Kurume Medical Journal最新文献_第5页

Rectal Metastasis from Early-Stage Endometrial Carcinoma Not Associated with Endometriosis: A Case Report and Literature Review. 与子宫内膜异位症无关的早期子宫内膜癌直肠转移一例报告并文献复习。

Kurume Medical Journal Pub Date : 2025-11-13 Epub Date: 2025-06-13 DOI: 10.2739/kurumemedj.MS7134005

Blagica Krsteska, Vladimir Risteski, Ana Jovceva, Svetozar Antovic

{"title":"Rectal Metastasis from Early-Stage Endometrial Carcinoma Not Associated with Endometriosis: A Case Report and Literature Review.","authors":"Blagica Krsteska, Vladimir Risteski, Ana Jovceva, Svetozar Antovic","doi":"10.2739/kurumemedj.MS7134005","DOIUrl":"10.2739/kurumemedj.MS7134005","url":null,"abstract":"Objective: Endometrial cancer (EC) is the third most common malignancy in woman with excellent prognosis when diagnosed in early-stage. Recurrences are extremely rare in Stage I EC especially in rectum when not associated with endometriosis. We present a case of rectal metastasis from endometrial carcinoma after 8 years of primary diagnosis. A review of the literature showed only 6 published cases.Case presentation: Herein we present a 59-year-old woman with a rectal tumor mass. The patient before 8 years was surgically treated for EC Stage IA with bilateral salpingo-oophorectomy and hysterectomy. After ultra-low anterior resection rectum was removed with the tumor. Histology revealed adenocarcinoma with positive immunohistochemistry for CK7, ER, PAX8, Vimentin which confirmed endometrial origin. Endometriosis was not found.Conclusion: Although rectum is a rare site of recurrence from endometrial cancer, rectal tumors should be sampled carefully. Previous patient history and positive immunohistochemistry for EC are in favor of recurrent disease. Screening of colorectal carcinoma should be performed in patients with previous gynecologic diagnosis. Further genetic analysis in bigger case series is needed in order to explain the time and the site of recurrence of early-stage endometrial carcinoma.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"163-166"},"PeriodicalIF":0.0,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery of Feeding Regulatory Peptides and The Importance of Peptide Discovery Research. 饲养调节肽的发现及肽发现研究的重要性。

Kurume Medical Journal Pub Date : 2025-11-13 Epub Date: 2025-04-18 DOI: 10.2739/kurumemedj.MS7134001

Takanori Ida, Kazuma Matsui, Sayaka Nagata, Tomoya Nakamachi, Yuki Shiimura, Takahiro Sato, Masayasu Kojima

引用次数: 0

Painful Os Peroneum Syndrome: An Unusual Diagnosis. 腓骨肌疼痛综合征：一个不寻常的诊断。

Kurume Medical Journal Pub Date : 2025-11-13 Epub Date: 2025-06-13 DOI: 10.2739/kurumemedj.MS7134006

Pedro Henrique Segatt, José Luiz Masson DE Almeida Prado, Márcio Luís Duarte

{"title":"Painful Os Peroneum Syndrome: An Unusual Diagnosis.","authors":"Pedro Henrique Segatt, José Luiz Masson DE Almeida Prado, Márcio Luís Duarte","doi":"10.2739/kurumemedj.MS7134006","DOIUrl":"10.2739/kurumemedj.MS7134006","url":null,"abstract":"The painful Os peroneum syndrome is subdivided into acute and chronic cases. The acute presentation is usually caused by trauma, most commonly a supination or inversion of the ankle, which consequently can lead to a fracture of the Os peroneum or even a rupture of the peroneus longus tendon. Furthermore, its chronic presentation comes as a result of recurrent foot injuries or even recovery from a fracture with calcification remodeling of this sesamoid bone. The problem of underdiagnosing this disease lies in the consequences attached to the remodeling of the peroneus longus tendon with its calcification, or even leading to a picture of tenosynovitis and subsequent tendon rupture. We report a 55-year-old female patient who complains of pain in the lateral region of her right foot for ten days. The right foot X-ray detected the presence of \"Os peroneum.\" Magnetic resonance imaging (MRI) shows edematous ossification in the peroneus longus tendon compatible with Os peroneum and with swelling of the surrounding soft tissue and tendinopathy of the peroneus longus, precisely in the region indicated by the skin marker. The set of findings is compatible with painful Os peroneum syndrome. The patient was treated with a non-steroidal anti-inflammatory for five days with the resolution of symptoms.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"153-156"},"PeriodicalIF":0.0,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comminuted Transverse Femoral Shaft Fractures Are at Risk for Nonunion. 粉碎性股骨横轴骨折有发生骨不连的风险。

