四川大学学报(医学版)最新文献

{"title":"[Physiological Characteristics of the Facial Skin in Ethnic Tibetan Population Living at High Altitudes].","authors":"Longwei Fang, Basangzhuoma, Danzengdeqiong, Nizhen, Jin Wang, Gesangdeji, Duojizhuoma, Yangla","doi":"10.12182/20250560608","DOIUrl":"10.12182/20250560608","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the characteristics of skin physiological parameters in ethnic Tibetan population living at ultra-high (4700 m) and high (3650 m) altitudes on the Xizang Plateau.</p><p><strong>Methods: </strong>Using a multi-stage cluster random sampling method, this study measured facial skin parameters related to the skin barrier system such as sebum secretion (SM), skin pH (pH), corneum moisture content (CM), and transepidermal water loss (TEWL), as well as melanin-related parameters such as erythema (E), melanin (M), individual typology angle (ITA), lightness (L), red-green chromaticity (a value, a), and yellow-blue chromaticity (b value, b) in ethnic Tibetans living at ultra-high (average altitude: 4700 m) and high (average altitude: 3650 m) altitudes. The control group primarily measured the skin parameters of unexposed areas (neck) in the high-altitude population, serving as the baseline reference values for skin parameters.</p><p><strong>Results: </strong>A total of 627 participants were enrolled, including 164 from ultra-high-altitude regions and 257 from high-altitude regions (128 males and 293 females; average age [48.03 ± 13.39] years), as well as 206 controls (72 males and 134 females; average age [48.67 ± 12.50] years). Other physiological indicators were mostly within normal ranges. Comparison of parameters showed that, compared with the high-altitude population, the ultra-high-altitude population showed significantly higher E value (<i>P</i> < 0.01), TEWL value (<i>P</i> < 0.001), and M value (<i>P</i> < 0.001), but lower CM, ITA, and L values (<i>P</i> < 0.001). There were no significant age-stratified differences, though age-related variation trends were observed. Gender differences showed that males had higher a, M, and TEWL values than females (<i>P</i> < 0.001), but lower ITA and L values (<i>P</i> < 0.001). In ultra-high-altitude areas, males had lower b value than females (<i>P</i> < 0.001), while in high-altitude areas, males showed higher E value (<i>P</i> < 0.001) and lower SM and pH values than females. These differences narrowed with increasing altitude. Ultra-high-altitude males had higher TEWL (<i>P</i> < 0.001) and M values (<i>P</i> < 0.05), but lower E, ITA, L, and b values (<i>P</i> < 0.01) than high-altitude males. Ultra-high-altitude females demonstrated higher TEWL, E, M, and b values, but lower CM, ITA, and L values compared with high-altitude females (<i>P</i> < 0.001), with statistically significant differences. Linear, correlation, and phenotypic network analyses showed that pH, CM, TEWL, ITA and L values were linearly correlated with altitude. The b values of both males and females showed a linear relationship with altitude, and the M value of females was linearly correlated with altitude. Significant correlations were observed among parameters, with strong positive correlations between E and a and between ITA and L, and strong negative correlations between value of M and ITA","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"831-839"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Correlation Between Inflammatory Cytokine Levels and Growth Restriction in Full-term Small-for-Date Infants].","authors":"Yaling Jin, Xiaocui Ren, Bao Geng, Xueai Fan","doi":"10.12182/20250560604","DOIUrl":"10.12182/20250560604","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP) in the serum of full-term small-for-date infants and their growth restriction.</p><p><strong>Methods: </strong>Pregnant women and their newborns who underwent routine check-ups at the Department of Obstetrics of Xingtai Central Hospital were enrolled. The mothers were admitted for delivery between January 2022 and December 2023. Newborns with a gestational age between 37 weeks and 41 weeks 6 days were included. A total of 83 newborns weighing < 2500 g at birth were included in the full-term small-for-date infant group, while 72 newborns weighing ≥ 2500 g at birth were included in the healthy control group. The maternal and neonatal serum levels of TNF-α, IL-6, and CPR were compared between the two groups. Logistic regression analysis was performed to screen for influencing factors. Receiver operating characteristic (ROC) curves were plotted to assess the predictive value of each influencing factor, and the optimal cutoff value, sensitivity, and specificity were derived subsequently.