Pediatriya - Zhurnal im G.N. Speranskogo最新文献

{"title":"DISEASES CAUSED BY HERPESVIRUSES: MECHANISMS OF DAMAGE, PATHOGENETIC THERAPY AND PREVENTION","authors":"A. Rumyantsev","doi":"10.24110/0031-403x-2023-102-2-116-123","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-2-116-123","url":null,"abstract":"Herpesviruses (HV) are DNA viruses united in the Herpesviridae family, which includes about 200 species, 8 of which are pathogenic to humans. Viruses are widespread in the human population and infect more than 90% of the world's population. The study of diseases caused by HV is an important scientific and clinical problem due to their specific affinity for cells of the immune system, lifelong persistence in the human body and a wide range of clinical forms of diseases. Molecular genetic analysis of the interaction of different types of HV with the immune system of the mother, fetus, newborn, child and adult explains the variety of disorders and clinical manifestations of the infection. Each of the 8 types of HV has a different affinity for target cells, does not have a cross-immune response, is capable of combined contamination and, possibly, reactivation, the formation of a wide range of somatic, including organ, disorders at different periods of development of a child and an adult. Epstein-Barr virus (EBV) is a significant contributor to the burden of cancer and autoimmune diseases, which poses a major public health threat. These disorders demonstrate molecular possibilities for targeted therapies, antiviral agents, immune and cell therapies. The article represents an up-to-date review on the main immune mechanisms of the interaction of HVs with the body of the mother and the child and new technologies for studying HV-infections.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"133 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82605114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROPHYLACTIC USE OF EMOLLIENTS IN CHILDREN WITH ATOPIC DERMATITIS AND POLLEN SENSIBILIZATION DURING THE FLOWERING SEASON OF VARIOUS PLANTS: A SINGLE CENTER, SIMPLE, OPEN, PROSPECTIVE COMPARATIVE STUDY","authors":"A. Litovkina, E. V. Smolnikov, O. Elisyutina, E. Fedenko","doi":"10.24110/0031-403x-2023-102-2-130-138","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-2-130-138","url":null,"abstract":"Penetration of pollen allergens through the damaged skin barrier in patients with atopic dermatitis (AD) can lead to a worsening of the severity of the disease in sensibilized patients during the flowering season, however, the preventive effect of agents that restore the structure of the epidermal barrier has not been studied enough as yet. The purpose of this research was to study the clinical efficacy and safety of the La Roche-Posay Lipikar Syndet AP+ and Lipikar AP+M cosmetic products for the prevention of AD exacerbations in children during the flowering season. Materials and methods used: a single-center prospective experimental randomized comparative open study was conducted in Apr. 22-Jul. 11, 2022. The study included 19 children aged 6 to 15 y/o with AD sensibilized to pollen allergens. The two groups were formed: patients in the main group used Lipikar for 28 days and received standard AD therapy during the flowering period; patients in the control group received the standard AD therapy only. The severity of AD was evaluated with the SCORAD as well as the quality of life, pruritus intensity and corneometry were assessed during each of the three visits to pediatric allergologists. Changes in SCORAD were considered the primary endpoint of the research. Results: a statistically significant decrease in SCORAD were revealed by the 14th day of the study (p=0.007) in the main group; whilst at the same time there were no statistically significant decrease in SCORAD in the control group. It was also found that the quality of life improved statistically significantly by the 28th day of the study (p=0.001) in patients of the main group when evaluated the secondary endpoints of the study. The pruritus intensity decreased statistically significantly (p=0.002) by the 14th day of the study; the skin hydration increased (p=0.001) as well (compared to the control group). Conclusion: the use of the Lipikar Syndet AP+ and Lipikar AP+M in children in the complex therapy of AD during the flowering season of causally significant allergens statistically significantly reduced the severity of AD, reduced the pruritus intensity, improved skin hydration and quality of life.