Current Urology最新文献

{"title":"Transurethral guidewire loop for manipulation and extraction of stent: A novel, innovative, video-endoscopic technique in ureteral stent removal","authors":"Ahmed Adam, M. Perera","doi":"10.1097/cu9.0000000000000170","DOIUrl":"https://doi.org/10.1097/cu9.0000000000000170","url":null,"abstract":"","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49516055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic robotic takedown ureterostomy with extravesical cross-trigonal reimplantation after end cutaneous ureterostomy","authors":"Binyamin B. Neeman, S. Kocherov, J. Jaber, A. Neheman, B. Chertin","doi":"10.1097/cu9.0000000000000174","DOIUrl":"https://doi.org/10.1097/cu9.0000000000000174","url":null,"abstract":"","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44315356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathologic features and parameters predicting recurrence potential of small renal masses","authors":"S. Bajramović, Berina Hasanović, J. Alić, N. Šabanović Bajramović, Damir Aganović","doi":"10.1097/cu9.0000000000000175","DOIUrl":"https://doi.org/10.1097/cu9.0000000000000175","url":null,"abstract":"","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46357255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing health literacy and subsequent implementation of an animated video to enhance understanding for patients with nephrolithiasis","authors":"Anand Prabhu, J. Bylund, J. Bell, A. Bhalodi, Andrew M. Harris","doi":"10.1097/cu9.0000000000000172","DOIUrl":"https://doi.org/10.1097/cu9.0000000000000172","url":null,"abstract":"","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42464180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate cancer screening: Continued controversies and novel biomarker advancements.","authors":"Atiyah Tidd-Johnson,&nbsp;Sneha Annie Sebastian,&nbsp;Edzel Lorraine Co,&nbsp;Munaza Afaq,&nbsp;Hansini Kochhar,&nbsp;Mona Sheikh,&nbsp;Arpit Mago,&nbsp;Sujan Poudel,&nbsp;John A Fernandez,&nbsp;Ivan D Rodriguez,&nbsp;Sanjay Razdan","doi":"10.1097/CU9.0000000000000145","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000145","url":null,"abstract":"<p><p>Prostate cancer (PCa) screening remains one of the most controversial topics in clinical and public health. Despite being the second most common cancer in men worldwide, recommendations for screening using prostate-specific antigen (PSA) are unclear. Early detection and the resulting postscreening treatment lead to overdiagnosis and overtreatment of otherwise indolent cases. In addition, several unwanted harms are associated with PCa screening process. This literature review focuses on the limitations of PSA-specific PCa screening, reasons behind the screening controversy, and the novel biomarkers and advanced innovative methodologies that improve the limitations of traditional screening using PSA. With the verdict of whether or not to screen not yet unanimous, we hope to aid in resolution of the long-standing debate.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"16 4","pages":"197-206"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/cc/curr-urol-16-197.PMC9875204.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9137318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidermoid cyst: An unusual presentation of a testicular mass.","authors":"Andrew Stemberger,&nbsp;Marc Zeffren,&nbsp;Ruth Birbe,&nbsp;Wei Phin Tan","doi":"10.1097/CU9.0000000000000123","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000123","url":null,"abstract":"A 24-year-oldman presented to the clinic for a painless right testicular mass on examination. α-Fetoprotein, β-human chorionic gonadotropin, and lactate dehydrogenase tumormarkers werewithin normal limits. Scrotal ultrasonography depicted a well-demarcated intratesticular mass measuring approximately 1 cmwith alternating hyperechoic and hypoechoic rings (Fig. 1). Given that ultrasonographic features were concerning for a testicular epidermoid cyst, the decision was made to undergo inguinal partial orchiectomy. Partial orchiectomy was performed with the aid of intraoperative ultrasonography to confirm the location of the mass (Fig. 2). Frozen sections were obtained and were negative. Histological examination confirmed the diagnosis of epidermoid cyst (Fig. 3). The testicle was reconstructed, and the tunica vaginalis was closed with a running mattress suture. The patient was discharged home on the same day, and his postoperative course was uncomplicated. Surveillance ultrasonography of the scrotum at 20-month follow-up was negative for recurrence. Epidermoid cysts of the testicle are rare lesions and account for 1% to 2% of all testicular masses. First described by Dockerty and Priestly in 1942, they can either present as a benign subtype or in association with invasive germ cell tumors. They have many characteristics that are common with testicular cancer, because both are painless masses in men between the second and fourth decades of life. Ultrasonography characteristically shows a well-defined mass with alternating layers of keratin and squamous cells, manifesting as hyperechogenic and hypoechogenic rings in the form of an “onion skin.” Testis-sparing surgery is the preferredmanagement for masses less than 2 cm; thus, a partial orchiectomy was performed.","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"16 4","pages":"267-268"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/16/curr-urol-16-267.PMC9875203.