四川大学学报(医学版)最新文献

{"title":"The Prevalence and Clinical Significance of the Centromere Protein-F-Like Immunofluorescence Staining Pattern in a Large ANA-positive Cohort.","authors":"Zhenzhen Su, Feng Zhang, Lijing Zhang, Yeerken Hayisaer, Bin Yang, Jing Hu, Li Wang, Xuedan Gao, Junlong Zhang, Zhuochun Huang","doi":"10.12182/20260360109","DOIUrl":"https://doi.org/10.12182/20260360109","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the prevalence and clinical significance of the centromere protein-F-like (CENP-F-like) immunofluorescence staining pattern in a large patient cohort and through literature review.</p><p><strong>Methods: </strong>We retrospectively analyzed antinuclear antibody (ANA) immunofluorescence assay results from 191274 patients at West China Hospital of Sichuan University between March 2018 and November 2020. Specific immunological markers were tested in sera with CENP-F-like patterns. Additionally, a narrative review of seven relevant studies was performed for comparison.</p><p><strong>Results: </strong>In Southwest China, ANA positivity was found in 32.09% of patients, with the CENP-F-like pattern detected in 0.015% of all cases and 0.05% of ANA-positive individuals. The CENP-F-like pattern appeared predominantly at titers ≥ 1∶320, most often in isolation (68.97%), but also mixed with cytoplasmic speckled patterns. Patients with cancers accounted for the highest proportion (31.03%), including solid tumors and hematologic malignancies. Metastasis was observed in patients with solid tumors, while graft-versus-host disease (GVHD) occurred in those with hematologic malignancies post-transplantation. Autoimmune diseases (AIDs) were diagnosed in 20.69% of cases, all showing disease-specific autoantibodies. These findings were broadly consistent with previous reports and suggest a possible association between the CENP-F-like pattern and malignancies.</p><p><strong>Conclusion: </strong>The CENP-F-like pattern is rare in ANA tests but may be associated with clinically important conditions, particularly cancers and AIDs. The occurrence of metastasis and GVHD in patients with this pattern highlights its potential clinical relevance, and concurrent autoantibodies may assist in diagnosing AIDs.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 2","pages":"473-481"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Establish Standardized Pathological and Genetic Examinations to Reduce the Incidence of Stillbirth].","authors":"Fan Zhou, Haiyan Yu, Wei Wang, Li Wan, Xiaodong Wang","doi":"10.12182/20260360510","DOIUrl":"https://doi.org/10.12182/20260360510","url":null,"abstract":"<p><p>Stillbirths represent the most severe adverse fetal outcomes and constitute a significant public health issue. China experiences considerable regional disparities in stillbirth rates, with the total number of stillbirths ranking fourth globally. Major challenges remain in improving the standardization of stillbirth management and reducing stillbirth incidence. This article presents a comprehensive review of the international classification systems for stillbirth causes, with particular emphasis on key components such as placental and fetal pathological examinations and genetic testing strategies. It highlights the critical role of pathological and genetic investigations in identifying the etiology and guiding the clinical management of stillbirth. Furthermore, the article advocates for the establishment of a tiered management framework for stillbirth etiology tailored to China's national context, promotes the standardization and clinical implementation of pathological and genetic testing, enhances understanding of the underlying pathophysiological mechanisms and causes of stillbirth, and thereby enables the development of preventive strategies at the causal level to effectively reduce stillbirth rates.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 2","pages":"608-613"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[ROMO1 Promotes the Repair of Radiation-induced Skin Injury by Regulating Mitochondrial Function and Keratinocyte Proliferation].","authors":"Tingyi Yang, Wenling Tu, Xiaoyou Tang, Mengjie DU, Adili Maheliya, Zuxiang Yu, Shuai Qu, Hao Bai, Shuyu Zhang","doi":"10.12182/20260360401","DOIUrl":"https://doi.org/10.12182/20260360401","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the molecular mechanisms of early mitochondrial stress in keratinocytes induced by ionizing radiation (IR), focusing on the key role of ROMO1 in radiation-induced skin injury (RISI).