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Pharmacological Approaches to Nonalcoholic Fatty Liver Disease: Current and Future Therapies 非酒精性脂肪肝的药物治疗方法：当前和未来的疗法
Diabetes Spectrum Pub Date : 2024-02-01 DOI: 10.2337/dsi23-0012
I. Genua, Kenneth Cusi
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引用次数: 3
A Sincere Thank You to the Reviewers of Diabetes Spectrum 衷心感谢《糖尿病谱》的审稿人
Diabetes Spectrum Pub Date : 2024-02-01 DOI: 10.2337/ds24-en01
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引用次数: 0
A Sincere Thank You to the Reviewers of Diabetes Spectrum 衷心感谢《糖尿病谱》的审稿人
Diabetes Spectrum Pub Date : 2024-02-01 DOI: 10.2337/ds24-en01
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引用次数: 0
About Kenneth Cusi: Guest Editor 关于肯尼斯-库西：客座编辑
Diabetes Spectrum Pub Date : 2024-02-01 DOI: 10.2337/ds24-ge01
{"title":"About Kenneth Cusi: Guest Editor","authors":"","doi":"10.2337/ds24-ge01","DOIUrl":"https://doi.org/10.2337/ds24-ge01","url":null,"abstract":"","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139813779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding the Burden of Nonalcoholic Fatty Liver Disease: Time for Action 了解非酒精性脂肪肝的负担：行动起来
Diabetes Spectrum Pub Date : 2024-02-01 DOI: 10.2337/dsi23-0010
Z. Younossi, Linda Henry
{"title":"Understanding the Burden of Nonalcoholic Fatty Liver Disease: Time for Action","authors":"Z. Younossi, Linda Henry","doi":"10.2337/dsi23-0010","DOIUrl":"https://doi.org/10.2337/dsi23-0010","url":null,"abstract":"The prevalence of nonalcoholic fatty liver disease (NAFLD) in the United States is 38%, having increased by 50% within the past 3 decades. The estimated NAFLD prevalence among people with type 2 diabetes is 55–70%. The presence of type 2 diabetes is associated with a higher likelihood of progression of NAFLD to fibrosis development, liver transplant, and death. Cardiovascular disease is the main cause of mortality among people with NAFLD, and the risk of death is significantly higher in people with both NAFLD and type 2 diabetes. NAFLD carries high patient and economic burdens but low awareness among both the general public and health care providers. This article reviews the epidemiology of NAFLD and discusses the need for appropriate risk stratification, referral for specialty care, management of cardiometabolic risk factors, and treatment of the disease. The authors present a call to action to raise awareness of NAFLD and address its increasing burden in a systematic and efficient manner.","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139818425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Making Sense of the Nonalcoholic Fatty Liver Disease Clinical Practice Guidelines: What Clinicians Need to Know 解读《非酒精性脂肪肝临床实践指南》：临床医生须知
Diabetes Spectrum Pub Date : 2024-02-01 DOI: 10.2337/dsi23-0014
Kenneth Cusi, Jeff Budd, Eric Johnson, Jay H. Shubrook
{"title":"Making Sense of the Nonalcoholic Fatty Liver Disease Clinical Practice Guidelines: What Clinicians Need to Know","authors":"Kenneth Cusi, Jeff Budd, Eric Johnson, Jay H. Shubrook","doi":"10.2337/dsi23-0014","DOIUrl":"https://doi.org/10.2337/dsi23-0014","url":null,"abstract":"Standards of care summarized in clinical practice guidelines for nonalcoholic fatty liver disease (NAFLD) offer clinicians a streamlined diagnostic and management approach based on the best available evidence. These recommendations have changed a great deal in recent years; today, there is a clear focus on screening for the early identification and risk stratification of patients at high risk of steatohepatitis and clinically significant fibrosis to promote timely referrals to specialty care when needed. This article reviews and provides the rationale for current guidelines for NAFLD screening, diagnosis, treatment, and monitoring and addresses barriers to providing evidence-based NAFLD care and how to overcome them. The current paradigm of care calls for primary care clinicians and specialists to work together, within a multidisciplinary care team familiar with obesity and diabetes care, to provide comprehensive management of these complex patients.","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139832039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Understanding the Burden of Nonalcoholic Fatty Liver Disease: Time for Action 了解非酒精性脂肪肝的负担：行动起来
Diabetes Spectrum Pub Date : 2024-02-01 DOI: 10.2337/dsi23-0010
Z. Younossi, Linda Henry
