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Myocardial Recovery versus Myocardial Regeneration: Mechanisms and Therapeutic Modulation. 心肌恢复与心肌再生：机制与治疗调节。
Methodist DeBakey cardiovascular journal Pub Date : 2024-08-20 eCollection Date: 2024-01-01 DOI: 10.14797/mdcvj.1400
John P Cooke, Keith A Youker, Li Lai
{"title":"Myocardial Recovery versus Myocardial Regeneration: Mechanisms and Therapeutic Modulation.","authors":"John P Cooke, Keith A Youker, Li Lai","doi":"10.14797/mdcvj.1400","DOIUrl":"10.14797/mdcvj.1400","url":null,"abstract":"<p><p>Myocardial recovery is characterized by a return toward normal structure and function of the heart after an injury. Mechanisms of myocardial recovery include restoration and/or adaptation of myocyte structure and function, mitochondrial activity and number, metabolic homeostasis, electrophysiological stability, extracellular matrix remodeling, and myocardial perfusion. Myocardial regeneration is an element of myocardial recovery that involves the generation of new myocardial tissue, a process which is limited in adult humans but may be therapeutically augmented. Understanding the mechanisms of myocardial recovery and myocardial regeneration will lead to novel therapies for heart failure.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"20 4","pages":"31-41"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flying Colors. 色彩飞扬
Methodist DeBakey cardiovascular journal Pub Date : 2024-08-20 eCollection Date: 2024-01-01 DOI: 10.14797/mdcvj.1450
Philip Alexander
{"title":"Flying Colors.","authors":"Philip Alexander","doi":"10.14797/mdcvj.1450","DOIUrl":"https://doi.org/10.14797/mdcvj.1450","url":null,"abstract":"<p><p>Philip Alexander, MD, is a native Texan, retired physician, and accomplished musician and artist. After 41 years as an internal medicine physician, Dr. Phil retired from his practice in College Station in 2016. A lifelong musician and former music professor, he often performs as an oboe soloist for the Brazos Valley Symphony Orchestra. He began exploring visual art in 1980, evolving from pencil sketches-including an official White House portrait of President Ronald Reagan-to the computer-generated drawings featured in this journal. His images, which first appeared in this journal in the spring of 2012, are his own original creations. If you would like to see your art published in the <i>Methodist DeBakey Cardiovascular Journal</i>, submit your creation online at journal.houstonmethodist.org as a \"Humanities\" entry.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"20 4","pages":"119-120"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Limericks for Myocardial Recovery and Regeneration. 促进心肌恢复和再生的打油诗
Methodist DeBakey cardiovascular journal Pub Date : 2024-08-20 eCollection Date: 2024-01-01 DOI: 10.14797/mdcvj.1442
James B Young, Albert E Raizner
{"title":"Limericks for Myocardial Recovery and Regeneration.","authors":"James B Young, Albert E Raizner","doi":"10.14797/mdcvj.1442","DOIUrl":"https://doi.org/10.14797/mdcvj.1442","url":null,"abstract":"<p><p>Limericks are an easy, casual, and entertaining way to have fun with the English language. Creating them can be an engaging pastime to assist in memorizing important anatomic relationships necessary for being an interventional cardiologist or simply an intellectual exercise that provides respite after a hectic day in the cardiac catheterization laboratory, surgical suite, outpatient clinic, or intensive care unit. Interest in this form of poetry often dates back to when we, as children, were taught the simplistic rhyming pattern of a traditional limerick or learned one during adolescence. As we age, our limericks often became more humorous, personal, and bawdy. That evolution is the beauty of this poetic form. For this edition of Poet's Pen, we invited Dr. Marshall S. Flam, a noted dabbler in the limerick world, to pen \"Limericks for Myocardial Recovery and Regeneration\" to accompany the theme of this issue.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"20 4","pages":"116-118"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Imaging and Biomarkers in Identifying, Monitoring, and Promoting Myocardial Recovery. 成像和生物标记在识别、监测和促进心肌恢复中的作用。
Methodist DeBakey cardiovascular journal Pub Date : 2024-08-20 eCollection Date: 2024-01-01 DOI: 10.14797/mdcvj.1381
Evelyne Meekers, Matthias Dupont