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9151715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Vitamin D receptor</i> polymorphism and prostate cancer prognosis.","authors":"Ahmed Z El-Attar,&nbsp;Samia Hussein,&nbsp;Mariam F A Salama,&nbsp;Hanaa M Ibrahim,&nbsp;Amira S AlKaramany,&nbsp;Mansour K Elsawi,&nbsp;Mohamed Hemeda,&nbsp;Ahmed Algazeery","doi":"10.1097/CU9.0000000000000141","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000141","url":null,"abstract":"<p><strong>Background: </strong>Prostatic epithelial cells synthesize the active form of vitamin D (1,25-dihydroxyvitamin D₃), which participates in regulating prostate growth. Calcitriol, a synthetic form of vitamin D₃, exhibits antiproliferative and prodifferentiation activities in prostate cancer. The function of 1,25-dihydroxyvitamin D₃ is mediated by its binding to vitamin D receptor (VDR). VDR forms a heterodimer, typically with retinoid X receptor, to regulate vitamin D target genes. We evaluated the relationship between <i>VDR</i> polymorphism and clinical characteristics associated with prostate cancer risk and prognosis among Egyptian men.</p><p><strong>Materials and methods: </strong>This case-control study included 2 groups of patients: group A, a control group of 50 subjects with benign prostate hyperplasia, and group B, 50 subjects newly diagnosed with prostate cancer. All participants performed complete blood count, liver and kidney function tests, prostate specific antigen measurement, histopathological analysis and immunohistochemistry for Dickkopf Homolog 3. Restriction fragment length polymorphism-polymerase chain reaction as performed to detect <i>VDR</i> polymorphism.</p><p><strong>Results: </strong>Patients with prostate cancer and controls showed a significantly different <i>CA</i> genotype frequency (<i>p</i> = 0.007). Furthermore, prostate-specific antigen levels were significantly different in different genotypes in patients with prostate cancer (<i>p</i> < 0.001). Finally, T stage and the <i>VDR ApaI C/A</i> polymorphism were significantly associated (<i>p</i> < 0.041).</p><p><strong>Conclusion: </strong>The <i>VDR ApaI C/A</i> polymorphism may be a diagnostic and prognostic marker for prostate cancer in Egyptian men.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"16 4","pages":"246-255"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/28/cb/curr-urol-16-246.PMC9875206.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9151717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An independent practice validation of the Prostate Imaging Reporting and Data System version 2 scoring system and the introduction of PDP (prostate-specific antigen density × PI-RADSv2) score to assist with further risk assessment.","authors":"Parth U Patel,&nbsp;David Bock,&nbsp;Christian A Hettinger","doi":"10.1097/CU9.0000000000000140","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000140","url":null,"abstract":"<p><strong>Objectives: </strong>To provide concise information to clinicians on how to better interpret multiparametric magnetic resonance imaging for prostate cancer risk stratification.</p><p><strong>Materials and methods: </strong>We analyzed 2 separate cohorts. For patients receiving a Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) score of 1 or 2, we reviewed the charts of 226 patients who underwent multiparametric magnetic resonance imaging of the prostate ordered from 2015 to 2017 to determine who developed clinically significant prostate cancer (csPCa) by August 27, 2020. For patients receiving PI-RADSv2 a score of 3, 4, or 5, we reviewed the results of 733 fusion biopsies on solitary lesions. Statistical analysis was used to further determine risk factors for csPCa.</p><p><strong>Results: </strong>Ten percent of men with PI-RADSv2 a score of 1 eventually developed csPCa. Seven percent with a score of 2 were eventually diagnosed with csPCa. Only 1 of 226 with a score of 1 or 2 developed metastasis. For PI-RADSv2 scores of 3, 4, and 5, csPCa was detected in 16%, 45%, and 67% of fusion biopsies. Peripheral zone (PZ) PI-RADSv2 score of 4 or 5 and prostate-specific antigen density (PSA-D) were significant predictors of csPCa on multivariable analysis. Using a PSA-D × PI-RADSv2 score of ≤0.39, we identified 38% of men with a PI-RADSv2 score of 3 in the PZ or 3, 4, or 5 in the transition zone who could have avoided a benign biopsy.</p><p><strong>Conclusions: </strong>The vast majority of patients with PI-RADSv2 scores 1 and 2 can be safely monitored with close surveillance. Lesions with PI-RADSv2 scores of 4 and 5 in the PZ should be biopsied. Peripheral zone lesions with a PI-RADSv2 score of 3 and transition zone lesions with 3, 4, or 5 can be risk-stratified using the PSA-D × PI-RADSv2 score to determine who may safely avoid a biopsy and who should proceed to fusion biopsy.