Kurume Medical Journal最新文献_第5页

Effects of Pemafibrate on Reducing Oxidative Stress and Augmenting Angiogenesis in Ischemic Limb Tissue. 培马贝特对减轻缺血肢体组织氧化应激和促进血管生成的影响

Kurume Medical Journal Pub Date : 2024-05-14 Epub Date: 2024-01-16 DOI: 10.2739/kurumemedj.MS6934006

Tomoyuki Anegawa, Ken-Ichiro Sasaki, Yuta Ishizaki, Shinya Negoto, Atsunobu Oryoji, Eiji Nakamura, Hiroyuki Otsuka, Shinichi Hiromatsu, Yoshihiro Fukumoto, Eiki Tayama

{"title":"Effects of Pemafibrate on Reducing Oxidative Stress and Augmenting Angiogenesis in Ischemic Limb Tissue.","authors":"Tomoyuki Anegawa, Ken-Ichiro Sasaki, Yuta Ishizaki, Shinya Negoto, Atsunobu Oryoji, Eiji Nakamura, Hiroyuki Otsuka, Shinichi Hiromatsu, Yoshihiro Fukumoto, Eiki Tayama","doi":"10.2739/kurumemedj.MS6934006","DOIUrl":"10.2739/kurumemedj.MS6934006","url":null,"abstract":"Objective: Oxidative damage is observed in the ischemic limbs of patients with arteriosclerosis obliterans. We investigated whether pemafibrate, a selective peroxisome proliferator-activated receptor alpha modulator, reduced oxidative stress in ischemic limbs and consequently rescued limb damage in model mice.Materials and methods: We surgically induced hind-limb ischemia in mice and orally administered pemafibrate solution (P-05 group, 0.5 mg/kg/day; P-10 group, 1.0 mg/kg/day) or control solution (control group). Seven days after the surgery, differences in reactive oxygen species (ROS) contents, antioxidative enzyme and transcription factor expression, blood flow, and capillary density in ischemic limbs were assessed.Results: Tissue ROS levels were lower in the P-05 and P-10 groups compared with those in the control group. Although the tissue expression levels of nuclear factor-erythroid 2-related factor 2 increased in the P-10 group compared with that in the control group, no corresponding changes were observed in the tissue expression of four antioxidative enzymes. The limb salvage rates and capillary densities in ischemic limbs were higher in the P-05 and P-10 groups than that in the control group.Conclusion: Pemafibrate treatment reduced oxidative stress and augmented angiogenesis in ischemic limbs, contributing to prevention of limb damage in mice.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"167-174"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors in Fetal Ovarian Cysts for Postnatal Adverse Outcomes. 胎儿卵巢囊肿导致产后不良后果的风险因素。

Kurume Medical Journal Pub Date : 2024-05-14 Epub Date: 2024-01-16 DOI: 10.2739/kurumemedj.MS6934002

Megumi Muto, Toshiyuki Yoshizato, Takashi Horinouchi, Masato Yokomine, Yoshitaka Sakamoto, Shinji Ishii, Masahiro Kinoshita, Yutaka Kozuma, Kimio Ushijima

