四川大学学报(医学版)最新文献

{"title":"[Interdisciplinary Research on Artificial Intelligence and Longevity Medicine: Global Landscape, Collaboration Networks, and Frontier Trends (2010-2025)].","authors":"Xinyan Huang, Jianshu Tan, Shuqin Cao, Longkang Di, Lunwei Kang, Zhuoli Zhu, Ga Liao","doi":"10.12182/20260760501","DOIUrl":"10.12182/20260760501","url":null,"abstract":"<p><strong>Objective: </strong>With the expansion of theories concerning aging and the rapid evolution of artificial intelligence (AI) methodologies, the integration of AI and longevity medicine has emerged as a critical pathway for extending human healthspan. This study is aimed at a systematic characterization of the research landscape, collaboration networks, and frontier trends in this interdisciplinary field, so as to inform clinical translation and the development of the health management industry.</p><p><strong>Methods: </strong>The Web of Science Core Collection, including Science Citation Index Expanded (SCIE) and Social Sciences Citation Index (SSCI), was used as the data source. English-language publications in the interdisciplinary field of AI and longevity medicine between 2010 and 2025 were systematically retrieved, and 4170 valid records were included for a joint analysis using Bibliometrix and CiteSpace 7.0.</p><p><strong>Results: </strong>Annual publication output showed exponential growth. The global research landscape exhibited a China-US dual-core and a multipolar pattern, with institutional collaborations clustering into 3 major networks spanning Asia-Europe, the United States, and Continental Europe. Research topics were clustered into five major themes-the core concepts of aging and multimorbidity, AI-driven body composition and musculoskeletal assessment, deep-learning-based evaluation of brain aging through neuroimaging, wearable sensing and mobile health, and digital phenotyping and mental health. Marked differences in research priorities were observed among the three leading contributors, including China, the United States, and the United Kingdom. China demonstrated broad research coverage and clinically oriented multi-track development, the United States led in methodological innovation and digital phenotyping, and the United Kingdom concentrated on brain age research.</p><p><strong>Conclusions: </strong>This study systematically delineates the research landscape, collaboration networks, and frontier trajectories in the interdisciplinary field of AI and longevity medicine, providing data-driven evidence and decision-making support for advancing clinical translation and the development of the health management industry in this field.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 4","pages":"966-973"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Metformin Inhibits Prostate Cancer Progression via Regulation of the AKT/mTOR Signaling Pathway].","authors":"Zhengkun Zhang, Zhiyou Quan, Panpan Dai, Keyi Xu, Zhaoru Yin, Dan Chen, Ruiman Geng, Xuxu Ji, Dingxue Wang, Shu Chen, Lihong Chen, Ji Liu","doi":"10.12182/20260760204","DOIUrl":"10.12182/20260760204","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of metformin on the proliferation, migration, and invasion of prostate cancer cells, and to determine whether its antitumor effects are mediated by regulation of human antigen R (HuR) and the AKT/mammalian target of rapamycin (mTOR) signaling pathway.</p><p><strong>Methods: </strong>Human prostate cancer cell lines PC3 and 22RV1 were used as the research models and were treated with metformin. HuR knockdown and overexpression experiments were performed to further verify the underlying mechanism. Cell proliferation was assessed using the cell counting kit-8 (CCK-8) assay. Cell migration and invasion were evaluated by Transwell assays. The expression levels of HuR and AKT/mTOR pathway-related proteins were measured by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting.</p><p><strong>Results: </strong>Metformin treatment reduced the proliferation, migration, and invasion abilities of PC3 and 22RV1 cells, and inhibited the expression of proteins associated with the AKT/mTOR signaling pathway (<i>P</i> < 0.05). HuR knockdown also decreased the proliferation, migration, and invasion abilities of prostate cancer cells and inhibited AKT/mTOR pathway activity. In contrast, HuR overexpression partially attenuated the inhibitory effects of metformin on the malignant biological behaviors of prostate cancer cells and its inhibitory effects on the AKT/mTOR signaling pathway. In addition, metformin downregulated HuR mRNA and protein expression levels in PC3 and 22RV1 cells in a concentration-dependent manner (<i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>Metformin may inhibit the activation of the AKT/mTOR signaling pathway by downregulating HuR expression, thereby reducing the proliferation, migration, and invasion of prostate cancer cells.