Marcell Székely, Valeria Duarte, Cindy Martin, Michael J Reardon, Andrea G Quarti
{"title":"Intra-atrial Baffling of an Infradiaphragmatic Scimitar Vein without Circulatory Arrest.","authors":"Marcell Székely, Valeria Duarte, Cindy Martin, Michael J Reardon, Andrea G Quarti","doi":"10.14797/mdcvj.1785","DOIUrl":"10.14797/mdcvj.1785","url":null,"abstract":"<p><p>Scimitar syndrome is a rare congenital anomaly characterized by anomalous right pulmonary venous drainage into the inferior vena cava, resulting in a left-to-right shunt. Surgical correction may be achieved by direct reimplantation of the scimitar vein or by intra-atrial baffling, which often requires deep hypothermic circulatory arrest. We report the case of a 47-year-old man with symptomatic scimitar syndrome and an infradiaphragmatic scimitar vein who underwent successful intra-atrial baffling without circulatory arrest. Preoperative imaging demonstrated a significant shunt with dilation of the right atrium and ventricle. Repair was performed using cardiopulmonary bypass with femoral venous cannulation and vacuum-assisted lower body venous drainage, allowing adequate visualization despite the challenging infradiaphragmatic localization of the anomalous vein without interruption of systemic perfusion. Postoperative echocardiography confirmed unobstructed pulmonary venous return with minimal gradient. The patient had an uneventful recovery and reported symptomatic improvement at 1-year follow-up. This case demonstrates that intra-atrial baffling of an infradiaphragmatic scimitar vein can be safely performed without circulatory arrest using vacuum-assisted venous drainage.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 1","pages":"22-25"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pericarditis in Patients with Autoimmune Disease: Insights into Prevalence and Optimal Management.","authors":"Yeva Fakikh, SaraH Kazzaz, Maan Malahfji","doi":"10.14797/mdcvj.1780","DOIUrl":"10.14797/mdcvj.1780","url":null,"abstract":"<p><p>Initially recognized as a key cardiac feature of systemic lupus erythematosus and rheumatoid arthritis, autoimmune pericarditis has gained increasing attention given the recent advances in cardiac imaging, biomarker assessment, and understanding of immune-mediated mechanisms. The prevalence of pericardial involvement varies considerably among autoimmune diseases. Patients may have a small pericardial effusion that remains clinically silent but could also present with acute, recurrent, or chronic pericarditis. A minority develop severe complications such as tamponade or constrictive physiology. Characterizing autoimmune pericarditis is critical, particularly in an era of expanding immunomodulatory therapies. This review summarizes current knowledge on prevalence, pathophysiology, clinical presentation, and diagnostic strategies, with a particular focus on emerging therapeutics in pericardial disease associated with autoimmune disorders. Integrating rheumatology and cardiology expertise is essential to optimize the care of this heterogeneous patient population.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 2","pages":"50-59"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12985930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation and Management of Post-Cardiotomy Syndrome.","authors":"Massimo Imazio, Mariacristina Tomat","doi":"10.14797/mdcvj.1783","DOIUrl":"10.14797/mdcvj.1783","url":null,"abstract":"<p><p>Post-cardiac injury syndrome (PCIS) encompasses inflammatory pericardial syndromes occurring after cardiac injury, including post-pericardiotomy syndrome (PPS) following cardiac surgery, post-myocardial infarction (Dressler syndrome), and post-traumatic pericarditis. With the expanding use of cardiac surgical and interventional procedures, PCIS has become increasingly prevalent despite a marked decline in Dressler syndrome in the contemporary reperfusion era. The syndrome is believed to result from an immune-mediated inflammatory response to myocardial and pericardial injury, leading to pericarditis with associated pericardial and, often, pleural effusions. Clinical presentation typically occurs days to weeks after the inciting event and includes fever, pleuritic chest pain, elevated inflammatory markers, and imaging evidence of pericardial effusion. Early recognition is essential, as prompt treatment can relieve symptoms and prevent complications such as cardiac tamponade or progression to constrictive pericarditis. First-line therapy consists of high-dose aspirin or nonsteroidal anti-inflammatory drugs combined with colchicine, which accelerates symptom resolution and reduces recurrence. In refractory or recurrent cases, corticosteroids or interleukin-1 inhibitors, such as anakinra, are effective. Prophylactic colchicine administered around the time of cardiac surgery significantly reduces the incidence of post-pericardiotomy syndrome. This review summarizes current evidence and incorporates the 2025 European Society of Cardiology guidelines to guide optimal evaluation and management of PCIS.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 2","pages":"27-40"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12985853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad A Alqahtani, Tom Kai Ming Wang, Allan L Klein
{"title":"Mechanistic Insights and Emerging Therapeutic Strategies in Recurrent Pericarditis.","authors":"Mohammad A Alqahtani, Tom Kai Ming Wang, Allan L Klein","doi":"10.14797/mdcvj.1760","DOIUrl":"10.14797/mdcvj.1760","url":null,"abstract":"<p><p>Recurrent pericarditis is a heterogeneous and often debilitating inflammatory disorder characterized by recurrent flares following a symptom-free interval of at least 4 to 6 weeks. Although most cases in developed countries are idiopathic or post-viral, the condition may arise from autoimmune disease, post-cardiac injury syndromes, infection, or systemic inflammatory disorders. Traditional management with nonsteroidal anti-inflammatory drugs, colchicine, and corticosteroids has historically provided symptomatic relief but is limited by high recurrence rates, steroid dependence, and substantial morbidity. Over the past decade, growing recognition of the central autoinflammatory mechanisms-particularly NOD-like receptor 3 (NLRP3) inflammasome activation and interleukin (IL-1)-mediated signaling-has transformed the therapeutic approach to this condition. The introduction of IL-1 inhibitors, including anakinra and rilonacept, has reshaped contemporary practice by reducing recurrence rates, minimizing corticosteroid dependence, and establishing a precision-based approach to disease activity-guided therapy. The purpose of this review is to synthesize contemporary evidence surrounding the pathophysiology and evolving treatment paradigms for recurrent pericarditis, with a focus on novel targeted therapies.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 2","pages":"4-13"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12985851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"State of the Art in Pericardial Disease.","authors":"Maan Malahfji","doi":"10.14797/mdcvj.1805","DOIUrl":"https://doi.org/10.14797/mdcvj.1805","url":null,"abstract":"","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 2","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12985802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jad Zeitoun, Yeva Fakih, Shahrukh Khan, Taha Jilani, Maan Malahfji