Kurume Medical Journal Pub Date : 2025-08-01 Epub Date: 2024-11-27 DOI: 10.2739/kurumemedj.MS7112005

Toru Matsugaki, Hideki Mizu-Uchi, Yuji Aratake, Keitarou Yasumoto

{"title":"Comminuted Transverse Femoral Shaft Fractures Are at Risk for Nonunion.","authors":"Toru Matsugaki, Hideki Mizu-Uchi, Yuji Aratake, Keitarou Yasumoto","doi":"10.2739/kurumemedj.MS7112005","DOIUrl":"10.2739/kurumemedj.MS7112005","url":null,"abstract":"Background: The purpose of this study was to investigate the effect of the main fragment fracture type (oblique or transverse) on the union rate of femoral shaft fractures.Methods: Patients who underwent surgical treatment with an antegrade intramedullary nail for femoral shaft fracture (Arbeitsgemeinschaft für Osteosynthesefragen / Orthopaedic Trauma Association; AO/OTA type 32 type B or C) between January 2009 and March 2021 were included in this study. Patients with oblique fractures of the two main fragments on radiographs immediately after surgery were classified into the oblique fracture group. Patients with at least one of the two main fractures being transverse fractures were classified into the transverse fracture group. We investigated age, sex, height, weight, body mass index (BMI), AO/OTA classification, time from fracture to surgery, intramedullary nail length and diameter, number of interlocking screws, and bone union rate.Results: A total of 55 fractures were included. The mean age was 34.4 ± 16.7 (range, 16-77) years. There were 41 fractures classified into the oblique fracture group and 14 fractures classified into the transverse fracture group. There was a significantly higher proportion of men in the transverse fracture group. Patients in the transverse fracture group were significantly younger and taller. Only 1 of 41 (2.4%) patients in the oblique group experienced nonunion, while 3 of 14 (21.4%) patients in the transverse group experienced nonunion (p = 0.030).Conclusion: Comminuted femoral shaft fractures with transverse fracture components are more prone to nonunion.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical Treatment of Simultaneous Common Femoral and Profunda Femoris Artery Aneurysms. 同时发生的股总动脉和股深动脉动脉瘤的手术治疗。

Kurume Medical Journal Pub Date : 2025-08-01 Epub Date: 2024-11-27 DOI: 10.2739/kurumemedj.MS7112006

Yusuke Shintani, Satoru Tobinaga, Hiroyuki Saisho, Shigeaki Aoyagi, Eiki Tayama, Hiroshi Yasunaga

引用次数: 0

Effects of Hyperbaric Oxygen Therapy for Malignant Bowel Obstruction Caused by Peritoneal Dissemination. 高压氧疗法对腹膜扩散引起的恶性肠梗阻的影响

Kurume Medical Journal Pub Date : 2025-08-01 Epub Date: 2024-09-27 DOI: 10.2739/kurumemedj.MS7112001

Daisuke Muroya, Shoichiro Arai, Takamichi Nishida, Takahide Ishimaru, Yuta Yamazaki, Youjirou Goto, Shinya Nadayoshi, Yutaro Kai, Tetsu Masuda, Hisaaki Shimokobe, Yuichi Goto, Yuichi Nagao, Yoshito Wada, Takayuki Torigoe, Yoshinori Tomoda, Yuji Maruyama, Hajime Imada, Hironobu Sou, Yoshito Akagi, Toru Hisaka

