四川大学学报(医学版)最新文献

{"title":"[Analyzing Frequency-Dependent Human Brain Information Flow in Resting-State fMRI Using Multiple Effective Connectivity Methods].","authors":"Zhizheng Zhuo, Zhuyuerong Li, Yaou Liu","doi":"10.12182/20250560508","DOIUrl":"10.12182/20250560508","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the information flow patterns in the human brain across different frequency bands of resting-state functional magnetic resonance imaging (rs-fMRI) using 7 analysis methods to assess effective brain network connectivity.</p><p><strong>Methods: </strong>The high spatio-temporal rs-fMRI data of 60 healthy volunteers (30 males and 30 females) aged between 22 and 35 years were downloaded from the Human Connectome Project (HCP) database. The information flow patterns of different frequency bands, including conventional low-frequency band (0.01-0.08 Hz), high-frequency band (0.08-0.69 Hz), and whole-frequency band (0.01-0.69 Hz), were analyzed by Granger causality analysis (including linear Granger causality model, kernel-based Granger causality model, and non-parametric multiplicative regression Granger causality model), transfer entropy (based on binning, k-nearest neighbors, and permutation), and convergent cross mapping.</p><p><strong>Results: </strong>Within the low frequency band, the preferred information flow showed similar topologies across all the analysis methods, with the information flow going predominantly from sub-cortical nucleus, limbic lobe, and a few regions of frontal and temporal lobes into occipital and parietal lobes and other regions of frontal and temporal lobes. In contrast, within the high and whole frequency bands, the information flow was in the opposite direction. Additionally, significant negative correlations were found between the preferred information flow direction and the relative power of low- and high-frequency bands, respectively.</p><p><strong>Conclusion: </strong>The multimodal effective connectivity analysis conducted in the study reveals rs-fMRI frequency-dependent information flow patterns in the human brain, validates the consistency of different methods in assessing the directional information transfer in the brain network, and offers new insights for understanding the regulatory mechanisms of resting-state brain functions.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"770-777"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Exposure Pathways of Polystyrene Nanoplastics Mediate Their Cellular Distribution and Toxicity].","authors":"Jing Li, Qixue Bao, Zeyan Li, Yuqin Yao, Dongsheng Wu, Lijun Peng, Zhenmi Liu, Lin Li, Ling Zhang","doi":"10.12182/20250560105","DOIUrl":"10.12182/20250560105","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate whether exposure pathways influence the distribution pattern and toxicity of polystyrene nanoplastics (PSNPs) in hepatic cells.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Male C57BL/6J wild-type healthy mice aged 6 to 8 weeks old and weighed 18 to 22 g were administered with PSNPs via gavage or tail vein injection. Then, we tracked PSNPs distribution in the major organs of mice via an &lt;i&gt;in vivo&lt;/i&gt; imaging system (IVIS). After that, we analyzed the cellular accumulation patterns in hepatic cell subpopulations (hepatocytes and Kupffer cells) using immunofluorescence and transmission electron microscopy (TEM). 300 nm PSNPs were administered via gastric gavage or tail vein injection, and 70 nm PSNPs were injected via the portal vein. The cellular localization of PSNPs in the liver was analyzed using immunofluorescence. Subsequently, using AML-12 cells, a normal mouse liver cell line, as the parenchymal hepatocyte model, the uptake of PSNPs in AML-12 cells was analyzed by confocal laser scanning microscope (CLSM). Flow cytometry was performed to observe and quantify PSNPs uptake, and to analyze the underlying endocytosis mechanisms. IVIS was used to analyze PSNPs uptake features &lt;i&gt;in vivo&lt;/i&gt;. Finally, using mouse macrophage line RAW264.7 as a Kupffer cell model and AML-12 cells as a parenchymal hepatocyte model, the cell-type-specific toxic effects induced by 100 μg/ml PSNPs were examined through transcriptomics and metabolomics analyses.