Current Urology最新文献

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Expression of HER2 in urothelial carcinoma and its significance. HER2在尿路上皮癌中的表达及其意义。
IF 0.9 4区 医学
Current Urology Pub Date : 2025-05-01 Epub Date: 2024-05-27 DOI: 10.1097/CU9.0000000000000249
Yao Chang, Delong Zhao, Zicheng Wang, Kejia Zhu, Andong Guo, Jishuang Cao, Chenrui Wu, Sentai Ding
{"title":"Expression of HER2 in urothelial carcinoma and its significance.","authors":"Yao Chang, Delong Zhao, Zicheng Wang, Kejia Zhu, Andong Guo, Jishuang Cao, Chenrui Wu, Sentai Ding","doi":"10.1097/CU9.0000000000000249","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000249","url":null,"abstract":"<p><strong>Objectives: </strong>We explored the expression levels and clinical significance of human epidermal growth factor receptor 2 (HER2) in urothelial carcinoma (UC) tissues.</p><p><strong>Materials and methods: </strong>Patient data were reviewed, and 111 paraffin specimens of UC obtained from the Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, from 2020 to 2021 were collected. Immunohistochemistry was used to detect HER2 protein expression in all UC tumor tissues. The <i>χ</i> <sup>2</sup> and Fisher exact tests were used to analyze the relationship between HER2 protein expression and clinicopathological data (sex, age, histopathological diagnosis, invasiveness, histopathological grade, maximum tumor diameter, muscle invasion, regional lymph node metastasis, and clinical stage).</p><p><strong>Results: </strong>In this study, 92 cases (82.88%) showed HER2 protein expression, and there was a statistically significant difference in the distribution of HER2 positivity (immunohistochemistry 2+ and 3+) according to the pathological grades of UC (<i>p</i> = 0.021). Human epidermal growth factor receptor 2 positivity was not associated with sex, age, histopathological diagnosis, invasiveness, maximum tumor diameter, muscle invasion, regional lymph node metastasis, or clinical stage (all <i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Human epidermal growth factor receptor 2 protein is highly expressed in UC, and its expression may be closely related to the high pathological grade of UC.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"19 3","pages":"201-207"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stereotactic body irradiation for metastasis from renal carcinoma: A retrospective study. 立体定向身体照射治疗肾癌转移的回顾性研究
IF 0.9 4区 医学
Current Urology Pub Date : 2025-05-01 Epub Date: 2023-03-28 DOI: 10.1097/CU9.0000000000000191
Hanan Rida, Hind Zaine, Hassan Jouhadi, Abdellatif Benider, Hamza Samlali, Redouane Samlali
{"title":"Stereotactic body irradiation for metastasis from renal carcinoma: A retrospective study.","authors":"Hanan Rida, Hind Zaine, Hassan Jouhadi, Abdellatif Benider, Hamza Samlali, Redouane Samlali","doi":"10.1097/CU9.0000000000000191","DOIUrl":"10.1097/CU9.0000000000000191","url":null,"abstract":"<p><strong>Background: </strong>Renal cell carcinoma (RCC) has traditionally been considered to be radioresistant. Response rates are believed to be improved by a high dose of stereotactic body radiotherapy (SBRT). A retrospective analysis was conducted of patients treated with SBRT for metastatic disease from RCC.</p><p><strong>Material and methods: </strong>We reviewed records from 20 patients who underwent SBRT for a total of 30 RCC metastases from 2015 to 2020. Patients were included who had a confirmed primary RCC and radiographic evidence of metastasis, either synchronous or metachronous. The most common SBRT fractionation was 30 Gy in 3 fractions.</p><p><strong>Results: </strong>Median age was 60 years (range, 40-77 years) and 60% were male. After a median follow-up of 18 months (range, 3-36 months), overall survival was estimated to be 85% and 70%, at 1 and 2 years, respectively, and local control at 2 years was 83.33%. Only 5 patients had documented progression of disease, all of whom received biologically effective dose inferior to 100 Gy, and no patients treated with a higher biologically effective dose had disease, which progressed. The most common acute toxicity was grade 1 fatigue (20%). No grade 3 or higher acute toxicity occurred.