Horizonte Médico (Lima)最新文献

{"title":"Cáncer de mama y mutación del gen ataxia telangiectasia: reporte de caso","authors":"Óscar Alejandro Bonilla Sepúlveda","doi":"10.24265/horizmed.2023.v23n1.11","DOIUrl":"https://doi.org/10.24265/horizmed.2023.v23n1.11","url":null,"abstract":"Among women, breast cancer is the most common cancer in the world, accounting for 25.7 % of all cancers and thus making it a topic of interest in public health. Breast cancer is a complex, heterogeneous genetic disease and, in the vast majority of cases, of unknown etiology. Around 7 % of breast cancer cases in the general population present a susceptibility gene mutation of Mendelian inheritance. The ataxia telangiectasia mutated (ATM) gene mutation is found in less than 1 % of the general population, and association studies conducted with controls have shown that these alleles are characterized by a moderate risk (RR: 2 ‐ 4) for hereditary cancer. Mutations in ATM incompletely cosegregate the disease, with an estimated 15 % of mutation carriers in this gene developing cancer. The incomplete penetrance of ATM, as well as other moderate‐risk genes, supports that they follow a polygenic model of cancer susceptibility. We report the case of a 35‐year‐old woman diagnosed with metachronous bilateral breast carcinoma—T4b N1 M0 stage IIIB left breast and T1c N0 stage I right breast, intrinsic luminal B subtype, HER2 overexpression and pathogenic variant of ATM gene c.7913 G>A, p. Trp2638*—who was treated with neoadjuvant chemotherapy, followed by mastectomy, sentinel node biopsy and radiotherapy. The objective of this case report is to describe the clinicopathological characteristics of breast cancer and its association with moderate‐risk gene mutations","PeriodicalId":396953,"journal":{"name":"Horizonte Médico (Lima)","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126260076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factor de crecimiento nervioso en neuropatía óptica traumática","authors":"Justiniano Oseas Zea Quispe, Roberto Michael Orihuela Echavigurin, Freddy Cristóbal López Gonzales","doi":"10.24265/horizmed.2023.v23n1.09","DOIUrl":"https://doi.org/10.24265/horizmed.2023.v23n1.09","url":null,"abstract":"","PeriodicalId":396953,"journal":{"name":"Horizonte Médico (Lima)","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121511657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluación de la efectividad de la vitamina E en la esteatosis hepática no alcohólica en pacientes diabéticos tipo 2 sin fibrosis avanzada","authors":"Gonzalo Miranda Manrique","doi":"10.24265/horizmed.2023.v23n1.02","DOIUrl":"https://doi.org/10.24265/horizmed.2023.v23n1.02","url":null,"abstract":"","PeriodicalId":396953,"journal":{"name":"Horizonte Médico (Lima)","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115059226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalencia y factores de riesgo asociados a infección por virus SARS-CoV-2 en trabajadores del Instituto Nacional de Salud del Niño de Perú, abril 2020 a marzo 2021","authors":"Cesar Walter Romero Ramos, V. Mamani-Urrutia, Alicia Bustamante-López, Gloria Ubillus Arriola, M. P. Tello D., María Esther Castillo Díaz, Margarita Alvarado Palacios","doi":"10.24265/horizmed.2023.v23n1.03","DOIUrl":"https://doi.org/10.24265/horizmed.2023.v23n1.03","url":null,"abstract":"Objective: To determine the prevalence and risk factors associated with SARS-CoV-2 infection among workers of Instituto Nacional de Salud del Niño (INSN) from April 2020 to March 2021. Materials and methods: A non-experimental, descriptive, cross-sectional study. The sample consisted of 608 workers who tested positive for COVID-19 using a rapid antigen test. The COVID-19 clinical-epidemiological research sheets prepared by the Ministry of Health of Peru and self-administered by the workers were reviewed. The INSN Department of Epidemiology staff verified the completion of the sheets. The data was entered into a database, which was used for the respective statistical analysis. The study was approved by the INSN Institutional Research Ethics Committee (registration code: PI-17/21). Results: COVID-19 prevalence among INSN workers was 