四川大学学报(医学版)最新文献

{"title":"[Effect of the Otago Exercise Program on Activities of Daily Living in Older Adults With Sarcopenia].","authors":"Yuxiang Liang, Renjie Wang, Jiaojiao Jiang, Liqiong Wang, Long Zhang, Xueli Chun, Quan Wei","doi":"10.12182/20250360608","DOIUrl":"10.12182/20250360608","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effects of the Otago Exercise Program (OEP) on activities of daily living, muscle strength, balance, and physical function in older adults with sarcopenia, to compare OEP with conventional exercise training, and to provide a basis for clinical rehabilitation programs for older adults with sarcopenia.</p><p><strong>Methods: </strong>In this randomized controlled trial, 120 older adults clinically diagnosed with sarcopenia were enrolled. The participants were randomly assigned to the OEP intervention group (experimental group) and the conventional exercise intervention group (control group), with 60 in each group. The experimental group underwent 12 weeks of OEP training, three times a week, with each session lasting 45 minutes. The control group underwent conventional exercise training following the same schedule. The Modified Barthel Index was used as the primary outcome measure to assess activities of daily living. Secondary outcome measures included muscle strength, gait stability, dynamic balance, and physical function status, evaluated using grip strength, 6-meter walking speed, the Timed Up and Go Test (TUGT), and the Short Physical Performance Battery (SPPB).</p><p><strong>Results: </strong>A total of 120 older adults with sarcopenia were included. The mean age of the participants was (80.17 ± 8.48) years. Baseline data before treatment showed no statistically significant differences between the two groups. Both groups completed the treatment within 12 weeks without experiencing any adverse events. The baseline data for the experimental group were as follows, MBI at (67.00 ± 22.76) points, hand grip strength at (15.29 ± 4.94) kg, gait speed at (0.61 ± 0.26) m/s, TUGT time at (15.05 ± 6.74) s, and SPPB score at (6.17 ± 1.40) points, while the corresponding post-intervention findings were as follows, (78.72 ± 15.83) points, (17.67 ± 5.83) kg, (0.77 ± 0.28) m/s, (13.49 ± 6.16) s, and (9.25 ± 1.71) points, respectively. The experimental group showed improvements in all measures from baseline to post-intervention (<i>P</i> < 0.05 for all measures). As for the control group, the baseline data for the corresponding measures were as follows, (67.20 ± 22.12) points, (15.00 ± 5.35) kg, (0.58 ± 0.23) m/s, (17.29 ± 6.90) s, and (6.00 ± 1.24) points, respectively. The post-intervention findings increased to (71.13 ± 20.28) points, (15.47 ± 5.72) kg, (0.64 ± 0.28) m/s, (16.50 ± 6.99) s, and (6.73 ± 1.61) points, respectively, but the changes were not statistically significant (<i>P</i> > 0.05). Furthermore, an intergroup comparison of intervention effects (post-intervention minus preintervention) revealed significant differences in mean changes from baseline. The experimental group demonstrated improvements of (+11.72 ± 6.32) points in modified Barthel Index, (+11.72 ± 6.32) kg in grip strength, (+0.16 ± 0.09) m/s in gait speed, (－1.56 ± 1.32) s in TUGT time, and (－1.56 ± 1.32) points in SPPB score. In contra","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 2","pages":"543-548"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Career Development of Graduates of 8-Year Clinical Medicine Programs in the Context of the New Medical Education Initiative].","authors":"Jun Ma, Li Shao","doi":"10.12182/20250360302","DOIUrl":"https://doi.org/10.12182/20250360302","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the outcomes and challenges of China's 8-year clinical medicine programs and to discuss preliminary suggestions and reflections on the reform of 8-year clinical medicine programs in line with the requirements of the New Medical Education Initiative.</p><p><strong>Methods: </strong>A nationwide survey was conducted to cover 680 graduates of 8-year clinical medicine programs. All participants graduated from 8-year programs in the past decade. Participants responded to a questionnaire on their career development. Multiple linear regression analysis was performed to identify the core factors affecting the career development of 8-year program graduates. In addition, 30 participants were selected to participate in an intensive interview.