Current Urology最新文献

{"title":"Androgen receptor signaling-mitochondrial DNA-oxidative phosphorylation: A critical triangle in early prostate cancer.","authors":"Minas Sakellakis,&nbsp;Laura Jacqueline Flores","doi":"10.1097/CU9.0000000000000120","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000120","url":null,"abstract":"<p><p>Mitochondria are more than just the cellular powerhouse. They also play key roles in vital functions such as apoptosis, metabolism regulation, and other intracellular interactions. The mitochondrial DNA (mtDNA) encodes for 12 subunits of the oxidative phosphorylation (OXPHOS) system. Depletion of mtDNA in androgen-dependent prostate cancer (PCa) cell lines renders them androgen-independent and more aggressive. Paradoxically, pharmaceutical inhibition of OXPHOS is lethal for subsets of PCa cells, whereas others become dependent on androgen receptor (AR) signaling for survival. Given that the AR-mitochondria interaction is critical for early PCa, it is crucial to understand the details of this interaction. Technical hurdles have made mitochondria traditionally difficult to study, with many techniques used for isolation masking the properties of given individual mitochondria. Although the isolation of mitochondria enables us to study OXPHOS, we miss the context in which mitochondria interact with the rest of the cell. Both AR signaling and mtDNA affect apoptosis, metabolism regulation, cellular calcium storage and homeostasis, intracellular calcium signaling, and redox homeostasis. In this review, we will attempt to understand how the crosstalk between AR-mtDNA-OXPHOS is responsible for \"life or death\" decisions inside the cells. Our aim is to point toward potential vulnerabilities that can lead to the discovery of novel therapeutic targets.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"16 4","pages":"207-212"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2b/46/curr-urol-16-207.PMC9875216.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9151718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in rates of pelvic lymph node dissection in National Comprehensive Cancer Network favorable, unfavorable intermediate- and high-risk prostate cancer across United States SEER registries.","authors":"Rocco Simone Flammia,&nbsp;Benedikt Hoeh,&nbsp;Francesco Chierigo,&nbsp;Lukas Hohenhorst,&nbsp;Gabriele Sorce,&nbsp;Zhen Tian,&nbsp;Costantino Leonardo,&nbsp;Markus Graefen,&nbsp;Carlo Terrone,&nbsp;Fred Saad,&nbsp;Shahrokh F Shariat,&nbsp;Alberto Briganti,&nbsp;Francesco Montorsi,&nbsp;Felix K H Chun,&nbsp;Michele Gallucci,&nbsp;Pierre I Karakiewicz","doi":"10.1097/CU9.0000000000000132","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000132","url":null,"abstract":"<p><strong>Background: </strong>The National Comprehensive Cancer Network (NCCN) guidelines recommend pelvic lymph node dissection (PLND) in NCCN high- and intermediate-risk prostate cancer patients. We tested for PLND nonadherence (no-PLND) rates within the Surveillance Epidemiology and End Results (2010-2015).</p><p><strong>Materials and methods: </strong>We identified all radical prostatectomy patients who fulfilled the NCCN PLND guideline criteria (n = 23,495). Nonadherence rates to PLND were tabulated and further stratified according to NCCN risk subgroups, race/ethnicity, geographic distribution, and year of diagnosis.</p><p><strong>Results: </strong>Overall, the no-PLND rate was 26%; it was 41%, 25%, and 11% in the NCCN intermediate favorable, intermediate unfavorable, and high-risk prostate cancer patients, respectively (<i>p</i> < 0.001). Over time, the no-PLND rates declined in the overall cohort and within each NCCN risk subgroup. Georgia exhibited the highest no-PLND rate (49%), whereas New Jersey exhibited the lowest (15%). Finally, no-PLND race/ethnicity differences were recorded only in the NCCN intermediate unfavorable subgroup, where Asians exhibited the lowest no-PLND rate (20%) versus African Americans (27%) versus Whites (26%) versus Hispanic-Latinos (25%).</p><p><strong>Conclusions: </strong>The lowest no-PLND rates were recorded in the NCCN high-risk patients followed by NCCN intermediate unfavorable and favorable risk in that order. Our findings suggest that unexpectedly elevated differences in no-PLND rates warrant further examination. In all the NCCN risk subgroups, the no-PLND rates decreased over time.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"16 4","pages":"191-196"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/c7/curr-urol-16-191.PMC9875209.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9151722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ABO blood group and unfavorable prostate cancer features after radical prostatectomy: Retrospective study of 1149 patients.","authors":"Antonio Benito Porcaro,&nbsp;Nelia Amigoni,&nbsp;Riccardo Rizzetto,&nbsp;Filippo Migliorini,&nbsp;Alessandro Tafuri,&nbsp;Pierluigi Piccoli,&nbsp;Leone Tiso,&nbsp;Mario De Michele,&nbsp;Alberto Bianchi,&nbsp;Sebastian Gallina,&nbsp;Paola Irene Ornaghi,&nbsp;Rossella Orlando,&nbsp;Francesco Cianflone,&nbsp;Alessandra Gozzo,&nbsp;Stefano Zecchini Antoniolli,&nbsp;Vincenzo Lacola,&nbsp;Matteo Brunelli,&nbsp;Maria Angela Cerruto,&nbsp;Walter Artibani,&nbsp;Alessandro Antonelli","doi":"10.1097/CU9.0000000000000146","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000146","url":null,"abstract":"<p><strong>Objectives: </strong>To test hypothesized associations between the ABO blood group (ABO-bg) system and the pathological features of prostate cancer (PCa).