</p><p><strong>Methods: </strong>HaCaT keratinocytes were used to assess cellular status, mitochondrial dysfunction and oxidative stress at various time points after different irradiation doses. Mitochondrial proteomics at 24 hours post-20 Gy irradiation identified ROMO1 as the protein with the greatest reduction in expression. <i>ROMO1</i>-overexpressing HaCaT cells and skin-specific <i>Romo1</i> knockout (<i>Romo1</i>-sKO) mice were established to investigate its functional mechanisms. ROMO1 expression and localization were analyzed by Western blot and immunofluorescence; flow cytometry measured ROS, mtROS, and mitochondrial membrane potential in <i>ROMO1</i>-overexpressing cells, while CCK-8, LDH release, and colony formation assays evaluated viability and proliferation. The role of <i>Romo1</i> in the progression and repair of radiation-induced skin injury was further examined in <i>Romo1</i>-sKO mice.</p><p><strong>Results: </strong>At 24 hours post-20 Gy irradiation, HaCaT cells exhibited inhibited proliferation (<i>P</i> < 0.05) and mitochondrial dysfunction (<i>P</i> < 0.0001). Mitochondrial proteomics identified 43 differentially expressed proteins (26 upregulated, 17 downregulated), with enrichment analysis indicating their involvement in oxidative phosphorylation, mitochondrial assembly and stress response. Among these, reactive oxygen species modulator 1 (ROMO1) was identified as the most significantly downregulated key protein in the early radiation response (<i>P</i> < 0.01, FDR = 0.03). <i>In vitro</i>, ROMO1 overexpression increased mtROS levels and mitochondrial membrane potential (<i>P</i> < 0.0001) but suppressed cell viability and promoted reproductive death (<i>P</i> < 0.05) after radiation. <i>In vivo</i>, <i>Romo1</i>-sKO mice showed accelerated wound healing, with a reduction in skin injury score by approximately 1 point, along with enhanced tissue regeneration at 25 days post-irradiation compared to control mice.</p><p><strong>Conclusion: </strong>The mitochondrial protein ROMO1 is a key regulator of the early keratinocyte stress response to radiation. It impedes the repair of radiation-induced skin injury by suppressing cell proliferation via modulation of mitochondrial function. Targeted inhibition of ROMO1 may represent a novel therapeutic strategy to promote healing and prevent chronic progression of radiation-induced skin injury.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 2","pages":"499-509"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Mechanism Study of Aconitase 1 Promoting Hepatocellular Carcinoma Growth via the Itaconic Acid-Autophagy Axis].","authors":"Sinan Lü, Yurong Yang, Kun Jiang, Chi Cheng, Kui Wang, Changlong Li","doi":"10.12182/20260360402","DOIUrl":"https://doi.org/10.12182/20260360402","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the expression level of aconitate decarboxylase 1 (ACOD1) in hepatocellular carcinoma (HCC) and its role in HCC cell growth, as well as the underlying mechanisms.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The expression of the &lt;i&gt;ACOD&lt;/i&gt;1 gene in HCC and its correlation with patient survival were analyzed using the GTEx and TCGA databases. ACOD1 protein expression in four paired HCC and adjacent non-tumor tissues was detected by Western blotting. After &lt;i&gt;ACOD&lt;/i&gt;1 knockdown in HepG2 and PLC/PRF/5 HCC cells, cell proliferation and death were assessed by MTT and LDH assays, respectively. Following &lt;i&gt;ACOD&lt;/i&gt;1 knockdown, 4-octyl itaconate (4-OI) was administered to observe changes in cell proliferation. Potential mechanisms were predicted using the cBioPortal database through KEGG enrichment analysis, and the expression of autophagy-related proteins LC3-Ⅱ and p62 was measured by Western blotting. After &lt;i&gt;ACOD&lt;/i&gt;1 knockdown, cells were treated with chloroquine (CQ) or supplemented with 4-OI to observe changes in autophagy marker proteins and cell proliferation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;ACOD1 protein expression was significantly overexpressed in HCC tissues than in adjacent tissues (approximately 2-fold). Patients with ACOD1 overexpression had shorter overall survival (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Knocking down &lt;i&gt;ACOD&lt;/i&gt;1 in HepG2 and PLC/PRF/5 cells, which expressed high levels of ACOD1, inhibited cell proliferation (by approximately 20% and 30%, respectively; both &lt;i&gt;P&lt;/i&gt; &lt; 0.05) and increased cell death (by approximately 30% in both cell lines; both &lt;i&gt;P&lt;/i&gt; &lt; 0.05). 