</p><p><strong>Results: </strong>Compared with the healthy group, the full-term small-for-date infant group had elevated maternal and neonate serum levels of TNF-α, IL-6, and CPR (<i>P</i> < 0.001). Maternal body mass index (BMI) (OR = 0.428; 95% CI, 0.238-0.768; <i>P</i> = 0.004), TNF-α levels (OR = 2.133; 95% CI, 1.012-4.496; <i>P</i> = 0.046), IL-6 levels (OR = 1.218; 95% CI, 1.121-1.322; <i>P</i> < 0.001), and CPR levels (OR = 1.733; 95% CI, 1.312-2.288; <i>P</i> < 0.001) were significantly associated with the incidence of full-term small-for-date infants (<i>P</i> < 0.05). The area under the ROC curve (AUC) for maternal BMI and maternal serum TNF-α, IL-6, and CPR levels were 0.358 (0.271-0.444), 0.735 (0.656-0.814), 0.838 (0.777-0.898), and 0.743 (0.666-0.820), respectively. Among the 83 cases of full-term small-for-date infants, 49 cases (59.04%) achieved satisfactory weight according to infant weight evaluation standards by the age of 6 months. Only birth weight (OR = 1.004; 95% CI, 1.312-2.288; <i>P</i> < 0.001) was identified as a significant influencing factor for satisfactory catch-up growth in full-term small-for-date infants. There was no significant association between the levels of inflammatory cytokines at birth and satisfactory catch-up growth at 6 months of age.</p><p><strong>Conclusion: </strong>Maternal BMI and maternal and neonatal serum levels of TNF-α, IL-6, and CPR are all associated with the occurrence of growth restriction in full-term small-for-date infants. Measuring maternal serum levels of TNF-α, IL-6, and CPR may have value in predicting the occurrence of full-term small-for-date infants. However, no significant correlation is identified between the neonate serum levels of TNF-α, IL-6, and CRP and their growth catch-up at 6 months of age.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"818-824"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical Characteristics, Risk Factors, and Development and Evaluation of a Prediction Model for Pressure Injury in Patients With Severe Neurological Diseases].","authors":"Mingya Yao, Xiaoqing Chen, Kejing Huang, Aimei Miao","doi":"10.12182/20250560610","DOIUrl":"10.12182/20250560610","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical characteristics and influencing factors of pressure injury in patients with severe neurological diseases and to construct and evaluate a predictive model for it.</p><p><strong>Methods: </strong>A retrospective research method was adopted to collect 250 patients with severe neuropathy admitted to the First Affiliated Hospital of Wenzhou Medical University from April 2020 to April 2024, and their clinical characteristics were collected. The patients were then divided into a pressure injury group (<i>n</i> = 58) and a non-pressure injury group (<i>n</i> = 192) based on whether they development pressure injury after treatment. Baseline data on patient coma or lethargy status, primary diagnosis requiring neurocritical care admission, and Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ scores were collected. The area under the curve (AUC) of the receiver operating characteristic (ROC) curves for acute cerebrovascular disease, coma or lethargy status, and APACHE Ⅱ scores of the subjects was compared.</p><p><strong>Results: </strong>Among the 250 patients with severe neurological diseases, 58 had pressure injuries. Of these, 35 (60.34%) had mucosal pressure injuries, while 23 (39.66%) had device-related pressure injuries. According to the National Pressure Injury Advisory Panel Pressure Injury Staging System, 46 cases (79.31%) had stage 1 pressure injuries, 8 cases(13.97%) had stage 2 pressure injuries, 4 cases (6.90%) had stage 3 pressure injuries, and no patients had stage 4 pressure injuries. Logistic multivariate regression analysis showed that primary diagnosis requiring neurocritical care admission (odds ratio [OR] = 3.102; 95% CI, 1.013-9.499), coma or lethargy status (OR =3.769; 95% CI, 1.237-11.478), and APACHE Ⅱ score (OR =0.201; 95% CI, 0.124-0.328) were influencing factors for pressure injury in patients with severe neurological diseases. The ROC results showed that the AUC of the prediction model combining the 3 influencing factors was 0.974 (95% CI, 0.957-0.992), and that the sensitivity and specificity were 91.40% and 93.70%, respectively. The prediction accuracy of the combination prediction model was 0.96, which was significantly higher than those of the prediction models based on the 3 separate influencing factors (<i>P</i> < 0.05). The Hosmer-Lemeshow test showed that the model had a good fit (<i>χ</i> ² = 4.779, <i>P</i> = 0.062), indicating that the model had a relatively high accuracy.