{"title":"Dysregulation and implications of N6-methyladenosine modification in renal cell carcinoma.","authors":"Yaohai Wu, Shiqiang Zhang, Chujie Chen, Jun Pang","doi":"10.1097/CU9.0000000000000135","DOIUrl":null,"url":null,"abstract":"<p><p>Increasing evidence indicates that N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) methylation modification serves important functions in biological metabolism. Dysregulation of m<sup>6</sup>A regulators is related to the progression of different malignancies, including renal cell carcinoma (RCC). Recent studies have reported preliminary findings on the influence of m<sup>6</sup>A regulator dysregulation on RCC tumorigenesis and development. However, no comprehensive review that integrates and analyzes the roles of m<sup>6</sup>A modification in RCC has been published to date. In this review, we focus on the dysregulation of m<sup>6</sup>A regulators as it relates to RCC tumorigenesis and development, as well as possible applications of m<sup>6</sup>A modification in RCC diagnosis and therapeutics.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"17 1","pages":"45-51"},"PeriodicalIF":0.9000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/51/76/curr-urol-17-45.PMC10487297.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Urology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/CU9.0000000000000135","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Increasing evidence indicates that N6-methyladenosine (m6A) methylation modification serves important functions in biological metabolism. Dysregulation of m6A regulators is related to the progression of different malignancies, including renal cell carcinoma (RCC). Recent studies have reported preliminary findings on the influence of m6A regulator dysregulation on RCC tumorigenesis and development. However, no comprehensive review that integrates and analyzes the roles of m6A modification in RCC has been published to date. In this review, we focus on the dysregulation of m6A regulators as it relates to RCC tumorigenesis and development, as well as possible applications of m6A modification in RCC diagnosis and therapeutics.
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