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83465890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPACT OF AGE AND ANTHROPOMETRIC FEATURES ON THE PREVALENCE OF DISANAPSIS IN CHILDREN AND ADOLESCENTS WITH BRONCHIAL ASTHMA","authors":"R. N. Khramova, T. Eliseeva, D. Ovsyannikov, E. Tush, K.D. Voronina, A. L. Gudim, E. A. Gorobets, N. Kubysheva, L. Postnikova, O. Khaletskaya","doi":"10.24110/0031-403x-2023-102-2-52-56","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-2-52-56","url":null,"abstract":"The purpose of the research was to study the impact of age on the incidence of disanapsis in children and adolescents with bronchial asthma (BA) taking into consideration the anthropometric features of the patients as well. Materials and methods used: a single-center observational cross-sectional pilot study was conducted with data obtained from 334 patients with atopic BA aged 7 to 17 years old (12.0 [9.0; 14.0] y/o), of which 241 (72.2%) were boys. All of the participants have undergone the spirometry and the diagnostics for disanapsis. Results: the incidence of disanapsis was higher in prepubertal children compared to adolescents, 57.0% (77 of 135) and 30.7% (61 of 199), respectively (p<0.001). These patterns were also typical for children with normal body weight (BW): 53.0% (44 of 83) vs. 22.3% (23 of 103); and for patients with excessive BW: 68.6% (24 of 35) vs. 33.3% (22 of 66) (p<0.001 and p<0.001, respectively). Incidence of disanapsis in patients with obesity was comparable in prepubertal age: 52.9% (9 of 17); and adolescence: 53.3% (16 of 30) (p=0.980). Conclusion: the incidence of disanapsis is higher in prepubertal age than in adolescence in patients with both normal and excessive BW. Incidence of disanapsis is comparable in prepubertal age and adolescence in patients with BA coupled with the obesity.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80097484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FACTORS INFLUENCING ADHERENCE TO AND PREVALENCE OF BREASTFEEDING: RESULTS OF AN ONLINE SURVEY OF MOTHERS IN RUSSIA (PART 2)","authors":"S. Ukraintsev, D. Ovsyannikov, E. Schepkina","doi":"10.24110/0031-403x-2023-102-2-65-71","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-2-65-71","url":null,"abstract":"The purpose of the research was to identify the reasons for the insufficient prevalence of breastfeeding (BF), to determine the ways to increase the prevalence of BF in Russia based on the data obtained during an online survey of mothers of infants in the first 6 months of life, which was conducted in two stages in 2020-2022. 1981 mothers from different age groups living in Russian cities with population from 100 thousand to 1 million and more participated in the study. Factors influencing the prevalence of BF were studied during the research. The analysis of data concerning the socio-demographic status of mothers and their observation during pregnancy in the antenatal clinic was carried out. Results: it was found out that the prevalence of exclusive BF was statistically significantly negatively affected by the period of breastfeeding after childbirth (p=0.005), repeated supplementary feeding with an infant formula in the maternity hospital (p<0.001), mother’s attitude to the fact of supplementing the infant with the formula (p=0.005): “calm” vs. “negative” (p<0.001), mother’s impression of insufficient lactation during the stay in the maternity hospital (p<0.001), lack of counseling of the mother about a possible temporary decrease in breast milk (BM) volume (p=0.022) as well as of the ways to increasing the BM volume (p<0.001). The later discharge from the maternity hospital (on the 5th to 7th days vs. on the 3rd day, p=0.005) as well as the mother’s confidence in the need for breastfeeding upon discharge from the maternity hospital after the child had been supplemented with an infant formula (p<0.001) also had negative impact. The main factor affecting the likelihood of breastfeeding at the outpatient stage was the absence of attempts by a local neonatologist/pediatric physician to returning the child to BF after supplementary feeding with an infant formula in the maternity hospital (p<0.001). Conclusion: recommendations are given that can contribute to increasing the prevalence of BF in Russia taking into consideration the data obtained during the survey.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83808475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROTRACTED BACTERIAL BRONCHITIS IN CHILDREN: ETIOLOGY, CLINICAL OPTIONS, X-RAY SEMIOTICS, COMORBIDITY","authors":"E. Makarenko, D. Ovsyannikov, M. Karpenko, T. Illarionova, O.V. Alekseeva, M. Kantemirova, N. Grigoriadis, A. Tsverava, P. V. Berejansky, Sh.A. Gitinov, V. V. Gorev, L. V. Smirnova, A. Vybornov, E. Boitsova, M. Khaled","doi":"10.24110/0031-403x-2023-102-2-57-64","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-2-57-64","url":null,"abstract":"Cough in childhood is one of the most common reasons for and symptoms when contacting a pediatric physician. Chronic (lasting over four weeks) wet/productive cough is of particular diagnostic difficulty when it is caused by protracted bacterial bronchitis (PBB). The purpose of this research was to study the etiology, clinical options, X-ray semiotics and comorbid diseases in children with PBB. Materials and methods used: clinical observation and