Kurume Medical Journal最新文献_第4页

Association of Chemotherapy Response Score with Multidrug Resistance 1 and CA125 ELIMination Rate Constant K in Patients with Advanced Ovarian Cancer Treated with Neoadjuvant Chemotherapy. 接受新辅助化疗的晚期卵巢癌患者的化疗反应评分与多药耐药性1和CA125 ELIMination Rate常数K的关系

Kurume Medical Journal Pub Date : 2024-07-02 Epub Date: 2024-03-29 DOI: 10.2739/kurumemedj.MS7012004

Ken Matsukuma, Shin Nishio, Shingo Tasaki, Jongmyung Park, Hiroki Nasu, Teruyuki Yoshimitsu, Kazuto Tasaki, Takahiro Katsuda, Atsumu Terada, Naotake Tsuda, Sakiko Sanada, Kimio Ushijima

{"title":"Association of Chemotherapy Response Score with Multidrug Resistance 1 and CA125 ELIMination Rate Constant K in Patients with Advanced Ovarian Cancer Treated with Neoadjuvant Chemotherapy.","authors":"Ken Matsukuma, Shin Nishio, Shingo Tasaki, Jongmyung Park, Hiroki Nasu, Teruyuki Yoshimitsu, Kazuto Tasaki, Takahiro Katsuda, Atsumu Terada, Naotake Tsuda, Sakiko Sanada, Kimio Ushijima","doi":"10.2739/kurumemedj.MS7012004","DOIUrl":"10.2739/kurumemedj.MS7012004","url":null,"abstract":"Aim: The relationship between chemotherapy response score (CRS), a widely used response predictor of neoadjuvant chemotherapy-interval debulking surgery (NAC-IDS), and multidrug resistance 1 (MDR1) and CA125 ELIMination rate constant K (KELIM), is undetermined. We evaluated CRS in advanced ovarian cancer patients undergoing NAC and looked for associations between CRS and MDR1 and CA125 KELIM. Our aim was to predict the therapeutic effect of NAC before interval debulking surgery (IDS) by examining its association with CRS.Methods: This retrospective cohort study included patients who underwent NAC-IDS (first-line treatment) at Kurume University Hospital, Japan, between 2004 and 2017. CRS association with MDR1 and CA125 KELIM was examined using Cox proportional hazard regression analyses. Survival curves used Kaplan-Meier method, and survival differences between groups used log-rank test.Results: Overall, 55 patients were classified into CRS1 (n=22), CRS2 (n=19), and CRS3 (n=14). The CRS3 group had a significantly better prognosis than the CRS1 or CRS2 group. CRS, age, and IDS status were clinical prognostic factors for ovarian cancer. MDR1 positivity for excision repair cross-complementing group 1, β-tubulin, and Y-box binding protein-1 occurred in 15, 17, and 11 patients, respectively, but these were not associated with CRS. CA125 KELIM was <0.5 (n=8), 0.5-1.0 (n=30), and ≥ 1.0 (n=17) but not associated with CRS.Conclusion: CRS is reconfirmed as a treatment response predictor for NAC-IDS, but its association with drug resistance factors remains unconfirmed.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the Clinical Course in a Population of Patients with Biliary Tract Cancer Diagnosed as Unresectable After Portal Vein Embolization: A Case Series. 门静脉栓塞术后诊断为不可切除的胆管癌患者临床病程分析：病例系列。

Kurume Medical Journal Pub Date : 2024-07-02 Epub Date: 2024-03-19 DOI: 10.2739/kurumemedj.MS7012001

Hajime Imamura, Tomohiko Adachi, Hajime Matsushima, Hideki Ishimaru, Masayuki Fukumoto, Kyohei Yoshino, Kunihiro Matsuguma, Ryo Matsumoto, Takanobu Hara, Akihiko Soyama, Masaaki Hidaka, Susumu Eguchi

