{"title":"Relapsing Pericarditis: Prediction of Relapses, Risk Scores, and Role of Exercise Restriction.","authors":"Joseph El Roumi, Jibran Ikram, Tom Kai Ming Wang","doi":"10.14797/mdcvj.1777","DOIUrl":"10.14797/mdcvj.1777","url":null,"abstract":"<p><p>Relapsing pericarditis (RP) is a chronic inflammatory disorder characterized by two or more episodes of acute pericarditis flares after a minimum of a 4-week symptom-free period. Recurrent pericarditis develops in approximately 15% to 30% of patients following an initial episode of acute pericarditis, and nearly half of these individuals experience subsequent recurrences. Although the course is heterogeneous, RP has substantial morbidity and impaired quality of life implications and is associated with pericardial complications, including cardiac tamponade and constrictive pericarditis. This review summarizes current knowledge about clinical perspectives, predictors, and risk stratification tools for relapses in RP and critically appraises the evolving role of exercise restriction as part of RP management. Many adverse prognosticators for RP in clinical, laboratory, multimodality cardiac imaging, and treatment factors have been identified from clinical trials, observational studies, and experiences of managing RP patients. Several risk scores have been recently developed to assist in risk stratification and treatment guidance for RP patients, such as the Athens, Torino, INFLA, and Klein scores. There is also growing evidence for exercise restriction strategies with a focus on practical individualized strategies in the multimodal treatment of RP that have been included in recent pericarditis guidance documents. Multicenter external validation and randomized trials remain necessary to assess the roles and performance of risk scores and exercise restriction in treating RP to improve their clinical outcomes.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 2","pages":"14-26"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12985884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of Multimodal Cardiac Imaging in Pericardial Effusions and Tamponade.","authors":"Rohan A Gajjar, Tahir S Kafil, Sushil Allen Luis","doi":"10.14797/mdcvj.1784","DOIUrl":"10.14797/mdcvj.1784","url":null,"abstract":"<p><p>Pericardial effusion represents a common clinical entity encountered across diverse medical settings, with presentations ranging from incidental findings to life-threatening cardiac tamponade. The accurate diagnosis and management of pericardial effusion and its hemodynamically significant sequelae demand a comprehensive multimodality imaging approach. Echocardiography remains the cornerstone of initial evaluation, providing real-time assessment of effusion size, hemodynamic impact, and guidance for therapeutic interventions. This review synthesizes contemporary evidence from major cardiology societies to present a structured approach to the diagnosis and management of pericardial effusion and tamponade. We emphasize the pivotal role of echocardiography while integrating complementary modalities, including cardiac computed tomography and cardiac magnetic resonance imaging. Key echocardiographic findings, Doppler parameters, and imaging-guided therapeutic strategies are discussed in detail, with attention to emerging techniques and evidence-based algorithms. Understanding the multimodality imaging approach is essential for optimizing patient outcomes in this potentially life-threatening condition.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 2","pages":"60-73"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12985857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Otherwise: A Discussion of Jane Kenyon and Her Place in the Medical Humanities.","authors":"Justin C Cordova, James B Young","doi":"10.14797/mdcvj.1717","DOIUrl":"10.14797/mdcvj.1717","url":null,"abstract":"<p><p>Jane Kenyon (1947-1995) died from leukemia in 1995, a writer in her prime whose work was steadily rising in popularity and amassing critical acclaim. Earlier that year, she had been appointed Poet Laureate of New Hampshire and left behind a rich body of work, including \"Otherwise\"-the featured work in this Poet's Pen. Kenyon was married to fellow writer Donald Hall (1928-2018) and wrote this piece in response to her husband's presumptively terminal cancer diagnosis. Though Hall's writings have been used extensively in the medical humanities, an argument can be made that several of Kenyon's works are just as worthy of inclusion. Many of her poems provide important insights into topics like bereavement, caregiving, and mental illness, making them ideally suited for consideration as part of health humanities education.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 2","pages":"117-120"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12985893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hemodynamics of Pericardial Constriction: Role of Echocardiography and Cardiac Catheterization.","authors":"David M Harmon, Jae K Oh","doi":"10.14797/mdcvj.1781","DOIUrl":"10.14797/mdcvj.1781","url":null,"abstract":"<p><p>Constrictive pericarditis is a condition of diastolic heart failure with unique hemodynamic manifestations. While potentially curable if treated appropriately, constrictive pericarditis remains a diagnostic challenge, particularly during early manifestation of disease when there are subtle clinical symptoms and when confounding comorbidities are present. In this focused review, we describe the characteristic and diagnostic hemodynamics of constrictive pericarditis as well as the utility of invasive (cardiac catheterization) and noninvasive (echocardiography) diagnostic testing for this complex disease.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 2","pages":"74-84"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12985938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lamis El Harake, Mohamed Al-Kazaz, Paul C Cremer, Douglas R Johnston