{"title":"Risk Factors in Fetal Ovarian Cysts for Postnatal Adverse Outcomes.","authors":"Megumi Muto, Toshiyuki Yoshizato, Takashi Horinouchi, Masato Yokomine, Yoshitaka Sakamoto, Shinji Ishii, Masahiro Kinoshita, Yutaka Kozuma, Kimio Ushijima","doi":"10.2739/kurumemedj.MS6934002","DOIUrl":"10.2739/kurumemedj.MS6934002","url":null,"abstract":"Aim: To investigate the natural history of fetal ovarian cysts and elucidate the risk factors for postnatal adverse outcomes in fetal ovarian cysts.Methods: The study subjects were 18 cases with ovarian cysts prenatally diagnosed using ultrasonography at our hospital between 2007 and 2020. The subjects were classified by cyst characteristics according to echogenic patterns [simple cyst (S) and complex cyst (C)], changes in echogenic patterns (S-to-S, S-to-C, and C-to-C), and diameters (<40 and ≥ 40 mm). Clinical parameters and outcomes were compared between S and C patterns, S-to-S and S-to-C patterns, and <40 and ≥ 40 mm diameters.Results: Cases with S and C patterns (15 and 3, respectively) had median gestational ages of 35 and 36 weeks, respectively, and maximum cyst diameters of 36 and 57mm, respectively. The number of cases with S-to-S, S-to-C and C-to-C patterns were 11, 4 and 3, respectively. The maximum cyst diameter in cases with S-to-C patterns (58 mm) was larger than that in cases with S-to-S patterns (34 mm) (P<0.05). Placental weight in cases with cysts >40 mm and/or cyst expansion was greater than that in cases with neither or both conditions (P<0.05). Spontaneous resolution (before and after birth) occurred in 8 of 9 and 3 of 9 cases with maximum cyst diameters <40 and ≥ 40 mm, respectively. Ovarian function was lost in 2 cases with S-to-C patterns and in 2 cases with C-to-C patterns.Conclusion: Cases with cyst diameters ≥ 40 mm and/or cyst expansion during the late third trimester had greater placental weight and more postnatal adverse outcomes.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"127-133"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination of Prednisolone and Calcineurin Inhibitors Prevents Lung Function Decline in Patients with Anti-aminoacyl-tRNA Synthetase Antibody-Positive Polymyositis/Dermatomyositis. 强的松龙联合钙调磷酸酶抑制剂预防抗氨基酰基trna合成酶抗体阳性的多发性肌炎/皮肌炎患者肺功能下降

Kurume Medical Journal Pub Date : 2023-11-30 Epub Date: 2023-08-07 DOI: 10.2739/kurumemedj.MS6912002

Yuki Yorishima, Masaki Tominaga, Kiminori Fujimoto, Shuji Nagata, Akiko Sumi, Tomonori Chikasue, Masaki Okamoto, Shinjiro Kaieda, Goushi Matama, Yoshiaki Zaizen, Hitoshi Obara, Tatsuyuki Kakuma, Hiroaki Ida, Tomotaka Kawayama, Tomoaki Hoshino

{"title":"Combination of Prednisolone and Calcineurin Inhibitors Prevents Lung Function Decline in Patients with Anti-aminoacyl-tRNA Synthetase Antibody-Positive Polymyositis/Dermatomyositis.","authors":"Yuki Yorishima, Masaki Tominaga, Kiminori Fujimoto, Shuji Nagata, Akiko Sumi, Tomonori Chikasue, Masaki Okamoto, Shinjiro Kaieda, Goushi Matama, Yoshiaki Zaizen, Hitoshi Obara, Tatsuyuki Kakuma, Hiroaki Ida, Tomotaka Kawayama, Tomoaki Hoshino","doi":"10.2739/kurumemedj.MS6912002","DOIUrl":"10.2739/kurumemedj.MS6912002","url":null,"abstract":"Objective: Anti-aminoacyl-tRNA synthetase antibody-positive polymyositis/dermatomyositis-associ ated interstitial lung disease (ARS-ILD) has a good prognosis, with few cases progressing to respiratory failure. This study aimed to determine factors predictive of lung function changes in patients with ARS-ILD.Methods: We retrospectively studied 49 patients with ARS-ILD treated at Kurume University Hospital Hospital between 2000 and 2018. We followed 30 patients for more than 2 years after prednisolone (PSL) therapy, with or without calcineurin inhibitors (CNIs), evaluating clinical, physiological, computed tomography, pulmonary func tion, and serological data.Results: After treatment for 24 months, no significant differences were noted between clinical parameters and improvement in forced vital capacity (FVC), %FVC, % carbon monoxide diffusing capacity/alveolar volume (%DLCO), and %DLCO/alveolar volume. Conversely, the annual change of %FVC significantly correlated with the Medical Research Council dyspnea scale grade and %FVC at the first visit and treatment. Furthermore, the annual change of %DLCO/VA significantly correlated with the duration from the first visit to treatment initiation.Conclusion: Compared with PSL monotherapy, combining PSL and CNI showed greater mitigation of %FVC decline. The time from onset of ARS-ILD to the first visit is critical for preventing a decline in lung function, and as such, patients should be monitored carefully.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"19-30"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10000127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Outcomes of Radiation Therapy for Choroidal Metastases and A Literature Review. 脉络膜转移瘤放射治疗的临床疗效及文献综述。

