Clinical Neurology最新文献_第4页

[Symptomatic narcolepsy type 2 in a patient with AQP4-positive neuromyelitis optica spectrum disorder]. [aqp4阳性视神经脊髓炎谱系障碍患者的2型症状性发作]。

Clinical Neurology Pub Date : 2025-04-25 Epub Date: 2025-03-27 DOI: 10.5692/clinicalneurol.cn-002048

Takashi Yoshimura, Masakazu Wakai, Takashi Kanbayashi, Masahisa Katsuno

引用次数: 0

[Rapidly progressive muscle weakness in anti-myelin associated glycoprotein (MAG) neuropathy successfully treated with intravenous immunoglobulin]. 静脉注射免疫球蛋白成功治疗抗髓鞘相关糖蛋白（MAG）神经病变的快速进行性肌肉无力。

Clinical Neurology Pub Date : 2025-04-25 Epub Date: 2025-04-11 DOI: 10.5692/clinicalneurol.cn-002030

Mari Fukuda, Kazutoshi Ikeda, Kentaro Yamakawa, Yohei Takenobu, Akihiko Ozaki

引用次数: 0

[Is neurofilament light chain useful as a disease progression marker for ATTRv amyloidosis? A literature review]. 神经丝轻链作为ATTRv淀粉样变的疾病进展标志物有用吗？文献综述]。

Clinical Neurology Pub Date : 2025-04-25 Epub Date: 2025-03-22 DOI: 10.5692/clinicalneurol.cn-002063

Yoshiki Sekijima, Mitsuharu Ueda, Kentaro Takahashi, Hiroaki Kitaoka

引用次数: 0

[Varicella zoster infection as a risk factor for dementia: a scoping review]. [水痘带状疱疹感染是痴呆的危险因素：一项范围综述]。

Clinical Neurology Pub Date : 2025-03-27 Epub Date: 2025-02-22 DOI: 10.5692/clinicalneurol.cn-002047

Yasuko Mori, Yoya Ono, Takayoshi Shimohata

引用次数: 0

[A case of possible multifocal motor neuropathy with suspected posterior interosseous nerve palsy]. [疑似多局灶性运动神经病伴后骨间神经麻痹1例]。

Clinical Neurology Pub Date : 2025-03-27 Epub Date: 2025-02-22 DOI: 10.5692/clinicalneurol.cn-002053

Koichi Tanaka, Akihiro Kitamura, Ryutaro Nakamura, Isamu Yamakawa, Tomoya Terashima, Makoto Urushitani

引用次数: 0

Undiagnosed headaches in the emergency department: clinical characteristics and outcomes. 急诊科未确诊的头痛：临床特征和结果

Clinical Neurology Pub Date : 2025-03-27 Epub Date: 2025-02-22 DOI: 10.5692/clinicalneurol.cn-002052

Ryo Sasaki, Yoshiaki Takahashi, Mizuki Morimoto, Kazuhiro Sasaki, Nobutoshi Morimoto

{"title":"Undiagnosed headaches in the emergency department: clinical characteristics and outcomes.","authors":"Ryo Sasaki, Yoshiaki Takahashi, Mizuki Morimoto, Kazuhiro Sasaki, Nobutoshi Morimoto","doi":"10.5692/clinicalneurol.cn-002052","DOIUrl":"10.5692/clinicalneurol.cn-002052","url":null,"abstract":"Headaches are a common complaint in the emergency department (ED). Understanding the characteristics and outcomes of headaches, especially in undiagnosed patients, is important for improving headache care in the ED. We conducted a retrospective study of 171 headache patients at the ED of Kagawa Prefectural Central Hospital, with a follow-up for the primary and undiagnosed headache groups via telephone to assess long-term outcomes. Primary, secondary, and undiagnosed headaches accounted for 15.2%, 58.4%, and 26.3% of cases, respectively. All life-threatening secondary headaches were successfully excluded with imaging tests performed on 73.7% of cases, despite the low rate of treatment in the ED (18.1%). Among the undiagnosed headache cases, the recurrence of severe headaches was low (11.9%), though awareness of chronic headaches was high (47.6%). Emergency physicians should be aware of the possibility that patients at an ED presenting an undiagnosed headache may include chronic headache patients. Seamless collaboration between the ED and headache specialists is needed to manage undiagnosed headaches in the ED.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"197-202"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A case of anti-synthetase syndrome: negative ELISA/immunoblot, but positive RNA immunoprecipitation with multiple antibodies]. 【抗合成酶综合征1例：ELISA/免疫印迹阴性，RNA免疫沉淀阳性，多抗体】。

Clinical Neurology Pub Date : 2025-03-27 Epub Date: 2025-02-27 DOI: 10.5692/clinicalneurol.cn-002009

Saya Ikeda, Takahiro Shimizu, Tadashi Adachi, Shigeakai Suzuki, Ichizo Nishino, Ritsuko Hanajima

引用次数: 0

[A case of meningitis due to anti-centromere antibody-positive Sjögren syndrome]. [抗着丝粒抗体阳性Sjögren综合征所致脑膜炎1例]。

Clinical Neurology Pub Date : 2025-03-27 Epub Date: 2025-02-22 DOI: 10.5692/clinicalneurol.cn-002058