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 4","pages":"1022-1031"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Oral Aging: Age-Related Changes and Their Association With Systemic Aging].","authors":"Yuanjia Gong, Chenchen Zhou, Yi Fan","doi":"10.12182/20260760106","DOIUrl":"10.12182/20260760106","url":null,"abstract":"<p><p>Aging is not driven by a single event but results from the synergistic effects of multiple mechanisms, including genetic instability, epigenetic dysregulation, metabolic imbalance, and disrupted cellular stress responses. Oral aging represents a localized manifestation of systemic aging in the oral cavity and acts as a key contributor to the accelerated aging of the whole body. It not only affects local oral homeostasis but also interacts bidirectionally with systemic aging through pathways such as the release of inflammatory mediators. Age-related oral diseases, such as root caries, gingival recession, alveolar bone resorption, xerostomia, taste impairment, and tooth loss and dentition defects, severely compromise the function of the oral and maxillofacial system in older adults and may exacerbate or trigger systemic diseases. Current research on oral aging faces several critical challenges, including limited translation from basic to clinical studies, an incomplete understanding of the mechanisms linking oral aging to systemic aging, and lack of strategies for early diagnosis and effective intervention. Future efforts should be focused on leveraging multi-omics approaches to construct comprehensive molecular maps of oral aging, systematically elucidating its developmental mechanisms and networks for interactions with systemic aging, and accelerating the clinical translation of novel intervention strategies, such as senolytic drugs. A systematic understanding of the biological mechanisms and developmental patterns of oral aging will not only support the preservation of natural dentition but also provide critical insights into oral and systemic health interactions and promote overall health. Furthermore, it may pave the way for novel preventive and therapeutic strategies for age-related oral diseases.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 4","pages":"933-940"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Neuropsychological Risk Factors for Chronic Postoperative Pain Following Abdominal Surgery].","authors":"Yanjun Huang, Weimin Yu, Jie Ning, Shuyuan Wang, Xiaohuan Li, Lipeng Sun","doi":"10.12182/20260760104","DOIUrl":"10.12182/20260760104","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the incidence of chronic postoperative pain (CPSP) after patients have undergone abdominal surgery and identify the neuropsychological risk factors involved.</p><p><strong>Methods: </strong>A total of 102 patients who underwent abdominal surgery at our hospital between January 2023 and January 2025 were enrolled. The general demographic and surgery-related data were collected. Three months after surgery, follow-up assessments were conducted via outpatient visits or telephone interviews. The occurrence of CPSP was assessed using the Numerical Rating Scale (NRS). Neuropsychological status was evaluated using the Mini-Mental State Examination (MMSE), the Self-Rating Anxiety Scale (SAS), the Self-Rating Depression Scale (SDS), and the Pain Catastrophizing Scale (PCS). Univariate and multivariate logistic regression analyses were performed to identify independent influencing factors associated with CPSP.