Interdisciplinary Perspectives on Infectious Diseases最新文献_第9页

Efficacy and Safety of Sarilumab in COVID-19: A Systematic Review. Sarilumab治疗COVID-19的疗效和安全性:一项系统评价

Interdisciplinary Perspectives on Infectious Diseases Pub Date : 2021-10-22 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8903435

Rajan Chamlagain, Sangam Shah, Basanta Sharma Paudel, Roman Dhital, Bipin Kandel

{"title":"Efficacy and Safety of Sarilumab in COVID-19: A Systematic Review.","authors":"Rajan Chamlagain, Sangam Shah, Basanta Sharma Paudel, Roman Dhital, Bipin Kandel","doi":"10.1155/2021/8903435","DOIUrl":"https://doi.org/10.1155/2021/8903435","url":null,"abstract":"Background: It has been found that there is overactivation of immune response in patients with COVID-19. Several studies are going on to assess the role of immunomodulation. IL-6 antibodies such as tocilizumab have been found to have efficacy in the treatment of COVID-19. We aim to assess the role of sarilumab in the treatment of COVID-19 through this review. Main Body. Functional outcomes were assessed on the basis of PaO2/FiO2 ratio, mortality, and ventilation. Adverse events of studies were also noted. Five studies were included in the study. There was improvement in PaO2/FiO2 ratio, reduction in the mortality of the patients, and less number of patients were on ventilation, but there were no significant differences among the comparison and sarilumab group. Sarilumab did not have notable adverse events and can be considered a safe drug.Conclusion: Sarilumab is a safe drug with good clinical outcomes in patients with COVID-19 and, hence, could be used as an alternative regimen for the treatment. Further prospective studies exploring the relations with baseline biomarkers of inflammation commonly measured such as C-reactive protein and IL-6 would be necessary for a correlation with the treatment.","PeriodicalId":39128,"journal":{"name":"Interdisciplinary Perspectives on Infectious Diseases","volume":"2021 ","pages":"8903435"},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39579434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

The COVID-19 Prevalence among Children: Hypotheses for Low Infection Rate and Few Severe Forms among This Age Group in Sub-Saharan Africa. COVID-19在撒哈拉以南非洲儿童中的流行:该年龄组感染率低和严重形式少的假设

Interdisciplinary Perspectives on Infectious Diseases Pub Date : 2021-10-12 eCollection Date: 2021-01-01 DOI: 10.1155/2021/4258414

Sylvain Raoul Simeni Njonnou, Nadia Christelle Noumedem Anangmo, Fernando Kemta Lekpa, Diomede Noukeu Njinkui, Dominique Enyama, Christian Ngongang Ouankou, Eric Vounsia Balti, Esther Astrid Mbono Samba Eloumba, Jean Roger Moulion Tapouh, Simeon Pierre Choukem

{"title":"The COVID-19 Prevalence among Children: Hypotheses for Low Infection Rate and Few Severe Forms among This Age Group in Sub-Saharan Africa.","authors":"Sylvain Raoul Simeni Njonnou, Nadia Christelle Noumedem Anangmo, Fernando Kemta Lekpa, Diomede Noukeu Njinkui, Dominique Enyama, Christian Ngongang Ouankou, Eric Vounsia Balti, Esther Astrid Mbono Samba Eloumba, Jean Roger Moulion Tapouh, Simeon Pierre Choukem","doi":"10.1155/2021/4258414","DOIUrl":"https://doi.org/10.1155/2021/4258414","url":null,"abstract":"Despite some cases of severe or critical manifestations of the coronavirus disease 2019 (COVID-19) described among children, the prevalence of this infection in the pediatric population is quite low worldwide, particularly in sub-Saharan Africa. Current data suggest indeed that, independent of the population considered overall, severe and critical cases of COVID-19 are rare among children. This observation prompted us to discuss the possible hypotheses which could explain the low prevalence of COVID-19 among children; amongst others, we discuss (1) immunomodulation by the Bacillus Calmette-Guerin vaccine or by some parasitic infections such as malaria, schistosomiasis, and helminthiasis and (2) cross immunization with other coronaviruses commonly found in the sub-Saharan African setting.","PeriodicalId":39128,"journal":{"name":"Interdisciplinary Perspectives on Infectious Diseases","volume":"2021 ","pages":"4258414"},"PeriodicalIF":0.0,"publicationDate":"2021-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39538933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Emergence of Highly Multidrug-Resistant Bacteria Isolated from Patients with Infections Admitted to Public Hospitals in Southwest Iran. 伊朗西南部公立医院感染患者中分离出高度耐多药细菌的研究

