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Analysis of heat induced changes in dental tissue for forensic application: A scanning electron microscope study 法医用牙组织热致变化的分析:扫描电子显微镜研究。
Morphologie Pub Date : 2025-01-07 DOI: 10.1016/j.morpho.2024.100948
R.A. Mathew , V.G. Doddawad , S. Shivananda , M.R. Dhakshaini , J. Suresh , A. Alex
{"title":"Analysis of heat induced changes in dental tissue for forensic application: A scanning electron microscope study","authors":"R.A. Mathew ,&nbsp;V.G. Doddawad ,&nbsp;S. Shivananda ,&nbsp;M.R. Dhakshaini ,&nbsp;J. Suresh ,&nbsp;A. Alex","doi":"10.1016/j.morpho.2024.100948","DOIUrl":"10.1016/j.morpho.2024.100948","url":null,"abstract":"<div><h3>Introduction</h3><div>In the forensic field, having accurate understanding of the macroscopic and microscopic alterations that occur in teeth when exposed to temperatures has remarkable significance. The preservation of delicate incinerated teeth is crucial in fire investigations that pertain to the temperature exposed, as well as the identification of victims. This preservation is necessary in order to conduct macroscopic and microscopic ultra-structural examinations, which provide valuable insights into the structural alterations that dental tissues undergo when exposed to low to high temperatures.</div></div><div><h3>Aim</h3><div>To analyze the macroscopic changes and the microscopic ultra-structural changes of dental hard tissue in permanent and deciduous dentition using stereomicroscope and scanning electron microscope (SEM).</div></div><div><h3>Materials and Methods</h3><div>The study was conducted on 40 healthy freshly extracted teeth (20 permanent and 20 deciduous) which were subjected to predetermined temperatures i.e., 200<!--> <!-->̊C, 400<!--> <!-->̊C, 600<!--> <!-->̊C and 800̊C respectively for fifteen minutes using muffle furnace. Teeth were examined under stereomicroscope, later which they were processed for SEM examination at a magnification of 1000×. The parameter for macroscopic observation is colour, translucency and surface texture of enamel and cementum. The parameters used in microscopic observation of enamel such as pit and fissure morphology, prism pattern, crack/fracture lines, microporosity, debris, erosion, while for cementum, the parameters considered were crack presence, fissure morphology, collagen bundle arrangement, pattern, and debris. Both macroscopic and microscopic observations of dentition at different specific temperatures were calculated using percentage. The difference in macroscopic and microscopic changes between permanent and deciduous teeth were analyzed using chi-square test.</div></div><div><h3>Results</h3><div>There was no significant correlation in macroscopic and microscopic changes between permanent and deciduous teeth. Observations of dentition at various specific temperatures, both at the macroscopic and microscopic levels, revealed a noticeable reduction in the presence of each of the selected parameters in enamel and cementum.</div></div><div><h3>Conclusion</h3><div>The study revealed significant macroscopic morphological alterations and consistent microscopic ultra-structural patterns alterations that were readily observable at specified temperatures. The use of scanning electron microscopy (SEM) in the examination of burnt dental remains has a special potential for enhancing victim identification and advancing the field of forensic odontology.</div></div>","PeriodicalId":39316,"journal":{"name":"Morphologie","volume":"109 365","pages":"Article 100948"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fortuitous discovery of a superior and posterior pancreaticoduodenal artery originating from the right branch of the hepatic artery during cadaver dissection 在尸体解剖时偶然发现一条起源于肝动脉右支的胰十二指肠上、后动脉。
Morphologie Pub Date : 2025-01-03 DOI: 10.1016/j.morpho.2024.100947
G. Pasinato , J. Peltier , E. Havet , J.-M. Regimbeau