Kurume Medical Journal Pub Date : 2023-11-30 Epub Date: 2023-10-03 DOI: 10.2739/kurumemedj.MS69120012

Masanari Niwa, Natsuo Tomita, Akifumi Miyakawa, Shiho Ayakawa, Natsuko Takama, Akira Torii, Nozomi Kita, Satoshi Ishikura, Yuta Shibamoto

{"title":"Clinical Outcomes of Radiation Therapy for Choroidal Metastases and A Literature Review.","authors":"Masanari Niwa, Natsuo Tomita, Akifumi Miyakawa, Shiho Ayakawa, Natsuko Takama, Akira Torii, Nozomi Kita, Satoshi Ishikura, Yuta Shibamoto","doi":"10.2739/kurumemedj.MS69120012","DOIUrl":"10.2739/kurumemedj.MS69120012","url":null,"abstract":"Introduction: Radiation therapy (RT) for choroidal metastasis (CM) aims to preserve vision and achieve local control (LC), thereby maintaining quality of life. The present study reports the clinical outcomes of RT for CM and reviews the literature.Methods: We retrospectively collected data on 11 patients with CM; their primary tumors were breast cancer (n=3), lung cancer (n=3), leukemia (n=2), lymphoma (n=2), and gastric cancer (n=1). Four patients had bilateral CM. The median radiation dose was 39 Gy in 13 fractions (range, 20-50 Gy in 10-25 fractions). We investigated changes in visual acuity, tumor responses, morbidities, LC, and overall survival (OS). A systematic review of literature published between 1990 and 2020 was performed using the PubMed database.Results: One, 1, and 6 patients had improved, stabilized, and worse visual acuity, respectively (data missing for 3 patients). Nevertheless, eight patients considered their visual acuity to have improved or remained the same after RT. Among 15 lesions in 11 patients, complete and partial responses were observed in 2 and 6, respectively (data missing for 7 lesions in 4 patients). Three-year LC and OS rates were 100 and 32%, respectively. Grade ≥ 3 morbidities were not observed. In the literature review, the most common primary cancer was breast cancer followed by lung cancer. Improvements in or the stabilization of visual acuity was observed in 80% of patients (range, 47-100), and the median survival time was 11 months (range, 4.9-23).Conclusion: RT is an efficient and safe palliative treatment for CM without severe toxicity.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"89-97"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41154105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Flow Nasal Oxygen for Severe COVID-19 Pneumonia in Greek Patients: A Prospective Observational Study. 希腊患者重度新冠肺炎肺炎的高-低鼻氧治疗：一项前瞻性观察研究。

Kurume Medical Journal Pub Date : 2023-11-30 Epub Date: 2023-10-03 DOI: 10.2739/kurumemedj.MS69120013

Petros Ioannou, Ioannis Akoumianakis, Theodosios D Filippatos, Evangelia Akoumianaki, Georgios Chamilos, Diamantis P Kofteridis

{"title":"High-Flow Nasal Oxygen for Severe COVID-19 Pneumonia in Greek Patients: A Prospective Observational Study.","authors":"Petros Ioannou, Ioannis Akoumianakis, Theodosios D Filippatos, Evangelia Akoumianaki, Georgios Chamilos, Diamantis P Kofteridis","doi":"10.2739/kurumemedj.MS69120013","DOIUrl":"10.2739/kurumemedj.MS69120013","url":null,"abstract":"Introduction: High-flow nasal oxygen (HFNO) and prone positioning may improve outcomes of coronavirus disease 2019 (COVID-19) patients treated in the intensive care unit (ICU). The aim of this study was to describe outcomes following the timely application of HFNO and prone positioning in COVID-19 patients treated in a ward setting.Methods: The study included 89 prospectively recruited subjects at the COVID-19 ward unit of the University Hospital of Heraklion, Greece, between March and December 2020.Results: Seventy-four (83%) of the 89 subjects in the study had severe COVID-19. Of those, 33 (45%) required HFNO treatment and prone positioning and 15 (45%) were transferred to the ICU, with 4 of them being intubated. Severe COVID-19 and HFNO needs were associated with an increased pneumonia severity index (PSI) score on admission and a worse PaO2/FiO2 ratio. In multivariate analysis, PSI was the only independent predictor of subsequent HFNO needs (OR=1.022). Overall intubation and mortality rates were 5.6% and 3.4%, respectively.Conclusion: This study shows that for patients with severe COVID-19 hospitalized in medical wards, standard COVID-19 treatment, along with the timely utilization of HFNO and prone positioning, resulted in excellent outcomes with fewer ICU admission rates.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"53-63"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Nivolumab and Ipilimumab Combined Therapy as a First-Line Therapy for Patients with Advanced Melanoma and the Urgent Need for an Effective Second-Line Therapy for Patients with Wild-Type BRAF in Japan: A Single Center Retrospective Study. Nivolumab和Ipilimumab联合治疗晚期黑色素瘤患者的一线疗效和日本野生型BRAF患者急需有效的二线治疗：一项单中心回顾性研究。

