Non-IgE mediated food allergy

Q3 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Disease Models Pub Date : 2015-12-01 DOI:10.1016/j.ddmod.2016.09.003

Daniel Lozano-Ojalvo , Guillaume Lezmi , Naima Cortes-Perez , Karine Adel-Patient

引用次数: 2

Abstract

Non-IgE-mediated food allergies (FA) are highly prevalent within food allergic patients, notably in the first years of life. The most prevalent non-IgE FA are mainly induced by cow's milk and soya, but many other foods can be involved. Non-IgE FA encompass a wide range of immune-related disorders that differ in prevalence, clinical manifestation, and pathophysiology. Although some in vivo models have been developed for their study, further investigations are needed to fully delineate the pathogenic mechanisms involved.

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非ige介导的食物过敏

非ige介导的食物过敏(FA)在食物过敏患者中非常普遍，特别是在生命的头几年。最普遍的非ige FA主要由牛奶和大豆引起，但许多其他食物也可能涉及。非ige FA涵盖了广泛的免疫相关疾病，在患病率、临床表现和病理生理学上有所不同。虽然已经建立了一些体内模型进行研究，但需要进一步的研究来充分描述所涉及的致病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.