4-OI promoted cell growth in a concentration-dependent manner and reversed the decrease in cell viability caused by &lt;i&gt;ACOD&lt;/i&gt;1 knockdown, restoring it to 93% and 90% of control levels, respectively (both &lt;i&gt;P&lt;/i&gt; &lt; 0.05). KEGG analysis suggested a potential association between ACOD1 and the autophagy pathway. &lt;i&gt;ACOD&lt;/i&gt;1 knockdown significantly increased LC3-Ⅱ levels (by approximately 7-fold and 10-fold, respectively; both &lt;i&gt;P&lt;/i&gt; &lt; 0.05) and decreased p62 levels (by 40% and 30%, respectively; both &lt;i&gt;P&lt;/i&gt; &lt; 0.05) in HepG2 and PLC/PRF/5 cells. CQ treatment increased the LC3-Ⅱ/LC3-Ⅰ ratio and p62 protein expression (both by approximately 2-fold; &lt;i&gt;P&lt;/i&gt; &lt; 0.05). Combined &lt;i&gt;ACOD1&lt;/i&gt; knockdown further increased the LC3-Ⅱ/LC3-Ⅰ ratio (by approximately 10%; &lt;i&gt;P&lt;/i&gt; &lt; 0.05), while p62 protein expression did not increase significantly (&lt;i&gt;P&lt;/i&gt; &gt; 0.05). Supplementation with 4-OI reversed the changes in LC3-Ⅱ and p62 protein expression induced by &lt;i&gt;ACOD1&lt;/i&gt; knockdown. Furthermore, CQ treatment partially rescued the decrease in viability of HepG2 and PLC/PRF/5 cells caused by &lt;i&gt;ACOD1&lt;/i&gt; knockdown (restoring viability to 75% and 80%, respectively; both &lt;i&gt;P&lt;/i&gt; &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;ACOD1 is overexpressed in HCC and its' overexpression is associated with poor prognosis. ACOD1 promotes HCC cell growth by synthesizing itaco","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 2","pages":"510-517"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of Clinical Characteristics and Diagnostic Indicators in Patients With Heparin-induced Thrombocytopenia After Cardiac Surgery].","authors":"Guoqiang Wang, Pinli Yue, Guoyan Zhu, Qiang Xu, Ximing Wang, Danyu Song, Zhangwei Gao, Yue Wang, Jianru Liu, Yang Zhang, Zhou Zhou","doi":"10.12182/20260360205","DOIUrl":"https://doi.org/10.12182/20260360205","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the diagnosis rate of heparin-induced thrombocytopenia (HIT), the incidence of new thrombosis, the dynamic evolution pattern of platelets, and the clinical characteristics in patients with suspected HIT after cardiac surgery; and to evaluate the diagnostic value of HIT antibodies (HIT-Ab), 4T's score, and Lillo-Le Louet (LLL) score for HIT.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective cohort study was conducted. A total of 307 patients with suspected HIT after cardiac surgery at Fuwai Hospital of the Chinese Academy of Medical Sciences from April 2023 to December 2024 were included. Clinical and laboratory data were collected. All patients underwent 4T's score, LLL score, and HIT-Ab testing. Patients were divided into the non-HIT group (&lt;i&gt;n&lt;/i&gt; = 269) and the HIT group (&lt;i&gt;n&lt;/i&gt; = 38) based on the final clinical diagnosis. The platelet evolution patterns and other clinical characteristics of the two groups were compared. HIT-Ab concentration was divided into four groups: negative (&lt; 1.0 U/mL, &lt;i&gt;n&lt;/i&gt; = 257), weakly positive (1.0-4.9 U/mL, &lt;i&gt;n&lt;/i&gt; = 34), moderately positive (5.0-9.9 U/mL, &lt;i&gt;n&lt;/i&gt; = 11), and strongly positive (≥ 10 U/mL, &lt;i&gt;n&lt;/i&gt; = 5). Differences in the incidence of new thrombosis and the diagnosis rate of HIT among the groups were analyzed, and the diagnostic efficacy of HIT-Ab concentration, 4T's score, and LLL score for HIT was evaluated using receiver operating characteristic (ROC) curves.