Kurume Medical Journal最新文献_第10页

A Case of Urinary Extravasation and Urolithiasis During Pregnancy. 妊娠期尿外渗及尿石症1例。

Kurume Medical Journal Pub Date : 2023-04-04 DOI: 10.2739/kurumemedj.MS681006

Masato Ishimatsu, Toshiyuki Yoshizato, Yusuke Kurokawa, Kosuke Kawakami, Naofumi Okura

引用次数: 0

Impact of Interferon on the Prognosis of Hepatitis C Virus-Related Hepatocellular Carcinoma Patients with a Sustained Virological Response -An Additional Comparison Between Preoperative and Postoperative Sustained Virological Response. 干扰素对持续病毒学应答的丙型肝炎病毒相关肝细胞癌患者预后的影响——术前和术后持续病毒学应答的额外比较

Kurume Medical Journal Pub Date : 2023-04-04 DOI: 10.2739/kurumemedj.MS681001

Daisuke Muroya, Taro Nishimura, Hiroki Kanno, Satoki Kojima, Shogo Fukutomi, Masanori Akashi, Yoriko Nomura, Yuichi Goto, Toshihiro Sato, Hisamune Sakai, Toru Hisaka, Yoshito Akagi, Koji Okuda

{"title":"Impact of Interferon on the Prognosis of Hepatitis C Virus-Related Hepatocellular Carcinoma Patients with a Sustained Virological Response -An Additional Comparison Between Preoperative and Postoperative Sustained Virological Response.","authors":"Daisuke Muroya, Taro Nishimura, Hiroki Kanno, Satoki Kojima, Shogo Fukutomi, Masanori Akashi, Yoriko Nomura, Yuichi Goto, Toshihiro Sato, Hisamune Sakai, Toru Hisaka, Yoshito Akagi, Koji Okuda","doi":"10.2739/kurumemedj.MS681001","DOIUrl":"https://doi.org/10.2739/kurumemedj.MS681001","url":null,"abstract":"Background: Several studies have reported that interferon (IFN) therapy improves the prognosis of patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC), especially for patients who have achieved a sustained virological response (SVR). We retrospectively evaluated the clinicopathological outcomes of patients who acquired an SVR through IFN therapy pre- or post-hepatectomy for treatment naïve HCC.Method: Among the 305 HCV-related HCC patients entered in this study, 59 patients (SVR group) achieved an SVR after IFN therapy and received hepatectomy either after or before achieving an SVR (n=36 and n=23, respectively), while the remaining 179 patients (control group) did not receive IFN therapy, or did not achieve an SVR through IFN therapy (n=67).Results: In the SVR group, the overall survival (OS) and disease-free survival (DFS) rates were significantly higher than in the control group. We evaluated the prognosis of patients with an SVR achieved pre- or post-hepatectomy separately. There were no significant differences in OS and DFS.Conclusion: This result suggests that the prognosis of naïve HCC may be improved by additional INF therapy to achieve SVR status after hepatectomy.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":"68 1","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9255628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Mitral Regurgitation After Blunt Chest Trauma: A Case Report. 钝性胸外伤后急性二尖瓣返流1例报告。