Kurume Medical Journal Pub Date : 2023-11-30 Epub Date: 2023-10-03 DOI: 10.2739/kurumemedj.MS6912008

Ikko Muto, Hiroshi Koga, Reiichi Doi, Eri Katayama, Kenta Nakama, Takekuni Nakama

{"title":"Efficacy of Nivolumab and Ipilimumab Combined Therapy as a First-Line Therapy for Patients with Advanced Melanoma and the Urgent Need for an Effective Second-Line Therapy for Patients with Wild-Type BRAF in Japan: A Single Center Retrospective Study.","authors":"Ikko Muto, Hiroshi Koga, Reiichi Doi, Eri Katayama, Kenta Nakama, Takekuni Nakama","doi":"10.2739/kurumemedj.MS6912008","DOIUrl":"10.2739/kurumemedj.MS6912008","url":null,"abstract":"Therapeutic advantages of immune checkpoint inhibitors, anti-programmed death-1 (PD-1), and anticytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) in melanoma have been reported recently. In this study, we conducted a retrospective study to evaluate the clinical efficacy and safety of the combined use of nivolumab and ipilimumab as a first-line therapy for Japanese patients with advanced melanoma. Moreover, we examined the effects of second-line treatment. Seven patients were enrolled in this study. The median progression-free survival (PFS) and median overall survival (OS) were 7 months (95%CI, 1.868-12.132) and 12 months (95%CI, 0.000- 27.397), respectively. The objective response rate (ORR) and the disease control rate (DCR) were 42.9 % and 85.7 %. Three patients chose pembrolizumab monotherapy as second-line therapy after the combination therapy due to their BRAF wild-type status, which resulted in progressive disease. ORR and DCR were 0% and 33.3%, respectively, with pembrolizumab. Grade 3 or 4 immune-related adverse events occurred in 71.4% of the patients treated with the combined-therapy. All irAEs were treated with corticosteroid or hormone replacement therapy. Although this single center retrospective study had some limitations, it demonstrated good efficacy for the combined use of nivolumab and ipilimumab as a first-line therapy for Japanese patients with advanced melanoma. Moreover, poor efficacy was observed for the second-line therapy after the combined therapy. These findings suggest that a novel second-line therapy is required for patients with advanced melanoma in Japan, particularly for patients with wildtype BRAF.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"75-80"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41139005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative Rotation Deformity of Head-Neck Fragments in Unstable Intertrochanteric Fractures Fixed with Intramedullary Nails. 髓内钉固定治疗不稳定转子间骨折头颈部骨折术后旋转畸形。

Kurume Medical Journal Pub Date : 2023-11-30 Epub Date: 2023-10-03 DOI: 10.2739/kurumemedj.MS6912007

Hidehiro Nakamura, Kotaro Jimbo, Shinji Morito, Toshiaki Haraguchi, Yuji Kawasaki, Masafumi Gotoh, Masahiro Shirahama, Kenji Yoshida, Naoto Shiba