{"title":"Role of Imaging and Biomarkers in Identifying, Monitoring, and Promoting Myocardial Recovery.","authors":"Evelyne Meekers, Matthias Dupont","doi":"10.14797/mdcvj.1381","DOIUrl":"10.14797/mdcvj.1381","url":null,"abstract":"<p><p>Reverse remodeling, the overarching concept behind myocardial recovery, describes the process in which the maladaptive cardiac structural and functional alterations are reversed by removing the underlying etiology or by therapy. This review addresses different imaging modalities and biomarkers as possible predictors for reverse remodeling in patients with chronic heart failure. Although echocardiography remains the imaging modality of choice in daily practice, the presence and amount of fibrosis on cardiac magnetic resonance is a better predictor and inversely correlated with the likelihood for reverse remodeling. A decrease in NT-proBNP levels and serum soluble ST3 during follow-up is associated with better clinical and structural outcomes. The role of troponins and galectine-3 is less clear. There is a promising role for microRNAs in the future, although more research is necessary. Accurate predictors of reverse remodeling could help identify patients with an increased likelihood for reverse remodeling and, in turn, improve patient-tailored medicine.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"20 4","pages":"42-53"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myocardial Recovery in the Systemic Context: A Philosophic Shift for the Heart Failure Subspecialty to Optimize Patient Care. 系统背景下的心肌恢复：心力衰竭亚专科优化患者护理的理念转变。
Methodist DeBakey cardiovascular journal Pub Date : 2024-08-20 eCollection Date: 2024-01-01 DOI: 10.14797/mdcvj.1416
Arjun Kapoor, Jehanzeb Kayani, Muhammad Saad, Anuradha Lala
{"title":"Myocardial Recovery in the Systemic Context: A Philosophic Shift for the Heart Failure Subspecialty to Optimize Patient Care.","authors":"Arjun Kapoor, Jehanzeb Kayani, Muhammad Saad, Anuradha Lala","doi":"10.14797/mdcvj.1416","DOIUrl":"10.14797/mdcvj.1416","url":null,"abstract":"<p><p>Heart failure poses a significant challenge to healthcare systems and society at large, mainly due to its increasing prevalence among the aging population and its association with frequent hospitalizations with high mortality rates. At its core, heart failure management seeks to emphasize myocardial recovery across the spectrum of disease, from acute cardiogenic shock to ambulatory heart failure, with care ranging from consideration of mechanical circulatory support to medication optimization. In this review, we propose a definition of \"recovery\" that extends beyond the restoration of normal myocardial dynamics to the entire human organism, ultimately improving functional capacity and clinical outcomes. Prioritizing this more holistic definition of \"recovery\" allows a broader representation of the spectrum of disease and corresponding management that falls under the \"heart failure\" umbrella. In so doing, a more synchronized delivery of care across settings and disciplines may be feasible for the modern patient living with heart failure.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"20 4","pages":"98-108"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Vein Thrombus After Mitral Valve Transcatheter Edge-to-Edge Repair. 二尖瓣经导管边缘到边缘修复术后的肺静脉血栓。
Methodist DeBakey cardiovascular journal Pub Date : 2024-08-12 eCollection Date: 2024-01-01 DOI: 10.14797/mdcvj.1428
Aakash Rana, Jack Xu, Jedidiah McMunn, Rupesh Manam
{"title":"Pulmonary Vein Thrombus After Mitral Valve Transcatheter Edge-to-Edge Repair.","authors":"Aakash Rana, Jack Xu, Jedidiah McMunn, Rupesh Manam","doi":"10.14797/mdcvj.1428","DOIUrl":"10.14797/mdcvj.1428","url":null,"abstract":"<p><p>A 76-year-old female with a complicated medical history presented for Watchman (Boston Scientific) placement 2 months after mitral valve transcatheter edge-to-edge repair (TEER). Preoperative workup before Watchman placement confirmed the presence of a thrombus in the left superior pulmonary vein. Post-procedure mitral valve TEER transesophageal echocardiogram showed no thrombus in the left atrium appendage or pulmonary veins. We believe the thrombus in the left superior pulmonary vein occurred secondarily due to epithelium damage during the mitral valve TEER.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"20 1","pages":"65-69"},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11328680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shepherd's Crook Curve: A Novel Technique for Angulated Side Branch Access in Bifurcation Angioplasty. Shepherd's Crook Curve：分叉血管成形术中角度侧支入路的新技术。
Methodist DeBakey cardiovascular journal Pub Date : 2024-08-06 eCollection Date: 2024-01-01 DOI: 10.14797/mdcvj.1413
Kanhai Lalani, M Sudhakar Rao, Suheil Dhanse, Tom Devasia, Hashir Kareem, Ganesh Paramasivam