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"16 4","pages":"213-217"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/eb/curr-urol-16-213.PMC9875202.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9137321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single tertiary cancer center experience on the management of pT3b prostate cancer after robotic-assisted laparoscopic prostatectomy.","authors":"Arvind Nayak,&nbsp;Omar El-Taji,&nbsp;Sugeeta Sukumar,&nbsp;John Piedad,&nbsp;Aruni Ghose,&nbsp;Rob Hughes,&nbsp;Roberto Alonzi,&nbsp;Peter Ostler,&nbsp;Anand Sharma,&nbsp;Tim Lane,&nbsp;Jim Adshead,&nbsp;Nikhil Vasdev","doi":"10.1097/CU9.0000000000000115","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000115","url":null,"abstract":"<p><strong>Background: </strong>Pathological involvement of the seminal vesicle poses a treatment dilemma following robotic prostatectomy. Margin status plays an important role in deciding further management. A wide range of treatment options are available, including active monitoring, adjuvant radiotherapy, salvage radiotherapy, and occasionally androgen deprivation therapy. Patients undergoing postoperative radiotherapy tend to have higher risk of urinary and bowel morbidities. The recent RADICALS-RT concluded that adjuvant radiotherapy did not have any benefit compared with salvage radiotherapy. We aim to audit the incidence, margin status, and management of T3b cancer cases at our center.</p><p><strong>Materials and methods: </strong>A retrospective analysis was conducted of all patients diagnosed with pathological T3b (pT3b) prostate cancer following robotic-assisted laparoscopic prostatectomy from January 2012 to July 2020. Preoperative parameters analyzed included prostate-specific antigen (PSA), T stage, and age. A chi-square test and 2-tailed <i>t</i> test were used to determine the relationship between categorical and continuous variables, respectively. Kaplan-Meier survival curves were generated to assess overall survival in patients with pT3b prostate cancer and used to compare unadjusted progression-free survival among those who underwent adjuvant and salvage radiotherapy.</p><p><strong>Results: </strong>A total of 83 (5%) of 1665 patients who underwent robotic prostatectomy were diagnosed with pT3b prostate cancer between January 2012 and July 2020. Among these, 36 patients (44%) did not receive any radiotherapy during follow-up, compared with 26 patients (31%) who received adjuvant radiotherapy and 21 (25%) who received salvage radiotherapy. The median age of our cohort was 64 (SD, 6.4) years. Mean PSA at presentation was 12.7 μg/L. Positive margins were seen in 36 patients (43%); however, there was no statistically significant difference between treatment groups (<i>p</i> = 0.49). The median overall survival was 96%. There was no significant difference between the adjuvant and salvage groups in terms of biochemical progression-free survival (<i>p</i> = 0.66). Five-year biochemical progression-free survival was 94% for those in the adjuvant radiotherapy group and 97% for those in the salvage radiotherapy group.</p><p><strong>Conclusions: </strong>Our audit corroborates with the recently concluded RADICALS-RT study, although we had fewer patients with positive margins. Radiotherapy can be avoided in patients with T3b prostate cancer, even if margin is positive, until there is definitive evidence of PSA recurrence. In keeping with the conclusion of RADICALS-RT, salvage radiotherapy may be preferable to adjuvant radiotherapy.</p>","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"16 4","pages":"227-231"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/16/94/curr-urol-16-227.PMC9875210.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9151714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 and priapism: An unexplored association.","authors":"Wai Gin Lee","doi":"10.1097/CU9.0000000000000139","DOIUrl":"https://doi.org/10.1097/CU9.0000000000000139","url":null,"abstract":"Our understanding of coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to evolve. Much has been written about the respiratory and proinflammatory sequelae of this condition. SARS-CoV-2 infection is mediated by the binding of the viral spike protein to angiotensin-convertingenzyme2(ACE2). [1] ACE2ishighlyexpressed in the endothelium (as well as in the lungs, kidney, liver, and heart), and this is thought to be the underlying cause of the thrombotic com-plications of COVID-19. Endothelial dysfunction resulting from endothelial activation and reduced endothelium-dependent vasodila-tation underlies the hallmark of COVID-19 as a proinflammatory and procoagulant milieu. [2]","PeriodicalId":39147,"journal":{"name":"Current Urology","volume":"16 4","pages":"265-266"},"PeriodicalIF":1.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9d/65/curr-urol-16-265.PMC9815694.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10518596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}