{"title":"Postoperative Rotation Deformity of Head-Neck Fragments in Unstable Intertrochanteric Fractures Fixed with Intramedullary Nails.","authors":"Hidehiro Nakamura, Kotaro Jimbo, Shinji Morito, Toshiaki Haraguchi, Yuji Kawasaki, Masafumi Gotoh, Masahiro Shirahama, Kenji Yoshida, Naoto Shiba","doi":"10.2739/kurumemedj.MS6912007","DOIUrl":"10.2739/kurumemedj.MS6912007","url":null,"abstract":"Background: Our purpose was to quantify the postoperative rotation deformity (RD) after osteosynthesis of unstable intertrochanteric fractures (ITFx) using 3D-CT / image processing software, and to clarify the clinical meaning of RD.Methods: Forty-six consecutive patients with unstable intertrochanteric fractures were enrolled in this study. All were fixed with Gamma 3 Trochanteric nail and RC Lag Screw® (Stryker). We performed 3D-CT evaluations for the rotational deformity of head-neck fragments, the medial cortex support (MCS) between main fragments and bone healing at 3 months postoperatively.Results: The RD was significantly larger in the patients without the MCS (5.1 ± 4.0°, N = 9) than those with the MCS (2.4 ± 2.6°, N = 37) (P = 0.006*). Delayed healing (N=3) was observed in patients without the MCS, and the association between RD and delayed healing was significant (P = 0.003*, cut-off value 6.4°, sensitivity 100% and specificity 90.7%, AUC 0.91).Conclusions: This study proposed a novel method of measuring postoperative RD. Lack of MCS may lead to RD and consequent delayed healing in unstable ITFx fixed with intramedullary nails.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41157763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reverse Obliquity Intertrochanteric Fracture Treated with a Dynamic Distal Locked Intramedullary Hip Nail. 动态远端锁定髓内钉治疗股骨粗隆间反向倾斜骨折。

Kurume Medical Journal Pub Date : 2023-11-30 Epub Date: 2023-08-07 DOI: 10.2739/kurumemedj.MS6912006

Toru Matsugaki, Hideki Mizu-Uchi, Hideaki Shibata, Yoshitaka Nakanishi, Tsunemasa Matsubara, Yuji Aratake, Takuma Fudo

{"title":"Reverse Obliquity Intertrochanteric Fracture Treated with a Dynamic Distal Locked Intramedullary Hip Nail.","authors":"Toru Matsugaki, Hideki Mizu-Uchi, Hideaki Shibata, Yoshitaka Nakanishi, Tsunemasa Matsubara, Yuji Aratake, Takuma Fudo","doi":"10.2739/kurumemedj.MS6912006","DOIUrl":"10.2739/kurumemedj.MS6912006","url":null,"abstract":"Introduction: The aim of this study was to describe the clinical and radiological results of reverse obliquity intertrochanteric fractures treated with dynamic distal locked intramedullary hip nails.Materials and methods: Patients with a reverse obliquity intertrochanteric fracture (AO/OTA type 31 A3.1 or A3.3) underwent surgical treatment with a dynamic distal locked intramedullary hip nail between August 2017 and September 2020. Fracture type, reduction quality, change in the position of the distal bone fragment, bone union, complications, and walking ability were evaluated.Results: Ten patients with reverse obliquity intertrochanteric fractures (seven females and three males) underwent dynamic distal locked intramedullary hip nailing. The mean age was 72.0 ± 18.9 years. Two patients were classi fied as having A3.1 fractures; eight patients were classified as having A3.3 fractures. Anatomical reduction was achieved in six patients, medial displacement remained in three patients, and lateral displacement remained in one patient postoperatively. In 9 out of 10 patients, the center of the proximal end of the distal bone fragment had moved laterally between the time immediately after surgery and the time of the final evaluation. Bone union was obtained uneventfully without any additional treatments in all patients. There were no complications such as infection or implant failure. Walking ability decreased in four patients.Conclusion: In all patients, bone union was achieved due to good contact of the medial cortices or the migration of the distal bone fragment into the proximal bone fragment. This procedure can be an option for treating reverse obliquity intertrochanteric fractures.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"31-38"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10000122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small Cell Neuroendocrine Carcinoma of the Parotid Gland: An Uncommon Example of Incompletely Encapsulated Tumor Including S100 Protein-Positive Clear Cells. 腮腺神经内分泌小细胞癌：包括S100蛋白阳性透明细胞在内的不完全包埋肿瘤的罕见例子。

Kurume Medical Journal Pub Date : 2023-11-30 Epub Date: 2023-10-03 DOI: 10.2739/kurumemedj.MS6912009

Hiroshi Harada, Takeharu Ono, Hideyuki Abe, Akihiko Kawahara, Shin-Ichi Nakatsuka, Keiichiro Honma, Hirohito Umeno, Jun Akiba, Akira Kurose