{"title":"Shepherd's Crook Curve: A Novel Technique for Angulated Side Branch Access in Bifurcation Angioplasty.","authors":"Kanhai Lalani, M Sudhakar Rao, Suheil Dhanse, Tom Devasia, Hashir Kareem, Ganesh Paramasivam","doi":"10.14797/mdcvj.1413","DOIUrl":"10.14797/mdcvj.1413","url":null,"abstract":"<p><p>Coronary intervention involving the region of bifurcation remains a challenging issue for the cardiologist as well as a complication. A number of factors including the angulation of side branch with the main branch determines the success. Though provisional strategy remains the best option in bifurcation intervention, at times a two-stent strategy cannot be avoided. We report a case in which percutaneous coronary intervention was performed on the left anterior descending artery (LAD) at its bifurcation with a major diagonal branch (> 2.5 mm). The ostium of the diagonal was diseased, and the branch took off from the LAD at an unfavorable angle (> 120°). We describe the use of the \"shepherd's crook wire curve\" approach, a modification of the reverse wire technique, which allowed us to successfully wire, dilate, and protect the diagonal and so named to reflect its resemblance to the shape of a shepherd's crook.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"20 1","pages":"59-64"},"PeriodicalIF":0.0,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11312719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapidly Progressive Apical Hypertrophic Cardiomyopathy: Not Everything is What It Seems. 快速进展的心尖肥厚型心肌病：并非一切都像看上去那样。
Methodist DeBakey cardiovascular journal Pub Date : 2024-06-21 eCollection Date: 2024-01-01 DOI: 10.14797/mdcvj.1386
Ahmed K Mahmoud, Juan M Farina, Kamal Awad, Milagros Pereyra, Isabel G Scalia, Mohammed Tiseer Abbas, Timothy Barry, Said Alsidawi, Chadi Ayoub, Reza Arsanjani
{"title":"Rapidly Progressive Apical Hypertrophic Cardiomyopathy: Not Everything is What It Seems.","authors":"Ahmed K Mahmoud, Juan M Farina, Kamal Awad, Milagros Pereyra, Isabel G Scalia, Mohammed Tiseer Abbas, Timothy Barry, Said Alsidawi, Chadi Ayoub, Reza Arsanjani","doi":"10.14797/mdcvj.1386","DOIUrl":"10.14797/mdcvj.1386","url":null,"abstract":"<p><p>Apical hypertrophic cardiomyopathy (HCM) is a rare variant of HCM. A 43-year-old female with a past medical history significant for hypertension and kidney transplantation presented with recurrent syncopal episodes and dyspnea on exertion. Electrocardiogram showed characteristic diffuse giant T-waves inversion, and cardiac magnetic resonance showed HCM with circumferential apical thickening. This case highlights the rapid development of apical HCM and its challenging diagnostic characteristics.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"20 1","pages":"54-58"},"PeriodicalIF":0.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11192092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Case of Internal Jugular Venous Malformation Treated by Surgical Excision. 通过手术切除治疗颈内静脉畸形的罕见病例
Methodist DeBakey cardiovascular journal Pub Date : 2024-06-11 eCollection Date: 2024-01-01 DOI: 10.14797/mdcvj.1336
Rishik Puppala, Bright Benfor, Shri Timbalia, Tiffany G Sheu, Alan B Lumsden
{"title":"A Rare Case of Internal Jugular Venous Malformation Treated by Surgical Excision.","authors":"Rishik Puppala, Bright Benfor, Shri Timbalia, Tiffany G Sheu, Alan B Lumsden","doi":"10.14797/mdcvj.1336","DOIUrl":"10.14797/mdcvj.1336","url":null,"abstract":"<p><p>This paper reports a case of an internal jugular venous malformation (IJVM) and route of treatment in a patient with limited symptoms. After history and imaging studies, a determination of surgical excision was made to rule out possible malignancy and future problems such as thrombosis. The mass was resected, and part of the IJVM was ligated. The mass had no identifiable malignancy, and the patient recovered fully with no complications. The paper highlights the importance of identifying venous malformations and highlights the reasoning behind the course of action.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"20 1","pages":"49-53"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repair of Dissecting Aortic Aneurysm in Post-LVAD Patient. 修复 LVAD 术后患者破裂的主动脉瘤
Methodist DeBakey cardiovascular journal Pub Date : 2024-06-06 eCollection Date: 2024-01-01 DOI: 10.14797/mdcvj.1363
Sanjay Chaubey, Parag Kale, Dan Meyer, Aldo Rafael
{"title":"Repair of Dissecting Aortic Aneurysm in Post-LVAD Patient.","authors":"Sanjay Chaubey, Parag Kale, Dan Meyer, Aldo Rafael","doi":"10.14797/mdcvj.1363","DOIUrl":"10.14797/mdcvj.1363","url":null,"abstract":"<p><p>Left ventricular assist devices (LVAD) are frequently used in the management of end-stage heart failure, especially given the limited availability of donor hearts. The latest HeartMate 3 LVAD delivers non-physiological continuous flow (CF), although the impact on the aorta is not well established. We highlight a case of aortic aneurysm formation complicated by dissection formation that necessitated high-risk re-operative surgery in a patient post CF-LVAD.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"20 1","pages":"45-48"},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11160387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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