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Que devraient savoir les cliniciens au sujet de la microbiologie des pneumocoques ? 关于肺炎球菌微生物学，临床医生应该知道什么？
Journal de Pediatrie et de Puericulture Pub Date : 2024-12-01 DOI: 10.1016/S0987-7983(24)00151-8
R. Cohen , E. Varon
{"title":"Que devraient savoir les cliniciens au sujet de la microbiologie des pneumocoques ?","authors":"R. Cohen ,&nbsp;E. Varon","doi":"10.1016/S0987-7983(24)00151-8","DOIUrl":"10.1016/S0987-7983(24)00151-8","url":null,"abstract":"<div><div>Pneumococci, encapsulated Gram-positive cocci whose polysaccharidic capsule is a key factor in their virulence, are aerotolerant anaerobic micro-organisms that require specific growth conditions. <em>S. pneumoniae</em> is a transformable species with a highly plastic genome. In the nasopharynx, in contact with other streptococci such as S. <em>mitis</em> or S. <em>oralis,</em> it is the key to numerous interspecifictransfers of genetic material, contributing to capsule diversification and protein modifications, including penicillin-binding proteins (PLPs). Molecular identification methods, which are more sensitive than conventional diagnostic methods, aim to detect one or more pneumococcal-specific genes (pneumolysin, autolysin, part of the capsule, etc.). The specificity of these molecular investigation methods increases with the number of genes targeted. © 2024 The Author(s). Published by Elsevier Masson SAS.</div></div>","PeriodicalId":39683,"journal":{"name":"Journal de Pediatrie et de Puericulture","volume":"37 5","pages":"Pages 5S4-5S7"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Page de titre 标题页
Journal de Pediatrie et de Puericulture Pub Date : 2024-12-01 DOI: 10.1016/S0987-7983(24)00147-6
{"title":"Page de titre","authors":"","doi":"10.1016/S0987-7983(24)00147-6","DOIUrl":"10.1016/S0987-7983(24)00147-6","url":null,"abstract":"","PeriodicalId":39683,"journal":{"name":"Journal de Pediatrie et de Puericulture","volume":"37 5","pages":"Page i"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spectre des infections pneumococciques chez l'enfant 儿童肺炎球菌感染的光谱
Journal de Pediatrie et de Puericulture Pub Date : 2024-12-01 DOI: 10.1016/S0987-7983(24)00152-X
R. Cohen , N. Ouldali , H. Haas
{"title":"Spectre des infections pneumococciques chez l'enfant","authors":"R. Cohen ,&nbsp;N. Ouldali ,&nbsp;H. Haas","doi":"10.1016/S0987-7983(24)00152-X","DOIUrl":"10.1016/S0987-7983(24)00152-X","url":null,"abstract":"<div><div>Pneumococcal infections cover a wide range of diseases, depending on the site of infection and severity. They are classified into two categories: invasive (such as meningitis or bacteremia) and non-invasive infections (such as otitis media). In other hand, pneumococci are normal hosts of the nasopharyngeal microbiota of young children (6 months to 6 years), and over a full year almost 100% of children are carriers, with carriage favored by respiratory infections and life in the community. This article describes four of the most common pneumococcal diseases: acute otitis media, pneumonia, occult bacteremia and meningitis. © 2024 The Author(s). Published by Elsevier Masson SAS.</div></div>","PeriodicalId":39683,"journal":{"name":"Journal de Pediatrie et de Puericulture","volume":"37 5","pages":"Pages 5S8-5S11"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact de l'implémentation des vaccins conjugués à 7- puis 13-valent sur les pathologies à pneumocoque 采用7价和13价结合疫苗对肺炎球菌疾病的影响
Journal de Pediatrie et de Puericulture Pub Date : 2024-12-01 DOI: 10.1016/S0987-7983(24)00156-7
R. Cohen , N. Ouldali , A. Rybak