{"title":"Effects of Hyperbaric Oxygen Therapy for Malignant Bowel Obstruction Caused by Peritoneal Dissemination.","authors":"Daisuke Muroya, Shoichiro Arai, Takamichi Nishida, Takahide Ishimaru, Yuta Yamazaki, Youjirou Goto, Shinya Nadayoshi, Yutaro Kai, Tetsu Masuda, Hisaaki Shimokobe, Yuichi Goto, Yuichi Nagao, Yoshito Wada, Takayuki Torigoe, Yoshinori Tomoda, Yuji Maruyama, Hajime Imada, Hironobu Sou, Yoshito Akagi, Toru Hisaka","doi":"10.2739/kurumemedj.MS7112001","DOIUrl":"10.2739/kurumemedj.MS7112001","url":null,"abstract":"Introduction: This study aimed to investigate the efficacy of hyperbaric oxygen therapy (HBOT) in patients presenting with malignant bowel obstruction (MBO) and peritoneal dissemination.Materials and methods: We retrospectively examined whether HBOT affects prognosis following MBO with peritoneal dissemination. This study included 44 patients diagnosed with MBO secondary to peritoneal dissemination at our hospital between January 2013 and December 2022. Among these patients, 30 underwent HBOT. The treatment protocol involved daily HBOT administration, comprising 100% oxygen at 2.5 atmospheres absolute for 60 min.Results: In a univariate analysis of HBOT and non-HBOT groups, the proportion of patients able to resume eating was significantly higher in the HBOT group. Therefore, the percentage of patients in the non-HBOT group whose MBO did not improve was significantly higher than that in the HBOT group. The percentage of patients undergoing surgery or receiving anticancer treatment did not differ significantly between the groups, whereas overall survival was significantly longer in the HBOT group. Furthermore, when examining inoperable patients, significantly more individuals in the HBOT group could resume eating, and their overall survival was significantly prolonged.Conclusions: HBOT may increase the spontaneous resolution rate and improve long-term prognoses of patients with MBO secondary to peritoneal dissemination.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"19-28"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Expression of NDRG1 is a Poor Prognostic Factor in Patients with Endometrial Endometrioid Carcinoma with Long-Term Observation. NDRG1的高表达是长期观察子宫内膜样癌患者的不良预后因素

Kurume Medical Journal Pub Date : 2025-08-01 Epub Date: 2024-11-27 DOI: 10.2739/kurumemedj.MS7112004

Morio Ijichi, Kimio Ushijima, Tomohiko Yamaguchi, Naoyo Nishida, Kazuto Tasaki, Jongmyung Park, Shin Nishio, Toshiharu Kamura, Jun Akiba, Tatsuyuki Kakuma, Michihiko Kuwano, Naotake Tsuda

引用次数: 0

Validity of High-Dose-Rate Interstitial Brachytherapy as Monotherapy for Mobile Tongue Cancer in Terms of the Acute Mucosal Reaction. 从急性黏膜反应角度看高剂量率间质近距离放射疗法作为移动性舌癌单一疗法的有效性

Kurume Medical Journal Pub Date : 2025-08-01 Epub Date: 2024-11-27 DOI: 10.2739/kurumemedj.MS7112003

Hironori Akiyama, Ken Yoshida, Tadayuki Kotsuma, Koji Masui, Tadashi Takenaka, Manabu Kano, Fumiaki Isohashi, Yuji Seo, Taiju Shimbo, Naoya Murakami, Yui Mori, Shinya Kotaki, Hitoshi Yoshimoto, Eiichi Tanaka, Nikolaos Tselis, Zoltán Takácsi-Nagy, Hideya Yamazaki, Satoaki Nakamura, Noboru Tanigawa, Kimishige Shimizutani, Kazuhiko Ogawa, Yoshiko Ariji

{"title":"Validity of High-Dose-Rate Interstitial Brachytherapy as Monotherapy for Mobile Tongue Cancer in Terms of the Acute Mucosal Reaction.","authors":"Hironori Akiyama, Ken Yoshida, Tadayuki Kotsuma, Koji Masui, Tadashi Takenaka, Manabu Kano, Fumiaki Isohashi, Yuji Seo, Taiju Shimbo, Naoya Murakami, Yui Mori, Shinya Kotaki, Hitoshi Yoshimoto, Eiichi Tanaka, Nikolaos Tselis, Zoltán Takácsi-Nagy, Hideya Yamazaki, Satoaki Nakamura, Noboru Tanigawa, Kimishige Shimizutani, Kazuhiko Ogawa, Yoshiko Ariji","doi":"10.2739/kurumemedj.MS7112003","DOIUrl":"10.2739/kurumemedj.MS7112003","url":null,"abstract":"Background: The present study investigated the acute mucosal reaction (AMR) after high-dose-rate interstitial brachytherapy at 54 Gy/9 fractions (HDR54) as monotherapy administered twice a day for tongue cancer in 13 patients, and attempted to validate HDR54 by comparing the AMR with that of our previously reported HDR at 60 Gy/10 fractions (HDR60), and low-dose-rate interstitial brachytherapy at approximately 70 Gy (LDR70).Methods: The European Organization for Research on Treatment of Cancer/ Radiation Therapy Oncology Group scoring system with modifications (score: 1-4.5) was used to evaluate AMR. The time courses of the AMR scores of HDR54 were recorded. The time courses of the AMR of HDR54, HDR 60, and LDR70 were each divided into 6 phases and compared.Results: The number of cases in the HDR54 group with a lower score (1-2) at the time of the initial response was significantly higher (12 cases) than those in the HDR60 group (1 case) (p=0.0077) and LDR70 group (1 case) (p=0.0077). In the HDR54 group, the time between the end of treatment and appearance of the first response was significantly longer (median: 3 days) than those in the HDR60 group (median: 1 day) (p<0.001) and LDR70 group (median: 1 day) (p<0.001). No significant differences were observed in the maximum score, its duration, or other parameters.Conclusions: The results indicated that the AMR of HDR54 started later and was gentler and more easily tolerated than the other two methods, suggesting the validity of HDR54 in terms of AMR.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"29-36"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upregulated Nuclear Y-box Binding Protein-1 Expression is Closely Associated with Mammalian Target of Rapamycin Expression in Endometrial Cancer. 细胞核Y-box结合蛋白-1表达上调与哺乳动物子宫内膜癌雷帕霉素靶蛋白表达密切相关

