{"title":"对欧洲非人类灵长类动物试验的意见","authors":"Michelle M. Epstein , Theo Vermeire","doi":"10.1016/j.ddmod.2017.09.001","DOIUrl":null,"url":null,"abstract":"<div><p>The Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) responded to a mandate from the European Commission on ‘The need for non-human primates in biomedical research, production and testing of products and devices’. An overview of this Opinion is presented. The Opinion focuses on the approaches aimed at the replacement, reduction and refinement (3Rs) of the use of non-human primates in scientific experimentation in the areas of 1) development and safety testing of pharmaceuticals and medical devices, 2) treatment and prevention of infectious diseases, 3) neuroscience, 4) ophthalmology and 5) (xeno)transplantation. While it is not possible to predict how long it will be before the use of NHPs in Europe are phased-out, the Opinion summarizes the research gaps and provides recommendations such as alternative methods, training, improvement of techniques and protocols, sharing of knowledge and removal of barriers. Finally, research needs are given.</p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2017.09.001","citationCount":"3","resultStr":"{\"title\":\"An Opinion on non-human primates testing in Europe\",\"authors\":\"Michelle M. Epstein , Theo Vermeire\",\"doi\":\"10.1016/j.ddmod.2017.09.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) responded to a mandate from the European Commission on ‘The need for non-human primates in biomedical research, production and testing of products and devices’. An overview of this Opinion is presented. The Opinion focuses on the approaches aimed at the replacement, reduction and refinement (3Rs) of the use of non-human primates in scientific experimentation in the areas of 1) development and safety testing of pharmaceuticals and medical devices, 2) treatment and prevention of infectious diseases, 3) neuroscience, 4) ophthalmology and 5) (xeno)transplantation. While it is not possible to predict how long it will be before the use of NHPs in Europe are phased-out, the Opinion summarizes the research gaps and provides recommendations such as alternative methods, training, improvement of techniques and protocols, sharing of knowledge and removal of barriers. Finally, research needs are given.</p></div>\",\"PeriodicalId\":39774,\"journal\":{\"name\":\"Drug Discovery Today: Disease Models\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ddmod.2017.09.001\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Discovery Today: Disease Models\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1740675717300427\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today: Disease Models","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740675717300427","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
An Opinion on non-human primates testing in Europe
The Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) responded to a mandate from the European Commission on ‘The need for non-human primates in biomedical research, production and testing of products and devices’. An overview of this Opinion is presented. The Opinion focuses on the approaches aimed at the replacement, reduction and refinement (3Rs) of the use of non-human primates in scientific experimentation in the areas of 1) development and safety testing of pharmaceuticals and medical devices, 2) treatment and prevention of infectious diseases, 3) neuroscience, 4) ophthalmology and 5) (xeno)transplantation. While it is not possible to predict how long it will be before the use of NHPs in Europe are phased-out, the Opinion summarizes the research gaps and provides recommendations such as alternative methods, training, improvement of techniques and protocols, sharing of knowledge and removal of barriers. Finally, research needs are given.
期刊介绍：
Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.
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