Methodist DeBakey cardiovascular journal最新文献_第10页

In Flanders Fields: John McCrae as Physician, Poet, Soldier. 《佛兰德斯战场》:约翰·麦克雷饰演的医生、诗人和士兵。

Methodist DeBakey cardiovascular journal Pub Date : 2023-11-16 eCollection Date: 2023-01-01 DOI: 10.14797/mdcvj.1283

James C Young

引用次数: 0

Networks that Govern Cardiomyocyte Proliferation to Facilitate Repair of the Injured Mammalian Heart. 调控心肌细胞增殖促进哺乳动物心脏损伤修复的网络。

Methodist DeBakey cardiovascular journal Pub Date : 2023-11-16 eCollection Date: 2023-01-01 DOI: 10.14797/mdcvj.1300

Daniel J Garry, Jianyi Jay Zhang, Thijs A Larson, Hesham A Sadek, Mary G Garry

{"title":"Networks that Govern Cardiomyocyte Proliferation to Facilitate Repair of the Injured Mammalian Heart.","authors":"Daniel J Garry, Jianyi Jay Zhang, Thijs A Larson, Hesham A Sadek, Mary G Garry","doi":"10.14797/mdcvj.1300","DOIUrl":"10.14797/mdcvj.1300","url":null,"abstract":"Cardiovascular diseases are the number one cause of death worldwide and in the United States (US). Cardiovascular diseases frequently progress to end-stage heart failure, and curative therapies are extremely limited. Intense interest has focused on deciphering the cascades and networks that govern cardiomyocyte proliferation and regeneration of the injured heart. For example, studies have shown that lower organisms such as the adult newt and adult zebrafish have the capacity to completely regenerate their injured heart with restoration of function. Similarly, the neonatal mouse and pig are also able to completely regenerate injured myocardium due to cardiomyocyte proliferation from preexisting cardiomyocytes. Using these animal models and transcriptome analyses, efforts have focused on the definition of factors and signaling pathways that can reactivate and induce cardiomyocyte proliferation in the adult mammalian injured heart. These studies and discoveries have the potential to define novel therapies to promote cardiomyocyte proliferation and repair of the injured, mammalian heart.","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"19 5","pages":"16-25"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging the Translational Gap in Heart Failure Research: Using Human iPSC-derived Cardiomyocytes to Accelerate Therapeutic Insights. 弥合心力衰竭研究的翻译差距:使用人类ipsc衍生的心肌细胞加速治疗见解。

Methodist DeBakey cardiovascular journal Pub Date : 2023-11-16 eCollection Date: 2023-01-01 DOI: 10.14797/mdcvj.1295

Leslye Venegas-Zamora, Matthew Fiedler, William Perez, Francisco Altamirano

{"title":"Bridging the Translational Gap in Heart Failure Research: Using Human iPSC-derived Cardiomyocytes to Accelerate Therapeutic Insights.","authors":"Leslye Venegas-Zamora, Matthew Fiedler, William Perez, Francisco Altamirano","doi":"10.14797/mdcvj.1295","DOIUrl":"10.14797/mdcvj.1295","url":null,"abstract":"Heart failure (HF) remains a leading cause of death worldwide, with increasing prevalence and burden. Despite extensive research, a cure for HF remains elusive. Traditionally, the study of HF's pathogenesis and therapies has relied heavily on animal experimentation. However, these models have limitations in recapitulating the full spectrum of human HF, resulting in challenges for clinical translation. To address this translational gap, research employing human cells, especially cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC-CMs), offers a promising solution. These cells facilitate the study of human genetic and molecular mechanisms driving cardiomyocyte dysfunction and pave the way for research tailored to individual patients. Further, engineered heart tissues combine hiPSC-CMs, other cell types, and scaffold-based approaches to improve cardiomyocyte maturation. Their tridimensional architecture, complemented with mechanical, chemical, and electrical cues, offers a more physiologically relevant environment. This review explores the advantages and limitations of conventional and innovative methods used to study HF pathogenesis, with a primary focus on ischemic HF due to its relative ease of modeling and clinical relevance. We emphasize the importance of a collaborative approach that integrates insights obtained in animal and hiPSC-CMs-based models, along with rigorous clinical research, to dissect the mechanistic underpinnings of human HF. Such an approach could improve our understanding of this disease and lead to more effective treatments.","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"19 5","pages":"5-15"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic Regulation of Angiogenesis in Peripheral Artery Disease. 外周动脉疾病血管生成的表观遗传调控。