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;IVIS revealed predominant hepatic accumulation of PSNPs regardless of exposure pathways via intragastric gavage or tail vein injection. Immunofluorescence/TEM demonstrated exposure pathway-dependent cellular distribution: intragastric PSNPs were localized mainly in hepatocytes, while intravenous PSNPs were accumulated in Kupffer cells. Changes in particle size (300 nm vs. 70 nm) did not alter the cellular distribution pattern, while 70 nm PSNPs injected via the portal vein accumulated in Kupffer cells, which suggested that the cell-type-specific distribution of PSNPs in the liver was independent of PSNPs size and might be related to the transport of PSNPs in the gastrointestinal tract. Flow cytometry showed that PSNPs uptake by AML-12 was time-dependent and that the underlying endocytosis mechanism involved pathways mediated by clathrin (&lt;i&gt;P&lt;/i&gt; &lt; 0.0001), macropinocytosis (&lt;i&gt;P&lt;/i&gt; = 0.0026), and lipid rafts (&lt;i&gt;P&lt;/i&gt; &lt; 0.0001). Findings on PSNPs distribution in blood revealed that the uptake of PSNPs by hepatocytes exhibited a rate saturation phenomenon. Multi-omics analysis identified distinct toxicity patterns: PSNPs disrupted lipid metabolism and neurotransmitter homeostasis in AML-12 cells and induced inflammation and oxidative stress in Kupffer cells.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Exposure pathways mediate the hepatic cell-type-specific distribution of PSNPs, thereby altering the downstream toxicological consequences induced by exposu","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"711-721"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Role of Intestinal Mucosal Barrier in Type 2 Diabetes Mellitus and Research Progress in Chinese Medicine Interventions].","authors":"Cong Yan, Qige Wang, Libin Zhan","doi":"10.12182/20250560107","DOIUrl":"10.12182/20250560107","url":null,"abstract":"<p><p>The intestinal mucosal barrier is closely associated with the occurrence and development of type 2 diabetes mellitus (T2DM). It plays an important role in maintaining the homeostasis of the internal environment and resisting pathogenic invasion by regulating the metabolic homeostasis, immune response, and microbial-host interactions in the human body. According to recent studies, intestinal mucosal barrier dysregulation may constitute a key link in the pathogenesis of T2DM. Herein, we systematically reviewed the mechanisms by which intestinal mucosal barrier damage contributes to the onset of T2DM and the latest advances in modern medical intervention strategies. We also discussed and summarized the latest research findings on using traditional Chinese medicine (TCM) to regulate the intestinal mucosal barrier in the management of T2DM. Currently, the causal relationship and mechanisms linking intestinal mucosal barrier damage to the onset of T2DM remain unclear, and systematic research on the synergistic regulatory mechanisms of approaches integrating TCM and Western medicine is lacking. The approach to manage T2DM through the integration of TCM and Western medicine can provide insights and basis from multiple aspects, such as TCM syndrome differentiation and treatment, balancing drug properties, and multi-targeted therapy. In the future, we should fully leverage the advantages of integrated TCM and Western medicine in treating T2DM and conduct in-depth research focused on the intestinal mucosal barrier, thereby informing evidence-based clinical applications.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"619-626"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Interpretation and Examples: Key Updates in SPIRIT 2025 Statement].","authors":"Zelei Dai, Renjie Zhao, Kefan Li, Yonggang Zhang, Nian Li, Wenjie Yang, Lei Liu, Lingmin Chen","doi":"10.12182/20250560505","DOIUrl":"10.12182/20250560505","url":null,"abstract":"<p><p>A high-quality clinical trial protocol is the cornerstone for ensuring the scientific integrity and ethical compliance of a study. The Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) has become the international benchmark for developing clinical trial protocols since its release in 2013. To adapt to the developing trends of open science and patient-centered principles, the SPIRIT group completed a comprehensive update in 2025. While retaining its core structure, this updated guideline introduces a new open science module and incorporates several new elements, including patient and public involvement, trial monitoring, and data sharing, alongside substantial revisions of five pre-existing items. In this article, we critically examine the core revisions in SPIRIT 2025 and, through analysis of representative case studies, illustrate the practical application of the new reporting guideline in drafting trial protocols. Our goal is to to provide Chinese researchers with a valuable reference for understanding and implementing this new reporting guideline, thereby enhancing the quality and rigor of clinical trial protocols developed in the country.