{"title":"Bilateral Persistent Sciatic Veins: A Cadaveric Case Report.","authors":"Renna Higa, Aya Han, Yoko Tabira, Keishiro Kikuchi, Kunimitsu Nooma, Tatsuya Harano, Keigo Shimizu, Eiko Inoue, Yuto Haikata, Joe Iwanaga, Tsuyoshi Saga, Koichi Watanabe","doi":"10.2739/kurumemedj.MS7134004","DOIUrl":"https://doi.org/10.2739/kurumemedj.MS7134004","url":null,"abstract":"<p><p>We encountered a cadaver with bilateral persistent sciatic veins (PSVs) in the anatomical dissection course at our institution. Although PSV is associated with Klippel-Tranaunay syndrome, there were no other findings typical of the syndrome in this case. The PSVs on each side differed. On the left, the PSV ascended in the posterior thigh and passed through the intramuscular space caudal to the quadratus femoris. It then coursed anteriorly and joined the deep femoral vein. The femoral vein originated from the popliteal vein; it passed through the adductor canal, ascended in the femoral triangle, and passed under the inguinal ligament after receiving the deep femoral vein. On the right, the PSV ascended in the posterior thigh and passed through the intermuscular space between the adductor magnus and adductor minor (a lower position than on the left); it then coursed anteriorly and merged with the femoral vein. The right femoral vein originated from the popliteal vein; it then passed through the adductor canal, ascended in the femoral triangle, and merged with the PSV. It is important to correctly diagnose PSV at the time of surgical or radiological intervention to avoid complications of the procedure and to improve outcomes. PSV can cause unexpected bleeding during lower extremity surgery. Clinicians should be aware of this rare anomaly.</p>","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intersegmental Fixation with an Interspinous Spacer (IFIS) for Lumbar Spinal Instability: Surgical Technique and Clinical Outcomes.","authors":"Kimiaki Sato, Kimiaki Yokosuka, Shinji Morito, Masafumi Goto, Suguto Futami, Yusuke Nishida, Kei Yamada, Koji Hiraoka","doi":"10.2739/kurumemedj.MS7134007","DOIUrl":"https://doi.org/10.2739/kurumemedj.MS7134007","url":null,"abstract":"<p><p>Surgical technique and the clinical outcomes of intersegmental fixation with an interspinous spacer (IFIS) for lumbar spinal instability are reported in this study. Four patients underwent surgery using this procedure. There were no surgical complications, and the clinical outcomes were satisfactory. Spinal alignment was maintained successfully as observed radiographically, and bone fusion was obtained in all cases. This technique may be an alternative for patients with degenerative lumbar disease such as spondylolisthesis and lumbar spinal stenosis (LSS) with mild spinal instability.</p>","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Discovery of Feeding Regulatory Peptides and The Importance of Peptide Discovery Research.","authors":"Takanori Ida, Kazuma Matsui, Sayaka Nagata, Tomoya Nakamachi, Yuki Shiimura, Takahiro Sato, Masayasu Kojima","doi":"10.2739/kurumemedj.MS7134001","DOIUrl":"https://doi.org/10.2739/kurumemedj.MS7134001","url":null,"abstract":"<p><p>Bioactive peptides consist of multiple linked amino acids that are secreted from cells and act on specific receptors in order to transmit information from one cell to another. Through signal transduction, bioactive peptides regulate various physiological functions in the body, and the discovery of new bioactive peptides is therefore likely to lead to the development of various diagnostic and therapeutic agents. In this article, we have focused on the bioactive peptides that are known as feeding regulatory peptides. They are among the bioactive peptides discovered as ligands for G protein-coupled receptors (GPCRs), and we have reviewed their diverse functions. In addition, the status of structural analysis of GPCRs, which is necessary in the drug discovery process, and research on orphan GPCRs, for which new ligands are expected to be discovered in the future, is introduced to systematize modern peptide research and discuss future developments in bioactive peptide research.</p>","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cell Type-Specific Relationships Among Immune Cells in Human Aortic Dissection Tissue.","authors":"Shinya Negoto, Hiroki Aoki, Koichi Ohshima, Eiji Nakamura, Takahiro Shojima, Kazuyoshi Takagi, Hiroyuki Otsuka, Tohru Takaseya, Shinichi Hiromatsu, Eiki Tayama","doi":"10.2739/kurumemedj.MS7034007","DOIUrl":"10.2739/kurumemedj.MS7034007","url":null,"abstract":"<p><strong>Background: </strong>Although recent studies have revealed the importance of inflammation in the pathogenesis of aortic dissection (AD), little is known about the relationships among inflammatory cells in human AD tissue.</p><p><strong>Methods and results: </strong>We assessed the relationships among various immune cell types, including neutrophils, macrophages (M1 and M2), B cells, and helper T cells (Th1, Th2, Th17, Treg and Tfh ) in human AD tissue. AD tissues displayed abundant infiltration of immune cells. Correlation analysis revealed two groups of highly correlated cell types: a group of neutrophils and M1 and M2 macrophages, and another group consisting of B cells and helper T cells. In one particular case of AD, we were able to analyze the correlations between neutrophils and M1 and M2 macrophages in the entry, border, and intact zones of the AD lesions. Neutrophils showed significant correlations with M1 and M2 macrophages in the border zones. The entry and border zones showed M1-dominant polarization, whereas the intact zone showed M2-dominant polarization.