Kurume Medical Journal Pub Date : 2023-04-04 DOI: 10.2739/kurumemedj.MS681002

Shigeaki Aoyagi, Satoru Tobinaga, Kumiko Wada, Shin-Ichi Nata, Hiroshi Yasunaga

{"title":"Acute Mitral Regurgitation After Blunt Chest Trauma: A Case Report.","authors":"Shigeaki Aoyagi, Satoru Tobinaga, Kumiko Wada, Shin-Ichi Nata, Hiroshi Yasunaga","doi":"10.2739/kurumemedj.MS681002","DOIUrl":"https://doi.org/10.2739/kurumemedj.MS681002","url":null,"abstract":"Myocardial contusion is the most common cardiac injury from blunt chest trauma (BCT), whereas isolated valve injury is uncommon. We report a case of acute mitral regurgitation (MR) due to isolated valve injury after BCT. A 60-year-old man received an impact on his left chest by a car wheel three weeks prior to visiting our hospital. At the time a diagnosis of contusion of the chest wall without rib and sternal fractures was made. Thereafter, the patient had progressive worsening of heart failure symptoms. Eventually he developed dyspnea on slight exertion but echocardiographic evaluation was not performed at the time of diagnosis or during the three weeks prior to admission. At admission a holosystolic murmur was heard. Transthoracic echocardiography revealed prolapse of the posterior mitral leaflet due to torn chordae tendineae with severe MR and normal left ventricular wall motion. At surgery, torn chordae tendineae and a leaflet tear of the posterior leaflet were detected, and mitral valve repair was achieved without residual MR. Pathological examination of the torn chordae showed no findings of endocarditis or myxomatous degeneration. Echocardiography may play an important role for accurate and prompt diagnosis of cardiac lesions in patients with recent or a history of high-energy BCT.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":"68 1","pages":"39-42"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9255627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of the Gerdq Questionnaire for Diagnosing Gastroesophageal Reflux Disease After Esophagectomy for Esophageal Cancer. Gerdq问卷对食管癌术后胃食管反流病的诊断价值

Kurume Medical Journal Pub Date : 2023-04-04 DOI: 10.2739/kurumemedj.MS681004

Kohei Saisho, Naoki Mori, Toshiaki Tanaka, Satoru Matono, Haruhiro Hino, Kazutaka Kadoya, Ryosuke Nishida, Masahiro Fujisaki, Masashi Nakagawa, Fumihiko Fujita, Masahiro Fujii, Takashi Yanagawa, Masahiro Mitsuoka, Yoshito Akagi

{"title":"Effectiveness of the Gerdq Questionnaire for Diagnosing Gastroesophageal Reflux Disease After Esophagectomy for Esophageal Cancer.","authors":"Kohei Saisho, Naoki Mori, Toshiaki Tanaka, Satoru Matono, Haruhiro Hino, Kazutaka Kadoya, Ryosuke Nishida, Masahiro Fujisaki, Masashi Nakagawa, Fumihiko Fujita, Masahiro Fujii, Takashi Yanagawa, Masahiro Mitsuoka, Yoshito Akagi","doi":"10.2739/kurumemedj.MS681004","DOIUrl":"https://doi.org/10.2739/kurumemedj.MS681004","url":null,"abstract":"Background: Gastroesophageal reflux disease (GERD) is a common complication after esophagectomy with gastric tube reconstruction. The GerdQ questionnaire was developed for diagnosing GERD in primary care patients. Its effectiveness in patients after esophagectomy remains unknown. In this study, we evaluated the usefulness of the GerdQ questionnaire for diagnosing GERD after esophagectomy for esophageal cancer.Materials and methods: A total of 124 patients with esophageal cancer underwent right transthoracic esophagectomy with gastric tube reconstruction between January 2010 and December 2016. Esophagogastroduodenoscopy and 24-hour esophageal pH-metry were performed at 1 month, 1 year, and 2 years postoperatively. The GerdQ questionnaire was administered at the same postoperative time points. We assessed any correlation between the GerdQ scores and the endoscopy and pH-metry findings.Results: The incidence rates of GERD at 1 month, 1 year and 2 years post-surgery were 31.6%, 46.9%, and 49.2%, respectively. The GerdQ questionnaire showed 77% sensitivity and 56% specificity for diagnosing GERD at 2 years after esophagectomy when the cutoff point was 7. However, the optimal cutoff points were different at each postoperative time, and the scores showed some imbalance between sensitivity and specificity. Regurgitation may be a useful indicator, as the frequency of regurgitation was significantly higher in patients with GERD than in patients without GERD at 1 year (P = 0.046) and 2 years postoperatively (P = 0.048).Conclusion: The GerdQ questionnaire is not a useful diagnostic tool for GERD in patients who have undergone esophagectomy for esophageal cancer.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":"68 1","pages":"25-31"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9255625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kurume Medical Journal Pub Date : 2023-04-04 DOI: 10.2739/kurumemedj.MS681005