{"title":"Fortuitous discovery of a superior and posterior pancreaticoduodenal artery originating from the right branch of the hepatic artery during cadaver dissection","authors":"G. Pasinato ,&nbsp;J. Peltier ,&nbsp;E. Havet ,&nbsp;J.-M. Regimbeau","doi":"10.1016/j.morpho.2024.100947","DOIUrl":"10.1016/j.morpho.2024.100947","url":null,"abstract":"<div><h3>Introduction</h3><div>The duodeno-pancreatic region is a highly vascularized area. The superior and posterior pancreaticoduodenal artery is a vessel primarily originating from the gastroduodenal artery. It exhibits rare anatomical variations, such as its emergence from the right branch of the hepatic artery, which we fortuitously identified during a cadaver dissection.</div></div><div><h3>Materials and methods</h3><div>The body studied in this dissection was from cadavers donated to science at the Anatomy Laboratory of the Faculty of Medicine in Amiens. This dissection was part of a Master's project aimed at studying the branches of the celiac trunk.</div></div><div><h3>Results</h3><div>We identified a superior and posterior pancreaticoduodenal artery arising from the right branch of the hepatic artery, coursing to the right of the gastroduodenal artery and sharing a very proximal anastomotic branch that gave rise to seven short retro-duodenal arteries. This artery provided branches to the bile duct and then ran along the duodenum and the pancreas while giving off about ten small branches to these two adjacent organs. It anastomosed with the posterior and inferior pancreaticoduodenal artery, which originated from the superior mesenteric artery.</div></div><div><h3>Conclusion</h3><div>Knowledge of this anatomical variation is fundamental for the visceral surgeon performing a cephalic duodenopancreatectomy, a resection of the pancreatic head with preservation of the duodenal framework, a resection of the pancreatic head with pancreatic-jejunostomy, or even in managing a hemorrhagic duodenal ulcer. This aberrant origin of the superior and posterior pancreaticoduodenal artery should also be known by the interventional radiologist during arterial embolizations related to the rupture of pseudoaneurysms of the pancreatic arcades.</div></div>","PeriodicalId":39316,"journal":{"name":"Morphologie","volume":"109 365","pages":"Article 100947"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge of gross human anatomy among Brazilian physical education students: A cross-sectional study 巴西体育学生对大体人体解剖学的了解:一项横断面研究。
Morphologie Pub Date : 2025-01-02 DOI: 10.1016/j.morpho.2024.100946
C.K.C. da Silva , K.J.N. Pessoa , A.C. de Lima , J.M. Ribeiro , J.A. da Silva , C.E.V. de Sousa , O. Barbosa Neto , F.B. de Oliveira , H.R. Machado , D.A.T Santos , C.A.B. de Lira , R.B. Viana
{"title":"Knowledge of gross human anatomy among Brazilian physical education students: A cross-sectional study","authors":"C.K.C. da Silva ,&nbsp;K.J.N. Pessoa ,&nbsp;A.C. de Lima ,&nbsp;J.M. Ribeiro ,&nbsp;J.A. da Silva ,&nbsp;C.E.V. de Sousa ,&nbsp;O. Barbosa Neto ,&nbsp;F.B. de Oliveira ,&nbsp;H.R. Machado ,&nbsp;D.A.T Santos ,&nbsp;C.A.B. de Lira ,&nbsp;R.B. Viana","doi":"10.1016/j.morpho.2024.100946","DOIUrl":"10.1016/j.morpho.2024.100946","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Gross human anatomy is essential in undergraduate programs across biological and health sciences. While extensive literature explores medical students’ knowledge in this area, studies on non-medical students, particularly those in physical education, are scarce.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;This study assessed the anatomy knowledge among Brazilian physical education students and explored differences based on employment status, type of class instruction (face-to-face vs. online), and involvement in academic activities. Additionally, we investigated students’ perceptions of the assessment instrument and the gross human anatomy course itself.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We conducted a cross-sectional study involving physical education students of both sexes, aged 18 and older, from four public Brazilian universities. Participants completed a 15-question multiple-choice survey on human anatomy systems. Correct answers received one point, with a total potential score of 15 points (100%). We categorized scores as excellent (≥ 90%), good (71–89%), sufficient (50–70%), and insufficient (&lt; 50%). Participants had 90&lt;!--&gt; &lt;!--&gt;minutes to complete the survey. We presented data as median and interquartile range [IQR], median difference (Δ), and 95% confidence intervals. Scores were compared against the median absolute (7.5 points) and relative (50%) values. We used rank-biserial correlation for effect size and set a significance level 0.05. The study included 216 students (143 males) with a median age of 22.4 years [IQR: 4.0].&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The final scores were significantly above the cut-offs, with a median absolute score of 9.0 [IQR: 3.0] and a relative score of 60% [IQR: 20%], showing large effects (Δ: +2.0 [1.5–2.0], &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.001; Δ: +13.33% [10.0–13.34%], &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.001). There were no significant differences in either the absolute or relative final scores (&lt;em&gt;P&lt;/em&gt; &lt;!