HIV-1感染中枢神经系统的体外模型

Q3 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Disease Models Pub Date : 2020-09-01 DOI:10.1016/j.ddmod.2019.10.007

Celeste Faia , Karlie Plaisance-Bonstaff , Francesca Peruzzi

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引用次数: 3

摘要

与HIV-1感染相关的神经认知障碍影响了一半以上接受抗逆转录病毒治疗的HIV感染者。了解神经功能障碍的分子机制和复杂的细胞网络通讯对于开发有效的治疗方法至关重要。与其他神经系统疾病一样，研究艾滋病毒感染大脑的挑战包括获得临床样本的机会有限，以及在细胞和动物模型中适当再现大脑网络的复杂性。本综述的重点是用于研究与HIV感染相关的神经功能障碍的各个方面的细胞模型。

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In vitro models of HIV-1 infection of the central nervous system

Neurocognitive disorders associated with HIV-1 infection affect more than half of persons living with HIV (PLWH) under retroviral therapy. Understanding the molecular mechanisms and the complex cellular network communication underlying neurological dysfunction is critical for the development of an effective therapy. As with other neurological disorders, challenges to studying HIV infection of the brain include limited access to clinical samples and proper reproducibility of the complexity of brain networks in cellular and animal models. This review focuses on cellular models used to investigate various aspects of neurological dysfunction associated with HIV infection.

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来源期刊

Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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发文量

期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.