Interdisciplinary Perspectives on Infectious Diseases Pub Date : 2021-08-13 eCollection Date: 2021-01-01 DOI: 10.1155/2021/5265379

Sepide Namdari, Ali Farhadi, Aida Khademalhoseini, Abbas Behzad-Behbahani, Afsaneh Moaddeb

{"title":"Emergence of Highly Multidrug-Resistant Bacteria Isolated from Patients with Infections Admitted to Public Hospitals in Southwest Iran.","authors":"Sepide Namdari, Ali Farhadi, Aida Khademalhoseini, Abbas Behzad-Behbahani, Afsaneh Moaddeb","doi":"10.1155/2021/5265379","DOIUrl":"https://doi.org/10.1155/2021/5265379","url":null,"abstract":"Background: The emergence of multidrug-resistant (MDR) microorganisms causing infections is increasing worldwide and becoming more serious in developing countries. Among those, Acinetobacter species are becoming prominent.Objectives: The aim of this study was to determine the rate of antimicrobial resistance of the bacteria causing infections, Acinetobacter species in particular, in local public hospitals in Firuzabad, Fars province, Iran.Methods: This cross-sectional study was performed on different clinical specimens collected from patients who were suspected of infections hospitalized from March 2016 to March 2019 in local hospitals of Firuzabad, Fars province, Iran. The bacterial isolates were identified following standard microbiological methods. Clinical and Laboratory Standards Institute guidelines were used to identify the antibiotic susceptibility of these isolates.Results: Overall, 1778 bacterial etiologies were isolated from 1533 patients diagnosed with infection. Of these, 1401 (78.8%) were Gram-negative and the remaining were Gram-positive bacteria. Escherichia coli (37.1%), Klebsiella spp. (13.9%), and Acinetobacter species (10.4%) were the most common isolated bacteria. Antibiotic sensitivity testing in this study showed a high resistance rate of Acinetobacter species to all antibiotics tested except Colistin. During the study period, the rate of infection with highly multidrug-resistant Acinetobacter species increased from 7.2% to 13.3%.Conclusions: This study highlights the emergence of MDR bacterial agents such as Acinetobacter species as a new threat in our region. However, a decrease in the rate of infection with Pseudomonas aeruginosa was noticeable.","PeriodicalId":39128,"journal":{"name":"Interdisciplinary Perspectives on Infectious Diseases","volume":"2021 ","pages":"5265379"},"PeriodicalIF":0.0,"publicationDate":"2021-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39334379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Social Consequences of the Novel Coronavirus Disease (COVID-19) Outbreak in Iran: Is Social Capital at Risk? A Qualitative Study. 伊朗新型冠状病毒病 (COVID-19) 爆发的社会后果：社会资本是否面临风险？定性研究。

Interdisciplinary Perspectives on Infectious Diseases Pub Date : 2021-06-10 eCollection Date: 2021-01-01 DOI: 10.1155/2021/5553859

