Open Biomarkers Journal最新文献_第7页

Lifestyle Factors that Can Induce an Independent and Persistent Low-GradeSystemic Inflammatory Response: A Wholistic Approach 生活方式因素可诱导独立和持续的低级别全身炎症反应:一个整体的方法

Open Biomarkers Journal Pub Date : 2015-06-10 DOI: 10.2174/1874220301603010034

George Vrousgos

{"title":"Lifestyle Factors that Can Induce an Independent and Persistent Low-GradeSystemic Inflammatory Response: A Wholistic Approach","authors":"George Vrousgos","doi":"10.2174/1874220301603010034","DOIUrl":"https://doi.org/10.2174/1874220301603010034","url":null,"abstract":"Subclinical inflammation was first shown in numerous chronic medical illnesses and in the early 1900s, activation of immune-inflammatory pathways was initially observed in a lifestyle-related disorder such as depression. A chronic mild inflammatory state is also a key feature of obesity as well as insulin resistance and other metabolic diseases. This particular form of immune process has given rise to the concept ofmetaflammation � (metabolically triggered inflammation) because it can target vital organs and tissues that are critical for the regulation of metabolism, and ultimately disrupt systemic homoeostasis with detrimental health effects. However, accumulating evidence demonstrates a link between metaflammation and a number of lifestyle factors. Lifestyle variables such as ultra-endurance exercise, physical inactivity, extremes of sleep duration, cigarette smoking, burnout, anxiety, and depression can activate multiple immune-inflammatory pathways. Therefore, this review of the literature that bears hallmarks of a systematic review investigates and presents published research data of these lifestyle factors that can induce an independent and persistent low-grade systemic inflammatory response, within the human body, evaluated through the measurement of various biomarkers.","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68057297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Current Candidate Genes as Biomarkers for Major Depressive Disorders: A Review of Current Approaches and Findings With Respect to Ethnicity 当前候选基因作为重度抑郁症的生物标志物:关于种族的当前方法和发现的综述

Open Biomarkers Journal Pub Date : 2015-03-20 DOI: 10.2174/1875318301507010001

S. Nair, C. Nair, S. Moochhala

{"title":"Current Candidate Genes as Biomarkers for Major Depressive Disorders: A Review of Current Approaches and Findings With Respect to Ethnicity","authors":"S. Nair, C. Nair, S. Moochhala","doi":"10.2174/1875318301507010001","DOIUrl":"https://doi.org/10.2174/1875318301507010001","url":null,"abstract":"Major Depressive Disorder (MDD) currently affects people worldwide. Despite its multi-faceted origins and symptoms, and its myriad manifestations and outcomes, work is underway to understand the root causes of the disorder. Genetic studies, in particular, have focused on finding candidate genes for MDD, and investigating links between these genes and any particular group of people. It is hoped that these studies may shed light on the types of people that are commonly affected, and what factors make a person more or less vulnerable to depressive disorders. Multiple factors have been considered, including socioeconomic status, urban versus rural environments, ethnicity, lifestyle factors such as substance abuse and both pre- and post-natal early traumas. Through various methods, including network analyses and bioinformatics among others, significant links have been found between socioeconomic status, urban living, and MDD. Moreover, epigenetic links have been discovered between the prevalence of MDD and the prevalence of other diseases such as cardiovascular disease and other forms of mental illness, making it clear that environment plays a key role in overall health and wellbeing. While no statistically significant link between ethnicity and MDD has been found in candidate genes thus far despite certain ethnicity-based polymorphisms influencing clinical outcomes with different treatments, it is much more apparent that urban environments and early stress contribute to the prevalence of MDD.","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":"7 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2015-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68110976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial Respiratory Disorders: A Perspective on their Metabolite Biomarkers and Implications for Clinical Diagnosis and Therapeutic Intervention. 线粒体呼吸疾病:代谢物生物标志物及其对临床诊断和治疗干预的意义。

