Clinical Neurology最新文献_第3页

[Proposals for the early diagnosis of late-onset hereditary ATTR amyloidosis in ‍nonendemic areas in Japan]. [关于在日本非流行区早期诊断晚发型遗传性 ATTR 淀粉样变性病的建议]。

Clinical Neurology Pub Date : 2024-10-29 Epub Date: 2024-10-26 DOI: 10.5692/clinicalneurol.cn-002002

Keiko Maruyama Saladini, Haruki Koike, Mitsuharu Ueda, Yoshiki Sekijima, Yukio Ando

引用次数: 0

[Amaurosis fugax in Marfan syndrome with myxomatous degeneration]. [马凡综合征伴肌瘤变性的大眼病]。

Clinical Neurology Pub Date : 2024-10-29 Epub Date: 2024-10-21 DOI: 10.5692/clinicalneurol.cn-001987

Takeo Sato, Mari Satake, Hiroki Iitsuka, Masahiro Mimori, Tadashi Umehara, Chisen Takeuchi, Yasuyuki Iguchi

引用次数: 0

[Acute internal carotid artery occlusion following administration of Andexanet alfa for the reversal of direct factor Xa inhibitors in patients with cerebral hemorrhage]. [脑出血患者使用安达赛酮α逆转直接 Xa 因子抑制剂后出现急性颈内动脉闭塞]。

Clinical Neurology Pub Date : 2024-10-29 Epub Date: 2024-10-21 DOI: 10.5692/clinicalneurol.cn-001997

Sota Uemura, Junji Takasugi, Nobuyuki Ohara, Masamori Koyanagi, Tsuyoshi Ohta, Michi Kawamoto

{"title":"[Acute internal carotid artery occlusion following administration of Andexanet alfa for the reversal of direct factor Xa inhibitors in patients with cerebral hemorrhage].","authors":"Sota Uemura, Junji Takasugi, Nobuyuki Ohara, Masamori Koyanagi, Tsuyoshi Ohta, Michi Kawamoto","doi":"10.5692/clinicalneurol.cn-001997","DOIUrl":"10.5692/clinicalneurol.cn-001997","url":null,"abstract":"An 87-year-old woman receiving aspirin and apixaban with a history of large artery atherosclerotic stroke, and pulmonary embolism presented to the hospital for aphasia and right hemiplegia. A head CT scan showed 18-ml hematoma in the left thalamus. Low-dose Andexanet alfa was administered 84 minutes after the onset of stroke, and 10 hours and 24 minutes after the last dose of apixaban. Three hours later after admission, she had flaccid hemiplegia and became comatose. CT and CT angiography revealed occlusion of left internal carotid artery (ICA) and no evidence of hematoma expansion. Although repetitive mechanical thrombectomy resulted in recanalization (modified TICI 2b), carotid ultrasound revealed the occlusion of left ICA on next day. On day 7, she died of brain herniation following extensive cerebral infarction. It has been reported that some patients did experience thrombotic events after administration of Andexanet alfa. Our case illustrates that even large vessel occlusion might occur after intravenous injection of Andexanet alfa. Thus, careful follow-up, including cerebrovascular imaging, is required immediately after administration of Andexanet alfa.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"730-735"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Clinical features of five Japanese cases with leucine-rich glioma inactivated-1 (LGI1) antibody-positive encephalitis]. [富亮氨酸胶质瘤灭活-1（LGI1）抗体阳性脑炎五例日本病例的临床特征]。

Clinical Neurology Pub Date : 2024-10-29 Epub Date: 2024-10-26 DOI: 10.5692/clinicalneurol.cn-001977

Naoki Moro, Masanori Nakajima, Hidenobu Shozawa, Kentaro Nagai, Ayumi Uchibori, Yaeko Ichikawa