Mohadeseh Motamed-Jahromi, Mohammad Hossein Kaveh

{"title":"The Social Consequences of the Novel Coronavirus Disease (COVID-19) Outbreak in Iran: Is Social Capital at Risk? A Qualitative Study.","authors":"Mohadeseh Motamed-Jahromi, Mohammad Hossein Kaveh","doi":"10.1155/2021/5553859","DOIUrl":"10.1155/2021/5553859","url":null,"abstract":"As well as causing a global health crisis, the COVID-19 pandemic has also generated multilevel social changes by damaging psychosocial and economic resources across Iranian society. Therefore, this qualitative study was conducted to examine and explain these social consequences and their impact on the social capital of Iran during the COVID-19 outbreak. Using a content analysis approach, nine experts participated in semistructured, in-depth interviews. Interviews were recorded and transcribed verbatim and analyzed using Lundman and Graneheim's method. The social impacts of COVID-19 can be summarized into six categories and 32 subcategories. Three positive-negative categories emerged from the data analysis: \"formation of new patterns of social communications; formation of new patterns of behavior; creation of economic changes.\" Three entirely negative categories included \"creating a climate of distrust; disruption of cultural, social, and religious values; psychosocial disorders.\" Overall, most findings (27 out of 32 subcategories) indicated the destructive effects of the COVID-19 pandemic on social capital. Therefore, this raises concerns about social capital endangerment in Iran. However, positive social impacts can guide policies that strengthen social action and improve social capital.","PeriodicalId":39128,"journal":{"name":"Interdisciplinary Perspectives on Infectious Diseases","volume":"2021 ","pages":"5553859"},"PeriodicalIF":0.0,"publicationDate":"2021-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39249086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Chest Computed Tomography versus Real Time Reverse Transcription Polymerase Chain Reaction for Diagnosis of COVID-19: A Systematic Review and Meta-Analysis. 胸部计算机断层扫描与实时逆转录聚合酶链反应在COVID-19诊断中的作用:系统综述和荟萃分析

Interdisciplinary Perspectives on Infectious Diseases Pub Date : 2021-05-28 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8798575

Dina M Ali, Lamiaa G Zake, Nevine K El Kady

{"title":"Role of Chest Computed Tomography versus Real Time Reverse Transcription Polymerase Chain Reaction for Diagnosis of COVID-19: A Systematic Review and Meta-Analysis.","authors":"Dina M Ali, Lamiaa G Zake, Nevine K El Kady","doi":"10.1155/2021/8798575","DOIUrl":"https://doi.org/10.1155/2021/8798575","url":null,"abstract":"Background: The current global pandemic of COVID-19 is considered a public health emergency. The diagnosis of COVID-19 depends on detection of the viral nucleic acid by real time reverse transcription polymerase chain reaction (RT-PCR). However, false-negative RT-PCR tests are reported and could hinder the control of the pandemic. Chest computed tomography could achieve a more reliable diagnosis and represent a complementary diagnostic tool.Aim: To perform a meta-analysis and systematic review to find out the role of chest computed tomography versus RT-PCR for precise diagnosis of COVID-19 infection.Methods: We searched three electronic databases (PubMed, ScienceDirect, and Scopus) from April 1 to April 20, 2020, to find out articles including the accuracy of chest computed tomography scan versus RT-PCR for diagnosis of SARS-CoV-2 infection. Observational studies, case series, and case reports were included.Results: A total of 238 articles were retrieved from the search strategy. Following screening, 39 articles were chosen for full text assessment and finally 35 articles were included for qualitative and quantitative analysis. Chest computed tomography showed a wide range of sensitivity varied from 12%-100%.Conclusion: Chest computed tomography is playing a key role for diagnosis and detection of COVID-19 infection. Computed tomography image findings may precede the initially positive RT-PCR assay.","PeriodicalId":39128,"journal":{"name":"Interdisciplinary Perspectives on Infectious Diseases","volume":"2021 ","pages":"8798575"},"PeriodicalIF":0.0,"publicationDate":"2021-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39057703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Probable Association between Chronic Toxoplasma gondii Infection and Type 1 and Type 2 Diabetes Mellitus: A Case-Control Study. 慢性刚地弓形虫感染与1型和2型糖尿病的可能关系:一项病例对照研究