</p><p><strong>Conclusions: </strong>Treatment with SBRT in patients with RCC metastases yielded a high local control rate, promising survival rate, and low toxicity.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":" ","pages":"187-191"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46822546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robot-assisted laparoscopic retroperitoneal lymph node dissection in testicular cancer using a single-position supine approach: A case report and literature review. 机器人辅助腹腔镜腹膜后淋巴结清扫在睾丸癌中使用单位仰卧入路:一例报告和文献复习。
IF 0.9 4区 医学
Current Urology Pub Date : 2025-05-01 Epub Date: 2024-07-30 DOI: 10.1097/CU9.0000000000000255
Lei Zhou, Kun Yao, Chao Li, Wei Xiong, Weibin Hou, Bingzhi Wang, Long Xu, Long Wang
{"title":"Robot-assisted laparoscopic retroperitoneal lymph node dissection in testicular cancer using a single-position supine approach: A case report and literature review.","authors":"Lei Zhou, Kun Yao, Chao Li, Wei Xiong, Weibin Hou, Bingzhi Wang, Long Xu, Long Wang","doi":"10.1097/CU9.0000000000000255","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000255","url":null,"abstract":"<p><p>This case study demonstrates a single-position supine approach for robotic retroperitoneal lymph node dissection (R-RPLDN) for the treatment of nonseminomatous germ cell tumors and residual masses after chemotherapy. We performed a bilateral R-RPLDN in a 33-year-old man with nonseminomatous germ cell tumors and residual postchemotherapy masses. For this approach, the patient was placed in a steep Trendelenburg position, and a 5-port transperitoneal technique was used, with the robot docked so that the arms were oriented cephalad. This approach allowed simultaneous access to both sides of the retroperitoneum, thereby eliminating the need for bilateral lymphadenectomy and patient repositioning. Bilateral R-RPLDN was performed using a single-position supine approach. This versatile approach offers a less invasive, more efficient, and safer solution for removing residual postchemotherapy testicular cancer masses.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"19 3","pages":"230-234"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is reducing the early postoperative complications of percutaneous suprapubic catheterization affected by the method of healthcare education in low-literacy patients? A prospective randomized comparative study. 低文化患者的健康教育方法对减少经皮耻骨上置管术后早期并发症有影响吗?一项前瞻性随机比较研究
IF 0.9 4区 医学
Current Urology Pub Date : 2025-05-01 Epub Date: 2022-09-19 DOI: 10.1097/CU9.0000000000000151
Rabea Ahmed Gadelkareem, Shalabia Elsayed Abozead, Rasha Abozead Khalaf, Nasreldin Mohammed, Shaymaa Sayed Khalil
{"title":"Is reducing the early postoperative complications of percutaneous suprapubic catheterization affected by the method of healthcare education in low-literacy patients? A prospective randomized comparative study.","authors":"Rabea Ahmed Gadelkareem, Shalabia Elsayed Abozead, Rasha Abozead Khalaf, Nasreldin Mohammed, Shaymaa Sayed Khalil","doi":"10.1097/CU9.0000000000000151","DOIUrl":"10.1097/CU9.0000000000000151","url":null,"abstract":"<p><strong>Background: </strong>Suprapubic catheters (SPCs) are associated with a wide spectrum of undesirable symptoms and complications, ranging from skin overgranulation to septicemia. They can be effectively managed through various medical and healthcare interventions. We compared the impact of illustrated brochure healthcare education (IBHE) and verbal-only healthcare education (VOHE) on early postoperative complications of SPC in patients with low literacy levels.</p><p><strong>Materials and methods: </strong>Eighty patients with low literacy levels who underwent SPC insertion were randomly allocated to receive either IBHE or VOHE between January 2019 and June 2020. Variables, including postoperative complications (within 30 days), were compared. This study was approved by our institutional review board (IRB number: 1780011/2019).