</p><p><strong>Results: </strong>A total of 676 valid responses were collected in this study, yielding a response rate of 99.41%. Among the participants, females slightly outnumbered males, accounting for 57.40% (388/676). In terms of subspecialty choices, surgery was the most popular, accounting for 35.21% (238/676), followed by internal medicine, which accounted for 16.12% (109/676). Self-assessed job competency ratings showed that 56.12% (348/620) felt competent, while 0.65% (4/620) reported being completely incompetent. In terms of employment status, 91.72% (620/676) of the participants completed their studies on time, 88.61% (599/676) were awarded diplomas as scheduled, and 91.72% (620/676) entered the healthcare industry, with 97.9% (607/620) working in tertiary-care hospitals. Regarding career development, by the tenth year after graduation, 89.13% (41/46) attained mid-level or senior professional titles. In terms of job satisfaction, 67.30% (455/676) reported moderate or higher levels of job satisfaction. In terms of academic achievements, the median number of papers published by the participants between graduation and the tenth year after graduation was 6, with a median of 5 papers published in journals included in the Science Citation Index (SCI). The quantity of publications and the length of time after graduation significantly correlated with professional advancement (<i>P</i> < 0.05). According to the interview results, 83.33% (25/30) of the participants suggested that research training should be increased and 60% (18/30) stated that interdisciplinary skills development should be prioritized.</p><p><strong>Conclusion: </strong>A high proportion of graduates from 8-year clinical medical programs become highly competent professionals with good employment prospects, strong self-efficacy, and favorable career trajectories. However, the participants are disproportionately concentrated in certain subspecialties. Furthermore, other issues, such as the conflict between curricular time constraints and the graduates' desire to strengthen research training, as well as insufficient interdisciplinary preparation, require collaborative solutions from the government, universities","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 2","pages":"596-602"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Biological Aging Affects the Rate of Cognitive Decline in Middle-aged and Elderly Populations: A Cohort Study Based on CHARLS].","authors":"Huiyu He, Mengling Wei, Jiao Zhong, Juan Wang, Lei Huang, Yajia Lan, Yang Zhang","doi":"10.12182/20250360203","DOIUrl":"10.12182/20250360203","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between biological aging and the rate of cognitive decline in middle-aged and elderly populations.</p><p><strong>Methods: </strong>Longitudinal tracking data of cognitive function were obtained from the China Health and Retirement Longitudinal Study (CHARLS). We employed the Klemera and Doubal method (KDM) to estimate biological age (BA), and calculate the biological aging index (BAI) and biological aging type (BAT). A multivariate linear regression model was employed to analyze the relationships between baseline BAI, BAT, and cognitive function scores. Based on the baseline analysis, a mixed-effects model was used to examine the longitudinal associations between baseline BAI, BAT, and cognitive function during follow-up.</p><p><strong>Results: </strong>A total of 5897 participants were included in the study. BAI was found to be negatively associated with baseline cognitive function scores, with the partial regression coefficient (<i>β</i>) (95% CI) being －0.185 (－0.231, －0.139) (<i>P</i> < 0.001). Compared with the lagged aging group, the premature aging group had lower cognitive function scores (<i>β</i> [95% CI]: －0.741 [－0.966, －0.516]). For age and sex, for each additional year of baseline BAI, cognitive function scores declined by an average of 0.012 (95% CI: －0.019, －0.005) points per year after adjusting for age and sex, and declined by 0.011 (95% CI: －0.018, －0.004) points per year after adjusting for other covariates. Compared with participants with lagged aging, those with premature aging experienced, on average, an additional decline of 0.042 (95% CI: －0.075, 0.009) points per year in cognitive function scores after adjusting for age and sex alone, and by 0.039 (95% CI: －0.072, －0.007) points per year after adjusting for other covariates.</p><p><strong>Conclusion: </strong>Biological aging affects the rate of cognitive decline in middle-aged and elderly populations. A higher BAI is associated with a faster decline in cognitive function. Compared with those with lagged aging, individuals with premature aging exhibit a more rapid rate of cognitive decline.