{"title":"[Clinical features of five Japanese cases with leucine-rich glioma inactivated-1 (LGI1) antibody-positive encephalitis].","authors":"Naoki Moro, Masanori Nakajima, Hidenobu Shozawa, Kentaro Nagai, Ayumi Uchibori, Yaeko Ichikawa","doi":"10.5692/clinicalneurol.cn-001977","DOIUrl":"10.5692/clinicalneurol.cn-001977","url":null,"abstract":"We studied the clinical features of five Japanese cases with leucine-rich glioma inactivated-1 (LGI1) antibody-positive encephalitis. Their symptoms included seizures, hallucinations, memory impairment, apathy, anxiety, agitation, faciobrachial dystonic seizure (FBDS), and ictal piloerection. All five patients showed hippocampal fluid attenuated inversion recovery (FLAIR) hyperintensity on brain MRI even though their cell counts of cerebrospinal fluid (CSF) were normal range. Four patients had syndrome of inappropriate secretion of antidiuretic hormone. One patient with FBDS also showed basal ganglia lesion on her brain MRI. Sodium channel blockers apparently lowered the frequency of FBDS. One patient had a thyroid cancer and underwent thyroidectomy. Substantial response to immunotherapy was seen in four out of five cases. At follow-up ≥2 years, all five patients had never relapsed. In cases of limbic encephalitis with normal CSF cell counts and hyponatremia, we should consider LGI1 antibody-positive encephalitis and conduct immunotherapy immediately.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"714-718"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A case of young onset cerebral amyloid angiopathy associated with dural grafting]. [一例与硬脑膜移植有关的年轻发病脑淀粉样血管病]。

Clinical Neurology Pub Date : 2024-10-29 Epub Date: 2024-10-21 DOI: 10.5692/clinicalneurol.cn-002006

Kengo Furutsuka, Aya Murakami, Haruka Iwamura, Kosuke Miyake, Akio Asai, Yusuke Yakushiji

{"title":"[A case of young onset cerebral amyloid angiopathy associated with dural grafting].","authors":"Kengo Furutsuka, Aya Murakami, Haruka Iwamura, Kosuke Miyake, Akio Asai, Yusuke Yakushiji","doi":"10.5692/clinicalneurol.cn-002006","DOIUrl":"10.5692/clinicalneurol.cn-002006","url":null,"abstract":"A 47-year-old man was admitted to our hospital because of sudden-onset motor aphasia and right hemiplegia. His past medical history was notable for left craniotomy and hematoma evacuation following a traumatic brain hemorrhage approximately 40 years earlier, for which dural grafting was performed. He also had a history of three lobar hemorrhages in the left hemisphere since the age of 42 years. Brain CT imaging revealed an acute left frontal lobar hemorrhage. His initial brain MRI conducted at our hospital demonstrated hemorrhagic findings with left hemisphere dominance, including acute and old lobar hemorrhage, cortical superficial siderosis, and cerebral microbleeds. Cerebrospinal fluid analyses demonstrated reduced levels of cerebral amyloid-β 42, and elevated total tau. His apolipoprotein E genotype was ε3/ε3. Whole-exome sequencing did not detect mutations in genes associated with Alzheimer's disease, including presenilin 1, presenilin 2, and amyloid precursor protein. These findings led to a clinical diagnosis of iatrogenic cerebral amyloid angiopathy (CAA) using recently proposed diagnostic criteria, which do not require pathological evaluation of the brain. Iatrogenic CAA should be considered as a cause of lobar hemorrhage in young patients, especially those with a past history of neurosurgery.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"736-741"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Utility of EEG in neurological emergencies and critical care]. [脑电图在神经系统急症和重症监护中的作用]。

Clinical Neurology Pub Date : 2024-10-29 Epub Date: 2024-10-26 DOI: 10.5692/clinicalneurol.cn-001928

Hajime Yoshimura

引用次数: 0

[Primary intramedullary spinal cord lymphoma with long spinal cord lesion]. [原发性髓内脊髓淋巴瘤伴脊髓长段病变]。

Clinical Neurology Pub Date : 2024-10-29 Epub Date: 2024-10-21 DOI: 10.5692/clinicalneurol.cn-002008

Atsushi Hara, Hideo Aihara, Hiroaki Hirata, Tokiko Nakai, Toshiyuki Uehara

引用次数: 0

[Anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated cortical encephalitis with low signal in subcortical white matter on MRI FLAIR imaging]. [抗髓鞘少突胶质细胞糖蛋白（MOG）抗体相关性皮质脑炎，核磁共振 FLAIR 成像显示皮质下白质呈低信号]。