7.24 % from April 2020 to March 2021. Out of the workers with COVID-19, Horiz Med (Lima) 2023; 23(1): e2132","PeriodicalId":396953,"journal":{"name":"Horizonte Médico (Lima)","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123349146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"El factor de transcripción nuclear NF-κB en cáncer","authors":"Franklin Aldecoa Bedoya","doi":"10.24265/horizmed.2023.v23n1.12","DOIUrl":"https://doi.org/10.24265/horizmed.2023.v23n1.12","url":null,"abstract":"","PeriodicalId":396953,"journal":{"name":"Horizonte Médico (Lima)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124425083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Riesgo cardiovascular en pacientes recuperados de COVID-19 a corto y mediano plazo: ¿qué concluye la evidencia actual?","authors":"Yelson Alejandro Picón Jaimes, German Josue Garcia Lovelo, Jessica Valentina Ellis Fritz, Antonio Luis Castro Castro, Jesus Miguel Villa Navarro, Daniela Andrea Soto Bossa, Sebastián Danilo Rojas Ortega, Tatiana Álvarez Saa, Michael Ortega Sierra","doi":"10.24265/horizmed.2023.v23n1.14","DOIUrl":"https://doi.org/10.24265/horizmed.2023.v23n1.14","url":null,"abstract":"","PeriodicalId":396953,"journal":{"name":"Horizonte Médico (Lima)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128606085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asociación entre el riesgo nutricional, estancia hospitalaria y diagnóstico médico en pacientes de un hospital del seguro social peruano","authors":"Erika Jauregui Romero, Esther Petronila García Herbozo, Jean Carlos Quispe Galvez, Carmen Fiorella Martinelli Mejía, Jose A. J. Gómez La Rosa","doi":"10.24265/horizmed.2023.v23n1.05","DOIUrl":"https://doi.org/10.24265/horizmed.2023.v23n1.05","url":null,"abstract":"Objective: To determine the association between nutritional risk, hospital stay and medical diagnosis among patients admitted at Centro Especializado de Rehabilitación Profesional (CERP) of Hospital Nacional Guillermo Almenara Irigoyen. Materials and methods: An observational retrospective longitudinal cohort study was conducted with inpatients between July 1, 2021 and February 27, 2022. The patients were followed up until they left the hospital (discharge). Individuals under 18 years of age, pregnant or puerperal women, and those whose stay was less than 24 hours were excluded. The data of interest was collected from the patients’ medical records and diet cards. The main variable was the nutritional risk, which was detected using the Nutritional Risk Screening (NRS) 2002. The secondary variables were age group, sex, hospital stay, main medical diagnosis, discharge condition and nutritional status. Data analysis was performed using the chi-square test to compare the qualitative or categorical variables, and the Student’s t-test and ANOVA for the quantitative variables. A value of p < 0.05 was considered as statistically significant. Erika Jauregui-Romero; Esther P. García-Herbozo; Jean Carlos Quispe-Galvez; Carmen Fiorella Martinelli-Mejía; Jose A. J. Gómez-La Rosa https://doi.org/10.24265/horizmed.2023.v23n1.05 INTRODUCCIÓN La desnutrición es un estado de deficiencia o desequilibrio de energía, proteína y otros nutrientes (1). Dicho estado desempeña un alto grado de relevancia durante los procesos patológicos y su evolución (2), lo que origina un aumento de 6 veces el riesgo de mortalidad en pacientes hospitalizados (3). Es así que la desnutrición es considerada un pronosticador negativo e independiente de fracaso terapéutico, lo cual incrementa los recursos y costos de la atención médica (4). Algunas de las causas o situaciones que llevan al desarrollo de esta condición son los ayunos prolongados, el inicio del soporte nutricional tardío, las interacciones fármaco-nutrientes, el inadecuado control de la ingesta y las indicaciones nutricionales, entre otras (5). El riesgo nutricional es un término acuñado hace casi 20 años que hace referencia a un grupo de pacientes hospitalizados que requieren un aporte nutricional alto debido a la severidad de su enfermedad, y que pueden desarrollar desnutrición hospitalaria o que ya está en curso (6). Hay evidencias concretas que señalan que el