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 2","pages":"470-477"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of ADAM12, S100A8, and Serum Tumor Markers on Chemotherapy Outcomes and Prognosis in Patients With Triple-Negative Breast Cancer].","authors":"Zifang Qin, Xu Wang, Zhaoxia Niu, Ruoxia Jiang, Lin Zhang","doi":"10.12182/20250360607","DOIUrl":"10.12182/20250360607","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the influence of a disintegrin and metalloproteinase 12 (ADAM12), S100 calcium binding protein A8 (S100A8), and serum tumor markers on chemotherapy outcomes and prognosis in patients with triple-negative breast cancer.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A totla of 300 patients with breast cancer admitted between January 2020 and January 2021 were included. Based on pathological immunohistochemistry findings, the patients were divided into a triple-negative group (&lt;i&gt;n&lt;/i&gt; = 98, triple-negative breast cancer) and a non-triple-negative group (&lt;i&gt;n&lt;/i&gt; = 202, non-triple-negative breast cancer). Serum tumor markers (carcinoembryonic antigen [CEA] and carbohydrate antigen 125 [CA125]), the levels of ADAM12 and S100A8, and tissue protein expression levels of ADAM12 and S100A8 were compared between the two groups. The relationship between the protein levels of ADAM12 and S100A8 in the cancer tissues and the clinicopathological characteristics of the triple-negative group was analyzed. Differences in the protein levels of ADAM12 and S100A8 between patients with different chemotherapy outcomes (remission vs. non-remission) and different follow-up outcomes (survival vs. death) were analyzed. Kaplan-Meier survival analysis was used to examine the relationship between the protein levels of ADAM12 and S100A8 in cancer tissues and the prognosis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The protein expression levels of ADAM12 and S100A8 in cancer tissues from the triple-negative group were higher than those in the non-triple-negative group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). The protein expression levels of ADAM12 and S100A8 in cancer tissues were correlated with tumor diameter, histological grading, axillary lymph node metastasis, TNM staging, and differentiation degree in the triple-negative group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). The levels of CEA, CA125, ADAM12, and S100A8, as well as the protein expression levels of ADAM12 and S100A8 in cancer tissues in the non-remission group, were higher than those in the remission group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Similarly, these markers were also significantly elevated in the death group compared to those in the survival group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). After 3 years of follow-up, the overall survival (OS) of patients with low ADAM12 expression was 36.0 (8.0, 36.0) months, while that of patients with high ADAM12 expression was 32.5 (4.0, 36.0) months, showing a statistically significant difference (log rank &lt;i&gt;χ&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt; = 12.913, &lt;i&gt;P&lt;/i&gt; &lt; 0.001). The OS of patients with low S100A8 expression was 36.0 (7.0, 36.0) months, while that of the high-expression group was 31.0 (4.9, 36.0) months, also showing a statistically significant difference (log rank &lt;i&gt;χ&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt; = 24.151, &lt;i&gt;P&lt;/i&gt; &lt; 0.001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;ADAM12 and S100A8 protein expression levels in triple-negative breast cancer tissues are higher than those in non- triple-negative breast cancer tissues. Serum tumor markers and ADAM12 and S1","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 2","pages":"528-535"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[High-resolution Differential Proteomic Analysis of Mouse Secondary Oocytes and First Polar Bodies].","authors":"Xiaodan Fan, Liming Zhou","doi":"10.12182/20250360603","DOIUrl":"10.12182/20250360603","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the proteomic differences between mouse secondary oocytes, also known as metaphase Ⅱ oocytes (MⅡ), and the first polar bodies (PB1) using high-resolution single-cell proteomics, to identify key proteins regulating embryonic development, and to provide a molecular basis for optimizing <i>in vitro</i> oocyte maturation systems.</p><p><strong>Methods: </strong>Paired samples of MⅡ (<i>n</i> = 5) and PB1 (<i>n</i> = 5) were analyzed using high-resolution single-cell mass spectrometry (timsTOF HT). Quantitative proteomics and bioinformatics approaches were employed to conduct differential protein screening and functional enrichment.