{"title":"Analysis of the Clinical Course in a Population of Patients with Biliary Tract Cancer Diagnosed as Unresectable After Portal Vein Embolization: A Case Series.","authors":"Hajime Imamura, Tomohiko Adachi, Hajime Matsushima, Hideki Ishimaru, Masayuki Fukumoto, Kyohei Yoshino, Kunihiro Matsuguma, Ryo Matsumoto, Takanobu Hara, Akihiko Soyama, Masaaki Hidaka, Susumu Eguchi","doi":"10.2739/kurumemedj.MS7012001","DOIUrl":"10.2739/kurumemedj.MS7012001","url":null,"abstract":"Portal vein embolization (PVE) is recommended as a preoperative procedure for patients with biliary tract cancer scheduled to undergo hepatic resection of more than 50%-60% of the liver. However, details and/or information regarding the follow-up of unresectable cases are often lacking, and the clinical course of unresectable cases is not well analyzed and reported. This study aimed to clarify the clinical prognosis of patients with unresectable biliary tract cancer after PVE. We retrospectively analyzed the clinical backgrounds of patients with biliary tract cancer who underwent PVE without subsequent resection between January 2011 and October 2022. Of the 21 patients with biliary tract cancer who underwent PVE during the study period, eight (38%) cases were unsuitable for resection after PVE for the following reasons: intraoperatively detected dissemination (n=2), para-aortic lymph node metastasis (n=1), liver metastasis (n=1), decreased liver function (n=2), development of liver metastasis while waiting (n=1), and insufficient residual liver volume (n=1). All patients received subsequent chemotherapy, including gemcitabine plus S-1 therapy in three cases, gemcitabine plus cisplatin plus S-1 in three cases, and gemcitabine plus cisplatin or S-1+cisplatin in one case each. As there is currently no curative treatment for biliary tract cancer other than surgery, multidisciplinary management and treatment of patient factors, including tumor factors and liver function, are essential to reducing the number of unresectable cases after PVE.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"77-81"},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Analysis for Potential Hospital-Acquired Infection Caused by Aspergillus Tubingensis Through the Environment. 通过环境对管曲霉引起的潜在医院感染进行分子分析。

Kurume Medical Journal Pub Date : 2024-05-14 Epub Date: 2024-01-16 DOI: 10.2739/kurumemedj.MS6934013

Chiyoko Tanamachi, Jun Iwahashi, Akinobu Togo, Keisuke Ohta, Miho Miura, Toru Sakamoto, Kenji Gotoh, Rie Horita, Katsuhiko Kamei, Hiroshi Watanabe

{"title":"Molecular Analysis for Potential Hospital-Acquired Infection Caused by Aspergillus Tubingensis Through the Environment.","authors":"Chiyoko Tanamachi, Jun Iwahashi, Akinobu Togo, Keisuke Ohta, Miho Miura, Toru Sakamoto, Kenji Gotoh, Rie Horita, Katsuhiko Kamei, Hiroshi Watanabe","doi":"10.2739/kurumemedj.MS6934013","DOIUrl":"10.2739/kurumemedj.MS6934013","url":null,"abstract":"The identification of Aspergillus species has been performed mainly by morphological classification. In recent years, however, the revelation of the existence of cryptic species has required genetic analysis for accurate identification. The purpose of this study was to investigate five Aspergillus section Nigri strains isolated from a patient and the environment in a university hospital. Species identification by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry identified all five black Aspergillus strains as Aspergillus niger. However, calmodulin gene sequence analysis revealed that all five strains were cryptic species, four of which, including the clinical strain, were Aspergillus tubingensis. Hospital-acquired infection of the patient with the A. tubingensis strain introduced from the environment was suspected, but sequencing of six genes from four A. tubingensis strains revealed no environmental strain that completely matched the patient strain. The amount of in vitro biofilm formation of the four examples of the A. tubingensis strain was comparable to that of Aspergillus fumigatus. An extracellular matrix was observed by electron microscopy of the biofilm of the clinical strain. This study suggests that various types of biofilm-forming A. tubingensis exist in the hospital environment and that appropriate environmental management is required.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"185-193"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual Assessment of Therapeutic Relationships in Psychiatric Patients: A Pilot Study Using the Pictorial Representation of Illness and Self Measure. 精神病患者治疗关系的视觉评估：使用 "疾病和自我测量的图画表现 "进行试点研究。

Kurume Medical Journal Pub Date : 2024-05-14 Epub Date: 2024-01-16 DOI: 10.2739/kurumemedj.MS6934005

Kiyoshi Naganuma, Misari Oe, Tetsuya Ishida, Yudai Kobayashi, Hiromi Chiba, Michiko Matsuoka, Motohiro Ozone

