Natalizumab相关的进行性多灶性白质脑病

Q3 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Disease Models Pub Date : 2020-09-01 DOI:10.1016/j.ddmod.2020.02.002

Lana Zhovtis Ryerson , Eugene O. Major

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引用次数: 0

摘要

进行性多灶性脑白质病(PML)是一种由JC病毒引起的机会性脑感染。它通常发生在患有潜在疾病的患者和用于治疗抑制正常免疫系统功能的疾病的疗法中。例如，使用natalizumab治疗的多发性硬化症患者已被确定有PML的风险。近年来，这一严重的不良事件对提高对PML发病机制、生物标志物和患者管理的认识具有重要的指导意义。

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Natalizumab related progressive multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML), is an opportunistic brain infection that is caused by the JC virus. It usually occurs in patients with an underlying disease and therapies used to treat such diseases that inhibit normal immune system function. For example, multiple sclerosis patients treated with natalizumab have been identified at risk for PML. This serious adverse event has been very instructive in improving understanding of PML pathogenesis, biomarkers and patient management with this disease in recent years.

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来源期刊

Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.