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"686-696"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Sevelamer vs. Calcium Acetate for Treating Hyperphosphatemia in Maintenance Hemodialysis Patients].","authors":"Kang Liu, Jin Zhao, Fan Wang, Xiaodong Liu, Jing Gao","doi":"10.12182/20250560605","DOIUrl":"10.12182/20250560605","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the efficacy of sevelamer (SL) and calcium acetate (CA) in treating hyperphosphatemia in patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis (MHD) and their effects on calcium-phosphorus metabolism and levels of peripheral blood fetuin-A and fibroblast growth factor-23 (FGF-23).</p><p><strong>Methods: </strong>A total of 92 ESRD patients attending the First Hospital of Zibo between January 2022 and December 2023 were enrolled. They were randomly assigned to either the CA group (46 cases) or the SL group (46 cases) using a random number table method. Patients in both groups received MHD and conventional treatment. Additionally, patients in the CA group were given CA, while those in the SL group were given SL, with the treatment continuing for 3 months. The outcome indicators were assessed and compared between the two groups. The primary outcome indicator was clinical efficacy. The secondary outcome indicators included calcium-phosphorus metabolism indicators (blood calcium, blood phosphorus, calcium-phosphorus product, and intact parathyroid hormone [iPTH]), coronary artery calcification score (CACs), serum biochemical indicators (including fetuin-A, FGF-23, and C-reactive protein [CRP]), and adverse reactions and cardiovascular events during the course of treatment.</p><p><strong>Results: </strong>There were no statistically significant differences in baseline data between the two groups (<i>P</i> > 0.05). There was a significant difference in clinical efficacy between the SL group and the CA group (<i>P</i> < 0.05). The differences in blood calcium, blood phosphorus, calcium-phosphorus product, iPTH, and CACs before and after treatment were statistically significant between the two groups (<i>P</i> < 0.05). The differences in fetuin-A, FGF-23, and CRP before and after treatment were also statistically significant between the two groups (<i>P</i> < 0.05). During treatment, there was no significant difference in the incidences of adverse reactions and cardiovascular events between the two groups (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>SL demonstrates superior efficacy compared to CA in treating hyperphosphatemia in MHD patients. SL effectively regulates calcium-phosphorus metabolism, reduces CACs, regulates peripheral blood fetuin-A and FGF-23 levels, and leads to fewer adverse reactions. SL may be a preferred option for clinical management.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"798-803"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[TruScreen Combined With High-Risk Human Papillomavirus Testing vs Thinprep Cytology Test Combined With High-Risk Human Papillomavirus Testing for Cervical Cancer Screening: A Comparative Clinical Study].","authors":"Yi Yang, Chunmei Li, Shuyun Jia, Yifeng Wang, Dengpan Wang, Liyin Zhang","doi":"10.12182/20250560609","DOIUrl":"10.12182/20250560609","url":null,"abstract":"<p><strong>Objective: </strong>To compare the clinical value of TruScreen, an artificial intelligence-based real-time cervical cancer screening system, combined with high-risk human papillomavirus (hr-HPV) test and Thinprep cytology test (TCT) combined with hr-HPV test in cervical cancer screening.