</p><p><strong>Results: </strong>Among the 102 patients, the incidence of CPSP at 3 months post-surgery was 31.37% (32 cases). Significant differences were observed between the CPSP and non-CPSP groups with respect to age, duration of surgery, postoperative length-of-stay in the hospital, SDS scores, and PCS scores (<i>P</i> < 0.05). Multivariate logistic regression analysis revealed that age (odds ratio [OR] = 1.336, 95% CI: 1.046-1.710), postoperative length-of-stay (OR = 0.495, 95% CI: 0.296-0.829), and PCS score (OR = 2.437, 95% CI: 1.137-5.224) were independent influencing factors associated with the development of CPSP at 3 months after abdominal surgery (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Age and PCS are risk factors for CPSP in patients undergoing abdominal surgery, while the length of postoperative length-of-stay is a protective factor. Targeted strategies, including preoperative screening, psychological interventions, and optimized pain management for high-risk patients are recommended to reduce the incidence of CPSP.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 4","pages":"1086-1092"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research Advances on the Role of the Oral Microbiota in Age-Related Homeostatic Dysregulation and Systemic Diseases].","authors":"Zhuojia He, Dongliang Li, Xian Peng","doi":"10.12182/20260760602","DOIUrl":"10.12182/20260760602","url":null,"abstract":"<p><p>The regulatory role of the microbiota in the aging process has increasingly attracted attention. As a crucial microbial ecosystem of the human body, the oral microbiota plays a unique role in maintaining host health and contributing to disease development. This review summarizes the dynamic changes in specific oral microbial genera under both healthy and diseased conditions, analyzes the impact of age-related physiological alterations of the oral cavity on the microbiota, and comprehensively elucidates the mechanisms by which age-associated oral microbial dysbiosis participates in oral and systemic diseases. Given the close interplay between the oral microbiota and aging, its significance in promoting healthy aging has become increasingly prominent. Investigating the succession patterns of the oral microbiota not only helps to unravel the mechanisms underlying the high incidence of systemic diseases in the elderly, but also provides a theoretical basis for developing microbiota-based intervention strategies and identifying novel early-biomarkers for healthy aging.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 4","pages":"953-958"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Efficacy and Long-term Prognosis of Flumatinib in the Treatment of Chronic Myelocytic Leukemia].","authors":"Liang Xia, Jing Bao, Zhenqi Huang, Wei Wu, Xiaowen Chen","doi":"10.12182/20260760108","DOIUrl":"10.12182/20260760108","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the clinical efficacy and safety of flumatinib in the treatment of chronic myelocytic leukemia (CML) by using propensity score matching (PSM) to balance baseline confounding factors.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective cohort of 201 patients with CML treated between January 2019 and January 2025 was selected for this study. Patients were stratified into imatinib and flumatinib groups based on their treatment regimens. PSM was employed to control for confounding variables, enabling a comparative analysis of early treatment responses and long-term survival outcomes, including overall survival (OS), between the two tyrosine kinase inhibitor therapies, as well as further analysis of long-term prognosis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Through PSM, a total of 61 patient pairs were successfully matched. In the flumatinib group, the rates of complete hematologic response (CHR) and early molecular response (EMR) at 3 months of first-line treatment were 96.72% and 83.61%, respectively, with the EMR rate being significantly higher than achieved with imatinib treatment (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). For flumatinib, the rates of cumulative major molecular response (MMR) at 6, 9, and 12 months of first-line therapy were 34.43%, 50.82%, and 59.02%, respectively, all exceeding those observed with imatinib (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). The molecular response 4 (MR&lt;sup&gt;4&lt;/sup&gt;) rates for flumatinib at 9 and 12 months of first-line treatment were 19.67% and 27.87%, respectively, also higher than those for imatinib (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Additionally, the cumulative complete cytogenetic response (CCyR) rates for flumatinib at 3, 6, and 12 months of first-line treatment were 67.21%, 85.25%, and 91.28%, respectively, consistently outperforming imatinib (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Generalized estimating equation analysis revealed that patients in the flumatinib group had a significantly