Clinical Neurology最新文献_第3页

[A case of Streptococcus suis meningitis in which the patient suffered sensorineural hearing loss and requring long-term antibacterial treatment]. [猪链球菌脑膜炎1例，患者出现感音神经性听力丧失，需要长期抗菌治疗]。

Clinical Neurology Pub Date : 2025-08-28 Epub Date: 2025-07-24 DOI: 10.5692/clinicalneurol.cn-002123

Tomoki Ishimaru, Kei Oiwa, Sho Seo, Takahiro Kano, Hideki Hozen

{"title":"[A case of Streptococcus suis meningitis in which the patient suffered sensorineural hearing loss and requring long-term antibacterial treatment].","authors":"Tomoki Ishimaru, Kei Oiwa, Sho Seo, Takahiro Kano, Hideki Hozen","doi":"10.5692/clinicalneurol.cn-002123","DOIUrl":"10.5692/clinicalneurol.cn-002123","url":null,"abstract":"A man in his 40s was transferred to our hospital due to headache, hearing loss, and altered consciousness, which developed several days after consuming a barbeque meal, including pork. Based on his clinical symptoms and various laboratory findings, he was diagnosed with bacterial meningitis caused by Streptococcus suis, and treatment was initiated with antibacterial agents and dexamethasone. After 3 weeks, his symptoms and laboratory results showed improvement, allowing for the discontinuation of the antibacterial therapy. However, a few days after stopping antibiotics, his symptoms and cerebrospinal fluid (CSF) findings worsened, prompting the resumption of antibacterial treatment. The therapy was ultimately terminated after 5 weeks, following confirmation of clinical and CSF improvement. Despite resolution of the meningitis symptoms, the patient was left with bilateral sensorineural hearing loss, predominantly affecting his right ear. Following systemic steroid administration and hyperbaric oxygen therapy, his left-sided hearing improved, but no improvement was observed in his right ear, and he continued to experience severe hearing loss.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"607-611"},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[An autopsy case of spinal bulbar muscular atrophy concomitant with multiple system atrophy pathology]. [脊髓球肌萎缩伴多系统萎缩病理尸检1例]。

Clinical Neurology Pub Date : 2025-08-28 Epub Date: 2025-07-24 DOI: 10.5692/clinicalneurol.cn-002087

Raita Kikuchi, Kenji Ishihara, Jun'ichi Shiota, Mitsuru Kawamura, Mari Yoshida

{"title":"[An autopsy case of spinal bulbar muscular atrophy concomitant with multiple system atrophy pathology].","authors":"Raita Kikuchi, Kenji Ishihara, Jun'ichi Shiota, Mitsuru Kawamura, Mari Yoshida","doi":"10.5692/clinicalneurol.cn-002087","DOIUrl":"10.5692/clinicalneurol.cn-002087","url":null,"abstract":"We describe an autopsy case of spinal bulbar muscular atrophy (SBMA) concomitant with multiple system atrophy (MSA). A Japanese male patient developed gait disturbance in his twenties. His brother and niece also presented with similar clinical symptoms. His condition gradually worsened, and he became immobile at the age of 50 years. Genetic analysis revealed the expansion of CAG repeats of the SBMA gene. At 63 years of age, cerebellar ataxia symptoms emerged. Magnetic resonance images of the head showed a \"hot cross bun sign\" at the pontine basis and bilateral atrophy of the middle cerebellar peduncles and cerebellar hemispheres, suggesting MSA. He died of pneumonia at the age of 65 years, with a clinical illness of approximately 40 years. The neuropathological diagnosis was consistent with both SBMA and MSA. Neurons of the spinal anterior horn and brainstem motor nuclei were diminished. 1C2 (polyglutamine) immunoreactive intranuclear and intracytoplasmic inclusions were observed in the neurons in the substantia nigra, brainstem tegmentum, pontine nuclei, spinal anterior horn cells and Onuf's nucleus. These findings were suggestive of SBMA. Meanwhile, neurons of the inferior olivary nuclei, pontine nuclei, and Purkinje cells were nearly completely lost. The cerebellar white matter, pontine basis, and middle cerebellar peduncles showed a prominent loss of fibers. α-synuclein positive glial cytoplasmic inclusions were observed in widespread areas. These findings were suggestive of MSA. To the best of our knowledge, another case of SBMA accompanying MSA, similar to the present case, have been reported to date. Moreover, several cases of pathologically proven amyotrophic lateral sclerosis and MSA have been reported. The development of molecular biological techniques and accumulation of pathologically diagnosed patients may reveal common pathological mechanisms in SBMA and MSA.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"588-594"},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A case of treatment-related leukoencephalopathy during combination therapy with daratumumab, lenalidomide, and low-dose dexamethasone for multiple myeloma]. [达拉单抗、来那度胺和小剂量地塞米松联合治疗多发性骨髓瘤期间发生治疗相关性白质脑病1例]。