</p><p><strong>Conclusion: </strong>Acute cerebrovascular disease, coma or lethargy, and APACHE Ⅱ score have different predictive values for pressure injury in patients with severe neurological diseases. While acute cerebrovascular disease and coma or lethargy have the same predictive value separately, the combination prediction incorporating the 3 influencing factors demonstrated superior accuracy and holds considerable potential for clinical application.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"858-863"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Efficacy of β-Blockers in Older Adults With Hypertension Combined With Vascular Dementia].","authors":"Zhaoxia Tian, Weiping Li, Weiwei Tian, Hongmei Li, Xiaoyan Xue, Na Zhao","doi":"10.12182/20250560607","DOIUrl":"10.12182/20250560607","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical efficacy of β-blockers in older patients with hypertension combined with vascular dementia.</p><p><strong>Methods: </strong>A total of 152 older patients with hypertension combined with vascular dementia who were admitted to Shanxi Provincial Fenyang Hospital between January 2022 and October 2024 were enrolled. The participants were randomly assigned to either the study group or the control group (76 patients each) using the randomized numerical table method. Both groups received conventional treatment, and the study group received metoprolol for 5 weeks in addition to the conventional treatment. Primary outcome indicators, including changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP) before and after treatment, were examined. Additionally, comparison was made to examine the intergroup difference in serological markers, including high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-8, matrix metalloproteinase 9 (MMP-9), homocysteine (Hcy), and superoxide dismutase (SOD) levels, and the scores for intelligence, cognitive, and behavioral assessments. Adverse reactions were recorded.</p><p><strong>Results: </strong>After treatment, the study group showed reduced SBP from (146.90 ± 7.35) mmHg (1 mmHg = 0.133 kPa) to (120.00 ± 6.03) mmHg and reduced DBP from (90.24 ± 5.97) mmHg to (77.23 ± 6.81) mmHg. The reduction in blood pressure in the study group became more significantly when compared with that of the control group, with intergroup difference in SBP reduction being －8.54 mmHg (<i>P</i> < 0.001) and intergroup difference in DBP reduction being －10.80 mmHg (<i>P</i> < 0.001). Patients in the 2 groups showed statistically significant differences in the levels of hs-CRP, TNF-α, IL-6, IL-8, MMP-9, and Hcy, and in their cognitive and behavioral scores (<i>P</i> < 0.05). No statistically significant differences were found in pulse pressure, von Willebrand factor (vWF) levels, or intelligence scores before and after treatment (<i>P</i> > 0.05). The main adverse reactions in the study group were central nervous system reactions (22.37%) and withdrawal syndrome (17.11%).</p><p><strong>Conclusion: </strong>The β-blocker metoprolol effectively controlled blood pressure, significantly reduced levels of pro-inflammatory factors and specific vascular injury markers, and improved cognitive function and behavioral symptoms in older patients with hypertension combined with vascular dementia, suggesting its therapeutic efficacy for this condition. However, attention should be paid to its associated adverse reactions.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"812-817"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical Efficacy of Acupuncture Combined With Acupoint Patching in Treating Chronic Pelvic Pain as a Sequela of Pelvic Inflammatory Disease].","authors":"Juyan Dun, Fen Wang, Liying Tian","doi":"10.12182/20250560601","DOIUrl":"10.12182/20250560601","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the efficacy of acupuncture therapy combined with acupoint patching in alleviating chronic pelvic pain, a sequela of pelvic inflammatory disease (SPID-CPP).</p><p><strong>Methods: </strong>A total of 120 SPID-CPP patients attending our hospital between January 2022 and November 2024 were enrolled and randomly assigned to either an experimental group or a control group, with 60 patients in each group. Both groups received conventional lifestyle guidance and anti-infection therapy. The control group received only acupuncture therapy, while the observation group received acupuncture combined with acupoint patching therapy. The duration of treatment was identical for both groups. The treatment effect, levels of high-sensitivity C-reactive protein (hs-CRP), white blood cell count (WBC), neutrophil percentage (NEUT), fibrinogen (FIB) level, quality-of-life scores, and visual analog scale (VAS) pain scores were compared between the experimental and control groups.