</p><p><strong>Results: </strong>The IBHE and VOHE groups included 40 patients each. The mean age ± standard deviation was 52.75 ± 16.46 and 53.25 ± 17.19 years, respectively. Acute urinary retention was the main presenting symptom (36 [90%] vs. 34 [85%]), and benign prostatic hyperplasia was the main underlying pathology (16 [40%] vs. 15 [37.5%]). The incidence of SPC obstruction (<i>p</i> = 0.000), urine leakage (<i>p</i> = 0.006), falling out (<i>p</i> = 0.003), suprapubic pain (<i>p</i> = 0.012), exit skin manifestations (<i>p</i> = 0.000), bleeding (<i>p</i> = 0.041), change (<i>p</i> = 0.003), and hematuria (<i>p</i> = 0.000) was significantly lower in IBHE than in VOHE. However, catheter-associated bladder discomfort (<i>p</i> = 0.247), bacteriuria (<i>p</i> = 0.154), and gross pyuria (<i>p</i> = 0.625) were not significantly different between the groups. The frequency of Clavien-Dindo grades was significantly higher in the VOHE group than in the IBHE group. Grade I (87.5% vs. 67.5%, <i>p</i> = 0.032) and grade IIIa (2.5% vs. 22.5%, <i>p</i> = 0.007) were significantly more frequent in the highest grade in IBHE and VOHE groups, respectively.</p><p><strong>Conclusions: </strong>Illustrated brochure healthcare education appears to be a suitable and effective method for educating low-literacy patients undergoing SPC insertion. It significantly reduced the incidence and grade of early postoperative SPC complications compared with VOHE, except for catheter-associated bladder discomfort, bacteriuria, and gross pyuria.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":" ","pages":"212-217"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47483032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of recombinant follicle-stimulating hormone treatment in patients with oligo-asthenospermia at different levels of DNA fragmentation index: A phase II clinical trial. 重组促卵泡激素治疗不同DNA片段化指数水平少弱精子症患者的疗效:一项II期临床试验。
IF 0.9 4区 医学
Current Urology Pub Date : 2025-05-01 Epub Date: 2024-10-22 DOI: 10.1097/CU9.0000000000000260
Salman Soltani, Nooshin Tafazoli, Maryam Emadzadeh, Atena Aghaee, Soheila Ebrahiminia Milani, Seyed Mohsen Seyedi Vostakolaee, Alireza Akhavan Rezayat
{"title":"Effectiveness of recombinant follicle-stimulating hormone treatment in patients with oligo-asthenospermia at different levels of DNA fragmentation index: A phase II clinical trial.","authors":"Salman Soltani, Nooshin Tafazoli, Maryam Emadzadeh, Atena Aghaee, Soheila Ebrahiminia Milani, Seyed Mohsen Seyedi Vostakolaee, Alireza Akhavan Rezayat","doi":"10.1097/CU9.0000000000000260","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000260","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to perform an evaluation of changes in spermogram parameters after follicle-stimulating hormone (FSH) therapy in infertile males having oligo-asthenospermia at different levels of DNA fragmentation index (DFI).</p><p><strong>Materials and methods: </strong>Infertile men with oligo-asthenospermia, no underlying urogenital disease (such as varicocele), and medically fertile partners were enrolled over 1 year. Semen parameters, FSH, luteinizing hormone, and testosterone levels were determined; also, a Sperm DNA Fragmentation Assay Kit (Hamun Teb Pishro, Tehran, Iran) was used for determining sperm DFI at baseline. Participants were categorized into 3 groups based on DFI: DFI <15% (group 1), DFI of 15%-30% (group 2), and DFI >30% (group 3). All participants received subcutaneous recombinant FSH (150 mg every other day) for 6 months. Sperm specimens were tested 6 months after intervention (a single sperm control test).