{"title":"Visual Assessment of Therapeutic Relationships in Psychiatric Patients: A Pilot Study Using the Pictorial Representation of Illness and Self Measure.","authors":"Kiyoshi Naganuma, Misari Oe, Tetsuya Ishida, Yudai Kobayashi, Hiromi Chiba, Michiko Matsuoka, Motohiro Ozone","doi":"10.2739/kurumemedj.MS6934005","DOIUrl":"10.2739/kurumemedj.MS6934005","url":null,"abstract":"Background: Although the therapeutic relationship (or 'alliance') is well known to be a key component of psychiatric treatment, there has been no simple way to objectively measure the patient-therapist relationship. Here, we measured the psychological distance between patients and their therapists by using the Pictorial Representation of Illness and Self Measure (PRISM).Patients and methods: We analyzed the patient-therapist relationship of 112 patients from two hospitals in Japan (54 males, 57 females, 1 unknown; age 46.20 ± 15.03 years [mean ± SD]) who completed the PRISM and self report questionnaires (LSNS-6, K6, and BASIS-32) about their social network, psychological distress, and outcomes of mental health treatment.Results: PRISM measurements were available for all patients who consented to participate. In the comparison by disease category, schizophrenia recorded the closest distance to the psychiatrist in charge, followed by bipolar disorder, depression, and neurotic disorder. Regarding the distance to the psychiatrist in charge, PRISM showed a weak negative correlation (r = -0.23, p < 0.05) with age, indicating that with increasing age, the therapeutic rela tionship was more important to the patients.Conclusion: Our findings indicate the possibility of implementing PRISM to assess the impact of the therapeutic relationship in patients with a wide range of psychiatric disorders, and they suggest that PRISM holds great potential for clinical application.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"159-165"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Associated with Perioperative Edema in Patients with Stage I Gastric Cancer Using a Body Composition Analyzer. 使用身体成分分析仪分析胃癌 I 期患者围手术期水肿的相关因素。

Kurume Medical Journal Pub Date : 2024-05-14 Epub Date: 2024-01-16 DOI: 10.2739/kurumemedj.MS6934010

Yuki Umetani, Keishiro Aoyagi, Hideaki Kaku, Yuya Tanaka, Taizan Minami, Taro Isobe, Junya Kizaki, Naotaka Murakami, Fumihiko Fujita, Yoshito Akagi

{"title":"Factors Associated with Perioperative Edema in Patients with Stage I Gastric Cancer Using a Body Composition Analyzer.","authors":"Yuki Umetani, Keishiro Aoyagi, Hideaki Kaku, Yuya Tanaka, Taizan Minami, Taro Isobe, Junya Kizaki, Naotaka Murakami, Fumihiko Fujita, Yoshito Akagi","doi":"10.2739/kurumemedj.MS6934010","DOIUrl":"10.2739/kurumemedj.MS6934010","url":null,"abstract":"Purpose: Assessment of nutritional status and nutritional interventions is important in gastric cancer patients. We investigated the factors associated with perioperative edema in patients with stage I gastric cancer using a body composition analyzer.Methods: The study included 106 patients with stage I gastric cancer who underwent distal gastrectomy. The body composition of each patient was evaluated by bioelectrical impedance analysis (BIA) using an InBody 720 body composition analyzer. Patients with an extracellular water to total body water ratio of ≥ 0.4 before and 1 week after gastrectomy were considered to have edema, the cause of which was determined retrospectively.Results: Patients with preoperative edema were significantly older, had a significantly higher lymph node metastasis rate and disease stage, and had a significantly poorer Controlling Nutritional Status (CONUT) score, and Prognostic Nutritional Index (PNI) compared with patients without preoperative edema. The group with postoperative edema had significantly higher proportions of elderly and female patients as well as a higher rate of Billroth-II reconstruction compared with the group without postoperative edema. The group with postoperative edema also had significantly lower intracellular water content, total body water content, protein content, skeletal muscle mass, and PNI.Conclusions: Preoperative edema occurs in elderly patients with poor nutritional status, and postoperative edema occurs in elderly patients with a shorter operative time. Perioperative edema status assessed by BIA is thought to be related to perioperative nutritional status.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"201-208"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are the Ethmoidal Foramina Through the Frontal Bone, Ethmoid Bone, or Frontoethmoidal Suture? 乙状窦是通过额骨、乙状骨还是前牙窦缝？

Kurume Medical Journal Pub Date : 2024-05-14 Epub Date: 2024-01-16 DOI: 10.2739/kurumemedj.MS6934012

Joe Iwanaga, Rishawn Dindial, Dany Hage, Mansour Mathkour, Marios Loukas, Jerzy A Walocha, Aaron S Dumont, R Shane Tubbs