</p><p><strong>Results: </strong>Using the timsTOF HT platform, we achieved the detection of over 3000 proteins per single cell and identified 277 proteins specifically enriched in MⅡ. Gene Set Enrichment Analysis (GSEA) revealed that these MⅡ-specific proteins were significantly enriched in gene regulation and DNA damage repair pathways associated with mitochondrial energy metabolism. Cross-species GSEA comparison between human and mouse homologs demonstrated elevated expression of heat shock proteins, including Hsp90b1, Hspa5, etc., in the mTORC1 pathway in MⅡ (<i>P</i> < 0.05). In addition, key factors regulating cumulus complex development, such as Calr, Aldoa, etc., were significantly upregulated.</p><p><strong>Conclusion: </strong>MⅡ strategically retains proteins essential for embryonic development through asymmetric division. The timsTOF HT platform demonstrated superior sensitivity in analyzing and identifying these proteins. According to the protein analysis results, the distribution of mTORC1 pathway proteins indicates that they play a key role in embryonic metabolism regulation. In particular, heat shock proteins facilitate protein folding and maintain endoplasmic reticulum homeostasis, thereby ensuring oocyte maturation and the embryonic developmental potential.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 2","pages":"419-424"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Differential Characteristics of Human Airway Organoids at Different Stages of Differentiation After Respiratory Syncytial Virus Infection].","authors":"Jiaxin Luo, Wenhao Yang, Yanan Hu, Danli Lu, Lina Chen, Hanmin Liu","doi":"10.12182/20250360508","DOIUrl":"10.12182/20250360508","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the differences in pathological changes and immune responses of human airway organoids at different stages of differentiation following respiratory syncytial virus (RSV) infection.</p><p><strong>Methods: </strong>Models of human fetal lung organoids (FLO) and induced airway organoids (iAO) were established to simulate immature and mature airway epithelium. Immunofluorescence staining, electron microscopy, and quantitative polymerase chain reaction (Q-PCR) were used to confirm the successful construction of the lung organoid models. Human lung organoids were infected with RSV, and samples were collected at 6 and 48 hours post-infection. The immune characteristics of immature and mature RSV-infected organoids were assessed using immunofluorescence staining, droplet digital PCR (DDPCR), and Q-PCR.</p><p><strong>Results: </strong>We successfully generated FLO expressing both the progenitor markers sex determining region Y-box transcription factor 2 (<i>SOX2</i>) and sex determining region Y-box transcription factor 9 (<i>SOX9</i>), as well as iAO containing basal cells, ciliated cells, club cells, and goblet cells. In addition, organoid models of RSV infection were established. DDPCR results showed that, at the initial stage of RSV infection, the viral load in iAO was significantly higher than that in FLO (<i>P</i> < 0.001). However, at 48 hours post-infection, the viral load in iAO was lower than that in FLO (<i>P</i> < 0.05). Q-PCR results indicated that the expression of RSV infection receptor genes, including epidermal growth factor receptor (<i>EGFR</i>), insulin-like growth factor 1 receptor (<i>IGF1R</i>), and nucleolin (<i>NCL</i>), was significantly higher in iAO compared to that in FLO (<i>P</i> < 0.001). RSV infection led to an increase in the expression levels of immune factors, including interleukin 6 (<i>IL-6</i>), interleukin 8 (<i>CXCL8</i>), interferon α (<i>IFN-α</i>), granulocyte colony-stimulating factor (<i>G-CSF</i>), granulocyte-macrophage colony-stimulating factor (<i>GM-CSF</i>), and tumor necrosis factor α (<i>TNF-α</i>), in iAO compared to those in FLO, and the differences were statistically significant (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The expression of RSV infection receptor proteins increases with airway maturation, and mature airway epithelial cells exhibit a stronger immune response than immature ones do, effectively inhibiting RSV replication.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 2","pages":"411-418"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Preliminary Study of Dilated Cardiomyopathy at a High Altitude Based on Cardiac Magnetic Resonance Feature Tracking].","authors":"Zhetao Wang, Chunhua Wang, Hongke Yin, Sisi Zhao, Jinghang Suo, Lei Wang, Yushu Chen, Peng Zhou, Fabao Gao","doi":"10.12182/20250460201","DOIUrl":"10.12182/20250460201","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the application of cardiovascular magnetic resonance feature tracking (CMR-FT) in assessing myocardial strain in dilated cardiomyopathy (DCM) patients residing at high altitudes.