</p><p><strong>Material and methods: </strong>Between January 2013 and September 2019, 1173 patients underwent radical prostatectomy. Associations between ABO-bg levels and pathological features were evaluated using statistical methods.</p><p><strong>Results: </strong>Overall, 1149 consecutive patients were evaluated using the ABO-bg system, which was represented by O-bg (42.8%) and A-bg (41.3%), followed by B-bg (11.1%) and AB-bg (4.8%). Only positive surgical margins (PSMs) was correlated with ABO-bg (Pearson correlation coefficient, <i>r</i> = 0.071; <i>p</i> = 0.017), and the risk was increased in group-O (odds ratio [OR], 1.497; 95% confidence interval, 1.149-1.950; <i>p</i> = 0.003) versus non-O-bg. In clinical and pathological models, O-bg was at increased risk of PSM after the adjustment for prostate-specific antigen, percentage of biopsy-positive cores, and high surgical volume (adjusted OR, 1.546; 95% confidence interval, 1.180-2.026; <i>p</i> = 0.002); however, the adjusted OR did not change after the adjustment for tumor load and stage as well as high surgical volume.</p><p><strong>Conclusions: </strong>In clinical PCa, the risk of PSM was higher in O-bg versus non-O-bg patients after the adjustment for standard predictors. Confirmatory studies are needed to confirm the association between ABO-bg and unfavorable PCa features.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"16 4","pages":"256-261"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/35/curr-urol-16-256.PMC9875211.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9137317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ductal prostate cancer: Clinical features and outcomes from a multicenter retrospective analysis and overview of the current literature.","authors":"Salvatore Cozzi,&nbsp;Lilia Bardoscia,&nbsp;Masoumeh Najafi,&nbsp;Sefik Igdem,&nbsp;Luca Triggiani,&nbsp;Stefano Maria Magrini,&nbsp;Andrea Botti,&nbsp;Ferran Guedea,&nbsp;Laura Melocchi,&nbsp;Patrizia Ciammella,&nbsp;Cinzia Iotti,&nbsp;Cristina Gutierrez","doi":"10.1097/CU9.0000000000000118","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000118","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study is to evaluate clinical features and outcomes after different therapeutic strategies for ductal prostate adenocarcinoma (DPC), a rare but aggressive subtype of invasive prostate cancer (PCa) accounting for, in the pure and mixed form, 1% or less and 5% or less, respectively, of all the newly diagnosed PCa.</p><p><strong>Materials and methods: </strong>Patients with a proven diagnosis of DPC undergoing surgery, radiotherapy, and androgen deprivation therapy, alone or in combination, were considered for this multicenter, retrospective study. The study assessed overall survival (OS), disease-free survival (DFS), and age-related disease-specific survival.</p><p><strong>Results: </strong>Eighty-one patients met the study inclusion criteria. Pure DPC was found in 29 patients (36%) and mixed ductal-acinar-PCa in 52 patients (64%). After a median follow-up of 63 months (range, 3-206 months), 3- and 5-year OS rates were 84% and 67%, respectively, and 3- and 5-year DFS rates were 54% and 34%, respectively. There were no significant differences in OS or DFS between the pure and mixed DPC groups. Pure DPC was associated with a higher rate of metastatic disease at onset. Patients 74 years or younger had better disease-specific survival (<i>p</i>=0.0019). A subgroup analysis favored radiotherapy as the primary treatment for nonmetastatic, organ-confined DPC (3- and 5-year DFS of 80% and 50%, respectively, compared with 5-year DFS of 35% for surgical patients; <i>p</i> = 0.023).</p><p><strong>Conclusions: </strong>Our study found DPC to be rarer, more aggressive, more likely to metastasize, and have a worse prognosis than the common acinar variant, especially in its pure form. Multicenter series are encouraged to obtain large data sets, or propensity score matching analyses with patients with conventional PCa are desirable to understand the best therapeutic approach and improve outcomes.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"16 4","pages":"218-226"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/0d/curr-urol-16-218.PMC9875213.