higher probability of achieving MMR than those in the imatinib group (Wald &lt;i&gt;χ&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt; = 16.280, &lt;i&gt;P&lt;/i&gt; &lt; 0.001, odds ratio [OR] = 2.130, 95% CI: 1.570-2.890). The time effect indicated that the probability of achieving MMR increased with the extension of treatment duration in both groups (Wald &lt;i&gt;χ&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt; = 48.720, &lt;i&gt;P&lt;/i&gt; &lt; 0.001). In addition, a statistically significant group-by-time interaction effect was observed (Wald &lt;i&gt;χ&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt; = 8.940, &lt;i&gt;P&lt;/i&gt; = 0.003). During the treatment period, the highest incidence of diarrhea was observed in the flumatinib group (26.23%), while thrombocytopenia was most prevalent in the imatinib group (31.15%). Furthermore, the imatinib group exhibited higher incidences of rash and edema compared to the flumatinib group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). No significant differences were observed in the incidence of other adverse events between the groups (&lt;i&gt;P&lt;/i&gt; &gt; 0.05). The median follow-up duration was 43 (37, 52) months. By the end of the follow-up, a total of 7 patients had died, with 4 deaths (6.56% [4/61]) in","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 4","pages":"1093-1097"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Development and Validation of a Nomogram Prediction Model for Pulmonary Infection in Cerebral Infarction Patients During the Recovery Phase After Acupuncture Treatment].","authors":"Jin Hu, Haoran Chu, Ying Wang, Chenglong Li","doi":"10.12182/20260760504","DOIUrl":"10.12182/20260760504","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the risk factors for pulmonary infection in convalescent patients with cerebral infarction under acupuncture and moxibustion intervention, and to develop a nomogram model.</p><p><strong>Methods: </strong>According to a modeling-to- verification set ratio of 7∶3, 350 patients with cerebral infarction treated in the hospital from January 2022 to January 2024 were selected as the modeling set. At the same time, 150 patients with cerebral infarction admitted from February 2024 to December 2024 were selected as the verification set. General patient information, laboratory indicators, and acupuncture intervention variables were collected. After screening variables using LASSO regression in the modeling set, multivariate logistic regression was performed. Based on the results of the multivariate regression, a nomogram prediction model was established, and the models were evaluated in the modeling and validation set, respectively.</p><p><strong>Results: </strong>The incidence of pulmonary infection in patients with cerebral infarction during convalescence was 26.20%(131/500), including 95 patients in the model group. A total of 147 pathogen strains were detected, mainly Gram- negative bacteria. Modeling concentration, LASSO regression, and multivariate stepwise logistic regression were used to identify factors influencing pulmonary infection: increased age (OR = 1.043, 95%CI: 1.010-1.077), higher Eating Assessment Tool 10 (EAT-10) score (OR = 1.249, 95%CI: 1.125-1.387), invasive procedures (OR = 2.715, 95%CI: 1.340-5.501), higher National Institutes of Health Stroke Scale (NIHSS) score (OR = 2.477, 95%CI: 1.951-3.144), lower albumin (OR = 0.856, 95%CI: 0.786-0.931), lower prealbumin (OR = 0.992, 95%CI: 0.987-0.997), needle retention time of 30 min (OR = 2.439,95%CI: 1.146-5.191), acupuncture course less than 14 d (OR = 2.463,95%CI: 1.157-5.243), and initiation of intervention acupuncture treatment more than >3 d after onset (OR = 2.660, 95%CI: 1.190-5.942). Based on these factors, a nomogram model was constructed, with areas under the curve (AUC) of 0.916 (95%CI: 0.877-0.954) and 0.923 (95%CI: 0.874-0.973). The calibration curve showed that the predicted probabilities of the model were in close agreement with the observed probabilities, and its application could yield positive net clinical benefits.</p><p><strong>Conclusion: </strong>The nomogram model constructed used Lasso-logistic regression can identify the risk of pulmonary infection in patients with cerebral infarction during convalescence after acupuncture treatment. Quantifying risk factors can guide patients in optimizing acupuncture treatment plans, achieving precise intervention, and reducing the risk of infection.