</p><p><strong>Methods: </strong>We retrospectively enrolled 29 DCM patients living at high altitudes (DCM-H), 27 DCM patients living in a low-altitude plain environment (DCM-P), 23 healthy volunteers living at a high altitude (HV-H), and 24 healthy volunteers living in a low-altitude plain environment (HV-P). All subjects underwent cine MRI scanning using a 3.0T rapid steady-state free precession sequence. The CMR images thus acquired were analyzed using cvi42, a post-processing software, to obtain left ventricular function and myocardial strain parameters.</p><p><strong>Results: </strong>Compared with the HV-H group, the DCM-H group showed higher left ventricle end-diastolic volume (LVEDV) and left ventricle end-systolic volume (LVESV), and lower left ventricular ejection fraction (LVEF) and stroke volume ( LVSV) (all <i>P</i> < 0.01). No significant difference was observed in cardiac function between the DCM-H and DCM-P groups (all <i>P</i> > 0.05). The absolute values of global radial strain (GRS), global circumferential strain (GCS), and global longitudinal strain (GLS) in the DCM-H group were lower than those in the HV-P group ([14.5 ± 6.5]% vs. [34.2 ± 10.7]%, [－11.1 ± 4.4]% vs. [－19.9 ± 2.8]%, and [－7.7 ± 3.2]% vs. [－13.6 ± 4.1]%, respectively), with the differences being statistically significant (all <i>P</i> < 0.001). The DCM-H group had higher absolute GRS, GCS, and GCS values than the DCM-P group did ([14.5 ± 6.5]% vs. [7.0 ± 2.7]%, [－11.1 ± 4.4]% vs. [－5.4 ± 2.2]%, and [－7.7 ± 3.2]% vs. [－4.3 ± 1.7]%, respectivley, all <i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>Myocardial strain in DCM patients living at a high altitude is lower than that in healthy volunteers living at a high altitude, but higher than that in DCM patients living in a low-altitude plain environment. CMR-FT can be used to quantitatively assess myocardial contractility in DCM patients living at a high altitude, showing promise for clinical application.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 2","pages":"489-494"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Urban-Rural Disparities in Activities of Daily Living Among Older Adults in Sichuan Province and the Influencing Factors].","authors":"Ting Song, Huan Xu, Xuewei Tang, Xueli Zhang, Linya Huang, Bing Guo, Juying Zhang","doi":"10.12182/20250360502","DOIUrl":"10.12182/20250360502","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the disparities in the activities of daily living (ADL) among older adults living in urban and rural areas of Sichuan Province, China and the influencing factors, and to provide a basis for promoting the health of older adults and formulating relevant policies.</p><p><strong>Methods: </strong>Using data from the Seventh Health Services Survey of Sichuan Province, we enrolled 7369 older adults from urban and rural areas and analyzed their ability to perform ADL and the relevant influencing factors. All participants were aged 60 years or older. Chi-square tests and logistic regression were performed to identify the influencing factors.</p><p><strong>Results: </strong>The ADL impairment rate among older adults living in urban areas of Sichuan Province was 17.7%, which was higher than the rate of 13.8% among older adults living in rural areas. According to the results of logistic regression analysis, age ≥ 80 years (odds ratio [OR] = 3.725; 95% CI, 2.460-5.639), accidental injuries (OR = 2.375; 95% CI, 1.597-3.532), and good sleep quality (OR = 0.420, 95% CI: 0.289-0.612) were factors influencing ADL among older adults living in urban areas, while age ≥ 80 years (OR = 1.867; 95% CI, 1.459-2.390), being married (OR = 0.805; 95% CI, 0.664-0.976), accidental injuries (OR = 1.936; 95% CI, 1.564-2.397), and participation in social activities (OR = 0.417; 95% CI, 0.352-0.495) were factors influencing ADL among older adults living in rural areas.</p><p><strong>Conclusion: </strong>There are differences in ADL impairment rates and the relevant influencing factors between urban and rural older adults in Sichuan Province. These findings underscore the need to consider urban-rural differences when adopting relevant policies and measures.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 2","pages":"478-483"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Esketamine Alleviates Postoperative Depressive Symptoms in Frail Elderly Patients Undergoing Thoracoscopic Radical Resection of Lung Cancer: A Randomized Double-Blind Controlled Trial].","authors":"Congli Zhang, Yan Yan, Junjie Ma, Ke Wang, Di Liu, Yang Zhang, Xiaohong Li, Li Ren","doi":"10.12182/20250360202","DOIUrl":"10.12182/20250360202","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the effect of esketamine on postoperative depression in frail elderly patients undergoing thoracoscopic radical resection of lung cancer.