</p><p><strong>Methods: </strong>A total of 297 women undergoing cervical cancer screening at Panzhihua Central Hospital between June 2020 and December 2023 were enrolled. All participants underwent hr-HPV testing, TCT, and TruScreen test. The diagnostic performance of TruScreen combined with hr-HPV test and TCT combined with hr-HPV test for low-grade squamous intraepithelial lesion positive (LSIL⁺) and high-grade squamous intraepithelial lesion positive (HSIL⁺) cervical lesions was evaluated.</p><p><strong>Results: </strong>Among the 297 enrolled women, pathology analysis identified 128 (43.10%) LSI⁺ cases and 67 (22.56%) HSIL⁺ cases. Additionally, there were 110 (37.04%) HPV16/18 positive cases, 177 (59.60%) cases with TCT results ≥ atypical squamous cells of undetermined significance (ASCUS), and 176 (59.26%) cases with abnormal TruScreen results. The area under the curve (AUC) of TruScreen combined with hr-HPV test in diagnosing LSIL⁺ and HSIL⁺ cervical lesions was higher than that of TCT combined with hr-HPV test (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>TruScreen combined with hr-HPV test demonstrates superior performance in cervical cancer screening compared with TCT combined with hr-HPV test. TruScreen combined with hr-HPV test may serve as an alternative to conventional cytology-based methods for cervical cancer screening in China.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"852-857"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Comparative Study of the Positive Psychological Resources Network of Adolescents With Non-Suicidal Self-Injury].","authors":"Yuge Jia, Xiao Liao, Yuan Feng, Ting Zhu, Xuan Cao, Wei Zhang","doi":"10.12182/20250560103","DOIUrl":"10.12182/20250560103","url":null,"abstract":"<p><strong>Objective: </strong>To explore the differences in positive psychological resources among elementary and secondary school students with and without non-suicidal self-injury (NSSI) behaviors.</p><p><strong>Methods: </strong>Between September and October 2023, the assessment data of 56870 students aged 9 to 18 years in Chengdu, Sichuan Province were collected. The R software package was used to evaluate the network structure and symptom centrality, and the global strength and structural differences of the networks of students with and without NSSI behaviors in elementary, junior high, and senior high schools were compared.</p><p><strong>Results: </strong>The prevalence of NSSI among elementary and secondary school students stands at 12.21%. Specifically, it peaks in junior high school students, reaching 14.22%, followed by that in senior middle school students at 13.66%, and is lowest in elementary school students at 10.17%. Regarding the network structure in elementary school students, irrespective of the presence or absence of NSSI behavior, subjective support exhibits the strongest network strength, and family functioning demonstrates the highest closeness centrality. Among junior high school students without NSSI behaviors, the strongest network strength was observed in subjective support, whereas for those with NSSI behaviors, self-esteem showed the strongest network strength. In addition, subjective support exhibited the highest closeness centrality in both groups. In senior high school students, self-esteem was the factor with the strongest network strength for students with or without NSSI behaviors. For senior high school students without NSSI, subjective support had the highest closeness centrality, while for those with NSSI, expressive suppression showed the highest closeness centrality. The edge weights differed significantly among elementary school students in family functioning-self-esteem (E = 0.093) and family functioning-objective support (E = 0.087). For junior high school students, significant differences were found in objective support-subjective support (E = 0.131) and family functioning-impulse control (E = 0.109). Among senior high school students, significant differences were observed in impulse control-family function (E = 0.133) and subjective support-utilization of support (E = 0.130) (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Excessive family involvement in elementary school students and expressive suppression in senior high school students may be important influencing factors for NSSI behaviors. The lack of social support has a greater impact on junior and senior high school students. The strength of the connection among subjective support, objective support, and utilization of support is an important indicator.