</p><p><strong>Results: </strong>The treatment efficacy rate of the experimental group was 93.00%, while that of the control group was only 73.33%, and the difference between the two groups was statistically significant (<i>P</i> < 0.05). Following therapy, the hs-CRP, WBC, NEUT, and VAS ratings of both the control and experimental groups decreased. Furthermore, findings of the experimental group were significantly lower than those of the control group (<i>P</i> < 0.05). The quality-of-life score of the experimental group was higher than that of the control group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Acupuncture combined with acupoint patching demonstrates significant efficacy in treating SPID-CPP. This combined therapy effectively reduces pain in SPID-CPP patients, decreases serum levels of inflammatory factors, and significantly improves patients' quality of life.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"672-677"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Mechanism of <i>Porphyromonas gingivalis</i> Inducing the Formation of a Local Immunosuppressive Microenvironment in Oral Squamous Cell Carcinoma].","authors":"Yibo Zhang, Liming Xu, Momin Naijibai, Jiaoyang Li, Bin Ling","doi":"10.12182/20250560602","DOIUrl":"10.12182/20250560602","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the role of <i>Porphyromonas gingivalis</i> (<i>P.g</i>) in the tumor microenvironment of oral squamous cell carcinoma (OSCC) and provide new insights for OSCC treatment.</p><p><strong>Methods: </strong>The murine squamous cell carcinoma cell line SCC7 was cultured <i>in vitro</i>, and a tumor-bearing model was established with C57BL/6 mice. Experimental mice were randomly assigned to the <i>P.g</i> activation group and the control group (<i>n</i> = 5 per group) based on the principles of randomization and control. After 16 days of feeding, the mice were sacrificed, and the weight and volume of the tumors in the two groups of mice were recorded. Immunohistochemistry was performed to analyze the expression levels of CD4⁺ T cells, CD8⁺ T cells, transforming growth factor-β (TGF-β), interleukin-10 (IL-10), interferon-γ (IFN-γ), E-cadherin, N-cadherin, Twist, vascular endothelial growth factor (VEGF), CD31, and Ki67 in the tumor tissues. Flow cytometry was performed to examine the tumor samples from the two groups of mice, and to quantify the proportional differences of CD4⁺ T cells, CD8⁺ T cells, as well as CD69⁺ and CD103⁺ on T lymphocytes from the samples.</p><p><strong>Results: </strong>The immunohistochemistry results showed that the expression of CD4⁺ T cells and their function-related cytokines in the tumor tissues of the activation group was higher than that of the control group, and the differences were statistically significant (<i>P</i> < 0.05). According to the flow cytometry results, the proportion of CD8⁺ T cells in the tumor tissues of the activation group decreased, and the proportion of CD103⁺CD8⁺ T cells, which played an anti-tumor immune role, also decreased, with the differences being statistically significant compared with the control group (<i>P</i> < 0.05). In addition, the expression of all the cytokines associated with malignant tumor phenotypes in the activation group increased, and the differences were statistically significant compared with the control group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>This study verified through animal experiments that by enhancing the infiltration of CD4⁺ T cells and suppressing the immunosuppressive function of CD8⁺ T cells in the OSCC tumor microenvironment, <i>P.g</i> enables tumor cell immune escape and accelerates epithelial-mesenchymal transition, angiogenesis, and tumor cell proliferation.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"746-753"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Oxidative Stress Induced by High Glucose Aggravates Immunosuppression in Diabetes Mellitus by Promoting Effector T Cell Apoptosis and Regulatory T Cell Differentiation].","authors":"Xiao Ma, Zhenhong Li, Wenjing Chen, Wei Zhang, Dunfang Zhang","doi":"10.12182/20250560108","DOIUrl":"10.12182/20250560108","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To explore the regulatory mechanisms underlying the increased proportion of CD4&lt;sup&gt;+&lt;/sup&gt; Foxp3&lt;sup&gt;+&lt;/sup&gt; regulatory T (Treg) cells in late-stage diabetes mellitus (DM) with poorly-controlled blood glucose, and to identify new approaches and therapeutic targets for the prevention and treatment of secondary infections in the late stage of DM.