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 88 frail elderly patients undergoing elective thoracoscopic radical resection of lung cancer were assigned randomly (using a randomization table) and in a double-blind way (blinding applies to both researchers and patients) to an esketamine group (Esk group, &lt;i&gt;n&lt;/i&gt; = 44) and a normal saline group (NS group, &lt;i&gt;n&lt;/i&gt; = 44). In the Esk group, 0.25 mg/kg esketamine was injected intravenously during anesthesia induction, followed by continuous infusion of esketamine at 0.125 mg/kg per hour until 20 min before the end of surgery. In the NS group, equivalent volumes of normal saline were administered using the same method. The primary outcome was the score for the 17-item Hamilton Rating Scale for Depression (HAMD-17) on days 7 and 30 after surgery. The secondary outcomes included sleep quality and cognitive function. Sleep quality was assessed using the numerical rating scale (NRS) on days 1, 3, and 7 after surgery and the Pittsburgh Sleep Quality Index (PSQI) on day 30 after surgery. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) on days 1, 3, 7, and 30 after surgery. The other indicators included the levels of serum brain-derived neurotrophic factor (BDNF), 5-hydroxytryptamine (5-HT), S100β protein, and neuron specific enolase (NSE) at 24 hours (T1), 48 hours (T2), and 72 hours (T3) after surgery, as well as perioperative data and postoperative safety outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Three patients were excluded from the Esk group and the NS group, respectively, and eventually, 41 patients in each group were included in the statistical analysis. There were no statistically significant differences between the two groups in terms of age, sex, body mass index, American Society of Anesthesiologists (ASA) classification, comorbidities, educational attainment, and the scores for HAMD-17, PSQI, and MMSE 1 day before surgery (&lt;i&gt;P&lt;/i&gt; &gt; 0.05). Concerning the primary outcome, compared with those of the NS group, the HAMD-17 scores of patients in the Esk group were significantly lower at 7 days (median [P&lt;sub&gt;25&lt;/sub&gt;, P&lt;sub&gt;75&lt;/sub&gt;]) (7 [6, 8] vs. 7 [6, 12], &lt;i&gt;P&lt;/i&gt; = 0.045) and 30 days (6 [6, 7] vs. 7 [6, 9], &lt;i&gt;P&lt;/i&gt; = 0.020) after surgery. Concerning the secondary outcomes, compared with those of the NS group, the sleep NRS scores of patients in the Esk group were significantly lower at 1, 3, and 7 days after surgery (&lt;i&gt;P&lt;/i&gt; &lt; 0.01), and the MMSE scores were significantly higher (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Concerning the other indicators, compared with those of the NS group, the concentrations of serum BDNF and 5-HT in the Esk group were significantly higher (&lt;i&gt;P&lt;/i&gt; &lt; 0.05 or 0.01) at T1-T3, while the content of S100β was significantly lower (&lt;i&gt;P&lt;/i&gt; &lt; 0.01) at T1-T3; the levels of serum NSE ","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 2","pages":"506-513"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in Multi-omics Analysis of Cervical Cancer].","authors":"Jianhong Wang, Xue Xiao, Yuan Yao","doi":"10.12182/20250360403","DOIUrl":"10.12182/20250360403","url":null,"abstract":"<p><p>Cervical cancer (CC), a common malignant tumor afflicting women, poses serious threats to their health. Therefore, it is critical to develop a thorough understanding of the molecular mechanisms underlying the pathogenesis of CC, and to identify new therapeutic targets and methods for early diagnosis. The multi-omics research in tumors, involving proteomics, transcriptomics, genomics, microbiomics, and metabolomic, offers valuable insights. The multi-omics analysis of biological samples from patients with cervical intraepithelial neoplasia (CIN) and CC can help clarify the pathways involved in the pathogenesis and development of CC. Furthermore, multi-omics studies have identified a number of molecules associated with CC, including actin, lumican, family member with sequence similarity 83 (FAM83A), cadherin EGF-LAG seven-pass G-type receptor 3 (CELSR3), and 5,10-methylenetetrahydrofolate reductase (MTHFR), all of which show potential to be used as new biomarkers. These biomarkers will help make early diagnosis, improve the survival and prognosis of CC patients, and ultimately reduce CC incidence and mortality. This review synthesizes current advances in multi-omics research on cervical cancer.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 2","pages":"571-576"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}