{"title":"Are the Ethmoidal Foramina Through the Frontal Bone, Ethmoid Bone, or Frontoethmoidal Suture?","authors":"Joe Iwanaga, Rishawn Dindial, Dany Hage, Mansour Mathkour, Marios Loukas, Jerzy A Walocha, Aaron S Dumont, R Shane Tubbs","doi":"10.2739/kurumemedj.MS6934012","DOIUrl":"10.2739/kurumemedj.MS6934012","url":null,"abstract":"Introduction: To investigate the locations of the anterior, middle, and posterior ethmoidal foramina and their relationships to the frontoethmoidal suture.Methods: One hundred twenty sides from sixty adult human skulls were used. Specimens with significant damage to the medial orbit wall were excluded. The number of ethmoidal foramina (anterior, middle, and posterior) on the medial orbital wall and the relationship of each foramen to the frontoethmoidal suture were recorded and classified as follows: Type I: superior to the frontoethmoidal suture; Type II: on the frontoethmoidal suture; Type III: inferior to the frontoethmoidal suture.Results: Of the ninety-four sides, fourteen (14.9%) had one foramen, sixty-two (66.0%) had two , and eighteen (19.1%) had three. In total, 192 ethmoidal foramina were observed. Among the fourteen sides with one foramen, eight foramina were anterior and six were posterior. Among the 192 ethmoidal foramina, 162 were eligible for fur ther classification (74 anterior, 14 middle, and 74 posterior). Types I, II, and III ethmoidal foramina were found in 38.3% (62/162), 61.7% (100/162), and 0% (0/162), respectively.Conclusions: Our current study found a higher incidence of type I than previously reported. It is important to be aware of the significant incidence of foramen variations when the medial orbit wall is manipulated during surgery. Unless caution is observed, an inadvertent surgical injury can occur and lead to life-threatening complications. Therefore, a good understanding of orbital anatomy and its potential variations is critical for improving patient out comes.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"195-199"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors for Desaturation in Anesthetic Management During Airway Stenting. 气道支架植入术中麻醉管理中出现饱和度降低的风险因素。

Kurume Medical Journal Pub Date : 2024-05-14 Epub Date: 2024-01-16 DOI: 10.2739/kurumemedj.MS6934003

Sakura Okamoto, Namie Somiya, Ran Hotta, Hideo Saka, Masahide Oki, Akira Tomita

{"title":"Risk Factors for Desaturation in Anesthetic Management During Airway Stenting.","authors":"Sakura Okamoto, Namie Somiya, Ran Hotta, Hideo Saka, Masahide Oki, Akira Tomita","doi":"10.2739/kurumemedj.MS6934003","DOIUrl":"10.2739/kurumemedj.MS6934003","url":null,"abstract":"Airway stenting involves a stent being inserted into a stenotic site in the airway. In patients with airway stenosis, the airway is the surgical field; therefore, anesthetic management is challenging, and avoiding hypoxia is important. Limited information is available on the anesthetic management of airway stenting. Risk factors for oxygen desaturation during airway stenting remain unknown. The present study was conducted to retrospectively examine patients who underwent airway stenting during a specific period and identify risk factors associated with oxygen desaturation. We performed univariate and multivariate analyses. The main evaluation items in a multivariate analysis were risk factors for desaturation (SpO2 ≤ 90%). Body mass index, preoperative orthopnea, the stenotic site of the airway, and severity of stenosis were selected for clinical usefulness. We analyzed 302 patients who underwent airway stenting at our hospital between July 2011 and June 2014 under general anesthesia with controlled ventilation. Total intravenous anesthesia with propofol target-controlled infusion and remifentanil was performed. Clinical data were extracted from electronic anesthetic records. The incidence of desaturation (SpO2 ≤ 90%) was 18.5% (56 out of 302 cases). Preoperative orthopnea (OR, 3.06)and stenosis distal to the bronchus (OR, 3.31) were identified as risk factors for desaturation in a multivariate analysis. We herein identified risk factors for desaturation during airway stenting. Anesthetic plans need to be carefully considered for patients with these risk factors.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"135-142"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality-Adjusted Survival in Patients with Recurrence of Breast Cancer Diagnosed by Asymptomatic or Symptomatic Opportunities. 通过无症状或有症状机会确诊的乳腺癌复发患者的质量调整生存率

Kurume Medical Journal Pub Date : 2024-05-14 Epub Date: 2024-01-16 DOI: 10.2739/kurumemedj.MS6934015