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The diagnosis rate of HIT was 12.38% (38/307), and the incidence of new thrombosis in the HIT group was 63.16%, higher than the 34.57% in the non-HIT group (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). Among HIT patients, 76.32% showed a biphasic decline pattern of platelets (pattern A), and their risk of HIT was significantly higher than that of patients with pattern B (odds ratio [OR] = 10.32, 95% confidence interval [CI]: 4.64-22.95). The incidence of new thrombosis increased stepwise with higher HIT-Ab concentration (32.7% in the negative group to 100% in the strongly positive group, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), and the diagnosis rate of HIT increased from 0 in the negative group to 64.71% in the weakly positive group, reaching 100% in the moderate/strong positive group. The areas under the ROC curves for HIT-Ab concentration, 4T's score, and LLL score for diagnosing HIT were 0.996 (95% CI: 0.991-1.000), 0.799 (95% CI: 0.727-0.870), and 0.860 (95% CI: 0.811-0.908), respectively. When the HIT-Ab concentration was 1 U/mL, the diagnostic sensitivity and negative predictive value (NPV) were both 100%. Compared with the traditional diagnostic criteria for high-risk HIT populations (4T's score cutoff of 4, LLL score cutoff of 2), the optimal cutoff value of 4T's score selected by the maximum Youden index was 5, and the optimal cutoff value of LLL score was 3.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The incidence of new thrombosis in patients with suspected HIT after cardiac surgery increases stepwise","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 2","pages":"367-375"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Construction and Efficacy Evaluation of a Highly Efficient Diagnostic Model for Neurosyphilis Driven by the Cerebrospinal Fluid/Serum Free Light Chain Index].","authors":"Jielun Deng, Sirui Wu, Fei Ye, Xiyue Huang, Dongdong Li, Jinbo Liu","doi":"10.12182/20260360204","DOIUrl":"https://doi.org/10.12182/20260360204","url":null,"abstract":"<p><strong>Objective: </strong>To determine free light chains (FLC) in cerebrospinal fluid (CSF) and serum, calculate the FLC index, and establish a model to evaluate its application value in diagnosing neurosyphilis.</p><p><strong>Methods: </strong>This study included 87 syphilis patients, comprising 48 neurosyphilis patients (NS group) and 39 non-neurosyphilis patients (n-NS group). CSF and serum samples were collected from all patients to measure kappa free light chains (FLC-κ) and lambda free light chains (FLC-λ). The FLC index, FLC-κ index, and FLC-λ index were calculated. Receiver operating characteristic (ROC) curves were used to evaluate these indices. A neurosyphilis diagnostic model based on the FLC index was established and its visualization was verified.</p><p><strong>Results: </strong>Statistically significant differences were observed between the two groups in serological syphilis screening, CSF nucleated cell count, CSF microprotein, CSF IgG, IgG synthesis rate, IgG index, and albumin quotient (<i>P</i> < 0.05). The areas under the ROC curves (AUC) for the FLC-κ index, FLC-λ index, and albumin quotient were 0.998 (95% CI: 0.990-1.000), 0.988 (95% CI: 0.961-1.000), and 0.635 (95% CI: 0.496-0.751), respectively. In the FLC-κ index model, the FLC-κ index (<i>P</i> < 0.05) significantly affected the diagnosis of neurosyphilis, while in the FLC-λ index model, only the FLC-λ index (<i>P</i> < 0.05) had a significant effect. The training ROC curve AUC for the diagnosis model based on the FLC-κ index was greater than 0.950. Its calibration curve showed good predictive performance when the predicted probability was close to 80%, but poor performance when the predicted probability was 40%-60%. The AUC for the diagnosis model based on the FLC-λ index was 0.926, with good predictive performance when the predicted probability was close to 85%, and poor performance when the predicted probability was 40%-70%.</p><p><strong>Conclusion: </strong>FLC-κ and FLC-λ have high diagnostic performance for neurosyphilis, and the FLC index has certain application value in the diagnosis of neurosyphilis.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 2","pages":"448-454"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Combined Analysis of Dyslipidemia and Tumor Markers for the Diagnosis of Gastric Cancer].","authors":"Jingbo Lu, Runhao Xu, Tinghua Li, Bing Zheng, Min Li","doi":"10.12182/20260360504","DOIUrl":"https://doi.org/10.12182/20260360504","url":null,"abstract":"<p><strong>Objective: </strong>To investigate changes in serum lipid profile parameters combined with tumor markers in gastric cancer (GC) patients and their value in GC screening.