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"864-872"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[YTHDF3 Regulates Macrophage Activation: Investigation of the Mechanisms Involved].","authors":"Keren Peng, Qimin Yin, Jiyu Tong","doi":"10.12182/20250560501","DOIUrl":"10.12182/20250560501","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the role and the underlying mechanisms of N⁶-methyladenosine (m⁶A) reader YTHDF3 in macrophages activation.</p><p><strong>Methods: </strong>shRNA-mediated <i>Ythdf3</i> knockdown in RAW264.7 cells was performed and these RAW264.7 cells were stimulated with LPS. Then, changes in the pro-inflammatory and anti-tumor functions, including cytokine production, phagocytosis, and tumoricidal ability were evaluated. The effect of <i>Ythdf3</i> knockdown on the activation of the Toll-like receptor 4 (TLR4) downstream MAPK and NF-κB pathways was assessed by immunoblotting. After <i>Ythdf3</i> knockdown, the expression levels and mRNA stability of key junction proteins and signaling molecules of the TLR4 signaling pathway were analyzed to identify YTHDF3 target genes and investigate the underlying regulatory mechanism.</p><p><strong>Results: </strong>After LPS stimulation of wild-type RAW264.7 cells, the level of pro-inflammatory factors increased and then decreased. However, the level of YTHDF3 showed the opposite trend to that of pro-inflammatory factors, suggesting that YTHDF3 might play a role in the negative regulation of macrophage activation. shRNA-mediated <i>Ythdf3</i> knockdown in RAW264.7 cells significantly increased the expression of pro-inflammatory factors, nitric oxide (NO) production, and phagocytosis. In addition, <i>Ythdf3</i> knocked-down RAW264.7 cells co-cultured with tumor cells exhibited enhanced tumor killing ability. The findings suggested that YTHDF3 deletion could promote LPS-induced activation of RAW264.7 cells and enhance their production of pro-inflammatory factors and tumor killing function. further investigation into the underlying mechanisms revealed that <i>Ythdf3</i> knockdown inhibited the degradation of <i>Cd36</i>, <i>Irak1</i>, <i>Tab1/2</i>, and <i>Tirap</i> mRNAs, which were key junction proteins and signaling molecules in the TLR4 pathway, which in turn, enhanced the phosphorylation of p38, a downstream key kinase and the activation of macrophages.</p><p><strong>Conclusion: </strong>By targeting the mRNA of the key junction proteins and signaling molecules of the TLR4 pathway, YTHDF3 accelerates their rapid degradation and suppresses macrophage activation. <i>Ythdf3</i> knockdown significantly promotes macrophage activation and enhances the tumor killing activities of macrophages.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"722-729"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Risk Factors for Recurrence and Their Predictive Value in Endometriosis Patients After Laparoscopic Surgery].","authors":"Xiaojuan Kong, Zhenyu Tan, Lei Lei","doi":"10.12182/20250560109","DOIUrl":"10.12182/20250560109","url":null,"abstract":"<p><strong>Objective: </strong>To identify the factors influencing postoperative recurrence in endometriosis patients after laparoscopic surgery and to evaluate their clinical predictive performance for postoperative recurrence.</p><p><strong>Methods: </strong>The clinical data of 190 endometriosis patients who underwent laparoscopic surgery at our hospital between January 2019 and January 2024 were retrospectively collected. Patients were divided into a non-recurrence group (109 cases) and a recurrence group (81 cases) based on their status of postoperative recurrence. Univariate analysis was performed with the clinical data. Multivariate logistic regression analysis was performed to identify the influencing factors of recurrence after laparoscopic surgery. Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive value of the relevant indicators.