Open Biomarkers Journal Pub Date : 2015-01-01 DOI: 10.21767/2472-1646.100001

M. Uittenbogaard, A. Chiaramello

{"title":"Mitochondrial Respiratory Disorders: A Perspective on their Metabolite Biomarkers and Implications for Clinical Diagnosis and Therapeutic Intervention.","authors":"M. Uittenbogaard, A. Chiaramello","doi":"10.21767/2472-1646.100001","DOIUrl":"https://doi.org/10.21767/2472-1646.100001","url":null,"abstract":"Mitochondrial respiratory disorders are incurable progressive degenerative diseases with multi-organ system manifestations. These orphan diseases are caused by mutations in the nuclear or mitochondrial genome affecting the oxidative phosphorylation (OXPHOS) system responsible for ATP synthesis. Currently, therapeutic treatments are not available to patients, resulting in significant disability and a poor prognosis. Patients exhibit a constellation of complex neurological and multisystem phenotypic symptoms. The hallmark of these diseases is their clinical heterogeneity and high variability among patients. Consequently, establishing an accurate diagnosis remains a challenging, invasive, and time-consuming process due to the limited sensitivity, specificity and reliability of the current serum biomarkers used in clinical settings. Recent mouse model-based research combined with patient studies led to the identification of fibroblast growth factor 21 (FGF-21) as a promising serum biomarker. With its high specificity and sensitivity, FGF-21 is a promising diagnostic tool for muscle-affecting mitochondrial respiratory disorders, which might be a useful first-line diagnostic tool instead of the invasive muscle biopsy currently performed in clinical settings. Discovering additional diagnostic biomarkers is critical for establishing an accurate diagnosis given the high clinical heterogeneity of these mitochondrial respiratory diseases. Ultimately, these novel biomarkers might be instrumental to monitor the progression of these diseases and the efficacy of novel therapeutic interventions.","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74495058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Detection of Tear Biomarkers for Future Prostate Cancer Diagnosis 泪液生物标志物的检测对未来前列腺癌的诊断

Open Biomarkers Journal Pub Date : 2014-05-30 DOI: 10.2174/1875318301003010026

Yong Li

引用次数: 5

Serum Endothelin-1, MMP-9, and Myeloperoxidase and Coronary Artery Morphology as Detected by Multi-Slice CT Angiography in Intermediate and High Risk Asymptomatic Subjects 多层螺旋CT血管造影检测中、高危无症状人群血清内皮素-1、MMP-9、髓过氧化物酶及冠状动脉形态

Open Biomarkers Journal Pub Date : 2014-05-30 DOI: 10.2174/1875318301003010007

E. Goldhammer, Y. B. Moshe, A. Lubovich, Y. Rivlin, I. Maor, R. Zeina, U. Rosenschein

{"title":"Serum Endothelin-1, MMP-9, and Myeloperoxidase and Coronary Artery Morphology as Detected by Multi-Slice CT Angiography in Intermediate and High Risk Asymptomatic Subjects","authors":"E. Goldhammer, Y. B. Moshe, A. Lubovich, Y. Rivlin, I. Maor, R. Zeina, U. Rosenschein","doi":"10.2174/1875318301003010007","DOIUrl":"https://doi.org/10.2174/1875318301003010007","url":null,"abstract":"Objectives: To study possible correlation between Endothelin-1, Matrix-metallo-proteinase- 9, and Myeloper- oxidase serum activity and coronary CT angiography findings of atherosclerotic coronary artery disease in intermediate - high risk asymptomatic subjects. Methods: 65 consecutive asymptomatic subjects, 53 males and 12 females, mean age 58.8 +/-10.9 s.d., referred by their primary practitioner for the evaluation of coronary artery atherosclerotic disease by Cardiac CT exam were selected for the study. One serum sample was drawn from each participant and examined for the levels of Endothelin -1, MMP-9, MPO serum activity. Obstructive coronary artery disease was defined as at least 50 percent stenosis of one or more coro- nary segments. Plaques were identified as calcified or soft according to the CT Hounsfield attenuation number. Results: The Endothelin activity level was significantly elevated in subjects with significant obstructive coronary artery disease (p=0.022). Furthermore, high Endothelin activity level was found to correlate with calcified plaque burden (p=0.006), and to be an independent determinant of lesion severity (R 2 = 0.124, R 2 change = 0.006, p= 0.008) Conclusions: Endothelin-1 may be a marker of significant obstructive coronary disease and calcified plaque burden in as- ymptomatic subjects. The significance of MMP-9 and MPO as markers of atherosclerosis in such subjects has not been definitely clarified.","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":"3 1","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2014-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68111140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

