【基底节T1信号强度变化诊断抗富亮氨酸胶质瘤失活1 (LGI1)脑炎1例报告及文献复习】。

Q4 Medicine
Clinical Neurology Pub Date : 2025-06-26 Epub Date: 2025-05-20 DOI:10.5692/clinicalneurol.cn-002084
Takanobu Kita, Hiroaki Okada, Yoshiyuki Nakai, Masahiro Kanai, Keiji Yamaguchi
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引用次数: 0

摘要

78岁男性,表现为行为异常,两周后发展为右上肢强直阵挛性发作,意识受损。最初的脑部MRI和脑脊液检查结果正常。然而,在第5天,弥散加权成像显示左侧基底额叶、纹状体和岛叶皮层有高信号区。第12天,t1加权成像显示左侧纹状体高强度。在开始免疫治疗前,症状几乎得到改善。根据MRI表现的时间变化和血清富含亮氨酸的胶质瘤失活1 (LGI1)抗体阳性结果,诊断为抗LGI1脑炎。患者还患有基底细胞癌。基底神经节T1高强度是抗lgi1脑炎的一个有用的诊断特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis diagnosed from T1 signal intensity changes in basal ganglia: a case report and literature review].

A 78-year-old male presented with abnormal behavior, which progressed to tonic-clonic seizures in right upper limb and impaired consciousness two weeks later. Initial brain MRI and cerebrospinal fluid findings were normal. However, on the 5th day, diffusion-weighted imaging revealed hyperintense areas in the left basal frontal lobe, striatum, and insular cortex. By the 12th day, T1-weighted imaging demonstrated hyperintensity in the left striatum. The symptoms almost improved before the initiation of immunotherapy. Based on the time-course changes in MRI findings and positive serum leucine-rich glioma-inactivated 1 (LGI1) antibody results, the patient was diagnosed with anti-LGI1 encephalitis. The patient also had basal cell carcinoma. T1 hyperintensity in the basal ganglia is a useful diagnostic feature of anti-LGI1 encephalitis.

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来源期刊
Clinical Neurology
Clinical Neurology Medicine-Neurology (clinical)
CiteScore
0.30
自引率
0.00%
发文量
147
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