--&gt;≥&lt;!--&gt; &lt;!--&gt;0.05) between students who participated in academic activities and those who did not, nor between students who attended face-to-face versus online gross human anatomy classes. However, we found a significant difference between non-working students and their employed counterparts, with non-workers scoring higher both absolutely (&lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.002) and relatively (&lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.002) on the gross human anatomy questionnaire. Most of the participants described the difficulty of the gross human anatomy questionnaire as “average” (51.39%, &lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;111) and rated the gross human anatomy course difficulty as “difficult” (52.8%, &lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;114).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Brazilian physical education students demonstrated only sufficient knowledge in gross human anatomy (60%). Therefore, strategies to enhance or maintain their knowledge throughout the educational program are vital.&lt;/d","PeriodicalId":39316,"journal":{"name":"Morphologie","volume":"109 365","pages":"Article 100946"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of dental anatomy knowledge among dental students: A preliminary study 牙科学生口腔解剖学知识的初步研究。
Morphologie Pub Date : 2024-12-20 DOI: 10.1016/j.morpho.2024.100945
M.A.A. de Paiva , M.A. Benjamim , J.H.S. Souza , D.O. Souza , M.G.B. Trócoli , Á.E.F. Alves , A.F.B. De Oliveira
{"title":"Analysis of dental anatomy knowledge among dental students: A preliminary study","authors":"M.A.A. de Paiva ,&nbsp;M.A. Benjamim ,&nbsp;J.H.S. Souza ,&nbsp;D.O. Souza ,&nbsp;M.G.B. Trócoli ,&nbsp;Á.E.F. Alves ,&nbsp;A.F.B. De Oliveira","doi":"10.1016/j.morpho.2024.100945","DOIUrl":"10.1016/j.morpho.2024.100945","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to compare the level of dental anatomy knowledge and visual acuity of dental students throughout their undergraduate course.</div></div><div><h3>Materials and methods</h3><div>This descriptive, observational, and cross-sectional study with a quantitative approach was conducted over one year. Thirty-seven students, divided into three groups based on the time spent studying dental anatomy and carving, had their theoretical knowledge and visual acuity assessed using two questionnaires. The former was organized into two groups of questions: (1) related to the anatomy of anterior teeth, and (2) the anatomy of posterior teeth. Data were analyzed using the Kruskal-Wallis test, Wilcoxon test, and Spearman correlation (α<!--> <!-->=<!--> <!-->0.05).</div></div><div><h3>Results</h3><div>No statistically significant difference was observed between sexes in the comparison of theoretical knowledge and photograph evaluation. Overall, participants performed similarly on both parts of the questionnaire about theoretical knowledge (anterior teeth group: 5.6<!--> <!-->±<!--> <!-->1.94; posterior teeth group: 5.7<!--> <!-->±<!--> <!-->2.32) with no statistical difference. There was no significant difference in the theoretical questionnaire results (<em>P</em> <!-->=<!--> <!-->0.615) or in the photograph evaluation (<em>P</em> <!-->=<!--> <!-->0.187) among the periods. In the intra-group comparison, P10 students scored higher in the photograph evaluation than in the theoretical questionnaire, showing a significant difference (<em>P</em> <!-->=<!--> <!-->0.027). No significant correlation was found between theoretical knowledge and sculpture evaluation (<em>r</em> <!-->=<!--> <!-->0.177; <em>P</em> <!-->=<!--> <!-->0.256).</div></div><div><h3>Conclusions</h3><div>Within the limits of this study, it was concluded that students had similar performance in theoretical knowledge of anterior and posterior teeth. However, P10 students performed better in photograph evaluation than in the theoretical questionnaire, suggesting an improvement in practical skills throughout the course.</div></div>","PeriodicalId":39316,"journal":{"name":"Morphologie","volume":"109 365","pages":"Article 100945"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the ventricular morphology of the heart of Brycon amazonicus (Agassiz, 1829) (Teleostei, Characiformes) 探索亚马孙Brycon amazonicus (Agassiz, 1829)心脏的心室形态(Teleostei, characteries)。
Morphologie Pub Date : 2024-12-20 DOI: 10.1016/j.morpho.2024.100944