Kurume Medical Journal Pub Date : 2025-08-01 Epub Date: 2025-03-07 DOI: 10.2739/kurumemedj.MS7112011

Teruyuki Yoshimitsu, Shin Nishio, Jongmyung Park, Hiroki Nasu, Ken Matsukuma, Kazuto Tasaki, Takahiro Katsuda, Atsumu Terada, Kimio Ushijima, Naotake Tsuda, Akihiko Kawahara, Jun Akiba, Michihiko Kuwano

{"title":"Upregulated Nuclear Y-box Binding Protein-1 Expression is Closely Associated with Mammalian Target of Rapamycin Expression in Endometrial Cancer.","authors":"Teruyuki Yoshimitsu, Shin Nishio, Jongmyung Park, Hiroki Nasu, Ken Matsukuma, Kazuto Tasaki, Takahiro Katsuda, Atsumu Terada, Kimio Ushijima, Naotake Tsuda, Akihiko Kawahara, Jun Akiba, Michihiko Kuwano","doi":"10.2739/kurumemedj.MS7112011","DOIUrl":"10.2739/kurumemedj.MS7112011","url":null,"abstract":"Enhanced oncogenic Y-box binding protein-1 (YB-1) expression, associated with the aberrant expression of genes involved in cell proliferation, survival, and drug resistance, can predict prognostic outcomes in patients with various malignancies. We examined whether YB-1 could predict prognostic outcomes in patients with endometrial cancer and whether enhanced YB-1 expression affects the expression of mammalian target of rapamycin (mTOR) in endometrial cancer. We examined the expression levels of YB-1 and mTOR in tumor samples of 166 patients with endometrial cancer, including those with endometrioid grade 1-3, serous carcinoma, and stage I-IV disease, who underwent surgery. The expression levels of both molecules were assessed using immunohistochemical analysis. The correlation between the expression levels of YB-1 or mTOR and prognosis was also confirmed.The positivity rate of nuclear YB-1 expression was 9.4%. YB-1 expression was associated with poor progression-free survival (P = 0.012) and overall survival (P = 0.003). Fifty-nine patients (35.5%) exhibited mTOR expression. Nuclear YB-1 expression was also correlated with mTOR expression (P = 0.006). We observed similar results when examining only patients who underwent adjuvant chemotherapy. Enhanced nuclear YB-1 expression could predict poor outcomes in endometrial cancer and was significantly associated with enhanced mTOR expression.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"51-60"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Sarcoid Reaction in Subcarinal Lymph Node in A Postoperative Breast Cancer Diagnosed by Thoracoscopic Biopsy. 一例通过胸腔镜活检确诊的乳腺癌术后心包下淋巴结肉样瘤反应病例

Kurume Medical Journal Pub Date : 2025-08-01 Epub Date: 2024-11-27 DOI: 10.2739/kurumemedj.MS7112009

Kunihiro Ozaki, Shintaro Yokoyama, Toshihiro Hashiguchi, Kensuke Tajiri, Kou Shigemura, Daigo Murakami, Yutaka Nishimura, Maki Tanaka, Ryouzou Hayashida, Fumihiko Fujita

引用次数: 0