Drug Discovery Today: Disease Models最新文献_第2页

Do herpesviruses play a role in Alzheimer’s disease pathogenesis? 疱疹病毒在阿尔茨海默病的发病机制中起作用吗?

Drug Discovery Today: Disease Models Pub Date : 2020-09-01 DOI: 10.1016/j.ddmod.2019.10.006

Mary Alice Allnutt, Steven Jacobson

{"title":"Do herpesviruses play a role in Alzheimer’s disease pathogenesis?","authors":"Mary Alice Allnutt, Steven Jacobson","doi":"10.1016/j.ddmod.2019.10.006","DOIUrl":"10.1016/j.ddmod.2019.10.006","url":null,"abstract":"<div>Recent studies have brought renewed interest to the hypothesis that infection plays a role in the pathogenesis of Alzheimer’s disease (AD). In particular, herpesviruses such as herpes simplex virus-1 (HSV-1) and human herpesvirus-6 (HHV-6) have had an extensive history of association with AD. The interplay between viral infection and a variety of neurological diseases has long been an area of interest but proving causality has been elusive. Two recent studies, Readhead et al. (2018) and Eimer et al. (2018) have again renewed the debate concerning the role of pathogens (herpesviruses) in AD. In this review, we will briefly discuss the literature in support of a herpesvirus role in AD pathogenesis and try to bridge two main observations in AD research; the ability of Aβ to aggregate with pathogens, and the detection of herpesviruses in AD brain material compared to non-AD controls. While the data linking AD and human herpesviruses suggest that these pathogens may contribute to disease progression, further work is needed to determine the significance of these observations, if any, to the etiology of the disease.</div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2019.10.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76902724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Mechanisms of neuroinflammation in epilepsy linked to HHV-6 infection 与HHV-6感染相关的癫痫神经炎症机制

Drug Discovery Today: Disease Models Pub Date : 2020-09-01 DOI: 10.1016/j.ddmod.2020.04.001

Luca Bartolini

引用次数: 1

Natalizumab related progressive multifocal leukoencephalopathy Natalizumab相关的进行性多灶性白质脑病

Drug Discovery Today: Disease Models Pub Date : 2020-09-01 DOI: 10.1016/j.ddmod.2020.02.002

Lana Zhovtis Ryerson , Eugene O. Major

引用次数: 0

Epstein-Barr virus infection in the development of neurological disorders 爱泼斯坦-巴尔病毒感染发展成神经系统疾病

Drug Discovery Today: Disease Models Pub Date : 2020-09-01 DOI: 10.1016/j.ddmod.2020.01.001

Samantha S. Soldan, Paul M. Lieberman

{"title":"Epstein-Barr virus infection in the development of neurological disorders","authors":"Samantha S. Soldan, Paul M. Lieberman","doi":"10.1016/j.ddmod.2020.01.001","DOIUrl":"10.1016/j.ddmod.2020.01.001","url":null,"abstract":"<div>Epstein-Barr Virus (EBV) is a ubiquitous human herpesvirus that contributes to the etiology of diverse human cancers and auto-immune diseases. EBV establishes a relatively benign, long-term latent infection in over 90 percent of the adult population. Yet, it also increases risk for certain cancers and auto-immune disorders depending on complex viral, host, and environmental factors that are only partly understood. EBV latent infection is found predominantly in memory B cells, but the natural infection cycle and pathological aberrations enable EBV to infect numerous other cell types, including oral, nasopharyngeal, and gastric epithelia, B-, T-, and NK-lymphoid cells, myocytes, adipocytes, astrocytes, and neurons. EBV infected cells, free virus, and gene products can also be found in the CNS. In addition to the direct effects of EBV on infected cells and tissue, the effect of chronic EBV infection on the immune system is also thought to contribute to pathogenesis, especially auto-immune disease. Here, we review properties of EBV infection that may shed light on its potential pathogenic role in neurological disorders.</div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2020.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38828256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

In vitro models of HIV-1 infection of the central nervous system HIV-1感染中枢神经系统的体外模型

Drug Discovery Today: Disease Models Pub Date : 2020-09-01 DOI: 10.1016/j.ddmod.2019.10.007

Celeste Faia , Karlie Plaisance-Bonstaff , Francesca Peruzzi

引用次数: 3

Viral infections and multiple sclerosis 病毒感染和多发性硬化

Drug Discovery Today: Disease Models Pub Date : 2020-09-01 DOI: 10.1016/j.ddmod.2020.02.003

