子宫内膜异位症腹腔镜术后复发的危险因素及其预测价值

Q3 Medicine

四川大学学报(医学版) Pub Date : 2025-05-20 DOI:10.12182/20250560109

Xiaojuan Kong, Zhenyu Tan, Lei Lei

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引用次数: 0

摘要

目的：探讨腹腔镜子宫内膜异位症患者术后复发的影响因素，并评价其对术后复发的临床预测能力。方法：回顾性收集2019年1月至2024年1月我院腹腔镜手术治疗的子宫内膜异位症患者190例的临床资料。根据患者术后复发情况分为非复发组（109例）和复发组（81例）。对临床资料进行单因素分析。采用多因素logistic回归分析，探讨腹腔镜术后复发的影响因素。采用受试者工作特征（ROC）曲线分析评价相关指标的预测价值。结果：单因素分析结果显示，未复发组患者术前痛经史、术前妊娠次数、既往子宫腔手术史、吸烟、饮酒等患病率均低于复发组（P < 0.05）。未复发组术前血清转化生长因子-β1 （TGF-β1）、白细胞介素(IL)-1β、IL-17、IL-22水平均低于复发组（P < 0.05）。除既往宫腔手术史、饮酒、IL-17水平外，其他因素均为腹腔镜术后复发的独立危险因素（P < 0.05）。术前血清TGF-β1 + IL-1β和TGF-β1 + IL-1β + IL-22曲线下面积（AUC）分别为0.980 （95% CI, 0.965 ~ 0.994）和0.982 (95% CI, 0.968 ~ 0.996)，对腹腔镜术后患者复发具有较高的预测价值。结论：术前痛经史、术前妊娠次数、吸烟、术前血清TGF-β1、IL-1β、IL-22水平是腹腔镜手术后子宫内膜异位症复发的危险因素。TGF-β1与IL-1β联用以及TGF-β1、IL-1β、IL-22联用对腹腔镜手术后子宫内膜异位症复发均有较好的预测效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

[Risk Factors for Recurrence and Their Predictive Value in Endometriosis Patients After Laparoscopic Surgery].

查看原文本刊更多论文

[Risk Factors for Recurrence and Their Predictive Value in Endometriosis Patients After Laparoscopic Surgery].

Objective: To identify the factors influencing postoperative recurrence in endometriosis patients after laparoscopic surgery and to evaluate their clinical predictive performance for postoperative recurrence.

Methods: The clinical data of 190 endometriosis patients who underwent laparoscopic surgery at our hospital between January 2019 and January 2024 were retrospectively collected. Patients were divided into a non-recurrence group (109 cases) and a recurrence group (81 cases) based on their status of postoperative recurrence. Univariate analysis was performed with the clinical data. Multivariate logistic regression analysis was performed to identify the influencing factors of recurrence after laparoscopic surgery. Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive value of the relevant indicators.

Results: According to the results of the univariate analysis, the prevalence of preoperative history of dysmenorrhea, number of preoperative pregnancies, history of previous uterine cavity procedures, smoking, and drinking in the non-recurrence group was lower than that in the recurrence group (P < 0.05). The non-recurrence group also had lower preoperative serum levels of transforming growth factor-β1 (TGF-β1), interleukin (IL)-1β, IL-17, and IL-22 compared with those of the recurrence group (P < 0.05). Except for the history of previous uterine cavity procedures, drinking, and the level of IL-17, all other factors were independent risk factors for recurrence after laparoscopic surgery (P < 0.05). The area under the curve (AUC) for preoperative serum TGF-β1 + IL-1β and TGF-β1 + IL-1β + IL-22 was 0.980 (95% CI, 0.965-0.994) and 0.982 (95% CI, 0.968-0.996), respectively, indicating a high predictive value for recurrence in patients after laparoscopic surgery.

Conclusion: The history of preoperative dysmenorrhea, number of preoperative pregnancies, smoking, and preoperative levels of serum TGF-β1, IL-1β, and IL-22 are risk factors for the recurrence of endometriosis after laparoscopic surgery. The combination of TGF-β1 and IL-1β, as well as the combination of TGF-β1, IL-1β, and IL-22, both demonstrated good performance for predicting the recurrence of endometriosis after laparoscopic surgery.

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来源期刊

四川大学学报(医学版) Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

0.70

自引率

0.00%

发文量

8695

期刊介绍： "Journal of Sichuan University (Medical Edition)" is a comprehensive medical academic journal sponsored by Sichuan University, a higher education institution directly under the Ministry of Education of the People's Republic of China. It was founded in 1959 and was originally named "Journal of Sichuan Medical College". In 1986, it was renamed "Journal of West China University of Medical Sciences". In 2003, it was renamed "Journal of Sichuan University (Medical Edition)" (bimonthly). "Journal of Sichuan University (Medical Edition)" is a Chinese core journal and a Chinese authoritative academic journal (RCCSE). It is included in the retrieval systems such as China Science and Technology Papers and Citation Database (CSTPCD), China Science Citation Database (CSCD) (core version), Peking University Library's "Overview of Chinese Core Journals", the U.S. "Index Medica" (IM/Medline), the U.S. "PubMed Central" (PMC), the U.S. "Biological Abstracts" (BA), the U.S. "Chemical Abstracts" (CA), the U.S. EBSCO, the Netherlands "Abstracts and Citation Database" (Scopus), the Japan Science and Technology Agency Database (JST), the Russian "Abstract Magazine", the Chinese Biomedical Literature CD-ROM Database (CBMdisc), the Chinese Biomedical Periodical Literature Database (CMCC), the China Academic Journal Network Full-text Database (CNKI), the Chinese Academic Journal (CD-ROM Edition), and the Wanfang Data-Digital Journal Group.