疱疹病毒引起的疾病:损害机制、病理治疗和预防

Q4 Medicine

Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-04-21 DOI:10.24110/0031-403x-2023-102-2-116-123

A. Rumyantsev

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引用次数: 0

摘要

疱疹病毒(HV)是疱疹病毒科的DNA病毒，包括约200种，其中8种对人类具有致病性。病毒在人群中广泛存在，感染了世界上90%以上的人口。由于其对免疫系统细胞的特异性亲和力、在人体内的终身持久性和广泛的临床疾病形式，对HV引起的疾病的研究是一个重要的科学和临床问题。不同类型的HV与母亲、胎儿、新生儿、儿童和成人免疫系统相互作用的分子遗传学分析解释了感染的各种疾病和临床表现。8种类型的HV中的每一种对靶细胞都有不同的亲和力，没有交叉免疫反应，能够综合污染，并可能再激活，在儿童和成人的不同发育时期形成广泛的躯体，包括器官，疾病。爱泼斯坦-巴尔病毒(EBV)是造成癌症和自身免疫性疾病负担的重要因素，对公共卫生构成重大威胁。这些疾病显示了靶向治疗、抗病毒药物、免疫和细胞治疗的分子可能性。本文综述了艾滋病毒与母婴相互作用的主要免疫机制以及研究艾滋病毒感染的新技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

DISEASES CAUSED BY HERPESVIRUSES: MECHANISMS OF DAMAGE, PATHOGENETIC THERAPY AND PREVENTION

Herpesviruses (HV) are DNA viruses united in the Herpesviridae family, which includes about 200 species, 8 of which are pathogenic to humans. Viruses are widespread in the human population and infect more than 90% of the world's population. The study of diseases caused by HV is an important scientific and clinical problem due to their specific affinity for cells of the immune system, lifelong persistence in the human body and a wide range of clinical forms of diseases. Molecular genetic analysis of the interaction of different types of HV with the immune system of the mother, fetus, newborn, child and adult explains the variety of disorders and clinical manifestations of the infection. Each of the 8 types of HV has a different affinity for target cells, does not have a cross-immune response, is capable of combined contamination and, possibly, reactivation, the formation of a wide range of somatic, including organ, disorders at different periods of development of a child and an adult. Epstein-Barr virus (EBV) is a significant contributor to the burden of cancer and autoimmune diseases, which poses a major public health threat. These disorders demonstrate molecular possibilities for targeted therapies, antiviral agents, immune and cell therapies. The article represents an up-to-date review on the main immune mechanisms of the interaction of HVs with the body of the mother and the child and new technologies for studying HV-infections.

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来源期刊

Pediatriya - Zhurnal im G.N. Speranskogo Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.60

自引率

0.00%

发文量

150

期刊介绍： Journal “Pediatria” named after G.N. Speransky (the official short names of the Journal are “Journal «Pediatria»,” “Pediatria,” and “«Pediatria,» the Journal”) is the oldest Soviet-and-Russian (in the Russian Federation, the CIS and former Soviet Union) scientific and practical medical periodical assigned for pediatricians that is published continuously since May, 1922, and distributed worldwide. Our mission statement specifies that we aim to the ‘raising the level of skills and education of pediatricians, organizers of children’s health protection services, medicine scientists, lecturers and students of medical institutes for higher education, universities and colleges worldwide with an emphasis on Russian-speaking audience and specific, topical problems of children’s healthcare in Russia, the CIS, Baltic States and former Soviet Union Countries and their determination with the use of the World’s best practices in pediatrics.’ As part of this objective, the Editorial of the Journal «Pediatria» named after G.N. Speransky itself adopts a neutral position on issues treated within the Journal. The Journal serves to further academic discussions of topics, irrespective of their nature - whether religious, racial-, gender-based, environmental, ethical, political or other potentially or topically contentious subjects. The Journal is registered with the ISSN, - the international identifier for serials and other continuing resources, in the electronic and print world: ISSN 0031-403X (Print), and ISSN 1990-2182 (Online). The Journal was founded by the Academician, Dr. Georgiy Nestorovich SPERANSKY, in May, 1922. Now (since 1973) the Journal bears his honorary name.