Diego D. dos Santos , Mario V. B. Gardinal , Thalles F. R. Ruiz , Rinaldo Florêncio-Silva , Mateus R. Vidal , Luiz R. Falleiros-Júnior , Sebartião R. Taboga , Irene B. Franceschini-Vicentini , Carlos A. Vicentini
{"title":"Exploring the ventricular morphology of the heart of Brycon amazonicus (Agassiz, 1829) (Teleostei, Characiformes)","authors":"Diego D. dos Santos ,&nbsp;Mario V. B. Gardinal ,&nbsp;Thalles F. R. Ruiz ,&nbsp;Rinaldo Florêncio-Silva ,&nbsp;Mateus R. Vidal ,&nbsp;Luiz R. Falleiros-Júnior ,&nbsp;Sebartião R. Taboga ,&nbsp;Irene B. Franceschini-Vicentini ,&nbsp;Carlos A. Vicentini","doi":"10.1016/j.morpho.2024.100944","DOIUrl":"10.1016/j.morpho.2024.100944","url":null,"abstract":"<div><div><em>Brycon amazonicus</em>, a fish species widely distributed along freshwater rivers in Latin America, is important in maintaining ecological balance. Although some morphological/physiological aspects of <em>B.</em> <em>amazonicus</em> have been reported, the cardiac histomorphology of this species remains poorly understood. Therefore, this study aimed to describe the heart, emphasizing coronary distribution and ventricular myoarchitecture, correlating its structure with its functional activity. Ten adult specimens were anesthetized and perfused with Trident® ink to highlight the coronary branching. Subsequently, the animals were euthanized to collect the hearts, which were collected and processed for histological and histochemical techniques and scanning electron microscopy. We observed that the heart of <em>B.</em> <em>amazonicus</em> has a pyramidal ventricle, mixed myocardium, and coronary vessels restricted to the compact layer, according to classifications in the literature. The compact layer comprises two types of muscle bundles, arranged in longitudinal and circular orientations. The coronary circulation, which originates in the lateral cephalic region, starts from the heart and extends to the ventricular myocardium. Therefore, <em>B.</em> <em>amazonicus</em> has a cardiac morphology similar to that of other teleost species already described in the literature, expanding information on the <em>Characiformes</em> group. The description obtained of the heart of this species may contribute to further studies that seek a better understanding of the ecophysiology and evolution of teleost fish in the freshwaters of the Neotropical region.</div></div>","PeriodicalId":39316,"journal":{"name":"Morphologie","volume":"109 365","pages":"Article 100944"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Alpinia officinarum Rhizome extract on experimentally induced lung fibrosis: The pertinent role of Sirt1 and Nrf2 antioxidant pathways 高寒提取物对实验性肺纤维化的影响:Sirt1和Nrf2抗氧化途径的相关作用。
Morphologie Pub Date : 2024-12-17 DOI: 10.1016/j.morpho.2024.100940
Marwa A.S. Al-Gholam , Huda I. Abd-Elhafiz , Sara G. Tayel
{"title":"Effect of Alpinia officinarum Rhizome extract on experimentally induced lung fibrosis: The pertinent role of Sirt1 and Nrf2 antioxidant pathways","authors":"Marwa A.S. Al-Gholam ,&nbsp;Huda I. Abd-Elhafiz ,&nbsp;Sara G. Tayel","doi":"10.1016/j.morpho.2024.100940","DOIUrl":"10.1016/j.morpho.2024.100940","url":null,"abstract":"<div><h3>Background</h3><div>Pulmonary fibrosis (PF) is a frequently reported COVID-19 sequela. It is a progressive disorder characterized by respiratory failure and death. The properties of Alpinia officinarum Rhizomes (AO) make it a highly potent antioxidant, anti-inflammatory, and antifibrotic agent. This study has evaluated AO's protective effects on bleomycin-induced PF in rats and investigated the underlying mechanisms.</div></div><div><h3>Material and methods</h3><div>Bleomycin (5<!--> <!-->mg/kg, intratracheally) was used to induce PF in albino rats, and then, AO extract (200<!--> <!-->mg/kg/daily, orally) was administrated for 28<!--> <!-->days post-bleomycin-instillation. After euthanizing the rats, the biochemical, quantitative real-time polymerase chain reaction (qPCR) and histopathological examination of lung tissue were determined.</div></div><div><h3>Results</h3><div>Findings have revealed that bleomycin significantly increased the tissue level of malondialdehyde, tumor necrosis factor-alpha, and interleukin-6, Silent information regulator 1 (Sirt1), and nuclear factor erythroid 2-related factor 2 (Nrf2) mRNA levels. Furthermore, the total antioxidant capacity level decreased in the lungs of bleomycin-instilled rats. However, AO extract significantly decreased histopathological injuries in hematoxylin &amp; eosin, Masson's trichrome-stained sections, inducible nitric oxide synthase and α-smooth muscle actin, transforming growth factor beta 1 immunoexpression.</div></div><div><h3>Conclusion</h3><div>Alpinia officinarum Rhizomes extract appears to protect against bleomycin-induced PF, possibly due to its antioxidant, anti-inflammatory, and antifibrotic properties.</div></div>","PeriodicalId":39316,"journal":{"name":"Morphologie","volume":"109 364","pages":"Article 100940"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bloom's taxonomy as a tool for educational objectives applied to human anatomy 布卢姆分类法作为教育目标的工具应用于人体解剖学。