</p><p><strong>Methods: </strong>A total of 100 patients diagnosed with GC at Renji Hospital (West) between May and September 2025 were consecutively enrolled as the GC group (54 cases in stage Ⅰ/Ⅱ and 46 cases in stage Ⅲ/Ⅳ). Additionally, 100 age- and sex-matched healthy individuals undergoing routine physical examinations were included as the healthy control (HC) group. The serum levels of nine lipid indicators (high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], total cholesterol [TC], triglycerides [TG], small and dense low-density lipoprotein cholesterol [sdLDL-C], apolipoprotein [Apo] A1, ApoB, ApoC2, and ApoC3) and five tumor markers (carcinoembryonic antigen [CEA], carbohydrate antigen [CA] 19-9, CA50, CA242, and CA72-4) were measured using an automatic biochemical analyzer and an electrochemiluminescence instrument. Intergroup differences were analyzed using the Mann-Whitney <i>U</i> test. A stepwise Fisher discriminant analysis was used to establish a screening model based on lipid profiles and tumor markers. Diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis, and the model's diagnostic performance was validated using 30 GC patients and 30 healthy controls consecutively enrolled from September to December 2025.</p><p><strong>Results: </strong>Compared with the HC group, the GC group showed significantly lower levels of ApoA1, ApoC3, TC, HDL-C, LDL-C, and sdLDL-C (<i>P</i> < 0.05), while CEA and CA50 levels were significantly higher (<i>P</i> < 0.05). Patients with stage Ⅲ-Ⅳ GC had lower levels of ApoA1, ApoB, TC, HDL-C, LDL-C, and sdLDL-C compared to those with stage Ⅰ-Ⅱ GC (<i>P</i> < 0.05). ROC analysis showed that among individual indicators, HDL-C had the highest diagnostic performance, with an area under the curve (AUC) of 0.797 (95% CI: 0.734-0.850), sensitivity of 78%, and specificity of 74%. The screening model including ApoA1, ApoC3, HDL-C, LDL-C, TC, sdLDL-C, CEA, CA50, and age achieved an AUC of 0.940 (95% CI: 0.891-0.971), with 83.75% sensitivity and 92.5% specificity, outperforming any single biomarker in diagnostic efficacy.</p><p><strong>Conclusion: </strong>The combined panel of ApoA1, ApoC3, HDL-C, LDL-C, TC, sdLDL-C, CEA, CA50 and age offers a potential auxiliary tool for detecting gastric cancer.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 2","pages":"435-440"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association Study of Parity With Adverse Pregnancy Outcomes].","authors":"Junxiu Yao, Xin Guo, Xudong Dong","doi":"10.12182/20260360505","DOIUrl":"https://doi.org/10.12182/20260360505","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between parity and adverse pregnancy outcomes.</p><p><strong>Methods: </strong>Keyword searches were conducted by 'parity', followed by random sampling to select 1200 patients: 400 from each of the first, second and third childbirths, designated as Groups 1, 2 and 3, respectively. A retrospective cohort study examined pregnancy outcomes across these three groups. Logistic regression was used to estimate the association between parity and pregnancy outcomes after adjusting for other confounding factors. We assessed the impact of parity on adverse pregnancy outcomes and the corresponding risk coefficients using receiver operating characteristic (ROC) curves and the area under the curve (AUC).</p><p><strong>Results: </strong>Multiparity (parity ≥ 2) is a risk factor for preterm birth (odds ratio [OR] = 1.602, 95% CI: 1.181-2.173), perinatal anemia (OR = 1.468, 95% CI: 1.099-1.963), and uterine rupture (OR = 2.752, 95% CI: 1.261-6.007). It is a protective factor against low birth weight (OR = 0.564, 95% CI: 0.321-0.992), meconium-stained amniotic fluid (OR = 0.556, 95% CI: 0.418-0.739), and fetal distress (OR = 0.171, 95% CI: 0.080-0.365) (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Increased parity is associated with a higher risk of certain adverse pregnancy outcomes, so it is important to be vigilant about the increased risk of specific complications, such as uterine rupture. Strictly controlling the indications for cesarean section and maintaining reasonable weight gain during pregnancy are effective measures to prevent adverse pregnancy outcomes in multiparous women.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 2","pages":"573-579"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association Between Blood Routine Index and Metabolic Syndrome in High-altitude Tibetan Population].","authors":"Jiaojiao Yan, Yufei Zhang, Jing Zhang, Yang Wan, Hai Xiong","doi":"10.12182/20260360506","DOIUrl":"https://doi.org/10.12182/20260360506","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between blood routine indicators and the prevalence of metabolic syndrome (MetS) and its risk factors in the Tibetan population in Xizang.