</p><p><strong>Results: </strong>Sixty males whose average age was 28.4 years were enrolled. Only group 3 (poor fertility) exhibited a significant rise in sperm concentration (<i>p</i> = 0.001) and motility (<i>p</i> < 0.05) after FSH treatment. Group 1 (DFI <15%) and group 2 (DFI of 15%-30%) showed increased mean sperm concentration and motility postintervention, although these alterations were not significantly different. Follicle-stimulating hormone levels increased significantly in all 3 groups after FSH administration. Serum luteinizing hormone and testosterone levels were not significantly increased in any of the groups.</p><p><strong>Conclusions: </strong>Follicle-stimulating hormone treatment improves sperm concentration and motility in men with oligo-asthenospermia, with significant improvements observed in men with DFI >30%. DNA fragmentation index can be a predictive indicator of response to FSH treatment in such patients.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"19 3","pages":"208-211"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robotic surgical techniques and methods for treating renal cell carcinoma with inferior vena cava tumor thrombus. 机器人手术治疗肾细胞癌伴下腔静脉肿瘤血栓的技术与方法。
IF 0.9 4区 医学
Current Urology Pub Date : 2025-05-01 Epub Date: 2025-01-27 DOI: 10.1097/CU9.0000000000000265
Jin Luo, Zhuoran Li, Qiwei Liu, Yuqi Jia, Jinqiao Li, Houming Zhao, Zhiqiang Chen, Yujie Dong, Xu Zhang, Xin Ma, Qingbo Huang, Cheng Peng, Baojun Wang
{"title":"Robotic surgical techniques and methods for treating renal cell carcinoma with inferior vena cava tumor thrombus.","authors":"Jin Luo, Zhuoran Li, Qiwei Liu, Yuqi Jia, Jinqiao Li, Houming Zhao, Zhiqiang Chen, Yujie Dong, Xu Zhang, Xin Ma, Qingbo Huang, Cheng Peng, Baojun Wang","doi":"10.1097/CU9.0000000000000265","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000265","url":null,"abstract":"<p><p>Renal cell carcinoma with inferior vena cava (IVC) tumor thrombus (RCC-IVCTT) has a high mortality rate, and surgery is the only promising treatment. Open surgery has been the gold standard treatment for several decades. However, with the development of minimally invasive surgical technologies, the advantages of robotic surgery have gradually emerged. The classic Mayo Clinic Classification system has certain limitations in guiding robotic surgery. Therefore, a new classification system that is compatible with robotic surgery is urgently needed. Advancements in robotic surgery must be systematically summarized and evaluated. Since Abaza's initial report on robotic surgery, the exploration of robotic radical nephrectomy (RRN) with IVC thrombectomy has resulted in numerous related techniques and approaches, including surgical positions and approaches, control of blood vessels, assisted exposure, step-by-step strategy, and preoperative and intraoperative auxiliary technology and equipment. Our team proposed a new tumor thrombus classification system termed the \"301 Classification\" based on RRN with venous thrombectomy, which matches each level of tumor thrombus with a distinct robotic surgical strategy. With advances in technology and accumulated experience, RRN with IVC thrombectomy holds promise as the preferred surgical option for RCC-IVCTT. Although \"301 Classification\" can provide objective advantages in robotic surgery, more cases are needed to be optimized for guiding surgery accurately. The overview provided in this paper aims to serve as a reference and inspiration for future research and clinical practice regarding RCC-IVCTT.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"19 3","pages":"177-186"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prolonged life-threatening anaphylaxis to Floseal during partial nephrectomy: A case report. 肾部分切除术中对Floseal的长期危及生命的过敏反应:一例报告
IF 0.9 4区 医学
Current Urology Pub Date : 2025-05-01 Epub Date: 2023-08-08 DOI: 10.1097/CU9.0000000000000200
George McClintock, David Frishling, Yen Lam, Pascal Mancuso