Clinical Neurology Pub Date : 2024-09-26 Epub Date: 2024-08-28 DOI: 10.5692/clinicalneurol.cn-001981

Ryoko Shibuya, Risako Furuta, Ryo Tanaka, Takamasa Nukui, Shunya Nakane, Yuji Nakatsuji

{"title":"[Anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated cortical encephalitis with low signal in subcortical white matter on MRI FLAIR imaging].","authors":"Ryoko Shibuya, Risako Furuta, Ryo Tanaka, Takamasa Nukui, Shunya Nakane, Yuji Nakatsuji","doi":"10.5692/clinicalneurol.cn-001981","DOIUrl":"10.5692/clinicalneurol.cn-001981","url":null,"abstract":"A 32-year-old male presented with unilateral orbital-temporal pulsatile headache, followed by fever in the 38°C range and nausea. The patient experienced two episodes of transient dysarthria and tinnitus, each lasting several minutes. MRI revealed swelling of the left cerebral cortex, enhancement of the leptomeninges, dilation of the left middle cerebral artery, and subcortical FLAIR hypointensity. The clinical presentation and MRI findings raised suspicions of myelin oligodendrocyte glycoprotein (MOG) antibody-associated cortical encephalitis. After two courses of steroid pulse therapy, the patient's headache subsided, and there was a significant improvement in the swelling of the left cerebral cortex. Subsequently, serum MOG antibody positivity was confirmed. While unilateral cortical FLAIR hyperintensity and increased blood flow can be observed in various diseases, MOG antibody-associated cortical encephalitis is notably characterized by subcortical FLAIR hypointensity, a finding more frequently observed in this condition compared to other diseases. In this case, the findings were useful for early diagnosis and intervention.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"654-657"},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A case of metronidazole-induced encephalopathy that is difficult to differentiate from Wernicke encephalopathy]. [一例甲硝唑诱发的脑病，与韦尼克脑病难以区分]。

Clinical Neurology Pub Date : 2024-09-26 Epub Date: 2024-08-24 DOI: 10.5692/clinicalneurol.cn-001972

Takayuki Konishi, Junichi Uemura, Shinji Yamashita, Hitoshi Mori, Takeshi Inoue, Katsumi Kurokawa

{"title":"[A case of metronidazole-induced encephalopathy that is difficult to differentiate from Wernicke encephalopathy].","authors":"Takayuki Konishi, Junichi Uemura, Shinji Yamashita, Hitoshi Mori, Takeshi Inoue, Katsumi Kurokawa","doi":"10.5692/clinicalneurol.cn-001972","DOIUrl":"10.5692/clinicalneurol.cn-001972","url":null,"abstract":"Herein, we present the case of a 76-year-old man diagnosed with an iliopsoas abscess 3 months prior and consequently administered metronidazole. The patient visited our facility complaining of difficulty in speaking and feeling unsteady when walking. Neurological findings showed dysarthria, nystagmus, and bilateral cerebellar ataxia. Head MRI-FLAIR demonstrated symmetrical hyperintensities in the bilateral cerebellar dentate nuclei, red nucleus, periaqueductal of the midbrain, periventricular third ventricle, and the corpus callosum. Although Wernicke's encephalopathy was among the differential diagnoses based on the imaging findings, the thiamine level was normal and improvement in symptoms and hyperintensity on FLAIR within 5 days of discontinuing metronidazole led to the diagnosis of metronidazole-induced encephalopathy. Although there were many similarities in the imaging findings of metronidazole-induced encephalopathy and Wernicke's encephalopathy, Metronidazole-induced encephalopathy should be initially considered when midbrain red nucleus lesions are observed.","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"637-641"},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A case of numb chin syndrome caused by postcentral gyrus infarction]. [一例由中央后回梗塞引起的麻木下巴综合征]。

Clinical Neurology Pub Date : 2024-09-26 Epub Date: 2024-08-24 DOI: 10.5692/clinicalneurol.cn-001984

Naoki Sawada, Miki Ueda, Toshitaka Umemura, Mikiko Kamijo, Takashi Kameyama

引用次数: 0