Donatella Donati

{"title":"Viral infections and multiple sclerosis","authors":"Donatella Donati","doi":"10.1016/j.ddmod.2020.02.003","DOIUrl":"10.1016/j.ddmod.2020.02.003","url":null,"abstract":"<div>The etiology and pathogenesis of MS is likely to involve multiple factors interacting with each other, and the role of infectious and viral agents is still under debate, however a consistent amount of studies suggests that some viruses are associated with the disease. The strongest documentation has come from the detection of viral nucleic acid or antigen or of an anti-viral antibody response in MS patients. A further step for the study of the mechanism viruses might be involved in can be made using in vitro and in vivo models. While in vitro models, based on glial and neural cell lines from various sources are widely used, in vivo animal models present challenges. Indeed neurotropic animal viruses are currently used to study demyelination in well-established models, but animal models of demyelination by human virus infection have only recently been developed, using animal gammaherpesviruses closely related to Epstein Barr virus (EBV), or using marmosets expressing the specific viral receptor for Human Herpesvirus 6 (HHV-6). The present review will illustrate the main potential mechanisms of MS pathogenesis possibly associated with viral infections and viruses currently used to study demyelination in animal models. Then the viruses most strongly linked with MS will be discussed, in the perspective that more than one virus might have a role, with varying degrees of interaction, contributing to MS heterogeneity.</div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2020.02.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37835335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Models of rare diseases 罕见病模型

Drug Discovery Today: Disease Models Pub Date : 2020-06-01 DOI: 10.1016/j.ddmod.2020.02.001

Daniela Braconi, Annalisa Santucci

引用次数: 1

Cell and tissue models of alkaptonuria 尿酸钠的细胞和组织模型

Drug Discovery Today: Disease Models Pub Date : 2020-06-01 DOI: 10.1016/j.ddmod.2019.12.001

Daniela Braconi, Lia Millucci, Ottavia Spiga, Annalisa Santucci

引用次数: 3

The complexity of Rett syndrome models: Primary fibroblasts as a disease-in-a-dish reliable approach Rett综合征模型的复杂性:原代成纤维细胞作为盘中疾病的可靠方法

Drug Discovery Today: Disease Models Pub Date : 2020-06-01 DOI: 10.1016/j.ddmod.2019.11.001

Valeria Cordone , Alessandra Pecorelli , Fernanda Amicarelli , Joussef Hayek , Giuseppe Valacchi

{"title":"The complexity of Rett syndrome models: Primary fibroblasts as a disease-in-a-dish reliable approach","authors":"Valeria Cordone , Alessandra Pecorelli , Fernanda Amicarelli , Joussef Hayek , Giuseppe Valacchi","doi":"10.1016/j.ddmod.2019.11.001","DOIUrl":"10.1016/j.ddmod.2019.11.001","url":null,"abstract":"<div>Rett syndrome (RTT) is a progressive neurodevelopmental disease, which affects almost exclusively the female gender (prevalence of about 1:10,000). RTT symptoms are usually characterized by loss of purposeful hand skills, mental retardation and motor impairment, resulting in a plethora of other systemic co-morbidities. Mutations in the methyl-CpG binding protein 2 gene (MECP2) are the main genetic cause of the disorder, however molecular mechanisms leading from MeCP2 defects to this complicated pathology still need to be clarified. To investigate this and other aspects of RTT, several experimental models have been generated that include animal models, and in vitro approaches. In this article we briefly summarized the main models used for RTT investigations, and special focus is given to the use of primary fibroblasts isolated from RTT patients, since they represent a reliable disease-in-a-dish model, which can help researcher to elucidate cellular and molecular mechanisms of this disease.</div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2019.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72446612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Chediak-Higashi syndrome: A review of the past, present, and future Chediak-Higashi综合征:回顾过去，现在和未来

Drug Discovery Today: Disease Models Pub Date : 2020-06-01 DOI: 10.1016/j.ddmod.2019.10.008

Prashant Sharma , Elena-Raluca Nicoli , Jenny Serra-Vinardell , Marie Morimoto , Camilo Toro , May Christine V. Malicdan , Wendy J. Introne

{"title":"Chediak-Higashi syndrome: A review of the past, present, and future","authors":"Prashant Sharma , Elena-Raluca Nicoli , Jenny Serra-Vinardell , Marie Morimoto , Camilo Toro , May Christine V. Malicdan , Wendy J. Introne","doi":"10.1016/j.ddmod.2019.10.008","DOIUrl":"10.1016/j.ddmod.2019.10.008","url":null,"abstract":"<div>Since the initial description of Chediak-Higashi syndrome (CHS), over 75 years ago, several studies have been conducted to underscore the role of the lysosomal trafficking regulator (LYST) gene in the pathogenesis of disease. CHS is a rare autosomal recessive disorder, which is caused by biallelic mutations in the highly conserved LYST gene. The disease is characterized by partial oculocutaneous albinism, prolonged bleeding, immune and neurologic dysfunction, and risk for the development of hemophagocytic lympohistiocytosis (HLH). The presence of giant secretory granules in leukocytes is the classical diagnostic feature, which distinguishes CHS from closely related Griscelli and Hermansky-Pudlak syndromes. While the exact mechanism of the formation of the giant granules in CHS patients is not understood, dysregulation of LYST function in regulating lysosomal biogenesis has been proposed to play a role. In this review, we discuss the clinical characteristics of the disease and highlight the functional consequences of enlarged lysosomes and lysosome-related organelles (LROs) in CHS.</div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2019.10.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39151418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23