糖尿病早期肾微血管病变的指标

Q3 Medicine

Open Biomarkers Journal Pub Date : 2011-12-28 DOI:10.2174/1875318301104010018

N. Futrakul, P. Futrakul

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引用次数: 7

摘要

肾脏微血管病变是肾脏疾病进展的关键。晚期糖尿病肾病的肾微血管病变与血管生成缺陷相关，血管扩张剂治疗无效。早期肾脏微血管疾病的识别是必要的，因为在这个阶段，血管内稳态功能良好，对血管扩张剂治疗有反应。早期肾脏微血管疾病的筛查指标包括肌酐清除率或肾小球滤过率、肾血浆流量或小管周围毛细血管流量和镁的分数排泄(FE Mg)。

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Indices Indicating Early Renal Microvascular Disease in Diabetes

Renal microvascular disease is crucial to renal disease progression. Renal microvascular disease in late stage diabetic nephropathy is associated with defective angiogenesis and fails to respond to vasodilator treatment. Recognition of early renal microvascular disease is necessary, since in this stage, the vascular homeostasis is adequately functional and responsive to vasodilator treatment. Indices that can screen early renal microvascular disease include creatinine clearance or glomerular filtration rate, renal plasma flow or peritubular capillary flow and fractional excretion of magnesium (FE Mg).

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来源期刊

Open Biomarkers Journal Medicine-Medicine (miscellaneous)

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Open Biomarkers Journal is an Open Access online journal, which publishes original full-length, short research articles and reviews on biomarkers in clinical, medical and pharmaceutical research. The coverage includes biomarkers of disease, new biomarkers, exposure to drugs, genetic effects, and applications of biomarkers. The Open Biomarkers Journal, a peer reviewed journal, aims to provide the most complete and reliable source of information on current developments in the field. The emphasis will be on publishing quality articles rapidly and freely available to researchers worldwide.