{"title":"Prolonged life-threatening anaphylaxis to Floseal during partial nephrectomy: A case report.","authors":"George McClintock, David Frishling, Yen Lam, Pascal Mancuso","doi":"10.1097/CU9.0000000000000200","DOIUrl":"10.1097/CU9.0000000000000200","url":null,"abstract":"<p><p>Floseal Hemostatic Matrix is a topical hemostatic agent used across specialties and commonly applied to the renal bed during partial nephrectomy. Here we present the first adult case of Floseal allergy in the literature. A 62-year-old man underwent partial nephrectomy for a Bosniak type IV cyst. After unclamping the kidney, the patient declined precipitously, later determined due to an anaphylactic reaction to the Floseal placed on the renal bed. The patient had a prolonged anaphylactic reaction that required ionotropic support for over 24 h, possibly due to continued exposure. His tryptase level was elevated, and allergy testing revealed an allergy to the gelatin matrix component of the Floseal. Floseal anaphylaxis should be considered during episodes of cardiovascular collapse after drug administration. However, consideration should be given to removing it to prevent continued exposure and weighed against the risk of prolonged surgery in an anaphylactic patient.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":" ","pages":"198-200"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43819529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Penile enhancement: A comprehensive and current perspective. 阴茎增强:一个全面的和当前的观点。
IF 0.9 4区 医学
Current Urology Pub Date : 2025-05-01 Epub Date: 2024-12-17 DOI: 10.1097/CU9.0000000000000264
Yuan Chen, Yinuo Jiang, Xiao Li, Bin Wang, Xiaofeng Guo, Zihang Mai, Weifen Deng, Yuanchang Zhu, Baoquan Han, Zhongyi Sun
{"title":"Penile enhancement: A comprehensive and current perspective.","authors":"Yuan Chen, Yinuo Jiang, Xiao Li, Bin Wang, Xiaofeng Guo, Zihang Mai, Weifen Deng, Yuanchang Zhu, Baoquan Han, Zhongyi Sun","doi":"10.1097/CU9.0000000000000264","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000264","url":null,"abstract":"<p><p>An increasing number of men with healthy and normal penises want to enlarge their penis. Therefore, this review evaluated the mental health status of men who complained of a small penis and examined the state of nonsurgical and surgical treatments for male patients seeking penile enlargement, along with a risk assessment for each. Various medical, tractional, injectable, and surgical modalities have been investigated for penile augmentation. However, the development of new products and surgical techniques, such as Penuma, and tissue engineering may yield fewer complications, good operative effects, shorter operative times, and high patient satisfaction, bringing hope to patients interested in penile enlargement.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"19 3","pages":"145-156"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of PD-1/PD-L1 inhibitor monotherapy or combination therapy versus platinum-based chemotherapy as a first-line treatment of advanced urothelial cancer: A systematic review and meta-analysis. PD-1/PD-L1抑制剂单药或联合治疗与铂基化疗作为晚期尿路上皮癌一线治疗的疗效和安全性:一项系统综述和荟萃分析
IF 0.9 4区 医学
Current Urology Pub Date : 2025-05-01 Epub Date: 2025-02-26 DOI: 10.1097/CU9.0000000000000275
Xiaohui He, Shibo Huang, Qiuhong Jiang, Conghui Huang, Weisheng Huang, Weiming Liang
{"title":"Efficacy and safety of PD-1/PD-L1 inhibitor monotherapy or combination therapy versus platinum-based chemotherapy as a first-line treatment of advanced urothelial cancer: A systematic review and meta-analysis.","authors":"Xiaohui He, Shibo Huang, Qiuhong Jiang, Conghui Huang, Weisheng Huang, Weiming Liang","doi":"10.1097/CU9.0000000000000275","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000275","url":null,"abstract":"<p><strong>Background: </strong>Recent clinical trials have shown that inhibitors targeting programmed cell death protein 1 (PD-1) or its ligand (programmed cell death-ligand 1 [PD-L1]) provide significant efficacy and clinical benefit in the treatment of advanced or metastatic urothelial carcinoma (UC). This systematic review and meta-analysis aimed to compare the effectiveness and safety of PD-1/PD-L1 inhibitors in combination with chemotherapy or PD-1/PD-L1 inhibitor monotherapy versus platinum-based chemotherapy as a first-line treatment for advanced UC.