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9137319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The unique landscape of coronavirus disease 2019 coagulopathy and imminent bleedings at unusual sites: Pathophysiology matters.","authors":"Eleni Paschou,&nbsp;Achilleas Betsikos,&nbsp;Georgios Zagkotsis,&nbsp;Nikolaos Sabanis","doi":"10.1097/CU9.0000000000000153","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000153","url":null,"abstract":"We read with great interest the article by Presicce et al. [1] entitled “ Wunderlich syndrome, an unexpected urological complication in a patient with coronavirus disease 2019 (COVID-19): A case report. ” The authors aimed to shed light on the pathophysiology, dif-ferential diagnosis, and management of a rare urological bleeding complication in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Although the findings of the present case study were also discussed in a well-written article by Singh et al., [2] we believe that several issues need to be highlighted and further clarified in this underrecognized field. First, both Presicce et al.","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"16 4","pages":"262-264"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f0/ef/curr-urol-16-262.PMC9875208.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9137320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the component-based operative time learning curve for robotic-assisted radical prostatectomy.","authors":"David Ambinder,&nbsp;Shu Wang,&nbsp;Mohummad Minhaj Siddiqui","doi":"10.1097/CU9.0000000000000119","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000119","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the learning curve (LC) of total operative time and the discrete components of the robotic-assisted radical prostatectomy (RARP) for a recent robotic fellowship-trained urologic surgeon.</p><p><strong>Materials and methods: </strong>We performed a retrospective analysis of RARP procedures performed by a single new attending surgeon from August 2015 to April 2019. Patients' demographics and operative details were assessed. Total operative time was divided and prospectively recorded in 7 parts: (<i>a</i>) docking robot, (<i>b</i>) dissecting seminal vesicles (SVs) (<i>c</i>) dissecting endopelvic fascia (EPF), (<i>d</i>) incising bladder neck (BN), (<i>e</i>) completing the dissection, (<i>f</i>) lymph node dissection, and (<i>g</i>) urethrovesical anastomosis (UVA) and robot undocking. Cumulative sum analysis was used to ascertain the LC for total operative time and the 7 parts of the procedure.</p><p><strong>Results: </strong>One hundred twenty consecutive RARPs were performed. The LC was overcome at 25 cases for total operative time, 13 cases for docking the robot, 33 cases for dissecting SVs, 31 cases for dissecting EPF, 46 cases for incising BN, 38 cases for prostate dissection, 25 cases for lymph node dissection, and 52 cases for UVA. Total operative time was decreased 22.8% (<i>p</i> < 0.0001) and time for robot docking, dissecting SVs, dissecting EPF, incising BN, completing prostate dissection, lymph node dissection, and UVA were decreased 16.7%, 30.5%, 29.5%, 36.2%, 37.3%, 32.2%, and 26.9%, respectively (all <i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>We observed a 25-case LC for a fellowship-trained urologist to achieve stable operative performance of RARP surgery. Procedural components demonstrated variable LCs including the UVA that required upward of 52 cases.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"16 4","pages":"240-245"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ba/7a/curr-urol-16-240.PMC9875207.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10586723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 on urology services at a quaternary referral center in Johannesburg, South Africa","authors":"C. Christofides, M. Carides, M. Masa, J. Zamparini, Ahmed Adam","doi":"10.1097/cu9.0000000000000168","DOIUrl":"https://doi.org/10.1097/cu9.0000000000000168","url":null,"abstract":"","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49097261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of Guy's stone score in evaluation and outcome of percutaneous nephrolithotomy","authors":"R. Kapoor, D. Mane, Siddharth Jai Singh, V. Satav, V. Sabale, P. Ranjan","doi":"10.1097/cu9.0000000000000165","DOIUrl":"https://doi.org/10.1097/cu9.0000000000000165","url":null,"abstract":"","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48862492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is reducing the early postoperative complications of percutaneous suprapubic catheterization affected by the method of healthcare education in low-literacy patients? A prospective randomized comparative study","authors":"R. Gadelkareem, S. Abozead, Rasha Abozead Khalaf, N. Mohammed, S. Khalil","doi":"10.1097/cu9.0000000000000151","DOIUrl":"https://doi.org/10.1097/cu9.0000000000000151","url":null,"abstract":"","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47483032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive visual report of urodynamic study in rats with spinal cord injury","authors":"H. Salehi-pourmehr, J. Mahmoudi, Arman Saeedi Vahdat, S. Hajebrahimi, N. Abolhasanpour","doi":"10.1097/cu9.0000000000000150","DOIUrl":"https://doi.org/10.1097/cu9.0000000000000150","url":null,"abstract":"","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43675254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}