Methodist DeBakey cardiovascular journal Pub Date : 2023-11-16 eCollection Date: 2023-01-01 DOI: 10.14797/mdcvj.1294

Naseeb Kaur Malhi, Kevin W Southerland, Li Lai, Zhen Bouman Chen

{"title":"Epigenetic Regulation of Angiogenesis in Peripheral Artery Disease.","authors":"Naseeb Kaur Malhi, Kevin W Southerland, Li Lai, Zhen Bouman Chen","doi":"10.14797/mdcvj.1294","DOIUrl":"10.14797/mdcvj.1294","url":null,"abstract":"Peripheral arterial disease (PAD) represents a global health concern with a rising prevalence attributed to factors such as obesity, diabetes, aging, and smoking. Among patients with PAD, chronic limb-threatening ischemia (CLTI) is the most severe manifestation, associated with substantial morbidity and mortality. While revascularization remains the primary therapy for CLTI, not all patients are candidates for such interventions, highlighting the need for alternative approaches. Impaired angiogenesis, the growth of new blood vessels, is a central feature of PAD, and despite decades of research, effective clinical treatments remain elusive. Epigenetics, the study of heritable changes in gene expression, has gained prominence in understanding PAD pathogenesis. Here, we explore the role of epigenetic regulation in angiogenesis within the context of PAD, with a focus on long non-coding RNAs and fibroblast-endothelial cell transdifferentiation. Additionally, we discuss the interplay between metabolic control and epigenetic regulation, providing insights into potential novel therapeutic avenues for improving PAD treatments. This review aims to offer a concise update on the application of epigenetics in angiogenesis and PAD research, inspiring further investigations in this promising field.","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"19 5","pages":"47-57"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic Control of Cardiomyocyte Cell Cycle. 心肌细胞周期的代谢控制。

Methodist DeBakey cardiovascular journal Pub Date : 2023-11-16 eCollection Date: 2023-01-01 DOI: 10.14797/mdcvj.1309

Ivan Menendez-Montes, Daniel J Garry, Jianyi Jay Zhang, Hesham A Sadek

引用次数: 0

ChatGPT and Artificial Intelligence in Hospital Level Research: Potential, Precautions, and Prospects. ChatGPT和人工智能在医院层面的研究:潜力、注意事项和前景。

Methodist DeBakey cardiovascular journal Pub Date : 2023-11-16 eCollection Date: 2023-01-01 DOI: 10.14797/mdcvj.1290