Yusuke Kurokawa, Toshiyuki Yoshizato, Hitoshi Obara, Takuya Shimomura, Yutaka Kozuma, Tatsuyuki Kakuma, Daizo Hori, Kimio Ushijima

{"title":"Related Factors for Abnormal Umbilical Cord Insertion: A Preliminary Study Based on Two Regional Tertiary Hospitals in Japan.","authors":"Yusuke Kurokawa, Toshiyuki Yoshizato, Hitoshi Obara, Takuya Shimomura, Yutaka Kozuma, Tatsuyuki Kakuma, Daizo Hori, Kimio Ushijima","doi":"10.2739/kurumemedj.MS681005","DOIUrl":"https://doi.org/10.2739/kurumemedj.MS681005","url":null,"abstract":"Objective: We elucidated maternal background, perinatal complications and outcomes as potential related factors for abnormal umbilical cord insertion (ACI) -velamentous and marginal- based on data from two tertiary perinatal hospitals in Japan.Materials and methods: The subjects were 3,741 women with singleton pregnancies who delivered at ≥ 22 weeks' gestation in Kurume University Hospital and St. Mary's Hospital, Kurume, Japan from January 2013 to December 2015. They were divided into two groups, with and without ACI. Related factors were extracted from the medical registry database of the perinatal committee in the Japan Society of Obstetrics and Gynecology. Random Forest and stepwise logistic regression models were employed to evaluate their impact on ACI.Results: Related factors for ACI in terms of maternal background and perinatal complications and outcomes were: pre-pregnancy smoking habit (adjusted odds ratio, OR, 3.38; 95% confidence interval, CI, 2.20-5.20; P < 0.0001); conception using assisted reproductive technology (adjusted OR, 2.00; 95% CI, 1.11-3.60; P = 0.021); placenta previa (adjusted OR, 4.74; 95% CI, 2.06-10.90; P < 0.0001); fetal growth restriction (adjusted OR, 2.43; 95% CI, 1.49-3.97; P < 0.0001); and non-reassuring fetal status during labor (adjusted OR, 2.74; 95% CI, 1.71-4.38; P < 0.0001).Conclusion: This was a preliminary study attempting to elucidate related factors for ACI in a Japanese population. However, further large-scale studies are needed in Japan.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":"68 1","pages":"19-23"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9255626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient-Specific Femoral Guide with 3-Dimensional Support Software in Anterolateral Supine Approach of Total Hip Arthroplasty: A Single-Arm Trial. 在全髋关节置换术的仰卧前外侧入路中，带三维支持软件的患者专用股骨导向器:单臂试验。

Kurume Medical Journal Pub Date : 2023-04-04 DOI: 10.2739/kurumemedj.MS681003

Daihei Kida, Hiroya Hashimoto, Noriko Ito, Yukari Kito, Kouichi Mori, Yosuke Hattori, Nobunori Takahashi, Masaaki Matsubara

