{"title":"Mechanisms of neuroinflammation in epilepsy linked to HHV-6 infection","authors":"Luca Bartolini","doi":"10.1016/j.ddmod.2020.04.001","DOIUrl":null,"url":null,"abstract":"<div><p><span>Over the past decade there has been growing interest in elucidating the role of neuroinflammation in seizure generation. Several </span>preclinical studies<span> have revealed that infection with neurotropic viruses such as HHV-6 can trigger an inflammatory cascade involving infected CNS cells. These findings are corroborated by clinical studies, that have shown an association with HHV-6 infection and different epilepsy syndromes and have detected HHV-6 viral DNA<span> in saliva, blood, CSF and resected epileptogenic tissue from children and adults with seizures and chronic epilepsy.</span></span></p><p>In this focused review we will analyze main clinical associations that link HHV-6 infection with seizures and proposed pathogenic mechanisms by which infection with HHV-6 can lead to a proinflammatory milieu contributing to seizure generation and in some instances later development of epilepsy.</p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2020.04.001","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today: Disease Models","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740675720300062","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 1
Abstract
Over the past decade there has been growing interest in elucidating the role of neuroinflammation in seizure generation. Several preclinical studies have revealed that infection with neurotropic viruses such as HHV-6 can trigger an inflammatory cascade involving infected CNS cells. These findings are corroborated by clinical studies, that have shown an association with HHV-6 infection and different epilepsy syndromes and have detected HHV-6 viral DNA in saliva, blood, CSF and resected epileptogenic tissue from children and adults with seizures and chronic epilepsy.
In this focused review we will analyze main clinical associations that link HHV-6 infection with seizures and proposed pathogenic mechanisms by which infection with HHV-6 can lead to a proinflammatory milieu contributing to seizure generation and in some instances later development of epilepsy.
期刊介绍：
Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.
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