Interdisciplinary Perspectives on Infectious Diseases Pub Date : 2021-05-24 eCollection Date: 2021-01-01 DOI: 10.1155/2021/2508780

Shahrzad Soltani, Sanaz Tavakoli, Mohamad Sabaghan, Mehdi Sagha Kahvaz, Marzieh Pashmforosh, Masoud Foroutan

{"title":"The Probable Association between Chronic Toxoplasma gondii Infection and Type 1 and Type 2 Diabetes Mellitus: A Case-Control Study.","authors":"Shahrzad Soltani, Sanaz Tavakoli, Mohamad Sabaghan, Mehdi Sagha Kahvaz, Marzieh Pashmforosh, Masoud Foroutan","doi":"10.1155/2021/2508780","DOIUrl":"https://doi.org/10.1155/2021/2508780","url":null,"abstract":"Purpose: The probable association between Toxoplasma gondii (T. gondii) infection and diabetes mellitus (DM) is still controversial, and there are several studies with conflicting results. Thus, this study was performed to assess the possible association between chronic T. gondii infection and type 1 diabetes mellitus (T1DM) and T2DM.Methods: In this case-control study, a total of 105 diabetic subjects including 36 patients with T1DM and 69 patients with T2DM were recruited. In addition, 150 nondiabetic subjects were enrolled as controls. Each case group had its own control group. Each participant completed a structured questionnaire obtaining demographic information. Serum samples were examined for T. gondii-specific IgG antibody using enzyme-linked immunosorbent assay (ELISA) method.Results: Analysis revealed that 69.4% and 34.0% of patients with T1DM and control subjects were serologically positive for T. gondii, respectively (odds ratio (OR): 4.41; 95% confidence interval (CI): 1.75-11.06; P=0.001). Moreover, 72.5% of T2DM patients and 29.0% of healthy individuals were seropositive for T. gondii (OR: 6.44; 95% CI: 3.25-12.74; P < 0.001). Among risk factors, only contact with cats was significantly associated with IgG seroprevalence in both T2DM patients (P < 0.001) and control subjects (P=0.045).Conclusion: Although the results showed that chronic T. gondii infection is significantly associated with T1DM and T2DM, there remain many questions regarding the exact mechanisms of T. gondii in the pathogenesis of DM.","PeriodicalId":39128,"journal":{"name":"Interdisciplinary Perspectives on Infectious Diseases","volume":"2021 ","pages":"2508780"},"PeriodicalIF":0.0,"publicationDate":"2021-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39089850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Severity and Mortality Associated with Steroid Use among Patients with COVID-19: A Systematic Review and Meta-Analysis. 与 COVID-19 患者使用类固醇相关的严重程度和死亡率：系统回顾与元分析》。

Interdisciplinary Perspectives on Infectious Diseases Pub Date : 2021-05-06 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6650469