{"title":"Patient-Specific Femoral Guide with 3-Dimensional Support Software in Anterolateral Supine Approach of Total Hip Arthroplasty: A Single-Arm Trial.","authors":"Daihei Kida, Hiroya Hashimoto, Noriko Ito, Yukari Kito, Kouichi Mori, Yosuke Hattori, Nobunori Takahashi, Masaaki Matsubara","doi":"10.2739/kurumemedj.MS681003","DOIUrl":"https://doi.org/10.2739/kurumemedj.MS681003","url":null,"abstract":"Currently, there is no surgical assistance system that can perform a three-dimensional (3D) planned total hip arthroplasty (THA) by methods other than surgical assistance navigation or robots. However, they are expensive, cumbersome, and subject to additional invasiveness, so there is a need for a simpler and less expensive 3D surgical support system. In this study, THA was performed using the anterolateral approach (Watson-Jones) in the supine position in 23 subjects to examine the efficacy and safety of a patient-specific femoral guide linked to 3D surgery support software. In 48% of the subjects, the difference in anterior torsion angle from the preoperative plan was within ±5 degrees, while in 83% of the subjects, the difference was within ±10 degrees. The 95% confidence interval (4.61-8.70) of the absolute difference did not fall below the pre-defined threshold of 7.2 degrees (p = 0.293). No adverse events were observed other than 2 cases (8.7%) of hemorrhage that required a blood transfusion. We confirmed the efficacy and safety of the patient-specific femoral guide in anterolateral supine approach THA.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":"68 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9255629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Unique Foramen Magnum with a Posterior Notch. 一个独特的枕骨大孔和一个后切迹。

Kurume Medical Journal Pub Date : 2023-02-06 DOI: 10.2739/kurumemedj.MS674003

Tess Decater, Joe Iwanaga, Marios Loukas, Aaron S Dumont, R Shane Tubbs

引用次数: 0

Trends in the Prevalence of Cancer in Cardiovascular Diseases: A Single Center Retrospective Study, 2011-2018. 2011-2018年心血管疾病中癌症流行趋势的单中心回顾性研究

Kurume Medical Journal Pub Date : 2023-02-06 DOI: 10.2739/kurumemedj.MS674007

Jiahui Sun, Koutatsu Shimozono, Hisashi Adachi, Shoichiro Nohara, Tatsuhiro Shibata, Yoichi Sugiyama, Yoshihiro Fukumoto

{"title":"Trends in the Prevalence of Cancer in Cardiovascular Diseases: A Single Center Retrospective Study, 2011-2018.","authors":"Jiahui Sun, Koutatsu Shimozono, Hisashi Adachi, Shoichiro Nohara, Tatsuhiro Shibata, Yoichi Sugiyama, Yoshihiro Fukumoto","doi":"10.2739/kurumemedj.MS674007","DOIUrl":"https://doi.org/10.2739/kurumemedj.MS674007","url":null,"abstract":"Background: Recent progress of cancer therapy has increased the number of cancer survivors, in whom cardiovascular diseases (CVDs) have become a big concern. This study aimed to clarify the prevalence of various types of CVDs in cancer patients, using the database of the Cardiovascular Medicine in Kurume University Hospital.Methods and results: This retrospective cohort study enrolled 11,093 hospitalized patients in Cardiovascular Medicine, Kurume University Hospital from April 2011 to March 2019. Among 11,093 enrolled patients, there were 992 CVDs patients with cancer (8.94%). The five most prevalent forms of cancer were colon cancer, prostate cancer, hepatocellular carcinoma, lung cancer, and gastric cancer. Although there was no statistical significance, the comorbidity of breast cancer gradually increased during the study period (2011-2018). In all CVDs, prostate cancer, lung cancer, and uterine cancer tended to increase as comorbidities, while hepatocellular carcinoma and tongue cancer tended to decrease during the observational period. The absolute number of patients with cancer increased in all CVDs, including coronary artery diseases, heart failure, arrhythmia, and pulmonary hypertension.Conclusions: The present study demonstrates that the prevalence of cancer in hospitalized CVDs patients was around 10%, and is showing a tendency to increase. Thus, cancer may have substantial impacts on CVDs treatment.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":"67 4","pages":"147-161"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9210054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The E2F6 Transcription Factor is Associated with the Mammalian SUZ12-Containing Polycomb Complex. E2F6转录因子与哺乳动物含有suz12的多梳复合物相关。

