{"title":"【基底节T1信号强度变化诊断抗富亮氨酸胶质瘤失活1 (LGI1)脑炎1例报告及文献复习】。","authors":"Takanobu Kita, Hiroaki Okada, Yoshiyuki Nakai, Masahiro Kanai, Keiji Yamaguchi","doi":"10.5692/clinicalneurol.cn-002084","DOIUrl":null,"url":null,"abstract":"<p><p>A 78-year-old male presented with abnormal behavior, which progressed to tonic-clonic seizures in right upper limb and impaired consciousness two weeks later. Initial brain MRI and cerebrospinal fluid findings were normal. However, on the 5th day, diffusion-weighted imaging revealed hyperintense areas in the left basal frontal lobe, striatum, and insular cortex. By the 12th day, T<sub>1</sub>-weighted imaging demonstrated hyperintensity in the left striatum. The symptoms almost improved before the initiation of immunotherapy. Based on the time-course changes in MRI findings and positive serum leucine-rich glioma-inactivated 1 (LGI1) antibody results, the patient was diagnosed with anti-LGI1 encephalitis. The patient also had basal cell carcinoma. T<sub>1</sub> hyperintensity in the basal ganglia is a useful diagnostic feature of anti-LGI1 encephalitis.</p>","PeriodicalId":39292,"journal":{"name":"Clinical Neurology","volume":" ","pages":"429-435"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis diagnosed from T<sub>1</sub> signal intensity changes in basal ganglia: a case report and literature review].\",\"authors\":\"Takanobu Kita, Hiroaki Okada, Yoshiyuki Nakai, Masahiro Kanai, Keiji Yamaguchi\",\"doi\":\"10.5692/clinicalneurol.cn-002084\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A 78-year-old male presented with abnormal behavior, which progressed to tonic-clonic seizures in right upper limb and impaired consciousness two weeks later. Initial brain MRI and cerebrospinal fluid findings were normal. However, on the 5th day, diffusion-weighted imaging revealed hyperintense areas in the left basal frontal lobe, striatum, and insular cortex. By the 12th day, T<sub>1</sub>-weighted imaging demonstrated hyperintensity in the left striatum. The symptoms almost improved before the initiation of immunotherapy. Based on the time-course changes in MRI findings and positive serum leucine-rich glioma-inactivated 1 (LGI1) antibody results, the patient was diagnosed with anti-LGI1 encephalitis. The patient also had basal cell carcinoma. T<sub>1</sub> hyperintensity in the basal ganglia is a useful diagnostic feature of anti-LGI1 encephalitis.</p>\",\"PeriodicalId\":39292,\"journal\":{\"name\":\"Clinical Neurology\",\"volume\":\" \",\"pages\":\"429-435\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Neurology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5692/clinicalneurol.cn-002084\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5692/clinicalneurol.cn-002084","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/20 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
[Anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis diagnosed from T1 signal intensity changes in basal ganglia: a case report and literature review].
A 78-year-old male presented with abnormal behavior, which progressed to tonic-clonic seizures in right upper limb and impaired consciousness two weeks later. Initial brain MRI and cerebrospinal fluid findings were normal. However, on the 5th day, diffusion-weighted imaging revealed hyperintense areas in the left basal frontal lobe, striatum, and insular cortex. By the 12th day, T1-weighted imaging demonstrated hyperintensity in the left striatum. The symptoms almost improved before the initiation of immunotherapy. Based on the time-course changes in MRI findings and positive serum leucine-rich glioma-inactivated 1 (LGI1) antibody results, the patient was diagnosed with anti-LGI1 encephalitis. The patient also had basal cell carcinoma. T1 hyperintensity in the basal ganglia is a useful diagnostic feature of anti-LGI1 encephalitis.