Hassaan B Arshad, Sara A Butt, Safi U Khan, Zulqarnain Javed, Khurram Nasir

{"title":"ChatGPT and Artificial Intelligence in Hospital Level Research: Potential, Precautions, and Prospects.","authors":"Hassaan B Arshad, Sara A Butt, Safi U Khan, Zulqarnain Javed, Khurram Nasir","doi":"10.14797/mdcvj.1290","DOIUrl":"https://doi.org/10.14797/mdcvj.1290","url":null,"abstract":"Rapid advancements in artificial intelligence (AI) have revolutionized numerous sectors, including medical research. Among the various AI tools, OpenAI's ChatGPT, a state-of-the-art language model, has demonstrated immense potential in aiding and enhancing research processes. This review explores the application of ChatGPT in medical hospital level research, focusing on its capabilities for academic writing assistance, data analytics, statistics handling, and code generation. Notably, it delves into the model's ability to streamline tasks, support decision making, and improve patient interaction. However, the article also underscores the importance of exercising caution while dealing with sensitive healthcare data and highlights the limitations of ChatGPT, such as its potential for erroneous outputs and biases. Furthermore, the review discusses the ethical considerations that arise with AI use in health care, including data privacy, AI interpretability, and the risk of AI-induced disparities. The article culminates by envisioning the future of AI in medical research, emphasizing the need for robust regulatory frameworks and guidelines that balance the potential of AI with ethical considerations. As AI continues to evolve, it holds promising potential to augment medical research in a manner that is ethical, equitable, and patient-centric.","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"19 5","pages":"77-84"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138465515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Exercise and Ischemia-Activated Pathways in Limb Muscle Angiogenesis and Vascular Regeneration. 肢体肌肉血管生成和血管再生中的运动和缺血激活途径。

Methodist DeBakey cardiovascular journal Pub Date : 2023-11-16 eCollection Date: 2023-01-01 DOI: 10.14797/mdcvj.1304

Vihang A Narkar

{"title":"Exercise and Ischemia-Activated Pathways in Limb Muscle Angiogenesis and Vascular Regeneration.","authors":"Vihang A Narkar","doi":"10.14797/mdcvj.1304","DOIUrl":"10.14797/mdcvj.1304","url":null,"abstract":"Exercise has a profound effect on cardiovascular disease, particularly through vascular remodeling and regeneration. Peripheral artery disease (PAD) is one such cardiovascular condition that benefits from regular exercise or rehabilitative physical therapy in terms of slowing the progression of disease and delaying amputations. Various rodent pre-clinical studies using models of PAD and exercise have shed light on molecular pathways of vascular regeneration. Here, I review key exercise-activated signaling pathways (nuclear receptors, kinases, and hypoxia inducible factors) in the skeletal muscle that drive paracrine regenerative angiogenesis. The rationale for highlighting the skeletal muscle is that it is the largest organ recruited during exercise. During exercise, skeletal muscle releases several myokines, including angiogenic factors and cytokines that drive tissue vascular regeneration via activation of endothelial cells, as well as by recruiting immune and endothelial progenitor cells. Some of these core exercise-activated pathways can be extrapolated to vascular regeneration in other organs. I also highlight future areas of exercise research (including metabolomics, single cell transcriptomics, and extracellular vesicle biology) to advance our understanding of how exercise induces vascular regeneration at the molecular level, and propose the idea of \"exercise-mimicking\" therapeutics for vascular recovery.","PeriodicalId":39207,"journal":{"name":"Methodist DeBakey cardiovascular journal","volume":"19 5","pages":"58-68"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reaching Beyond. 超越。

Methodist DeBakey cardiovascular journal Pub Date : 2023-11-16 eCollection Date: 2023-01-01 DOI: 10.14797/mdcvj.1293

Philip Alexander

引用次数: 0

Iatrogenic Left Ventricle Outflow Tract Ventricular Tachycardia Following Transcatheter Aortic Valve Replacement: A Case Series. 经导管主动脉瓣置换术后医源性左心室流出道室性心动过速：一个病例系列。

Methodist DeBakey cardiovascular journal Pub Date : 2023-10-20 eCollection Date: 2023-01-01 DOI: 10.14797/mdcvj.1284

Ahmed Hassaan Qavi, Aditi Naniwadekar, Neeraj N Shah

引用次数: 0

Triple Threat: Triple-Valve Endocarditis Case Report and Literature Review. 三重威胁：三瓣膜心内膜炎病例报告及文献复习。

Methodist DeBakey cardiovascular journal Pub Date : 2023-10-12 eCollection Date: 2023-01-01 DOI: 10.14797/mdcvj.1277

Kiriti S Vattikonda, Christopher J Peterson, Jordan L Torres, Michael Sternberg, Ijeoma Okogbue, Anthony Baffoe-Bonnie, Tasaduq Fazili

引用次数: 0