</p><p><strong>Materials and methods: </strong>From the beginning of the database construction to February 4, 2024, a combination of medical subject headings and free-text words was searched using the Population Intervention Comparison Outcome Study design framework. The PubMed, Cochrane Library, Embase, and Web of Science electronic databases were searched. Meta-analyses of progression-free survival, overall survival, objective response rate (ORR), complete remission rate, duration of remission, and grade ≥3 adverse events were performed.</p><p><strong>Results: </strong>Four studies were included in the meta-analysis. The PD-1/PD-L1 inhibitors plus chemotherapy therapy is associated with significantly better ORR compared with chemotherapy. Unfortunately, there were no significant differences between PD-1/PD-L1 inhibitor monotherapy and chemotherapy in terms of ORR, duration of remission, or overall survival.</p><p><strong>Conclusions: </strong>Our findings indicate that PD-1/PD-L1 inhibitors plus chemotherapy therapy provides more oncological advantages than standard chemotherapy and should be recommended as a first-line treatment for advanced or metastatic UC. Attention must also be paid to the adverse effects of the combination of PD-1/PD-L1 inhibitors and chemotherapy.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"19 3","pages":"157-167"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laparoscopic robotic takedown ureterostomy with extravesical cross-trigonal reimplantation after end cutaneous ureterostomy. 输尿管末端皮肤造口术后腹腔镜机器人取下输尿管造口术及体外跨三角再植术
IF 0.9 4区 医学
Current Urology Pub Date : 2025-05-01 Epub Date: 2023-01-17 DOI: 10.1097/CU9.0000000000000174
Binyamin B Neeman, Stanislav Kocherov, Jawdat Jaber, Amos Neheman, Boris Chertin
{"title":"Laparoscopic robotic takedown ureterostomy with extravesical cross-trigonal reimplantation after end cutaneous ureterostomy.","authors":"Binyamin B Neeman, Stanislav Kocherov, Jawdat Jaber, Amos Neheman, Boris Chertin","doi":"10.1097/CU9.0000000000000174","DOIUrl":"10.1097/CU9.0000000000000174","url":null,"abstract":"<p><strong>Introduction: </strong>The main goal of managing an obstructed megaureter (OMU) is to preserve the function of the affected kidney. To preserve the upper urinary tract, end cutaneous ureterostomy (ECU) seems to be a promising temporizing option. We aimed to evaluate our experience with ECU in patients with primary and secondary OMU and to demonstrate an efficacy of robot-assisted laparoscopic takedown ureterostomy and subsequent extravesical ureteric reimplantation.</p><p><strong>Materials and methods: </strong>Retrospective analysis of patients that underwent ECU due to primary or secondary megaureter between 2003 and 2020. Nineteen patients (12 males, 7 females) with a mean age of 4.2 ± 3.5 months (mean ± standard deviation) underwent ECU of 27 renal units. Of those, 11 (57.9%) had primary OMU and 8 (42.1%) had secondary OMU. Undiversion was performed in 16 (84%) out of 19 patients (20 renal units out of 27 [74%]).</p><p><strong>Results: </strong>In the vast majority of the cases, we have observed improvement in the hydronephrosis and renal function after ureterostomy. After reimplantation ultrasonography showed either stable or further improvement in hydronephrosis in 80% of patients. Robot-assisted laparoscopic patients had shorter admission period and indwelling catheter time after the surgery.</p><p><strong>Conclusions: </strong>End cutaneous ureterostomy is a safe and effective temporary procedure for the treatment of progressive primary and secondary megaureters. Robot-assisted laparoscopic takedown of ureterostomy with subsequent reimplantation seems to be a good alternative for undiversion and subsequent reimplantation in these patients.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":" ","pages":"173-176"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44315356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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