Morphologie Pub Date : 2024-12-13 DOI: 10.1016/j.morpho.2024.100943
M.B. Montello, S.A. Bezerra de Moura, B.J. Abreu
{"title":"Bloom's taxonomy as a tool for educational objectives applied to human anatomy","authors":"M.B. Montello,&nbsp;S.A. Bezerra de Moura,&nbsp;B.J. Abreu","doi":"10.1016/j.morpho.2024.100943","DOIUrl":"10.1016/j.morpho.2024.100943","url":null,"abstract":"<div><h3>Background</h3><div>Human anatomy has long been a foundational aspect of medical education. To innovate and refine educational methodologies, it is necessary to employ tools that streamline the organization of classroom objectives. One such tool is Bloom's taxonomy (BT), a two-dimensional framework that guides the selection of verbs in defining educational objectives for curriculum components and lesson plans.</div></div><div><h3>Objectives</h3><div>Develop Bloom's taxonomy verbs by creating a reference table for educators of human anatomy.</div></div><div><h3>Methods</h3><div>A two-dimensional BT's table was constructed, allocating verbs applicable to the context of human anatomy and potential classroom application scenarios with descriptions of usage examples.</div></div><div><h3>Results and discussion</h3><div>Twenty-four verbs were assigned with proper allocation in the two-dimensional table, along with the description of the expected objective corresponding to each verb, including examples of how it would be used within an educational context in the discipline of human anatomy. The need to develop proposals that incorporate descriptions of BT verbs in healthcare settings has been identified, particularly focusing on metacognitive aspects and the development of lesson plans with objectives based on BT.</div></div><div><h3>Conclusion</h3><div>This resource can be used by educators to consult when initiating the development of objectives to be achieved in a class, curriculum component, or educational activity.</div></div>","PeriodicalId":39316,"journal":{"name":"Morphologie","volume":"109 364","pages":"Article 100943"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the genetics, mechanisms, and therapeutic innovations in non-syndromic tooth agenesis 探索非综合征性牙齿发育的遗传学、机制和治疗创新。
Morphologie Pub Date : 2024-12-09 DOI: 10.1016/j.morpho.2024.100941
Guilherme Henrique Borges , Caio Luiz Lins-Candeiro , Isabela Vinhal Henriques , Rui Barbosa de Brito Junior , Matheus Melo Pithon , Luiz Renato Paranhos
{"title":"Exploring the genetics, mechanisms, and therapeutic innovations in non-syndromic tooth agenesis","authors":"Guilherme Henrique Borges ,&nbsp;Caio Luiz Lins-Candeiro ,&nbsp;Isabela Vinhal Henriques ,&nbsp;Rui Barbosa de Brito Junior ,&nbsp;Matheus Melo Pithon ,&nbsp;Luiz Renato Paranhos","doi":"10.1016/j.morpho.2024.100941","DOIUrl":"10.1016/j.morpho.2024.100941","url":null,"abstract":"<div><div>Tooth agenesis is the congenital absence of one or more teeth in the normal series due to failures during dental development in the odontogenesis process. Although tooth development mechanisms are more precise in the literature, the etiology of non-syndromic tooth agenesis remains partially unknown. Mutations in genes that regulate the transcription factors involved in tooth development are associated with this condition. Despite advances in genetic research, questions remain about whose understanding might enable more precise and customized treatments. This study aimed to explain the molecular mechanisms associated with non-syndromic tooth agenesis and treatment progression regarding the condition in genetics. The search was non-systematic and performed in MedLine (via PubMed). The inclusion criteria were observational and experimental studies published in English, Portuguese, and Spanish, with open access and without time restrictions. The data analysis was narrative/descriptive. Fifty-three articles were selected. The primary genes associated with non-syndromic tooth agenesis identified in the