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 4","pages":"1145-1152"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Characteristics and Drug Resistance Analysis of Urogenital Mycoplasma Infections in Patient Specimens From Non-Gynecologic Departments].","authors":"Dan Zhou, Yu Yuan, Ya Liu, Yuling Xiao","doi":"10.12182/20260760208","DOIUrl":"10.12182/20260760208","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the epidemiological characteristics and drug resistance patterns of urogenital mycoplasma infections in patient specimens from non-gynecologic departmentsat West China Hospital, Sichuan University between 2020 and 2024, and to provide evidence for clinical diagnosis, treatment, and antimicrobial stewardship of mycoplasma infections in non-gynecologic patients.</p><p><strong>Methods: </strong>A total of 856 <i>Mycoplasma</i> culture specimens were retrospectively analyzed in the study. All specimens were submitted for lab analysis by urology, dermatovenereology, and other relevant departments (excluding gynecology) of our hospital between 2020 and 2024. <i>Mycoplasma</i> culture, identification, and antimicrobial susceptibility testing were performed using the bioMérieux colorimetric kit (France). The detection rate, species distribution, demographic characteristics, and antimicrobial resistance profiles of mycoplasma infections were analyzed accordingly.</p><p><strong>Results: </strong>The overall positivity rate was 14.02% (120/856), with urethral secretions constituting the predominant specimen type (48.33%). <i>Ureaplasma spp.</i> infections accounted for 89.17% (107/120), <i>Mycoplasma hominis</i> infections for 4.17% (5/120), and co-infections for 6.66% (8/120). Among patients with non-gynecologic urogenital mycoplasma infections, the positive rate in women (24.67%) was higher than that in men (8.27%) (<i>P</i> < 0.05), with women exhibiting a 2.98-fold higher risk of infection (risk ratio [RR] = 2.98, 95% CI: 2.12-4.19) compared to men. The peak incidence occurred in the 30-39 age group (50.00%). High resistance to quinolones was prevalent, with resistance rates exceeding 80% for both ofloxacin and ciprofloxacin. Among macrolides, josamycin exhibited the highest susceptibility rate (93.33%). Among tetracycline-class antibiotics, all isolates were 100% susceptible to doxycycline.</p><p><strong>Conclusion: </strong>Urogenital mycoplasma infections are predominantly caused by <i>Ureaplasma spp.</i> infection, with higher incidence among women and individuals aged 30-39 years. When clear clinical indications are present, tetracycline-class antibiotics, such as doxycycline, should be considered preferential therapeutic options. Special attention should also be given to the high rates of macrolide resistance of <i>Mycoplasma hominis</i> infections and co-infections.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 4","pages":"1160-1164"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation of the Effects of Body Scan Mindfulness Training in Patients With Burning Mouth Syndrome].","authors":"Jing He, Ning Xiao, Mingjia Hu, Jia Li, Fan Liu","doi":"10.12182/20260760503","DOIUrl":"10.12182/20260760503","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of body scan mindfulness training as an intervention for patients with burning mouth syndrome (BMS).</p><p><strong>Methods: </strong>This randomized, controlled, single-blind clinical trial enrolled patients with BMS who met the inclusion and exclusion criteria. Participants were assigned to a control group or an intervention group using a random number table. The control group received pharmacological treatment and routine psychological care, while the intervention group additionally received two weeks of body scan mindfulness training. The Visual Analog Scale (VAS), Insomnia Severity Index (ISI), Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and Oral Health Impact Profile (OHIP-14) were used to assess pain intensity, sleep quality, anxiety, depression, and oral health-related quality of life, respectively, at baseline, immediately after the intervention, and 3 months after the intervention. The efficacy of body scan mindfulness training for patients with BMS was evaluated by comparing changes in the primary outcome measure (VAS) and secondary outcome measures (ISI, GAD-7, PHQ-9, and OHIP-14) between the two groups before and after the intervention.