riesgo nutricional se asocia con la incidencia de reingreso, con una estancia hospitalaria más larga (7) y con una mayor probabilidad de muerte intrahospitalaria (8). En relación con esto, sociedades científicas como la Sociedad Europea de Nutrición Clínica y Metabólica (ESPEN) y la Sociedad Americana de Nutrición Enteral y Parenteral (ASPEN) han desarrollado herramientas de tamizaje nutricional dirigidas a identificar a los pacientes con riesgo nutricional (dentro de las primeras 24 a 48 horas de ingreso) (9). Existen diversos tipos de tamizajes nutricionales para los","PeriodicalId":396953,"journal":{"name":"Horizonte Médico (Lima)","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120979490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clima organizacional del personal de salud y satisfacción de usuarios atendidos por Servicio de Atención Móvil de Urgencia (SAMU) en el contexto COVID-19, Piura 2021","authors":"Fernanda Belén Guerra Elera, Ricardo Aldo Lama Morales, Marco Sergio Guerra Delgado, Rosario Nelly Elera Ojeda","doi":"10.24265/horizmed.2023.v23n1.04","DOIUrl":"https://doi.org/10.24265/horizmed.2023.v23n1.04","url":null,"abstract":"Objective: To determine the relationship between the organizational climate among healthcare personnel and the satisfaction of users assisted by the Mobile Emergency Care Service (SAMU) in the context of COVID-19, Piura. Material(s) and Method(s): A Likert-scale survey was administered to 80 healthcare workers to assess the organizational climate and 110 SAMU users to assess their satisfaction level and whether they met the selection criteria. The survey had one section addressed to SAMU workers and another one to SAMU users. Result(s): Out of all healthcare personnel, 51.3 % were men with an average age of 32.65 +/- 6.8 % years, and there were more registered nurses (32.50 %) than doctors (31.30 %). Out of all users, 54.5 % were men with an average age of 58.78 +/- 20.97 years, 57.3 % had no comorbidities and 84.5 % used the service once. The organizational climate and its dimensions showed healthy outcomes (96.58 +/- 3.21). Most SAMU users (51.60 %) were satisfied (57/110) while 38.20 % (42/110) were moderately satisfied and 10.20 % (11/110) showed dissatisfaction. The main hypothesis concerning the relationship between the organizational climate and the satisfaction of SAMU users (p < 0.005) was confirmed. Moreover, there was a relationship between the five dimensions and the satisfaction of users. Conclusion(s): There is a relationship between the organizational climate among SAMU healthcare workers and the satisfaction of SAMU users in Piura. The organizational climate and its dimensions, compared to the instrument developed by MINSA, showed healthy outcomes. Most patients were satisfied with the care received and the most frequent comorbidities were hypertension and type 2 diabetes mellitus.Copyright © La revista. Publicado por la Universidad de San Martin de Porres, Peru.","PeriodicalId":396953,"journal":{"name":"Horizonte Médico (Lima)","volume":"62 9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128525652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calidad de sueño en docentes en una institución educativa durante la emergencia sanitaria COVID-19, Perú, 2021","authors":"C. Sisniegas-Vergara, Selene Sayuri Díaz Huertas, Kiara Marysol Ojeda Campos","doi":"10.24265/horizmed.2023.v23n1.07","DOIUrl":"https://doi.org/10.24265/horizmed.2023.v23n1.07","url":null,"abstract":"","PeriodicalId":396953,"journal":{"name":"Horizonte Médico (Lima)","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129269282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Características y frecuencia de tuberculosis antes y durante la pandemia por COVID-19 en adultos atendidos en un centro de atención primaria, Lima-Perú, 2019-2020","authors":"Franco Calixto E., Lilian R. Pantoja S.","doi":"10.24265/horizmed.2023.v23n1.06","DOIUrl":"https://doi.org/10.24265/horizmed.2023.v23n1.06","url":null,"abstract":"","PeriodicalId":396953,"journal":{"name":"Horizonte Médico (Lima)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133005308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}