Tamiru Sahilu, Tadesse Sheleme, Tsegaye Melaku

{"title":"Severity and Mortality Associated with Steroid Use among Patients with COVID-19: A Systematic Review and Meta-Analysis.","authors":"Tamiru Sahilu, Tadesse Sheleme, Tsegaye Melaku","doi":"10.1155/2021/6650469","DOIUrl":"10.1155/2021/6650469","url":null,"abstract":"Background: There are controversial suggestions about steroid use to treat patients infected with COVID-19. Conclusive evidence regarding the use of steroids to treat COVID-19 is still lacking. This meta-analysis aimed to determine the mortality and severity associated with corticosteroid therapy compared to noncorticosteroid treatment in patients with COVID-19.Methods: The information was collected from electronic databases: PubMed, CINAHL, the Cochrane Library, clinicaltrials.gov, and Google scholar through January 30, 2021. Risk ratios (RRs) with 95% confidence intervals (CIs) were performed using random effect models. Endnote citation manager software version X9 for Windows was utilized to collect and organize search outcomes (into relevant and irrelevant studies) and to remove duplicate articles.Results: Thirty-two studies were included in the meta-analysis, including 14,659 COVID-19 patients. No significant differences in mortality between the steroid and nonsteroid treatment groups (RR = 0.95; 95% CI: 0.80-1.13; p = 0.57). There was no significant reduction in mortality in critically ill COVID-19 patients treated with corticosteroid (RR = 0.89; 95% CI: 0.62-1.27; p = 0.52). Significant differences were observed in severe disease conditions between the steroid and nonsteroid treatment groups (RR = 1.10; 95% CI, 1.03-1.19, p = 0.007).Conclusion: There was no significant difference in all-cause mortality between the steroid and nonsteroid treatment users' of COVID-19 patients. There was no significant reduction of all-cause mortality in critically ill COVID-19 patients treated with corticosteroids.","PeriodicalId":39128,"journal":{"name":"Interdisciplinary Perspectives on Infectious Diseases","volume":"2021 ","pages":"6650469"},"PeriodicalIF":0.0,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39032169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C-Reactive Protein as a Prognostic Indicator in COVID-19 Patients. c -反应蛋白作为COVID-19患者预后指标

Interdisciplinary Perspectives on Infectious Diseases Pub Date : 2021-04-23 eCollection Date: 2021-01-01 DOI: 10.1155/2021/5557582

Mahmoud Sadeghi-Haddad-Zavareh, Masomeh Bayani, Mehran Shokri, Soheil Ebrahimpour, Arefeh Babazadeh, Rahele Mehraeen, Emadoddin Moudi, Ali Rostami, Mohammad Barary, Akram Hosseini, Ali Bijani, Mostafa Javanian

{"title":"C-Reactive Protein as a Prognostic Indicator in COVID-19 Patients.","authors":"Mahmoud Sadeghi-Haddad-Zavareh, Masomeh Bayani, Mehran Shokri, Soheil Ebrahimpour, Arefeh Babazadeh, Rahele Mehraeen, Emadoddin Moudi, Ali Rostami, Mohammad Barary, Akram Hosseini, Ali Bijani, Mostafa Javanian","doi":"10.1155/2021/5557582","DOIUrl":"https://doi.org/10.1155/2021/5557582","url":null,"abstract":"While some biomolecules have been explored to identify potential biomarkers for the prognosis of COVID-19 patients, there is no reliable prognostic indicator of the disease progression and severity. We aimed to evaluate the ability of the C-reactive protein (CRP) to predict COVID-19 infection outcome. This retrospective study was conducted on 429 patients diagnosed with COVID-19 between March 30, 2020, and April 30, 2020. The study population was divided into severe (n = 175) and nonsevere cases (n = 254). Data on demographic characteristics, clinical features, and laboratory findings on admission were collected. The proportion of patients with increased CRP levels was significantly higher in severe cases than in nonsevere patients. Analysis of the receiver operating characteristic (ROC) curve found that CRP could be used as an independent factor in predicting the severity of COVID-19. Also, patients with CRP >64.75 mg/L were more likely to have severe complications. In conclusion, CRP serum levels can predict the severity and progression of illness in patients with COVID-19.","PeriodicalId":39128,"journal":{"name":"Interdisciplinary Perspectives on Infectious Diseases","volume":"2021 ","pages":"5557582"},"PeriodicalIF":0.0,"publicationDate":"2021-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38963731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 58

Knowledge and attitude of Iranian university students toward genital warts 伊朗大学生对生殖器疣的认识和态度

Interdisciplinary Perspectives on Infectious Diseases Pub Date : 2021-04-20 DOI: 10.1101/2021.04.15.21255532