DNA Damage and Oxidative Stress in Patients with Chronic ObstructivePulmonary Disease 慢性阻塞性肺疾病患者的DNA损伤和氧化应激

Open Biomarkers Journal Pub Date : 2013-05-17 DOI: 10.2174/1875318301306010001

A. L. D. Silva, H. T. D. Rosa, Clara F. Charlier, M. Salvador, D. Moura, A. Valim, T. Guecheva, J. Henriques

{"title":"DNA Damage and Oxidative Stress in Patients with Chronic ObstructivePulmonary Disease","authors":"A. L. D. Silva, H. T. D. Rosa, Clara F. Charlier, M. Salvador, D. Moura, A. Valim, T. Guecheva, J. Henriques","doi":"10.2174/1875318301306010001","DOIUrl":"https://doi.org/10.2174/1875318301306010001","url":null,"abstract":"Background: We aimed to assess the level of DNA damage and susceptibility to exogenous mutagens in pe- ripheral blood cells of Chronic Obstructive Pulmonary Disease (COPD) patients and healthy individuals by comet assay. Oxidative stress was also evaluated by means of thiobarbituric acid reactive species (TBARS) in blood plasma. Methods: Case-control study enrolling 51 COPD patients and 51 controls. Peripheral blood was used to perform the alka- line (pH>13) and neutral (pH=8.5) comet assay. For the assessment of susceptibility to exogenous DNA damage, the cells were treated with methylmethane sulfonate (MMS) for 1-hour or 3-hour at 37° C. The percentage of residual DNA dam- age after 3-h MMS treatment was calculated using the value of 1-h MMS treatment for each subject as 100%. Lipid per- oxidation was evaluated by measuring TBARS in blood plasma. Results: DNA damage in patients was significantly higher than in controls as measured by the neutral and alkaline comet assay. Residual DNA damage detected after MMS treatment increased in patients, in contrast to controls, indicating high- er susceptibility to alkylation damage and/or repair inhibition. High susceptibility to exogenous DNA damage in COPD patients correlates with high amount of TBARS and low forced vital capacity and expiratory volume. Conclusion: The positive correlation between increased susceptibility to exogenous DNA damage and TBARS levels in COPD patients suggests the possible involvement of oxidative stress in damage induction and/or repair inhibition.","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":"6 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2013-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68110935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Mini-Review Article - Current Opinion on Salivary Biomarkers as a Measurement for Stress and Fatigue 关于唾液生物标志物作为应激和疲劳测量的最新观点

Open Biomarkers Journal Pub Date : 2013-05-17 DOI: 10.2174/1875318301306010009

T. Yi, S. Moochhala

引用次数: 13

Opinion on Salivary Biomarkers as a Measurement for Stress and Fatigue 唾液生物标志物作为应激和疲劳测量的观点

Open Biomarkers Journal Pub Date : 2013-05-09 DOI: 10.2174/1875318320130509001

T. Yi

引用次数: 1

Comparison of Two Measures of Missing Cofactor in Cofactor-Dependent Enzymes: Proportion Versus Relative Increase 辅助因子依赖性酶中缺失辅助因子的两种测量方法的比较:比例与相对增加

Open Biomarkers Journal Pub Date : 2012-11-30 DOI: 10.2174/1875318301205010016

Tomas Hansson

引用次数: 2

Indices Indicating Early Renal Microvascular Disease in Diabetes 糖尿病早期肾微血管病变的指标

Open Biomarkers Journal Pub Date : 2011-12-28 DOI: 10.2174/1875318301104010018

N. Futrakul, P. Futrakul

引用次数: 7