{"title":"Understanding the Burden of Nonalcoholic Fatty Liver Disease: Time for Action","authors":"Z. Younossi, Linda Henry","doi":"10.2337/dsi23-0010","DOIUrl":"https://doi.org/10.2337/dsi23-0010","url":null,"abstract":"The prevalence of nonalcoholic fatty liver disease (NAFLD) in the United States is 38%, having increased by 50% within the past 3 decades. The estimated NAFLD prevalence among people with type 2 diabetes is 55–70%. The presence of type 2 diabetes is associated with a higher likelihood of progression of NAFLD to fibrosis development, liver transplant, and death. Cardiovascular disease is the main cause of mortality among people with NAFLD, and the risk of death is significantly higher in people with both NAFLD and type 2 diabetes. NAFLD carries high patient and economic burdens but low awareness among both the general public and health care providers. This article reviews the epidemiology of NAFLD and discusses the need for appropriate risk stratification, referral for specialty care, management of cardiometabolic risk factors, and treatment of the disease. The authors present a call to action to raise awareness of NAFLD and address its increasing burden in a systematic and efficient manner.","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139878407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Project ECHO for Diabetes Improves Primary Care Providers’ Comfort With and Use of Diabetes Medications and Technology 糖尿病 ECHO 项目提高初级保健提供者对糖尿病药物和技术的舒适度和使用率
Diabetes Spectrum Pub Date : 2024-01-26 DOI: 10.2337/ds23-0050
Nicole Ehrhardt, Celeste C. Thomas, Tracy Zou, Ana Gabriela Vasconcelos, Matt Bouchonville
{"title":"Project ECHO for Diabetes Improves Primary Care Providers’ Comfort With and Use of Diabetes Medications and Technology","authors":"Nicole Ehrhardt, Celeste C. Thomas, Tracy Zou, Ana Gabriela Vasconcelos, Matt Bouchonville","doi":"10.2337/ds23-0050","DOIUrl":"https://doi.org/10.2337/ds23-0050","url":null,"abstract":"","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139594643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role and Perspective of Certified Diabetes Care and Education Specialists in the Development of the 4T Program 认证糖尿病护理和教育专家在制定 4T 计划中的作用和观点
Diabetes Spectrum Pub Date : 2024-01-19 DOI: 10.2337/ds23-0010
Jeannine Leverenz, Brianna Leverenz, Priya Prahalad, Franziska K. Bishop, Piper Sagan, Anjoli Martinez-Singh, Barry Conrad, Annette Chmielewski, Julianne Senaldi, D. Scheinker, David M. Maahs
{"title":"Role and Perspective of Certified Diabetes Care and Education Specialists in the Development of the 4T Program","authors":"Jeannine Leverenz, Brianna Leverenz, Priya Prahalad, Franziska K. Bishop, Piper Sagan, Anjoli Martinez-Singh, Barry Conrad, Annette Chmielewski, Julianne Senaldi, D. Scheinker, David M. Maahs","doi":"10.2337/ds23-0010","DOIUrl":"https://doi.org/10.2337/ds23-0010","url":null,"abstract":"","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139526080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycemic Management in Insulin Naive Patients in the Inpatient Setting 住院环境中胰岛素无效患者的血糖管理
Diabetes Spectrum Pub Date : 2024-01-18 DOI: 10.2337/ds23-0007
M. Goldstein, Shahidul Islam, Sophie Nicolich-Henkin, Lauren Bellavia, Stanislaw Klek
{"title":"Glycemic Management in Insulin Naive Patients in the Inpatient Setting","authors":"M. Goldstein, Shahidul Islam, Sophie Nicolich-Henkin, Lauren Bellavia, Stanislaw Klek","doi":"10.2337/ds23-0007","DOIUrl":"https://doi.org/10.2337/ds23-0007","url":null,"abstract":"\u0000 \u0000 The ideal inpatient insulin regimen efficiently attains the target blood glucose range, effectively treats hyperglycemia, and minimizes the risk of hypoglycemia. The objective of this study was to compare glycemic targets achieved by using correctional monotherapy (CM) and basal-bolus therapy (BBT) in insulin-naive patients in the inpatient setting to determine optimal blood glucose management for these patients.\u0000 \u0000 \u0000 \u0000 This was a retrospective observational cohort study of 792 patients with diabetes not on home insulin therapy who were admitted to an academic hospital over a 5.5-month period. The percentage of hyperglycemic and hypoglycemic values in each group were compared.\u0000 \u0000 \u0000 \u0000 Among the 3,112 measured blood glucose values obtained from 792 patients within the first 24 hours of insulin administration, 28.5% were hyperglycemic in the BBT group compared with 23.5% in the CM group. When adjusted for covariates, there was a 23% decrease in hyperglycemia in the BBT group (incidence rate ratio = 0.77, 95% CI 0.64–0.95, P = 0.006). Increases in A1C and admission blood glucose, as well as decreases in admission creatinine and inpatient steroid use, were independently associated with higher rates of hyperglycemia, adjusted for all other covariates. There was no significant difference between the groups in the rate of hypoglycemia, which was 1.9% in the BBT group and 1.4% in the CM group (P = 0.301).\u0000 \u0000 \u0000 \u0000 Utilizing BBT in insulin-naive patients admitted to the hospital within the first 24 hours of insulin administration results in lower rates of hyperglycemia without higher rates of hypoglycemia when compared with CM.\u0000","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139616116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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