{"title":"Perioperative and Surgical Management of Constrictive Pericarditis.","authors":"Lamis El Harake, Mohamed Al-Kazaz, Paul C Cremer, Douglas R Johnston","doi":"10.14797/mdcvj.1789","DOIUrl":"10.14797/mdcvj.1789","url":null,"abstract":"<p><p>Constrictive pericarditis represents a form of severe diastolic heart failure characterized by impaired diastolic filling due to a rigid, noncompliant pericardium. Surgical pericardiectomy is the definitive treatment for chronic or refractory subacute constrictive pericarditis; however, outcomes vary widely depending on disease etiology, chronicity, myocardial involvement, end-organ dysfunction, and surgical technique. This review summarizes contemporary best practices for the surgical management of constrictive pericarditis, with emphasis on patient selection, timing of intervention, operative approach, and perioperative considerations. Accurate differentiation between inflammatory, transient constrictive phenotypes and irreversible fibrotic disease is central to therapeutic decision-making. Etiology-based risk stratification, assessment of hepatic and renal dysfunction, and careful evaluation of myocardial involvement provide critical prognostic information. Multimodality imaging plays a central role in diagnosis, surgical planning, and identification of patients most likely to benefit from intervention. Radical pericardiectomy is associated with superior functional recovery compared with partial resection, whereas radiation-associated disease, mixed constrictive-restrictive physiology, and advanced end-organ dysfunction are consistently linked to worse outcomes. High-volume centers of excellence in pericardial disease are critical in optimizing results after radical pericardiectomy.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 2","pages":"97-109"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12985804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Coronary Conundrum: Anomalous Pan-Coronary Origin from the Right Sinus with a \"Type X\" Dual LAD.","authors":"Abhinand J, Anil Kumar Choudhary, Neeraj Rao, Shrividya Rao, Devesh Kumar","doi":"10.14797/mdcvj.1775","DOIUrl":"10.14797/mdcvj.1775","url":null,"abstract":"<p><p>A 49-year-old man presented with acute onset chest pain and new-onset right bundle branch block. Echocardiography revealed mild apical hypokinesia with an ejection fraction of 45%. Coronary angiography showed all three major coronary arteries originating from the right coronary sinus with normal flow. Further evaluation identified an obstructed accessory left anterior descending (LAD) artery arising from the left sinus. Successful wire crossing, balloon dilatation, and deployment of a drug-eluting stent restored TIMI 3 flow. Subsequent computed tomography angiography confirmed a rare Type X dual LAD anatomy. This case highlights the importance of recognizing uncommon coronary artery anomalies since they may significantly influence diagnostic and therapeutic strategies.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 1","pages":"19-21"},"PeriodicalIF":0.0,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Left Ventricular Pericardial Strangulation: A Diagnostic Challenge in Acute Coronary Syndrome.","authors":"Sergey Yakovlev, Anna Gvozdeva","doi":"10.14797/mdcvj.1743","DOIUrl":"10.14797/mdcvj.1743","url":null,"abstract":"<p><p>Partial congenital pericardial defects are exceptionally uncommon and typically asymptomatic. In rare circumstances, cardiac herniation through the defect may precipitate mechanical strangulation with extrinsic coronary artery compression and myocardial infarction (MI). We describe a young man who presented with ST-elevation MI attributed to left ventricular (LV) herniation through a previously unrecognized pericardial defect. Despite a typical clinical presentation of MI, the highly atypical angiographic and echocardiographic findings required further investigation. Cardiac magnetic resonance was crucial for excluding alternative causes of LV wall thickening and coronary artery compression, such as tumors or infiltrative diseases, and contributed to identifying the pericardial defect. Although rare, partial pericardial defects should be considered in the differential diagnosis of acute coronary syndrome, especially in young patients with atypical presentations or findings.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 1","pages":"14-18"},"PeriodicalIF":0.0,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12922657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Right Coronary Artery to Coronary Sinus Fistula with Giant Coronary Sinus Aneurysm.","authors":"Damandeep Singh, Niraj Nirmal Pandey, Rakesh Yadav","doi":"10.14797/mdcvj.1771","DOIUrl":"10.14797/mdcvj.1771","url":null,"abstract":"<p><p>Coronary artery fistulas represent abnormal connections between the coronary arterial system and cardiac chambers or other vascular structures. Depending on various morphological characteristics of the fistula, the clinical presentation may vary from being asymptomatic to having clinically significant myocardial ischemia. The present case highlights a rare instance of a right coronary artery to coronary sinus fistula with a giant coronary sinus aneurysm.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 1","pages":"11-13"},"PeriodicalIF":0.0,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12904117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intramyocardial Lipoma of the Left Ventricle: A Diagnostic Conundrum Solved with Multimodality Imaging.","authors":"Arun Sharma, Mansi Verma, Shouvik Paul, Anuja Gadre, Manoj Kumar Rohit, Manphool Singhal","doi":"10.14797/mdcvj.1767","DOIUrl":"10.14797/mdcvj.1767","url":null,"abstract":"<p><p>Intramyocardial lipomas are rare benign cardiac tumors that often present a diagnostic dilemma due to their nonspecific clinical and imaging features on initial evaluation. We report the case of a 40-year-old asymptomatic male who presented with a large intramyocardial lipoma arising from the basal inferior wall of the left ventricle. Initial transthoracic echocardiography revealed an echogenic mass in the region of the left ventricle basal septum but was insufficient for definite characterization. Cross-sectional imaging, including computed tomography (CT) and cardiac magnetic resonance imaging (MRI), demonstrated a homogeneous fat-density mass consistent with lipoma. This case highlights the pivotal role of multimodality imaging in accurately characterizing a rare primary cardiac tumor.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 1","pages":"7-10"},"PeriodicalIF":0.0,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Absent Left Main Coronary Artery with Separate Origin of Left Anterior Descending Artery and Left Circumflex Artery from Left Coronary Sinus.","authors":"Damandeep Singh, Niraj Nirmal Pandey, Neeraj Parakh","doi":"10.14797/mdcvj.1738","DOIUrl":"10.14797/mdcvj.1738","url":null,"abstract":"<p><p>We report a case of a 49-year-old female who presented with atypical chest pain. An electrocardiogram-gated coronary computed tomography angiography revealed the absence of the left main coronary artery segment with direct origin of the left anterior descending artery and the left circumflex artery from the left coronary sinus having separate ostia. The case highlights a rare anomaly of coronary artery origin with procedural implications.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 1","pages":"4-6"},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146054245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}