</p><p><strong>Methods: </strong>From August 2021 to August 2023, a multi-stage stratified cluster random sampling method was used to conduct a questionnaire survey, anthropometric measurements, and laboratory examinations of the Tibetan population in the Lhasa, Ali, and Naqu areas of Xizang. A total of 2 832 people were included in the study. After adjusting for potential confounding factors, logistic regression analysis was used to examine the correlation between blood routine indicators and MetS.</p><p><strong>Results: </strong>The prevalence of MetS was 11.5%, with rates of 12.9% among males and 10.6% among females. After adjusting for confounding factors, white blood cell count (WBC), hemoglobin (Hb), hematocrit (HCT), and platelet distribution width (PDW) were associated with MetS prevalence. Compared with the lowest tertile (Q1), the odds ratios (ORs) for Q2 and Q3 of WBC were 1.629 (95% CI: 1.164-2.279, <i>P</i> = 0.004) and 1.621 (95% CI: 1.14-2.292, <i>P</i> = 0.006), respectively. For Hb, the ORs in Q2 and Q3 were 0.523 (95% CI: 0.325-0.843, <i>P</i> = 0.008) and 0.435 (95% CI: 0.212-0.889, <i>P</i> = 0.022), respectively. The ORs for HCT in Q2 and Q3 were 1.818 (95% CI: 1.123-2.943, <i>P</i> = 0.015) and 2.480 (95% CI: 1.208-5.089, <i>P</i> = 0.013), respectively. The ORs for PDW in Q2 and Q3 were 0.562 (95% CI: 0.358-0.881, <i>P</i> = 0.012) and 0.614 (95% CI: 0.381-0.991, <i>P</i> = 0.046), respectively.</p><p><strong>Conclusion: </strong>WBC, Hb, HCT, and PDW in the complete blood count were associated with the prevalence of MetS, WBC and HCT were risk factors for the prevalence of MetS, while Hb and PDW were protective factors. It is recommended that complete blood counts be included in the monitoring and management of metabolic diseases.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 2","pages":"524-531"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Apply the Miettinen Formula to Assess the Health Benefits of the PM_2.5 Simulation Intervention on Metabolic Syndrome].","authors":"Kejun Chen, Xinyu Han, Yongxin Yang, Peng Wang","doi":"10.12182/20260360102","DOIUrl":"https://doi.org/10.12182/20260360102","url":null,"abstract":"<p><strong>Objective: </strong>Quantify the health benefits of various strategies for reducing PM_2.5 (aerodynamic diameter ≤ 2.5 μm) concentrations on the prevalence of metabolic syndrome (MetS) in the population, and provide more direct scientific evidence to support air pollution control efforts.</p><p><strong>Methods: </strong>By integrating PM_2.5 exposure concentrations, population sizes of various cities in China, and relative risk data for PM_2.5-MetS from previous studies, the generalized impact fraction (GIF) for equivalent, fixed, threshold, and ratio interventions on PM_2.5 concentrations was estimated using the Miettinen formula. Specifically, the proportion of MetS cases that could be reduced by lowering the current exposure level to a specified level of interest was calculated.</p><p><strong>Results: </strong>Reducing PM_2.5 concentrations by 5, 10, 15, or 20 μg/m³ can lead to decreases in the number of MetS cases by 10.54% (95% CI: 10.52%-10.57%), 19.94% (95% CI: 19.90%-19.99%), 28.24% (95% CI: 28.16%-28.33%), and 35.41% (95% CI: 35.27%-35.55%), respectively. When the concentration is controlled to the minimum observed value (5.95 μg/m³) or does not exceed the WHO annual average standard (10 μg/m³), the proportions of MetS cases that can be avoided are 22.71% (95% CI: 18.77%-26.65%) and 17.24% (95% CI: 16.86%-17.62%), respectively. Using the ratio intervention method, reducing PM_2.5 concentrations by 30% and 50% can reduce the number of MetS cases by 7.41% (95% CI: 7.28%-7.53%) and 12.16% (95% CI: 11.96%-12.36%), respectively.</p><p><strong>Conclusion: </strong>All four PM_2.5 intervention strategies can reduce the number of patients with MetS to varying degrees, with equivalent, minimum-value, and WHO threshold-based interventions demonstrating the greatest effects. Taking into comprehensive consideration, equivalent intervention is more efficient. In the future, efforts should be gradually focused on the correlation between actual environmental control measures and intervention strategies to directly guide the formulation of environmental protection policies.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 2","pages":"518-523"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}