{"title":"Impact de l'implémentation des vaccins conjugués à 7- puis 13-valent sur les pathologies à pneumocoque","authors":"R. Cohen ,&nbsp;N. Ouldali ,&nbsp;A. Rybak","doi":"10.1016/S0987-7983(24)00156-7","DOIUrl":"10.1016/S0987-7983(24)00156-7","url":null,"abstract":"<div><div>The introduction of pneumococcal conjugate vaccines (PCV) in the early 2000s had a major impact on public health, both in terms of the incidence of infections and antibiotic prescriptions. Rapidly adopted in the USA with remarkable effectiveness, 7-valent PCV was then introduced in Europe and the UK. In France, implementation has been more gradual, and the impact of this vaccination has been less obvious due to rapid serotype replacement, despite the efficacy of the vaccine serotypes. Here, we present efficacy results for France, based on time-series studies of pneumococcal meningitis, invasive pneumococcal infections, pneumonia and pleuropneumonia, acute otitis media and invasive infections in adults.</div><div>© 2024 The Author(s). Published by Elsevier Masson SAS.</div></div>","PeriodicalId":39683,"journal":{"name":"Journal de Pediatrie et de Puericulture","volume":"37 5","pages":"Pages 5S31-5S35"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Résistance aux antibiotiques des pneumocoques 肺炎球菌抗生素耐药性
Journal de Pediatrie et de Puericulture Pub Date : 2024-12-01 DOI: 10.1016/S0987-7983(24)00155-5
R. Cohen , A. Rybak , C. Levy , S. Bonacorsi , E. Varon
{"title":"Résistance aux antibiotiques des pneumocoques","authors":"R. Cohen ,&nbsp;A. Rybak ,&nbsp;C. Levy ,&nbsp;S. Bonacorsi ,&nbsp;E. Varon","doi":"10.1016/S0987-7983(24)00155-5","DOIUrl":"10.1016/S0987-7983(24)00155-5","url":null,"abstract":"<div><div>Since the early 1990s, pneumococcal resistance to antibiotics has grown to became a major public health issue worldwide and in France. It particularly affects the most frequently carried serotypes, and varies according to disease, age, region and the β-lactam prescribed. This article describes the factors that influence antibiotic resistance, as well as the evolution of β-lactam and macrolide resistance in pneumococci isolated from the nasopharyngeal flora of children with acute otitis media.</div><div>©2024 The Author(s). Published by Elsevier Masson SAS.</div></div>","PeriodicalId":39683,"journal":{"name":"Journal de Pediatrie et de Puericulture","volume":"37 5","pages":"Pages 5S25-5S30"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comité de Rédaction 编辑委员会
Journal de Pediatrie et de Puericulture Pub Date : 2024-12-01 DOI: 10.1016/S0987-7983(24)00148-8
{"title":"Comité de Rédaction","authors":"","doi":"10.1016/S0987-7983(24)00148-8","DOIUrl":"10.1016/S0987-7983(24)00148-8","url":null,"abstract":"","PeriodicalId":39683,"journal":{"name":"Journal de Pediatrie et de Puericulture","volume":"37 5","pages":"Page ii"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intérêt de la surveillance des pneumocoques dans le microbiote rhinopharyngé 监测鼻咽微生物中肺炎球菌的重要性
Journal de Pediatrie et de Puericulture Pub Date : 2024-12-01 DOI: 10.1016/S0987-7983(24)00153-1
R. Cohen , C. Levy , N. Ouldali , S. Bonacorsi , E. Varon
{"title":"Intérêt de la surveillance des pneumocoques dans le microbiote rhinopharyngé","authors":"R. Cohen ,&nbsp;C. Levy ,&nbsp;N. Ouldali ,&nbsp;S. Bonacorsi ,&nbsp;E. Varon","doi":"10.1016/S0987-7983(24)00153-1","DOIUrl":"10.1016/S0987-7983(24)00153-1","url":null,"abstract":"<div><div>The nasopharyngeal microbiota represents a complex ecosystem made up of several hundred bacterial species, f ve of which are frequently associated with paediatric infections: <em>Streptococcus pneumoniae</em> (Sp), <em>Haemophilus influenzas</em> (Hi), <em>Moraxelle catarrhalis</em> (Mc), <em>Streptococcus pyogenes</em> and <em>Staphylococcus aureus</em> (SA), and will be discussed here.