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Wild-type C57BL/6 mice aged 6 to 8 weeks were randomly assigned to two groups, the experimental and the control groups (&lt;i&gt;n&lt;/i&gt; = 5 per group). Mice in the experimental group were injected with streptozotocin (STZ) to induce the mouse model of type 1 diabetes mellitus (T1D), while those in the control group received injection of an an equal volume of 0.1 mol/L citrate buffer. In addition, wild-type C57BL/6 mice aged 6 to 8 weeks were fed with high-fat diet for 2 months and subsequently randomly assigned to two groups, the experimental and the control groups (&lt;i&gt;n&lt;/i&gt; = 3 per group). Mice in the experimental group were injected with low-dose STZ for multiple times to induce the mouse model of type 2 diabetes mellitus (T2D), while those in the control group received an equal volume of 0.1 mol/L citrate buffer. The spleen and peripheral lymph nodes of the mice were collected 2 weeks after the stable onset of diabetes, and T cell immune responses were examined by flow cytometry. Naive T cells isolated by immunomagnetic beads were cultured to investigate the mechanisms by which high glucose regulates T cell differentiation and function. The frequency of Treg cells and effector T (Teff) cells, the expression levels of Ki67, a cell proliferation marker, cell apoptosis rate, and intracellular reactive oxygen species (ROS) levels in the mouse tissue single cell suspension and T cell culture samples were assessed by multicolor flow cytometry.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Late-stage T1D and T2D mice with poorly-managed blood glucose exhibited increased peripheral CD4&lt;sup&gt;+&lt;/sup&gt; Foxp3&lt;sup&gt;+&lt;/sup&gt; Treg frequencies (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). In these diabetic mice with poorly-managed blood glucose, the expression of Ki67 in Treg cells was significantly upregulated (&lt;i&gt;P&lt;/i&gt; &lt; 0.05), while the apoptosis of non-Treg cells (Foxp3&lt;sup&gt;－&lt;/sup&gt; non-Treg cells) increased markedly (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Under high-glucose treatment conditions, the ROS levels in Teff cells increased significantly, and the cell apoptosis also increased significantly. High-glucose treatment induced the activation of transforming growth factor-β (TGF-β) and promoted the differentiation of Treg cells, whereas blocking the TGF-β signaling pathway or neutralizing ROS completely inhibited high glucose-induced Treg differentiation (&lt;i&gt;P&lt;/i&gt; &lt; 0.01).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Sustained hyperglycemic internal environment in poorly-controlled diabetic mice causes high level of ROS production in Teff cells by inducing oxidative stress, which leads to increased apoptosis of Teff cells, promote","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"603-612"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The Innovative Education of Cross-Disciplinary Integration of Narrative Medicine With Medical Animation: Exploring the Potential of Health Humanities].","authors":"Rui Zhang, Liang Xu, Jiaxin Li, Lili Wang","doi":"10.12182/20250560302","DOIUrl":"https://doi.org/10.12182/20250560302","url":null,"abstract":"<p><p>Health humanities are concerned with exploring the novel concept of integrating the humanities with health-related fields. Traditionally, medicine and healthcare have been primarily focused on a biomedical paradigm, with particular emphasis on the pathological mechanisms and treatment protocols of diseases. However, in recent years, there has been growing recognition that health is a holistic concept influenced not only by biological factors but also by psychological, social, cultural, and other factors, which leads to the emergence of medical humanities. Herein, we constructed a narrative community shared by physicians and patients through the frameworks of phenomenology, social design, and health design. By integrating narrative medicine with medical animation through storytelling and focusing on the feasibility study of an undergraduate course on medical animation, this study synthesizes the conceptual frameworks and methodologies of the humanities with health-related practices, integrating the theories and techniques of narrative medicine with those of medical animation. Through this interdisciplinary approach, we investigated innovative pathways in medical education, attempting to establish new foundations for a more comprehensive understanding and promotion of human health.