</p><p><strong>Results: </strong>A total of 80 patients were enrolled in this study; 3 were lost to follow-up, and 77 patients (38 in the control group and 39 in the intervention group) were included in the analysis. The median changes (P₂₅, P₇₅) in VAS, ISI, GAD-7, and PHQ-9 scores after the intervention in the experimental group were 2.00 (1.00, 3.00), 3.00 (0.00, 8.00), 3.00 (1.00, 6.75), and 2.00 (0.00, 5.00), respectively. These were all greater than the corresponding changes in the control group (0.95 [0.00, 2.50], 0.00[0.00, 3.00], 1.00 [0.00, 3.25], and 1.00 [0.00, 2.00]), with statistically significant differences. (<i>P</i> < 0.05). No significant difference was observed in the reduction of OHIP-14 scores between the two groups (<i>P</i> > 0.05). Both immediately after the intervention and at 3 months post-intervention, the VAS score remained significantly lower in the intervention group than in the control group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>For patients with BMS, implementing body scan mindfulness training alongside conventional drug treatment has proven effective in alleviating the intensity of oral burning pain, improving sleep quality, and reducing anxiety and depression. These findings suggest that body scan mindfulness training is a promising adjuvant therapy for patients with BMS receiving conventional drug treatment, and warrants broader clinical adoption.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 4","pages":"1080-1085"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of Blood Flow Restriction Training on Muscle Strength and Physical Function in Older Adults With Sarcopenia].","authors":"Yuxiang Liang, Yuqi Wu, Xueli Chun, Ruili Wang, Jiaojiao Jiang","doi":"10.12182/20260760203","DOIUrl":"10.12182/20260760203","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of blood flow restriction (BFR) training on muscle strength, physical function, functional mobility, and activities of daily living (ADL) in hospitalized older adults with sarcopenia, and to compare its efficacy with that of traditional resistance training (RT), thereby providing a research basis for the development of clinical rehabilitation strategies.</p><p><strong>Methods: </strong>In this randomized controlled trial, 40 hospitalized older adults clinically diagnosed with sarcopenia were enrolled. By using a computer-generated randomization sequence, the participants were randomly assigned at a 1∶1 ratio to an experimental group (<i>n</i> = 20) receiving BFR training or a control group (<i>n</i> = 20) receiving RT. Both groups underwent a 12-week supervised program, with training sessions conducted 3 times per week. Outcome measures were assessed at baseline, 4 weeks, and 12 weeks. The primary outcome measure was muscle strength, assessed by dominant-hand grip strength. Secondary outcomes included physical function assessed with the Short Physical Performance Battery (SPPB), functional mobility assessed by the 6-meter (6-m) gait speed and the Timed Up and Go (TUG) test, and ADL assessed with the Modified Barthel Index (MBI).</p><p><strong>Results: </strong>No participants were lost to follow-up, and no adverse events were reported. After 4 weeks of intervention, grip strength improved significantly in both groups compared with the baseline data (all <i>P</i> < 0.001), with the BFR group demonstrating higher grip strength than the RT group ([24.35 ± 5.43] kg vs [20.96 ± 5.25] kg), although the between-group difference was not statistically significant (<i>P</i> = 0.051). Regarding secondary outcomes, the BFR group showed significant improvements in SPPB and MBI scores compared with the RT group (all <i>P</i> < 0.05), with the most pronounced differences in TUG performance and 6-m gait speed (<i>P</i> < 0.01). After 12 weeks of intervention, grip strength was significantly higher in the BFR group than that in the RT group ([25.25 ± 5.34] kg vs. [21.66 ± 5.19] kg; P = 0.039). Moreover, the BFR group demonstrated significantly better outcomes in SPPB score, 6-m gait speed, TUG time, and MBI score than the RT group did (all <i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>BFR training significantly improves muscle strength, physical function, functional mobility, and ADL in hospitalized older adults with sarcopenia, showing superior efficacy compared with conventional RT.</p>","PeriodicalId":39321,"journal":{"name":"四川大学学报(医学版)","volume":"57 4","pages":"1009-1014"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}