study include <em>PAX9</em> and <em>MSX1</em> – essential for molar and premolar formation; <em>WNT10A</em> and <em>WNT10B</em> – involved in cell signaling during odontogenesis; <em>AXIN2</em> – related to the regulation of cell control and colorectal cancer risk; <em>EDA</em> and <em>EDAR</em> – crucial for ectodermal structures; and <em>BMP4</em> – regulates cell differentiation and morphogenesis. These lesions directly affect tooth formation and quantity. Understanding these genetic foundations and the molecular mechanisms of tooth agenesis is essential to improve diagnosis, develop customized therapies, and enhance patients’ quality of life. Continuous research is critical to establish genetic-based therapeutic innovations.</div></div>","PeriodicalId":39316,"journal":{"name":"Morphologie","volume":"109 364","pages":"Article 100941"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Population comparison of facial soft tissue thickness 面部软组织厚度的人群比较。
Morphologie Pub Date : 2024-12-06 DOI: 10.1016/j.morpho.2024.100939
S. Kalafutová , M. Chmelík , J. Gaľová , E. Petrejčíková
{"title":"Population comparison of facial soft tissue thickness","authors":"S. Kalafutová ,&nbsp;M. Chmelík ,&nbsp;J. Gaľová ,&nbsp;E. Petrejčíková","doi":"10.1016/j.morpho.2024.100939","DOIUrl":"10.1016/j.morpho.2024.100939","url":null,"abstract":"<div><div>The thickness of the face's soft tissue has been widely measured through different populations around the world. In this study, we gathered and compared multiple measurements including our study group. We set the variables and included studies in which only females with normal values of BMI, age from 18 to 30<!--> <!-->years old were studied, and we included research with more than 10 study participants. We gathered 32 various studies and tested them with Kruskal-Wallis's test in RStudio. Statistical significance in tissue thickness was not confirmed when compared with the results of studies of different populations, which may indicate a greater importance in the bony mass in facial identification.</div></div>","PeriodicalId":39316,"journal":{"name":"Morphologie","volume":"109 364","pages":"Article 100939"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
During the breeding season, lymphocytes assemble into ellipse-shaped clusters in the uropygial gland of the jungle crow Corvus macrorhynchos 在繁殖季节,淋巴细胞在丛林乌鸦的尾腺中聚集成椭圆形簇。
Morphologie Pub Date : 2024-12-06 DOI: 10.1016/j.morpho.2024.100924
A.J. Hirao , M. Aoyama , S. Sugita
{"title":"During the breeding season, lymphocytes assemble into ellipse-shaped clusters in the uropygial gland of the jungle crow Corvus macrorhynchos","authors":"A.J. Hirao ,&nbsp;M. Aoyama ,&nbsp;S. Sugita","doi":"10.1016/j.morpho.2024.100924","DOIUrl":"10.1016/j.morpho.2024.100924","url":null,"abstract":"<div><h3>Background</h3><div>Recent studies indicate that the uropygial gland produces intraspecific chemosensory cues. The jungle crow <em>Corvus macrorhynchos</em>, which is a type of passerine, exhibits extreme morphological variation in the gonadal gland during the breeding season. Because the uropygial gland of the jungle crow sometimes exhibits morphological changes during the breeding season, we attempted to clarify the morphological changes in the uropygial gland of the jungle crow according to development and season.</div></div><div><h3>Methods</h3><div>Captured birds were divided into three age groups according to the color of their upper palate: &lt;<!--> <!-->1 year, 1–2 years, and &gt;2 years old. Paraffin sections of the uropygial gland were stained with hematoxylin and eosin, Elastica van Gieson, Giemsa, and a proliferating cell nuclear antigen antibody.</div></div><div><h3>Results</h3><div>Sexual dimorphism was not seen in the morphology of the uropygial gland in the jungle crow. However, changes due to growth and season were identified. During the breeding season in birds<!--> <!-->&gt;<!--> <!-->2 years old, lymphocytes formed ellipse-shaped clusters around the glandular cavity. These clusters were invaded by collagen fibers from spherical cells.</div></div><div><h3>Conclusions</h3><div>Collagen fibers, which develop from spherical cells, seem to be related to lymphoid cluster migration. Ellipse-shaped lymphoid clusters may play a crucial role in reproductive behavior during the breeding season.</div></div>","PeriodicalId":39316,"journal":{"name":"Morphologie","volume":"109 364","pages":"Article 100924"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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