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"887-892"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of <i>CYP3A5</i> Genetic Polymorphisms on the Blood Drug Concentration of Tacrolimus in Patients With Lupus Nephritis and the Relationship With Patient Prognosis].","authors":"Ling Wei, Tao Wang, Yongmei Hu, Qibing Xie","doi":"10.12182/20250560509","DOIUrl":"10.12182/20250560509","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the effect of cytochrome P450 3A5 (&lt;i&gt;CYP3A5&lt;/i&gt;) genetic polymorphism on the blood drug concentration of tacrolimus (TAC) in patients with lupus nephritis (LN), to determine the appropriate initial dose for LN patients of different genotypes and the differences in time to remission, and to analyze factors associated with LN prognosis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Patients with active LN attending the outpatient clinic of the Department of Rheumatology and Immunology, West China Hospital, Sichuan University were enrolled. Their &lt;i&gt;CYP3A5&lt;/i&gt; genotypes were determined. According to the different genotypes, the patients were assigned to two groups, the AA + GA group, or the rapid metabolism group with the genotype &lt;i&gt;CYP3A5&lt;/i&gt;*1/*1, i.e., AA + &lt;i&gt;CYP3A5&lt;/i&gt;*1/*3, and the GG group, or the slow metabolism group with the genotype &lt;i&gt;CYP3A5&lt;/i&gt;*3/*3. The basic information, clinical manifestations, history of other diseases, and medication history of the enrolled patients were collected. According to the principle of simple random grouping, patients in each group were randomly divided into two subgroups, receiving TAC at initial doses of 0.05 mg/(kg·d) and 0.075 mg/(kg·d), respectively. Data on laboratory test indicators, including TAC blood drug concentration, blood pressure, and other relevant clinical follow-up indicators, were collected each month from each group. Patients were also evaluated each month for their clinical remission status. When patients in the 0.05 mg/(kg·d) initial dose group did not achieve clinical remission after 2 months, the TAC dose was increased to 0.075 mg/(kg·d), and the patients were observed until the end of the 6th month. Patients in the 0.075 mg/(kg·d) initial dose group were observed for 6 months, regardless of their remission status.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In the LN patient subgroups receiving TAC at the same initial dose, the cumulative remission rate of patients with the GG genotype was higher than that of patients with the AA+GA genotype, but only in the 0.05 mg/(kg·d) initial dose group, the difference in cumulative remission rate between the two genotypes was statistically significant (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). According to a comparison of patients with the same genotype who received TAC at different initial doses, the remission rate of patients receiving 0.075 mg/(kg·d) initial dose was higher than that of the 0.05 mg/(kg·d) initial dose group, but only in patients with AA + GA genotype, the difference in remission rate between the two initial dose groups was statistically significant (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Whether it was different genotypes in the same TAC initial dose group or different TAC initial doses of the same genotype, there was no statistically significant difference in the time to achieve complete remission (&lt;i&gt;P&lt;/i&gt; &gt; 0.05). Regardless of the different initial TAC doses, patients with the GG genotype maintained higher TAC blood concentrations than those wi","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"739-745"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The Role of Fasting-Mimicking Diet in Cancer Therapy: Mechanisms, Challenges, and Clinical Prospects].","authors":"Yuanxin Liu, Laiyan Zhou, Jianxin Xue","doi":"10.12182/20250560301","DOIUrl":"10.12182/20250560301","url":null,"abstract":"<p><p>The fasting-mimicking diet (FMD), an emerging cyclic low-calorie dietary intervention strategy, has garnered significant attention in the field of tumor therapy with its ability to remodelthe body's metabolic and immune microenvironment. Studies have shown that FMD not only extends the lifespan and reduces the incidence of cancer and other diseases in healthy individuals, but also enhances the protective effects on normal cells. Furthermore, FMD increases the sensitivity of tumor cells to multiple therapeutic treatments. FMD activates the protective pathways of normal cells by lowering the levels of blood glucose, insulin, and insulin-like growth factor-1, while it induces differential stress sensitization of tumor cells, thereby enhancing the sensitivity of cancer cells to tumor therapy and providing new targets for individualized therapy. Herein, we provide a brief overview of the fundamental concept of FMD, the underlying mechanisms, and its potential application in cancer treatment, highlighting the synergistic effects of FMD applied in combination with conventional cancer therapies, such as chemotherapy and immunotherapy. Moreover, the challenges encountered in translating FMD into clinical practice are discussed, along with the promising future applications of this dietary regimen.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"56 3","pages":"873-880"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}