{"title":"Effusive-Constrictive Pericarditis.","authors":"Jad Zeitoun, Yeva Fakih, Shahrukh Khan, Taha Jilani, Maan Malahfji","doi":"10.14797/mdcvj.1786","DOIUrl":"10.14797/mdcvj.1786","url":null,"abstract":"<p><p>Multimodality imaging is used to diagnose a patient with prior acute pericarditis and demonstrated effusive-constrictive physiology characterized by pericardial thickening with effusion, pericardial enhancement consistent with active inflammation, and ventricular interdependence. These findings highlight the complementary role of cardiac magnetic resonance in the diagnosis and management of inflammatory constrictive pericardial disease.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 2","pages":"114-116"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12985896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Malignant Pericardial Effusion: Heart-Breaking Tumors.","authors":"Mohammed A R Chamsi-Pasha","doi":"10.14797/mdcvj.1761","DOIUrl":"10.14797/mdcvj.1761","url":null,"abstract":"<p><p>Pericardial effusion secondary to an underlying neoplasm carries a poor prognosis because it often represents an advanced stage of malignancy. In approximately one-third of affected patients, the initial presentation may be cardiac tamponade.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 2","pages":"110-113"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12985846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of Cardiac MRI and CT in Pericarditis and Pericardial Constriction.","authors":"Kazim Baser, Nisha Ali, Yeva Fakikh, Sadeer Al-Kindi, Mouaz Al-Mallah, Dipan Shah, Maan Malahfji","doi":"10.14797/mdcvj.1779","DOIUrl":"10.14797/mdcvj.1779","url":null,"abstract":"<p><p>Pericardial diseases span a spectrum from acute and recurrent pericarditis to chronic constrictive pericarditis. While echocardiography remains the first-line test in the evaluation of patients with suspected pericardial disease, advanced cardiac imaging with cardiac magnetic resonance and computed tomography have become complementary and often essential in refining diagnosis and guiding management in many patients. The recent Concise Clinical Guidance Statement from the American College of Cardiology as well as updated European Society of Cardiology guidelines have given new emphasis and recommendations on the use of advanced imaging in both pericarditis and pericardial constriction. This review summarizes the techniques, indications, and recent studies on the use of advanced cardiac imaging in pericarditis and pericardial constriction.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 2","pages":"41-49"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12985800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Envisioning the Heart.","authors":"Philip Alexander, Muhammad Umair","doi":"10.14797/mdcvj.1758","DOIUrl":"10.14797/mdcvj.1758","url":null,"abstract":"<p><p>Philip Alexander, MD, is a native Texan, retired physician, and accomplished musician and artist. After 41 years as an internal medicine physician, Dr. Phil retired from his practice in College Station in 2016. A lifelong musician and former music professor, he often performs as an oboe soloist for the Brazos Valley Symphony Orchestra. He began exploring visual art in 1980, evolving from pencil sketches-including an official White House portrait of President Ronald Reagan-to the computer-generated drawings featured in this journal. His images, which first appeared in this journal in the spring of 2012, are his own original creations. This issue of the <i>Journal</i> also includes an artistic submission by Muhammad Umair, MD, assistant professor of radiology at the New York Presbyterian Hospital-Columbia University, whose work focuses on cardiovascular imaging (MRI and CT). He adds that he \"sometimes indulges in abstract paintings, inspired by his work in cardiac and vascular imaging.\" If you would like to see your art published in the <i>Methodist DeBakey Cardiovascular Journal</i>, submit your creation online at journal.houstonmethodist.org as a \"Humanities\" entry.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 2","pages":"121-123"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12985801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Constrictive Pericarditis and Effusive Constrictive Pericarditis: Is There a Role for Medical Therapy?","authors":"Lamis El Harake, Mohamed Al-Kazaz, Paul C Cremer","doi":"10.14797/mdcvj.1788","DOIUrl":"10.14797/mdcvj.1788","url":null,"abstract":"<p><p>Constrictive pericarditis (CP) represents a spectrum of pericardial diseases characterized by impaired ventricular filling due to a noncompliant pericardium. Within this continuum, effusive constrictive pericarditis (ECP) and transient constrictive pericarditis are characterized by active inflammation. ECP combines pericardial effusion and constrictive physiology, whereas transient constrictive pericarditis is characterized by resolution, often after anti-inflammatory therapy. These conditions often result from idiopathic, post-surgical, autoimmune, or tuberculous causes and may progress from acute inflammation to chronic fibrosis and calcification, termed chronic constrictive pericarditis. Multimodality imaging, including echocardiography, cardiac magnetic resonance imaging, and cardiac computed tomography, plays a key role in establishing the diagnosis, assessing inflammation, and guiding treatment. In patients with active pericardial inflammation, increasing evidence and practice supports the early and combined initiation of anti-inflammatory therapy including nonsteroidal agents, colchicine, corticosteroids, and interleukin-1 inhibitors to reverse constrictive pathophysiology.</p>","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"22 2","pages":"85-96"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12985894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}