</div><div>The introduction of pneumococcal conjugate vaccines, however, represented a veritable ecological revolution in the respiratory tract microbiota, altering the carriage of pneumococci, causing vaccine serotypes to be replaced by other, less pathogenic serotypes, and reducing both invasive and non-invasive infections.</div><div>The impact of vaccination programs with conjugate vaccines, carriage in healthy children and in children with acute otitis media are reported here through a study of over 20,000 children over the past 25 years.</div><div>© 2024 The Author(s). Published by Elsevier Masson SAS.</div></div>","PeriodicalId":39683,"journal":{"name":"Journal de Pediatrie et de Puericulture","volume":"37 5","pages":"Pages 5S12-5S17"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Éditorial 社论
Journal de Pediatrie et de Puericulture Pub Date : 2024-12-01 DOI: 10.1016/S0987-7983(24)00150-6
R. Cohen , E. Varon
{"title":"Éditorial","authors":"R. Cohen ,&nbsp;E. Varon","doi":"10.1016/S0987-7983(24)00150-6","DOIUrl":"10.1016/S0987-7983(24)00150-6","url":null,"abstract":"","PeriodicalId":39683,"journal":{"name":"Journal de Pediatrie et de Puericulture","volume":"37 5","pages":"Pages 5S1-5S3"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spectre potentiel d'activité des nouveaux vaccins contre le pneumocoque 新肺炎球菌疫苗的潜在效力
Journal de Pediatrie et de Puericulture Pub Date : 2024-12-01 DOI: 10.1016/S0987-7983(24)00158-0
R. Cohen , C. Levy , E. Varon
{"title":"Spectre potentiel d'activité des nouveaux vaccins contre le pneumocoque","authors":"R. Cohen ,&nbsp;C. Levy ,&nbsp;E. Varon","doi":"10.1016/S0987-7983(24)00158-0","DOIUrl":"10.1016/S0987-7983(24)00158-0","url":null,"abstract":"<div><div>The implementation of pneumococcal conjugate vaccines (PCV7 and PCV13) in children has led to a dramatic reduction in vaccine-type pneumococcal infections, with additional benefits for adults through herd immunity. However, serotypes 3, 19A, and 19F persist at low levels in children, and new non-vaccine serotypes (NVTs) now predominate in IPD. Among the new pneumococcal vaccines approved in Europe, PCV20 covers more than 40% of invasive isolates, compared to less than 10% for PCV15. Some NVTs like 24F, not included in PCV20, remain problematic. The choice of future vaccines will depend on their ability to cover these replacement serotypes.</div><div>©2024 The Author(s). Published by Elsevier Masson SAS.</div></div>","PeriodicalId":39683,"journal":{"name":"Journal de Pediatrie et de Puericulture","volume":"37 5","pages":"Pages 5S41-5S45"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunogénicité et nombre de doses de vaccins antipneumococciques conjugués chez les jeunes enfants 幼儿肺炎球菌结合疫苗的免疫原性和剂量
Journal de Pediatrie et de Puericulture Pub Date : 2024-12-01 DOI: 10.1016/S0987-7983(24)00157-9
R. Cohen , C. Levy
{"title":"Immunogénicité et nombre de doses de vaccins antipneumococciques conjugués chez les jeunes enfants","authors":"R. Cohen ,&nbsp;C. Levy","doi":"10.1016/S0987-7983(24)00157-9","DOIUrl":"10.1016/S0987-7983(24)00157-9","url":null,"abstract":"<div><div>Pneumococcal vaccine schedules, using the same vaccines, vary from country to country (3+1, 2+1, 1+1), with similar levels of efficacy.</div><div>Whatever the initial vaccination schedule, the booster dose achieves comparable immunogenicity and similar real-life efficacy. However, with fewer doses, if vaccination coverage is insufficient, individual protection may be compromised.</div><div>© 2024 The Author(s). Published by Elsevier Masson SAS.</div></div>","PeriodicalId":39683,"journal":{"name":"Journal de Pediatrie et de Puericulture","volume":"37 5","pages":"Pages 5S36-5S40"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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