</p><p><strong>Conclusions: </strong>These findings indicate the existence of cell type-specific and site-specific interactions among immune cell types in human AD tissues.</p>","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"145-155"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinicopathological Evaluation of Postpancreaticoduonenectomy Hemorrhage with Endovascular Treatment.","authors":"Tomoko Kugiyama, Masamichi Koganemaru, Akiko Sumi, Shuichi Tanoue, Asako Kuhara, Masaaki Nonoshita, Ryoji Iwamoto, Masashi Kusumoto, Masakazu Nabeta, Miyuki Sawano, Norimitsu Tanaka, Kiminori Fujimoto, Jun Akiba, Toshi Abe","doi":"10.2739/kurumemedj.MS7034001","DOIUrl":"10.2739/kurumemedj.MS7034001","url":null,"abstract":"<p><strong>Introduction: </strong>Postpancreaticoduodenectomy hemorrhage (PPH) is a serious complication. Fatty or nonfibrous pancreas, or both, is a risk factor for pancreatic fistula. This study assessed various prognostic factors for interventional procedures for PPH, also focusing on the degree of pancreatic fatty infiltration/fibrosis evaluated histopathologically.</p><p><strong>Material and methods: </strong>The participants were 29 patients with PPH who underwent endovascular treatment from September 2001 to March 2020. Univariate analysis was performed to determine whether the histopathological degree of pancreatic fatty infiltration/fibrosis and other factors were associated with complications and mortality after endovascular treatment for PPH.</p><p><strong>Results: </strong>Of 39 treatment sessions overall, 38 (97%) achieved technical success and 34 (87%) had clinical success. In-hospital mortality occurred in five patients (17%). No association was found between the pancreatic fistula and the histopathological degree of pancreatic fatty infiltration/fibrosis. Fourteen patients with hemorrhagic shock before endovascular treatment included all five patients with in-hospital mortality, while the 15 patients without hemorrhagic shock survived (P = 0.017). A bleeding tendency was associated with complications after endovascular treatment for PPH (P = 0.033).</p><p><strong>Conclusions: </strong>Although our results revealed no significant relation between the histopathological degree of pancreatic fatty infiltration/fibrosis and clinical success, including prognosis, endovascular treatment may be effective for PPH.</p>","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"97-104"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of Anorectal Function and Quality of Life Measures in Patients Following Intersphincteric Resection and Lower Anterior Resection.","authors":"Susumu Shimomura, Tomoya Sudo, Kenta Murotani, Kenji Fujiyoshi, Takefumi Yoshida, Kenichi Koushi, Fumihiko Fujita, Yoshito Akagi","doi":"10.2739/kurumemedj.MS7034002","DOIUrl":"10.2739/kurumemedj.MS7034002","url":null,"abstract":"<p><p>This study explored postoperative outcomes for patients with lower rectal cancer who underwent low anterior resection (LAR) or intersphincteric resection (ISR). A total of 49 patients (33 LAR, 16 ISR) were followed using anorectal manometry and quality of life (QOL) questionnaires over a year, pre- and post surgery. The primary aim of this study is to clarify differences in anal manometry, sphincter function, fecal incontinence, and QOL between the two surgical arms. The secondary aim was to identify indicators suitable for assessing relationships between anorectal manometry measurements, fecal incontinence, and QOL. Anorectal manometry elements (AMEs), such as atmospheric maximum mean squeeze pressure (aMSP), maximum tolerable volume (MTV), and incremental maximum mean squeeze pressure (iMSP), showed no significant differences during the observation period. However, maximum resting pressure (MRP), high-pressure zone length (HPZ), and threshold volume (TV) were significantly worse in the ISR group. Fecal incontinence, measured by Wexner and Kirwan scores, was significantly better in the LAR group. We observed no differences in SF36 between the two groups. Multi-correlation analysis revealed positive and negative correlations among these factors, with inverse correlations between anorectal manometry measurements and incontinence assessments decreasing post-surgery. We found no correlation between SF36 and anorectal manometry at any time. The findings indicate that surgical technique affects postoperative anal function, fecal incontinence, and SF36. However, combined assessment methods should be used with caution when deriving relationships between anal function and SF36.</p>","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"105-113"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kurume Medical JournalPub Date : 2024-12-10Epub Date: 2024-09-02DOI: 10.2739/kurumemedj.MS7034011
Shota Tsuji