</p><p><strong>Results: </strong>According to the results of the univariate analysis, the prevalence of preoperative history of dysmenorrhea, number of preoperative pregnancies, history of previous uterine cavity procedures, smoking, and drinking in the non-recurrence group was lower than that in the recurrence group (<i>P</i> < 0.05). The non-recurrence group also had lower preoperative serum levels of transforming growth factor-β1 (TGF-β1), interleukin (IL)-1β, IL-17, and IL-22 compared with those of the recurrence group (<i>P</i> < 0.05). Except for the history of previous uterine cavity procedures, drinking, and the level of IL-17, all other factors were independent risk factors for recurrence after laparoscopic surgery (<i>P</i> < 0.05). The area under the curve (AUC) for preoperative serum TGF-β1 + IL-1β and TGF-β1 + IL-1β + IL-22 was 0.980 (95% CI, 0.965-0.994) and 0.982 (95% CI, 0.968-0.996), respectively, indicating a high predictive value for recurrence in patients after laparoscopic surgery.</p><p><strong>Conclusion: </strong>The history of preoperative dysmenorrhea, number of preoperative pregnancies, smoking, and preoperative levels of serum TGF-β1, IL-1β, and IL-22 are risk factors for the recurrence of endometriosis after laparoscopic surgery. The combination of TGF-β1 and IL-1β, as well as the combination of TGF-β1, IL-1β, and IL-22, both demonstrated good performance for predicting the recurrence of endometriosis after laparoscopic surgery.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"846-851"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Correlation Between Inflammatory Cytokine Levels and Growth Restriction in Full-term Small-for-Date Infants].","authors":"Yaling Jin, Xiaocui Ren, Bao Geng, Xueai Fan","doi":"10.12182/20250560604","DOIUrl":"10.12182/20250560604","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP) in the serum of full-term small-for-date infants and their growth restriction.</p><p><strong>Methods: </strong>Pregnant women and their newborns who underwent routine check-ups at the Department of Obstetrics of Xingtai Central Hospital were enrolled. The mothers were admitted for delivery between January 2022 and December 2023. Newborns with a gestational age between 37 weeks and 41 weeks 6 days were included. A total of 83 newborns weighing < 2500 g at birth were included in the full-term small-for-date infant group, while 72 newborns weighing ≥ 2500 g at birth were included in the healthy control group. The maternal and neonatal serum levels of TNF-α, IL-6, and CPR were compared between the two groups. Logistic regression analysis was performed to screen for influencing factors. Receiver operating characteristic (ROC) curves were plotted to assess the predictive value of each influencing factor, and the optimal cutoff value, sensitivity, and specificity were derived subsequently.</p><p><strong>Results: </strong>Compared with the healthy group, the full-term small-for-date infant group had elevated maternal and neonate serum levels of TNF-α, IL-6, and CPR (<i>P</i> < 0.001). Maternal body mass index (BMI) (OR = 0.428; 95% CI, 0.238-0.768; <i>P</i> = 0.004), TNF-α levels (OR = 2.133; 95% CI, 1.012-4.496; <i>P</i> = 0.046), IL-6 levels (OR = 1.218; 95% CI, 1.121-1.322; <i>P</i> < 0.001), and CPR levels (OR = 1.733; 95% CI, 1.312-2.288; <i>P</i> < 0.001) were significantly associated with the incidence of full-term small-for-date infants (<i>P</i> < 0.05). The area under the ROC curve (AUC) for maternal BMI and maternal serum TNF-α, IL-6, and CPR levels were 0.358 (0.271-0.444), 0.735 (0.656-0.814), 0.838 (0.777-0.898), and 0.743 (0.666-0.820), respectively. Among the 83 cases of full-term small-for-date infants, 49 cases (59.04%) achieved satisfactory weight according to infant weight evaluation standards by the age of 6 months. Only birth weight (OR = 1.004; 95% CI, 1.312-2.288; <i>P</i> < 0.001) was identified as a significant influencing factor for satisfactory catch-up growth in full-term small-for-date infants. There was no significant association between the levels of inflammatory cytokines at birth and satisfactory catch-up growth at 6 months of age.</p><p><strong>Conclusion: </strong>Maternal BMI and maternal and neonatal serum levels of TNF-α, IL-6, and CPR are all associated with the occurrence of growth restriction in full-term small-for-date infants. Measuring maternal serum levels of TNF-α, IL-6, and CPR may have value in predicting the occurrence of full-term small-for-date infants. However, no significant correlation is identified between the neonate serum levels of TNF-α, IL-6, and CRP and their growth catch-up at 6 months of age.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"818-824"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}