoke epithelial activation resulting in production of T</span></span><sub>H</sub><span>2 driving immune mediators. Preserving epithelial homeostasis is important to suppress allergic sensitization. This review describes </span><em>in vitro</em><span> models of human intestinal epithelial cells and co-culture models that are currently available to determine barrier disruption or immune activation induced by food allergens. These can be used for future development of </span><em>in vitro</em> models to study the contribution of intestinal epithelial cells in allergic sensitization and to identify sensitizing properties of novel proteins.</p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":"17 ","pages":"Pages 29-36"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2016.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89652213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Static and dynamic in vitro digestion models to study protein stability in the gastrointestinal tract 静态和动态体外消化模型研究蛋白质在胃肠道中的稳定性
Drug Discovery Today: Disease Models Pub Date : 2015-12-01 DOI: 10.1016/j.ddmod.2016.06.002
Didier Dupont , Alan R. Mackie
{"title":"Static and dynamic in vitro digestion models to study protein stability in the gastrointestinal tract","authors":"Didier Dupont ,&nbsp;Alan R. Mackie","doi":"10.1016/j.ddmod.2016.06.002","DOIUrl":"10.1016/j.ddmod.2016.06.002","url":null,"abstract":"<div><p><span><span>Food protein allergenicity has been linked to the survival of the allergen in the </span>gastrointestinal tract. Therefore, </span><em>in vitro</em> digestion models have been widely used as tools to help predicting allergenicity. A huge diversity of static <em>in vitro</em> digestion models based on different experimental conditions have been proposed in the literature making the comparison between studies impossible. For this reason, an internationally harmonized static model has recently been developed. Dynamic <em>in vitro</em> digestion models are complex but more physiologically relevant and could represent an excellent alternative to study allergenic food digestion. Overall, these models have shown that the ability of a protein to survive in the gastrointestinal tract highly depends on whether the protein is pure or embedded into a complex food matrix.</p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":"17 ","pages":"Pages 23-27"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2016.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83995207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
In silico tools for exploring potential human allergy to proteins 用于探索人类对蛋白质潜在过敏的计算机工具
Drug Discovery Today: Disease Models Pub Date : 2015-12-01 DOI: 10.1016/j.ddmod.2016.06.001
Maria Hayes , Pierre Rougé , Annick Barre , Corinne Herouet-Guicheney , Erwin L. Roggen
{"title":"In silico tools for exploring potential human allergy to proteins","authors":"Maria Hayes ,&nbsp;Pierre Rougé ,&nbsp;Annick Barre ,&nbsp;Corinne Herouet-Guicheney ,&nbsp;Erwin L. Roggen","doi":"10.1016/j.ddmod.2016.06.001","DOIUrl":"10.1016/j.ddmod.2016.06.001","url":null,"abstract":"<div><p>Bioinformatics can help scientists to develop hypotheses about proteins that may need to be tested further for risks of causing allergy. <em>In silico</em><span><span> methodologies and tools like databases and comparison software, play an important role in the assessment of protein allergenicity and allergenicity mechanisms. They can identify whether a novel protein is an existing allergen and/or has the potential to cross-react with an existing allergen. They cannot identify whether a novel protein will ‘become’ an allergen. AllergenOnline is the tool currently used for the safety assessment of novel proteins, but other tools are also available including the Structural Database of Allergenic Proteins (SDAP) and AllerTOP. Information concerning PeptideRanker, as well as the Hydrophobic Cluster Analysis (HCA) method used for identifying IgE-binding epitopes in </span>food allergens is discussed.</span></p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":"17 ","pages":"Pages 3-11"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2016.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74486774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
The use of animal models to discover immunological mechanisms underpinning sensitization to food allergens 利用动物模型发现对食物过敏原致敏的免疫机制
Drug Discovery Today: Disease Models Pub Date : 2015-12-01 DOI: 10.1016/j.ddmod.2016.09.001
Joost J. Smit , Mario Noti , Liam O’Mahony
{"title":"The use of animal models to discover immunological mechanisms underpinning sensitization to food allergens","authors":"Joost J. Smit ,&nbsp;Mario Noti ,&nbsp;Liam O’Mahony","doi":"10.1016/j.ddmod.2016.09.001","DOIUrl":"10.1016/j.ddmod.2016.09.001","url":null,"abstract":"<div><p>In almost all countries, food allergy<span><span> is of growing concern affecting all age groups. Given the increased prevalence of food allergies, current research focuses on developing new treatment strategies and to predict allergenicity of novel and modified food proteins. The recent use of </span>animal models has significantly contributed to a better understanding of the complex immunological and pathophysiological mechanisms of food allergies. Central to the development of food allergy is the allergic cascade driven by cells of the innate and adaptive immune system. These models can now be integrated into the risk assessment of possible allergenic proteins. In this review, we discuss the role of the immune system as a qualitative readout for the sensitizing potential and risk assessment of food proteins.</span></p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":"17 ","pages":"Pages 63-69"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2016.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73129372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Editorial and introduction by Kitty Verhoeckx, Liam O’Mahony and Michelle M. Epstein 基蒂·维霍克斯、利亚姆·奥马奥尼和米歇尔·m·爱泼斯坦的社论和引言