Clinical Neurology Pub Date : 2025-08-28 Epub Date: 2025-07-24 DOI: 10.5692/clinicalneurol.cn-002069

Keiko Maezono-Kandori, Hiroki Suo, Naoki Tokuda, Atsushi Yamamoto, Shiori Ogura, Yoshinari Nagakane

引用次数: 0

[A case of POEMS syndrome presenting craniocervical vascular stenosis]. [一例POEMS综合征表现为颅颈血管狭窄]。

Clinical Neurology Pub Date : 2025-07-25 Epub Date: 2025-06-21 DOI: 10.5692/clinicalneurol.cn-002064

Minori Sawada, Gaku Okumura, Ken Takasone, Nagaaki Katoh, Yoshiki Sekijima

{"title":"[A case of POEMS syndrome presenting craniocervical vascular stenosis].","authors":"Minori Sawada, Gaku Okumura, Ken Takasone, Nagaaki Katoh, Yoshiki Sekijima","doi":"10.5692/clinicalneurol.cn-002064","DOIUrl":"10.5692/clinicalneurol.cn-002064","url":null,"abstract":"A 54-years-old Japanese man visited local hospital with six-month history of progressive numbness and muscle weakness in his lower limbs. He was diagnosed with POEMS syndrome based on positive serum M-protein, elevated serum VEGF, and splenomegaly. MRI showed multiple cerebral infarcts in the watershed area, and MRA showed complete vascular occlusion of the right internal carotid artery and severe vascular stenosis of the left common carotid artery, suggesting hemodynamic cerebral infarction. He was referred to our department and treated with three courses of Daratumumab-Bortezomib-Dexamethasone (DBd) therapy. After normalization of VEGF was confirmed, right superficial temporal artery-middle cerebral bypass surgery was performed. He has been kept in good condition with improved muscle strength and walking ability, and normalized VEGF level under the maintenance Daratumumab-Lenalidomide-Dexamethasone (DLd) therapy. Because POEMS syndrome-associated vasculopathy can develop even in the very early stage of the disease, intensive evaluation of craniocervical vessels before treatment initiation is very important for treatment selection and risk assessment.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"511-515"},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Remarkable improvement of metastatic occipital condyle syndrome in a patient with lung adenocaricinoma treated with osimertinib]. [奥西替尼治疗肺腺癌患者转移性枕髁综合征的显著改善]。

Clinical Neurology Pub Date : 2025-07-25 Epub Date: 2025-06-21 DOI: 10.5692/clinicalneurol.cn-002115

Fujio Umehara

{"title":"[Remarkable improvement of metastatic occipital condyle syndrome in a patient with lung adenocaricinoma treated with osimertinib].","authors":"Fujio Umehara","doi":"10.5692/clinicalneurol.cn-002115","DOIUrl":"10.5692/clinicalneurol.cn-002115","url":null,"abstract":"A woman in her 50s. Since October of X-1, she had been suffering from lower back and occipital pain. Despite undergoing medical evaluations at multiple hospitals, no discernible abnormalities were identified. As her symptoms worsened, she presented to our department in January of X, reporting severe pain in the left occipital to posterior neck that increased with both neck flexion and extension. A neurological examination revealed a left-sided deviation of the tongue (left hypoglossal nerve paralysis). A head MRI revealed signal abnormalities in the left occipital condyle and multiple nodules with contrast effects in the brain parenchyma. A computed tomography (CT) scan revealed a mass in the left lung, multiple intrahepatic masses, and bone destruction in the spine and left occipital condyle. In light of these findings, a diagnosis of lung cancer with metastasis to multiple organs and occipital condyle syndrome due to metastasis to the left occipital condyle was suspected. Subsequent cytological analysis of bronchoalveolar lavage fluid and liver biopsy substantiated the diagnosis of adenocaricinoma. The subsequent administration of osimertinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, led to a reduction in the size of the tumor, as well as improvements in the hypoglossal nerve palsy and occipital pain. It is imperative to note that occipital condyle syndrome signifies the metastasis of a malignancy to the base of the skull, necessitating meticulous observation and management.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"531-535"},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A case report of leptomeningeal amyloidosis presenting with meningoencephalitis-resembling manifestations in a 54-year-old woman]. [一例54岁女性脑膜淀粉样变伴类似脑膜脑炎的表现报告]。