Yoko Tsuboyama, Akihiko Mitsutake, Yuto Sakai, Nobue K Iwata

{"title":"[A case of meningitis due to anti-centromere antibody-positive Sjögren syndrome].","authors":"Yoko Tsuboyama, Akihiko Mitsutake, Yuto Sakai, Nobue K Iwata","doi":"10.5692/clinicalneurol.cn-002058","DOIUrl":"10.5692/clinicalneurol.cn-002058","url":null,"abstract":"A 79-year-old woman was diagnosed with Sjögren's syndrome (SjS) at the age of 73 years by lip biopsy, gum test, and salivary gland scintigraphy with positive antinuclear (ANA), positive anti-centromere (ACA), and negative anti-Ro/SS-A antibodies. Seven days before admission, the patient developed gait disturbance, which progressed to difficulty in walking two days before admission. She was hospitalized because of subacute gait disturbance. Neurological examination showed gait disturbances characterized by small steps, wide-based gait, left upper limb clumsiness, and frontal lobe dysfunction. Laboratory tests confirmed positive ANA and ACA and negative anti-Ro/SS-A and anti-La/SS-B antibodies. Cerebrospinal fluid analysis showed mildly elevated protein levels and increased monocyte count. Brain MRI showed hyperintensity in the bilateral frontal regions on fluid-attenuated inversion recovery (FLAIR)/contrast-enhanced T1-weighted imaging, and N-isopropyl-p-123I-iodoamphetamine single-photon emission computed tomography (123I-IMP SPECT) showed decreased accumulation in the frontal region. After excluding cancerous, infectious, and immune-mediated causes, ACA-single-positive SjS-related meningitis was diagnosed. The patient responded well to steroid therapy. The patient was able to walk short distances and showed improvement in frontal lobe function. Follow-up MRI and 123I-IMP SPECT demonstrated the resolution of previous abnormalities. Knowingly, there have been no reported cases of SjS-related meningitis with positive ACA. Considering that anti-Ro/SS-A antibodies are involved in the pathogenesis of meningitis, this case is extremely rare. We propose that ACA-positive SjS be considered in the differential diagnosis of aseptic meningitis.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"236-239"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Spinal and bulbar muscular atrophy with hyper CKemia and selective muscle atrophy of the lower extremities]. [脊髓和球性肌肉萎缩伴重度肾血症和下肢选择性肌肉萎缩]。

Clinical Neurology Pub Date : 2025-03-27 Epub Date: 2025-02-22 DOI: 10.5692/clinicalneurol.cn-002057

Keisuke Hara, Maiko Umeda, Yoshitaka Umeda, Mutsuo Oyake, Nobuya Fujita

引用次数: 0

[Identification of potential embolic source and consideration for ischemic lesion formation using the consecutive patient registry of acute embolic stroke]. [利用急性栓塞性卒中的连续患者登记识别潜在栓塞源并考虑缺血性病变形成]。

Clinical Neurology Pub Date : 2025-03-27 Epub Date: 2025-02-27 DOI: 10.5692/clinicalneurol.cn-002054

Yasumasa Yamamoto, Yoshinari Nagakane

{"title":"[Identification of potential embolic source and consideration for ischemic lesion formation using the consecutive patient registry of acute embolic stroke].","authors":"Yasumasa Yamamoto, Yoshinari Nagakane","doi":"10.5692/clinicalneurol.cn-002054","DOIUrl":"10.5692/clinicalneurol.cn-002054","url":null,"abstract":"We investigated the 992 consecutive patients with acute embolic stroke and identified potential embolic sources (PES) for 88.3% applying transesophageal echocardiography (TEE). We classified patients into 3 groups, the Group A (n ‍= ‍560): PES were identified after general examinations, the Group B (n ‍= ‍366): PES were identified after TEE or long-term EEG monitoring and the Group C (n ‍= ‍66): TEE could not be performed. In Group A, continuous atrial fibrillation (cAf) was most prevalent (n ‍= ‍464, 82.8%), succeeded by myocardial infarction (n ‍= ‍39, 6.9%) and Trousseau syndrome (n ‍= ‍27, 4.8%), etc. In Group B, paroxysmal atrial fibrillation (pAf) was most prevalent (n ‍= ‍168, 45.9%), succeeded by paradoxical embolism (n ‍= ‍77, 21.0%) and aorto-embolism (n ‍= ‍77, 19.3%). We investigated the association of topographic diffusion-weighted imaging patterns (DWI) with PES. DWI was determined based on the arterial supply. Middle cerebral arteries were particularly divided into 4 segments, i.e., M1~M4. Moreover, M2 segments were subdivided into superior and inferior branches. The infarcts of larger caliber arteries such as internal carotid artery, M1 and M2, and multiple cortical branches were mostly associated with atrial fibrillation including cAf and pAf. Striatocapsular infarction were significantly associated with paradoxical embolism. Multiple small scattered infarcts were predominant in aorto-embolism as well as paradoxical embolism, Trousseau syndrome and thrombocytosis. The associations of DWI with different PES have their distinctive characteristics and may help predict PES in patients with embolic stroke of undetermined source. DWI pattern may be determined by the composition of thrombi and hydrodynamics of cerebral vasculature.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"203-210"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0