analysis of case histories of 76 children aged starting 4.5 months up to 16 years old with PBB were carried out from Mar. 2017 to Jun. 2022. Research methods: microbiological, radiography and computed tomography (CT) of the chest, bronchoscopy, allergy diagnostics, spirometry. The design of the study was as follows: multicentre, non-comparative, open-label, non-randomized, ambispective pilot study. Results: PBB is more common in boys (57%) aged 3 to 7 y/o (59%) and is rare in infancy (7%). The majority of patients met the clinical definition of PBB (86%) and responded to 2 weeks of antibiotic therapy with amoxicillin/clavulanate (78%). The microbiological diagnosis of PBB was confirmed in 14% of children based on bronchoscopy with microbiological examination of bronchoalveolar lavage (BAL) fluid or sputum examination. The most common pathogens encountered in BAL, sputum and discharge from the nasopharynx, oropharynx are as follows: S. aureus, M. catarrhalis, H. influenzae and S. pneumoniae. The chest X-ray showed bronchitis changes; the chest CT, which was performed in 10 patients, had showed thickening of the bronchial walls. Bronchial dilatation was found in 3 children, bronchiectasis was found in a single patient. Bronchial asthma was comorbid with PBB, occurred in 22% of PBB cases. Conclusion: it is necessary for a pediatric physician to keep PBB in mind as one of the reasons for chronic wet/productive cough in children in order to correctly and timely diagnose the disease and prescribe its adequate treatment.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86979173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HEPATOSPLENOMEGALY AS A MANIFESTATION OF RARE (ORPHAN) DISEASES: GAUCHER DISEASE","authors":"T. A. Bokova","doi":"10.24110/0031-403x-2023-102-2-124-129","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-2-124-129","url":null,"abstract":"Hepatosplenomegaly occurs in many diseases. Physicians of various specialties often encounter it in their practice. It is the main clinical symptom in a number of rare (orphan) diseases and in Gaucher disease, in particular. A detailed description of this hereditary disease related to lysosomal storage diseases is presented in the Article as well as its modern diagnostic and treatment features. A clinical case of a six y/o pediatric patient with hepatosplenomegaly who was diagnosed with Gaucher disease type 1 based on a complex of laboratory and instrumental examination methods and prescribed with pathogenetic enzyme replacement therapy is observed.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89301677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANATOMICAL AND PHYSIOLOGICAL FEATURES OF LATE PREMATURE INFANTS LEADING TO THE FORMATION OF VARIOUS PATHOLOGICAL PROCESSES","authors":"E. Sarkisyan, S. V. Dumova, O. Chugunova, E.S. Ustenko, P. Shumilov","doi":"10.24110/0031-403x-2023-102-1-71-81","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-1-71-81","url":null,"abstract":"Late premature infants are those who were born at GA of 34 to 36 weeks. Despite the GA, the high weight and growth rates, this group of newborns is much more likely than full-term children to experience disruptions in neonatal adaptation, damage to the respiratory system, CNS, the development of infectious complications, asphyxia, hypothermia, hypoglycemia, hyperbilirubinemia. All of these lead to an increase in morbidity, mortality and disability not only in the first months of life, but also in the future, therefore late premature infants cannot be treated as/kind of “almost full-term.” This bibliographical review represents the data on the features of the development of various pathological processes, outcomes and treatment options in late preterm infants.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81579219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MICROBIOME OF THE UPPER RESPIRATORY TRACT IN INFANTS AND PRESCHOOL CHILDREN","authors":"T.I. Kurdiukova, O.N. Krasnorutskaia","doi":"10.24110/0031-403x-2023-102-1-98-105","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-1-98-105","url":null,"abstract":"This bibliographical review provides an analysis of modern domestic and foreign sources on the microbiome of the upper respiratory tract (URT) in children of early and preschool ages. It was discovered using the genetic sequencing method that the mucous membranes of the URT are inhabited by a wide range of bacteria belonging to the genera Firmicutes, Actinobacteria, Bacteroidetes, Proteobacteria and Fusobacteria, with the predominant genera Moraxella, Haemophilus, Streptococcus, Flavobacteria, Corynebacterium and Neisseria. Colonization of the URT begins at birth and continues into the first 3 years of a child's life. It is influenced by the method of delivery as well as the environmental microbiome in the baby's environment. Normal microbiota has colonization resistance, prevents the colonization of pathogenic flora, and also competes with pathogens. It has been proven that microbiota profiles in infants and preschool children vary depending on the season. One of the important areas of research is the assessment of the impact of antiseptics and antibiotics, as well as probiotic preparations, on the microbiota.