Kosho Yamanouchi, Shigeto Maeda

{"title":"Quality-Adjusted Survival in Patients with Recurrence of Breast Cancer Diagnosed by Asymptomatic or Symptomatic Opportunities.","authors":"Kosho Yamanouchi, Shigeto Maeda","doi":"10.2739/kurumemedj.MS6934015","DOIUrl":"10.2739/kurumemedj.MS6934015","url":null,"abstract":"After radical surgery for breast cancer, screening to diagnose recurrence in asymptomatic patients is not recommended. We retrospectively evaluated quality-adjusted survival. Included were fifty-seven recurrent breast cancer patients who died. Survival was partitioned into 3 health states by two different definitions: definition a) time with toxicities due to chemotherapy before progression (TOX1), time from the diagnosis of recurrence to progression without toxicities (TWiST1), and time from progression to death (REL1); definition b) time from the diagnosis of recurrence to death with toxicities (TOX2), without toxicities or hospitalization (TWiST2), and with hospitalization (REL2). Q-TWiST was calculated by multiplying the time in each health state by its utility (uTOX, uTWiST, and uREL). In threshold analyses, uTOX and uREL ranged from 0.0 to 1.0 whereas uTWiST was maintained at 1.0. We compared the patients with (n=32) and without (n=25) symptoms at the time of the diagnosis of recurrence. There was no difference in overall survival after primary surgery, although survival after the diagnosis of recurrence was significantly longer in the asymptomatic patients (p<0.01). Q-TWiST1 and Q-TWiST2 from the diagnosis of recurrence in the asymptomatic patients were significantly longer. Q-TWiST2 from primary surgery in the asymptomatic patients was significantly longer with some combinations of higher uTOX2 and lower uREL2. In conclusion, the asymptomatic detection of recurrence was associated with significantly longer quality-adjusted survival in comparison to symptomatic detection with some combinations of uTOX2 and uREL2. A prospective evaluation would clarify adequate follow-up methods after radical surgery for breast cancer.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"175-184"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subacute Neurotoxicity as an Adverse Reaction to Ceftazidime: A Case Report. 头孢他啶不良反应引起的亚急性神经中毒：病例报告。

Kurume Medical Journal Pub Date : 2024-05-14 Epub Date: 2024-01-16 DOI: 10.2739/kurumemedj.MS6934009

Filipe Oliveira Pinheiro, Delfim Duarte, Pedro Rodrigues, Luís Nogueira-Silva, José Carlos Martins, Jorge Almeida

{"title":"Subacute Neurotoxicity as an Adverse Reaction to Ceftazidime: A Case Report.","authors":"Filipe Oliveira Pinheiro, Delfim Duarte, Pedro Rodrigues, Luís Nogueira-Silva, José Carlos Martins, Jorge Almeida","doi":"10.2739/kurumemedj.MS6934009","DOIUrl":"10.2739/kurumemedj.MS6934009","url":null,"abstract":"Neurotoxicity associated with cephalosporins is an increasingly recognized complication, although among cephalosporins, ceftazidime is rarely reported for such an adverse reaction. Moreover, subacute, rather than acute, presentation of neurotoxicity associated with cephalosporins is rare. A 77-year-old female patient with stage 4 chronic renal disease was admitted due to cellulitis in her right lower limb, multiorgan dysfunction complicated by oliguric acute kidney injury, and a need for hemodialysis via a central venous catheter. On the 13th day after admission, she became febrile, and bacteremia associated with a central venous catheter was identified, which prompted the initiation of empirical antibiotic therapy with vancomycin and ceftazidime. After 13 days of antibiotic therapy with vancomycin and ceftazidime, the patient became confused, with temporal-spatial disorientation and myoclonus, especially in the upper limbs, with worsening renal function. Ceftazidime was discontinued, and the patient's condition improved with complete remission of symptoms on the 8th day after symptom onset. Neurotoxicity associated with ceftazidime is a rare but probably underdiagnosed adverse reaction. It is more frequent in elderly patients with previous neurological dysfunction and end-stage kidney disease and/or acute kidney injury, and it usually manifests soon after starting treatment. Early identification and monitoring of risk factors and symptoms should lead the physician to a rapid withdrawal of the offending drug.","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"261-263"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of Pneumocystography for Navigation of Stereotaxic Core-needle Biopsy in Complex Breast Cysts: Case Report. 在复杂乳腺囊肿的立体定向核心针活检中使用气囊造影术导航：病例报告。

Kurume Medical Journal Pub Date : 2024-05-14 Epub Date: 2024-01-16 DOI: 10.2739/kurumemedj.MS6934011

G A Belonenko, A A Aksyonov, N A Sukhina, E G Aksyonova

引用次数: 0