Kurume Medical Journal Pub Date : 2023-02-06 DOI: 10.2739/kurumemedj.MS674006

Yuko Shirahama, Ken Yamamoto

{"title":"The E2F6 Transcription Factor is Associated with the Mammalian SUZ12-Containing Polycomb Complex.","authors":"Yuko Shirahama, Ken Yamamoto","doi":"10.2739/kurumemedj.MS674006","DOIUrl":"https://doi.org/10.2739/kurumemedj.MS674006","url":null,"abstract":"The Polycomb group protein (PcG) SUZ12 forms Polycomb repressive complexes together with histone methyltransferase EZH2. Although the complexes have been demonstrated to be involved in epigenetic maintenance of gene expression in a transcriptional repressive state, it is unclear how they are recruited to the target genes. Here we report that SUZ12 directly interacts with site-specific transcriptional repressor E2F6 and forms a complex together with EZH2. SUZ12 interacts with E2F6 selectively among the E2F family proteins and E2F6- containing SUZ12-EZH2 complex was biochemically purified from HEK293 cells stably expressing Flag-tagged SUZ12. Chromatin immunoprecipitation assays revealed the target genes of the E2F6-SUZ12-EZH2 complex. Contrary to expectation, the promoter regions of these genes are not or only weakly tri-methylated at histone H3-K27, and their expression is down-regulated by depletion of EZH2. Given that the transactivation function of SUZ12-EZH2 has been previously reported, the inhibitory effect on E2F6-mediated transcriptional repression by physical interaction can be considered a candidate mechanism of gene activation by these PcGs.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":"67 4","pages":"171-183"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10697016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Walking Combined with Neuromuscular Electrical Stimulation on Liver Stiffness and Insulin Resistance in Patients with Non-alcoholic Fatty Liver Disease: An Exploratory Randomized Controlled Trial. 步行联合神经肌肉电刺激对非酒精性脂肪肝患者肝脏僵硬和胰岛素抵抗的影响:一项探索性随机对照试验

Kurume Medical Journal Pub Date : 2023-02-06 DOI: 10.2739/kurumemedj.MS674001

Sohei Iwanaga, Hiroo Matsuse, Ryuki Hashida, Masafumi Bekki, Takumi Kawaguchi, Naoto Shiba

{"title":"The Effect of Walking Combined with Neuromuscular Electrical Stimulation on Liver Stiffness and Insulin Resistance in Patients with Non-alcoholic Fatty Liver Disease: An Exploratory Randomized Controlled Trial.","authors":"Sohei Iwanaga, Hiroo Matsuse, Ryuki Hashida, Masafumi Bekki, Takumi Kawaguchi, Naoto Shiba","doi":"10.2739/kurumemedj.MS674001","DOIUrl":"https://doi.org/10.2739/kurumemedj.MS674001","url":null,"abstract":"Increased liver stiffness and insulin resistance are important therapeutic targets in patients with nonalcoholic fatty liver disease (NAFLD). A hybrid training system (HTS) has been developed which combines application of electrical stimulation and volitional contractions. We compared the effect of walking exercise (5.6 km/h) both with and without simultaneous HTS on liver stiffness and insulin resistance. In a single-blind, controlled trial, 32 subjects with NAFLD were randomized to 12 weeks of triweekly 30 minute walking exercise with either HTS (HTS group) or without HTS (control group). Transient elastography for the assessment of liver stiffness, body weight, visceral fat, the homeostasis model assessment of insulin resistance, fasting blood glucose, serum aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase were evaluated. Data were evaluated using the linear model after adjusting the baseline value. In the subjects with BMI of 27 kg/m2 or more, the decrement of transient elastography in the HTS group was significantly larger than in the control group (mean ± standard error: Δ2.13 ± 0.64 kPa vs. Δ-0.67 ± 0.42 kPa, p=0.0009). There were no significant differences between groups in other endpoints. These results showed that simultaneously combining electrical stimulation with walking exercise could potentially improve liver stiffness in people who have NAFLD. In fact, because the exercise effect was increased by HTS without increasing the walking speed, this HTS could be especially useful for obese or overweight subjects, in whom NAFLD and joint problems often coexist. However, its effects on insulin resistance and body composition were not clear.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":"67 4","pages":"137-146"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10654717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0