{"title":"Pilot Study on Reading and Writing Characteristics in Children with Attention-Deficit Hyperactivity Disorder.","authors":"Shota Tsuji","doi":"10.2739/kurumemedj.MS7034011","DOIUrl":"10.2739/kurumemedj.MS7034011","url":null,"abstract":"<p><p>This study surveys the factors regarding reading and writing difficulties in children with attentiondeficit hyperactivity disorder (ADHD) and uses these results to provide support. We conducted surveys on 16 elementary school children from 3rd to 6th grades who were diagnosed with ADHD by a physician based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). We conducted a Hiragana reading test, a Kanji reading and writing test, and a visual perception test on the subject children. We requested that the parents of the children complete a reading and writing symptom checklist, the Developmental Coordination Disorder Questionnaire (DCDQ), the Strength and Difficulties Questionnaire (SDQ), the ADHD-Rating Scale (ADHD-RS), and the Autism-Spectrum Quotient (AQ). We conducted a multiple regression analysis using the Kanji reading and writing test as the dependent variable. Results revealed that the positional task score in the visual perception test was a factor that influences Kanji writing. Meanwhile, gender, reading-related items on the reading and writing symptom checklist, and performance such as misreading of hiragana were factors that influenced Kanji reading. Based on the results, we suggested that when teaching Kanji writing, children's visual cognition ability should be assessed, and ways to incorporate learning methods that supplement visual perception, such as color masses and electronic learning materials, should be devised. When teaching reading, we suggest using teaching materials that present not only text but also audio as needed, and support the awareness of parents.</p>","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"157-164"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Morphometry of the Foramen Ovale in Adult Human Skulls from a Clinical Perspective.","authors":"Anupama Kodialbail, Radhika Paramesh Mudaliar, Jyothi Krishnarajanagar Chandrachari, Shailaja Shetty","doi":"10.2739/kurumemedj.MS7034010","DOIUrl":"10.2739/kurumemedj.MS7034010","url":null,"abstract":"<p><strong>Introduction: </strong>The foramen ovale (FO) is present in the posterior part of the greater wing of sphenoid. A trauma or space-occupying lesion in this area would result in clinical manifestations due to compression of the structures passing through it. This study was undertaken because of the clinical significance of the FO in radiological and neurological procedures. The aim is to study the morphometry of the FO and its bilateral variations.</p><p><strong>Material and methods: </strong>Fifty adult dry human skulls of unknown age and sex were studied. The shape of the FO, presence of accessory foramina or abnormal bony outgrowths, if any, were noted. Maximum length and width of FO were measured.</p><p><strong>Results: </strong>The FO was present bilaterally in all 50 skulls. Accessory foramen was present in 17 (34%) and 13 (26%) skulls on the right and left side, respectively. Bony out growths were present in 9 (18%) and 15 (30%) skulls on the right and the left side, respectively.</p><p><strong>Conclusion: </strong>Understanding the exact topography, morphometry and variations of the FO is required to enable the clinician to correctly interpret radiographs and help in planning the surgical procedures. The findings presented here should be taken into account when neurological procedures of the middle cranial fossa are performed.</p>","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"91-95"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kurume Medical JournalPub Date : 2024-12-10Epub Date: 2024-09-13DOI: 10.2739/kurumemedj.MS7034008
Sayaka Fujimaru, Hiroki Inutsuka, Tatsuyuki Kakuma, Kimiko Morimoto, Mitsuyoshi Ayabe
{"title":"Development and Psychometric Verification of a Self-Administered Scale for Family Needs in Japanese Critical Care Settings.","authors":"Sayaka Fujimaru, Hiroki Inutsuka, Tatsuyuki Kakuma, Kimiko Morimoto, Mitsuyoshi Ayabe","doi":"10.2739/kurumemedj.MS7034008","DOIUrl":"10.2739/kurumemedj.MS7034008","url":null,"abstract":"<p><strong>Aim: </strong>We developed and evaluated the statistical reliability and validity of a family needs scale directly answerable by families in critical care settings.</p><p><strong>Methods: </strong>In this qualitative study, 39 questions were drafted to capture family needs. These questions were then administered to the families of patients in emergency care settings. Exploratory factor analyses identified several needs factors and factor structures of the questions with oblique rotation. A confirmatory factor analysis examined internal consistency and criterion-related and construct validity.</p><p><strong>Results: </strong>Three factors comprising 32 items were extracted from the exploratory factor analysis: \"Needs for fulfilling family roles,\" \"Needs for appropriate treatment and care,\" and \"Needs for respecting family ties.\" Cronbach's α was 0.949 for the total score and 0.927, 0.914, and 0.896 for factors A-C, respectively, with cumulative variance of 50.0%. The three factors' confirmatory factor analysis revealed a relatively good model fit. A significant correlation was found between this scale and the assessment scale for the needs of families of patients in the intensive care unit.</p><p><strong>Conclusions: </strong>A new scale assessing family needs was developed, and its reliability and validity were confirmed. The scale has acceptable psychometric properties and can be used to measure family needs in critical care settings, particularly in Japanese cultural contexts.</p>","PeriodicalId":39559,"journal":{"name":"Kurume Medical Journal","volume":" ","pages":"131-144"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}