Drug Discovery Today: Disease Models Pub Date : 2015-12-01 DOI: 10.1016/j.ddmod.2016.11.002
{"title":"Editorial and introduction by Kitty Verhoeckx, Liam O’Mahony and Michelle M. Epstein","authors":"","doi":"10.1016/j.ddmod.2016.11.002","DOIUrl":"https://doi.org/10.1016/j.ddmod.2016.11.002","url":null,"abstract":"","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":"17 ","pages":"Pages 1-2"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2016.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138263889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applicability of epithelial models in protein permeability/transport studies and food allergy 上皮模型在蛋白质通透性/转运研究和食物过敏中的适用性
Drug Discovery Today: Disease Models Pub Date : 2015-12-01 DOI: 10.1016/j.ddmod.2016.08.002
N. Cubells-Baeza , K.C.M. Verhoeckx , C. Larre , S. Denery-Papini , M. Gavrovic-Jankulovic , A. Diaz Perales
{"title":"Applicability of epithelial models in protein permeability/transport studies and food allergy","authors":"N. Cubells-Baeza ,&nbsp;K.C.M. Verhoeckx ,&nbsp;C. Larre ,&nbsp;S. Denery-Papini ,&nbsp;M. Gavrovic-Jankulovic ,&nbsp;A. Diaz Perales","doi":"10.1016/j.ddmod.2016.08.002","DOIUrl":"10.1016/j.ddmod.2016.08.002","url":null,"abstract":"<div><p>Measurement of protein transport<span> across the intestinal barrier<span> might be a relevant approach in allergenicity risk assessment. Traditionally, studies on protein transport, were performed using stable cell lines cultured as a monolayer. One of the major advantages of these models is their relatively low price and easy handling. However, monolayers lack a physiologically relevant environment (presence of other cell-types and a mucus layer), which may have an effect on transport characteristics and thus correct prediction of protein allergenicity. This paper summarizes the most widely used epithelial models and discusses their benefits and limitations for measuring protein transport and allergic sensitization to food.</span></span></p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":"17 ","pages":"Pages 13-21"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2016.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87270521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Contents page 内容页面
Drug Discovery Today: Disease Models Pub Date : 2015-12-01 DOI: 10.1016/S1740-6757(16)30014-7
{"title":"Contents page","authors":"","doi":"10.1016/S1740-6757(16)30014-7","DOIUrl":"https://doi.org/10.1016/S1740-6757(16)30014-7","url":null,"abstract":"","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":"17 ","pages":"Page i"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1740-6757(16)30014-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138263886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-IgE mediated food allergy 非ige介导的食物过敏
Drug Discovery Today: Disease Models Pub Date : 2015-12-01 DOI: 10.1016/j.ddmod.2016.09.003
Daniel Lozano-Ojalvo , Guillaume Lezmi , Naima Cortes-Perez , Karine Adel-Patient
{"title":"Non-IgE mediated food allergy","authors":"Daniel Lozano-Ojalvo ,&nbsp;Guillaume Lezmi ,&nbsp;Naima Cortes-Perez ,&nbsp;Karine Adel-Patient","doi":"10.1016/j.ddmod.2016.09.003","DOIUrl":"10.1016/j.ddmod.2016.09.003","url":null,"abstract":"<div><p><span>Non-IgE-mediated food allergies<span><span> (FA) are highly prevalent within food allergic patients, notably in the first years of life. The most prevalent non-IgE FA are mainly induced by cow's milk and soya, but many other foods can be involved. Non-IgE FA encompass a wide range of immune-related disorders that differ in prevalence, clinical manifestation, and </span>pathophysiology. Although some </span></span><em>in vivo</em> models have been developed for their study, further investigations are needed to fully delineate the pathogenic mechanisms involved.</p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":"17 ","pages":"Pages 45-53"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2016.09.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78540312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Influence of microbiome and diet on immune responses in food allergy models 食物过敏模型中微生物组和饮食对免疫反应的影响
Drug Discovery Today: Disease Models Pub Date : 2015-12-01 DOI: 10.1016/j.ddmod.2016.06.003
Weronika Barcik , Eva Untersmayr , Isabella Pali-Schöll , Liam O’Mahony , Remo Frei
{"title":"Influence of microbiome and diet on immune responses in food allergy models","authors":"Weronika Barcik ,&nbsp;Eva Untersmayr ,&nbsp;Isabella Pali-Schöll ,&nbsp;Liam O’Mahony ,&nbsp;Remo Frei","doi":"10.1016/j.ddmod.2016.06.003","DOIUrl":"10.1016/j.ddmod.2016.06.003","url":null,"abstract":"<div><p><span>The intestinal immune system is intimately connected with the vast array of microbes present within the gut and the diversity of food components that are consumed daily. The discovery of novel molecular mechanisms, which mediate host–microbe–nutrient communication, have highlighted the important roles played by microbes and dietary factors in influencing mucosal inflammatory and allergic responses. In this review, we summarize the recent important findings in this field, which are important for </span>food allergy<span> and particularly relevant to animal models of food allergy.</span></p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":"17 ","pages":"Pages 71-80"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2016.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36278543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
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