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78332838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FOLLOW-UP RESULTS AND FEATURES OF THE COURSE OF COVID-19 IN PATIENTS WITH NEUROENDOCRINE CELL HYPERPLASIA OF INFANСY","authors":"M. Karpenko, D. Ovsyannikov, E. V. Shchepkina, O.V. Bystrova, N. Bondarenko, O.V. Alekseeva, N. Grigoriadis, I. Osmanov, E. Samitova, E.M. Gabliya, V. Larina","doi":"10.24110/0031-403x-2023-102-1-64-70","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-1-64-70","url":null,"abstract":"Neuroendocrine cell hyperplasia of infancy (NEHI) is a rare interstitial lung disease in children. The clinical features of the disease are characterized by tachypnea, moist rales/crepitus, retraction of compliant chest areas and delayed weight gain. The disease is diagnosed using the NEHI clinical scale coupled with the computed tomography of the chest organs. The clinical manifestations of NEHI regress as the child grows, but may persist up to the age of 10 y/o. The purpose of the research was to characterize the course of NEHI including the features of COVID-19 and the impact of passive smoking in children below the age of 8 y/o. Materials and methods: a single-center longitudinal study with follow-up observation of 29 patients with NEHI in January 2012 - December 2022 aged 8 months to 8 years old, 21 of which had COVID-19. Results: 20 of 29 patients with a known follow-up have undergone the long-term oxygen therapy (LTOT) at home lasting from 2 weeks up to 5.5 years (Me 1 year and 2 months; IQR 6 months - 4.5 years). Bronchial asthma was diagnosed in 2. 8 (28%) were diagnosed with atopic dermatitis, 6 (21%) with mental retardation, 3 (10%) with acute urticaria, and 2 (7%) with allergic rhinitis. Gastroesophageal reflux disease (GERD) was diagnosed in 7, all requiring LTOT. The frequency of episodes of respiratory infection was maximum in the first 2 years of life, amounting to 16 episodes per 2 years (Me 7; IQR 4 to 10), and the maximum frequency of hospitalizations during this age period was 5 (Me 2; IQR 1 to 2). Children-passive smokers were diagnosed with malnutrition more often (75%, p=0.449) and required LTOT more often (75%, p=0.694), were more often hospitalized (42%, p=0.422). Despite the possible need for LTOT patients with NEHI had COVID-19 in the form of nasopharyngitis in the majority of cases (89%). Only 8 out of 14 patients had symptoms of NEHI after 5 years of age, and only 1 out of 5 after 7 years. Malnutrition (body mass index for the age<-2) in the first year of life was diagnosed in 13 (45%) children. Malnutrition persisted in 9 out of 24 (37%) by the second year of life, in 5 out of 19 (26%) by the third year, and in 2 out of 14 (14%) by the fourth year of life. Not a single child died. Conclusion: the course of NEHI is characterized by the absence of lethal outcomes, frequent respiratory infections that led to hospitalizations in the first 2 years of life, mild course of COVID-19, regression of clinical symptoms and malnutrition as the child grows, comorbidity with atopic diseases and GERD. The priority should be given to the prevention of passive smoking in children with NEHI.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83662630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BENIGN TRANSIENT HYPERPHOSPHATASEMIA IN CHILDREN: TWELVE NEW CLINICAL CASES AND THE BIBLIOGRAPHICAL REVIEW","authors":"E. Frolova, A. Anushenko, I. Shirokova, M. Venediktova, M. Varichkina, C.A. Kazakova","doi":"10.24110/0031-403x-2023-102-1-165-170","DOIUrl":"https://doi.org/10.24110/0031-403x-2023-102-1-165-170","url":null,"abstract":"Benign transient hyperphosphatasemia of childhood (TH, BTH, BTHC) is a condition characterized by a temporary significant increase in the level of alkaline phosphatase in healthy people. This condition is transient and it does resolve without treatment within 2 to 4 months, does not have any long-term consequences (according to the analysis of the bibliographical sources and the Authors’ own observations). BTH is most often detected in children under the age of 5 y/o with the peak under 2 years, however there are sporadic cases in adults observed. In addition, there are descriptions of familial cases of TH that are clinically identical to the sporadic ones. Authors present twelve own observations of BTH cases and the bibliographical review on the topic. The criteria for BTH diagnosing are formed and a benign course of this condition had been confirmed.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":"379 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74041826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}