{"title":"Small Cell Neuroendocrine Carcinoma of the Parotid Gland: An Uncommon Example of Incompletely Encapsulated Tumor Including S100 Protein-Positive Clear Cells.","authors":"Hiroshi Harada, Takeharu Ono, Hideyuki Abe, Akihiko Kawahara, Shin-Ichi Nakatsuka, Keiichiro Honma, Hirohito Umeno, Jun Akiba, Akira Kurose","doi":"10.2739/kurumemedj.MS6912009","DOIUrl":"10.2739/kurumemedj.MS6912009","url":null,"abstract":"Small cell carcinoma is rare in salivary glands and has recently been termed small cell neuroendocrine carcinoma. We herein describe an uncommon example arising in the parotid gland. The patient was a 75 yearold Japanese male who had swelling in the right parotid area. He underwent a superficial lobectomy and, after a histological diagnosis was made, a total parotidectomy. Histologically, the tumor had a thick hyalinized capsule that was incomplete, beyond which the tumor invaded into the surrounding parotid parenchyma. The tumor consisted of typical small basophilic cells intermingled with bland clear cells, between which a gradual transition was observed both inside and outside the capsule. Small basophilic cells were immunoreactive for chromograninA as well as synaptophysin, while clear cells were positive for S100 protein. The Ki-67 labeling rate reached 30-40% at the high points of small basophilic cells, but clear cells were minimally labelled. The present case was considered a dedifferentiated carcinoma of the parotid gland, possibly with acinic cell carcinoma as a precursor. This tumor could also be considered a \"mixed exocrine-endocrine carcinoma,\" which may explain the histogenesis of neuroendocrine carcinomas in non-endocrine organs that are not included in the diffuse (dispersed) neuroendocrine system, such as the parotid gland.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"103-109"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41151646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-Myc Downstream Regulated Gene-1 May Play an Important Role in the Prognosis of Ovarian Cancer, in Its Association with Beta-Catenin. N-Myc下游调控基因-1可能在卵巢癌症预后中发挥重要作用，其与β-儿茶素的关系。

Kurume Medical Journal Pub Date : 2023-11-30 Epub Date: 2023-10-03 DOI: 10.2739/kurumemedj.MS6912010

Atsumu Terada, Naotake Tsuda, Shingo Tasaki, Jangmyong Park, Hiroki Nasu, Kazuto Tasaki, Takahiro Katsuda, Shin Nishio, Tomohiko Yamaguchi, Sakiko Sanada, Jun Akiba, Michihiko Kuwano, Mayumi Ono, Kimio Ushijima

{"title":"N-Myc Downstream Regulated Gene-1 May Play an Important Role in the Prognosis of Ovarian Cancer, in Its Association with Beta-Catenin.","authors":"Atsumu Terada, Naotake Tsuda, Shingo Tasaki, Jangmyong Park, Hiroki Nasu, Kazuto Tasaki, Takahiro Katsuda, Shin Nishio, Tomohiko Yamaguchi, Sakiko Sanada, Jun Akiba, Michihiko Kuwano, Mayumi Ono, Kimio Ushijima","doi":"10.2739/kurumemedj.MS6912010","DOIUrl":"10.2739/kurumemedj.MS6912010","url":null,"abstract":"NDRG1 is a nickel- and calcium-inducible gene that plays important roles in the primary growth of malignant tumors, as well as in invasion and metastasis. This study investigated the associations of NDRG1 expression with cell adhesion and other clinicopathological factors in ovarian cancer. The clinical records of 123 women who underwent surgery for ovarian cancer in our institute were reviewed retrospectively. The expression of NDRG1, E-cadherin, and beta-catenin in surgical specimens were evaluated immunohistochemically. The NDRG1 expression level was significantly associated with beta-catenin expression, peritoneal metastasis outside the pelvic cavity, lymph node metastasis, and FIGO stages. The Kaplan-Meier analysis showed a significant association between the NDRG1 expression level and progression-free survival: high NDRG1 expression was related to poor survival. Our results suggest that the increased expression of NDRG1 is associated with cell adhesion and may be a poor prognostic indicator in women with ovarian cancer.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"39-46"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41158563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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