Clinical Neurology Pub Date : 2025-07-25 Epub Date: 2025-06-26 DOI: 10.5692/clinicalneurol.cn-002066

Naomi Suzuki, Takao Fukushima, Ryota Kishi, Masaki Namekawa, Junsuke Shimbo, Kunihiko Wakaki, Kunihiko Makino

引用次数: 0

[Molecular genetics of benign adult familial myoclonus epilepsy]. [成人良性家族性肌阵挛性癫痫的分子遗传学]。

Clinical Neurology Pub Date : 2025-07-25 Epub Date: 2025-06-26 DOI: 10.5692/clinicalneurol.cn-002111

Hiroyuki Ishiura

引用次数: 0

[A case of severe COVID-19 infection with multiple brain microbleeds spreading to the ‍subcortical white matter, internal capsule and splenium of the corpus callosum]. [重症COVID-19感染伴多发脑微出血扩散至‍皮层下白质、内囊及胼胝体脾1例]。

Clinical Neurology Pub Date : 2025-07-25 Epub Date: 2025-06-21 DOI: 10.5692/clinicalneurol.cn-002072

Shoko Aburatani, Eito Miura, Yoshitaka Umeda, Shimon Aoki, Nobuya Fujita, Mutsuo Oyake

引用次数: 0

[Questionnaire survey regarding pediatric to adult transitional medical care targeting members of Japanese Society of Neurology]. [以日本神经病学学会会员为对象的儿童到成人过渡医疗护理问卷调查]。

Clinical Neurology Pub Date : 2025-07-25 Epub Date: 2025-07-05 DOI: 10.5692/clinicalneurol.cn-002055

Toshio Saito, Yoshio Sakiyama, Katsuhisa Ogata, Yoko Mochizuki, Ichiro Yabe, Hideki Mochizuki

{"title":"[Questionnaire survey regarding pediatric to adult transitional medical care targeting members of Japanese Society of Neurology].","authors":"Toshio Saito, Yoshio Sakiyama, Katsuhisa Ogata, Yoko Mochizuki, Ichiro Yabe, Hideki Mochizuki","doi":"10.5692/clinicalneurol.cn-002055","DOIUrl":"10.5692/clinicalneurol.cn-002055","url":null,"abstract":"The Special Committee on Measures for Transition from Pediatric to Adult Health Care surveyed approximately 9,000 members of the Japanese Society of Neurology regarding transitional care. Only 744 responses were returned, less than 10% of the total number of members contacted. More than half answered that they generally provide treatment for adult patients with a childhood-onset disease, with many noting as reasons that the related diseases and ages in such cases are targeted by neurology specialists, and that other adult medical departments are not equipped to treat them. As for reasons given for not treating such patients, lack of knowledge related to developmental disorders, lack of support system, and difficulties with communication were noted. There were no noticeable differences in the responses of providing treatment for adult patients with a childhood-onset disease in association with the affiliated regional association or branch. These results indicate that resolution of issues related to neurologist unfamiliarity with pediatric neurological disorders and lack of relevant information are important issues to be addressed for establishment of a smooth medical care transition.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"503-510"},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A case of recurrence after more than 20 years from transverse myelitis suspected to be neuromyelitis optica spectrum disorder]. [横贯脊髓炎20多年后复发1例，怀疑为视神经脊髓炎谱系障碍]。

Clinical Neurology Pub Date : 2025-07-25 Epub Date: 2025-06-26 DOI: 10.5692/clinicalneurol.cn-002108

Toshiyuki Mizukura, Yu Sugiyama

引用次数: 0