Z. Aryanian, M. Mohammadi, A. Babazadeh, I. Etesami, Parvaneh Hatami, M. Barary, S. Ebrahimpour, Parisa Sabbagh, A. Goodarzi

{"title":"Knowledge and attitude of Iranian university students toward genital warts","authors":"Z. Aryanian, M. Mohammadi, A. Babazadeh, I. Etesami, Parvaneh Hatami, M. Barary, S. Ebrahimpour, Parisa Sabbagh, A. Goodarzi","doi":"10.1101/2021.04.15.21255532","DOIUrl":"https://doi.org/10.1101/2021.04.15.21255532","url":null,"abstract":"Human papillomavirus (HPV) is one of the well-known causes of cervical cancer and one of the most prevalent sexually transmitted diseases (STDs). Since cervical cancer is one of the most common causes of morbidity and mortality in women, this study was performed to investigate students' knowledge and attitudes in Babol University of Medical Sciences, Northern Iran, towards genital warts. This cross-sectional study assessed the perception and attitudes of 385 students at Babol University of Medical Sciences using a preconceived questionnaire. The data collection tool used in this study was a questionnaire that was confirmed to be valid and reliable. The participants' mean age was 23.70 +- 3.27 years, with a range of 20-50 years. Evaluation of these students' level of general information about HPV showed that 7 (1.8%) students had inadequate general information, 34 (8.8%) had moderate knowledge, and 344 (89.4%) had good general knowledge in this setting. There was also a significant association between students' general knowledge of HPV and their field of study. Based on the present study results, the knowledge of the majority of Babol University of Medical Sciences students about genital warts was in a good range, and their knowledge about HPV routes of transmission was of moderate level. Moreover, the majority had an appropriate attitude to interact with people infected with HPV.","PeriodicalId":39128,"journal":{"name":"Interdisciplinary Perspectives on Infectious Diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48006421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of the RCOS Prognostic Index: A Bedside Multivariable Logistic Regression Model to Predict Hypoxaemia or Death in Patients with SARS-CoV-2 Infection RCOS预后指数的开发和验证：一个预测严重急性呼吸系统综合征冠状病毒2型感染患者缺氧或死亡的床边多变量Logistic回归模型

Interdisciplinary Perspectives on Infectious Diseases Pub Date : 2021-03-30 DOI: 10.1101/2021.03.29.21254393

G. Alvarez-Uria, S. Gandra, V. R. Gurram, Raghuprakash Reddy, Manoranjan Midde, Praveen Kumar, Ketty E Arce

{"title":"Development and Validation of the RCOS Prognostic Index: A Bedside Multivariable Logistic Regression Model to Predict Hypoxaemia or Death in Patients with SARS-CoV-2 Infection","authors":"G. Alvarez-Uria, S. Gandra, V. R. Gurram, Raghuprakash Reddy, Manoranjan Midde, Praveen Kumar, Ketty E Arce","doi":"10.1101/2021.03.29.21254393","DOIUrl":"https://doi.org/10.1101/2021.03.29.21254393","url":null,"abstract":"Previous COVID-19 prognostic models have been developed in hospital settings, and are not applicable to COVID-19 cases in the general population. There is an urgent need for prognostic scores aimed to identify patients at high risk of complications at the time of COVID-19 diagnosis. The RDT COVID-19 Observational Study (RCOS) collected clinical data from patients with COVID-19 admitted regardless of the severity of their symptoms in a general hospital in India. We aimed to develop and validate a simple bedside prognostic score to predict the risk of hypoxaemia or death. 4035 patients were included in the development cohort and 2046 in the validation cohort. The primary outcome occurred in 961 (23.8%) and 548 (26.8%) patients in the development and validation cohorts, respectively. The final model included 12 variables: age, systolic blood pressure, heart rate, respiratory rate, aspartate transaminase, lactate dehydrogenase, urea, C-reactive protein, sodium, lymphocyte count, neutrophil count and neutrophil/lymphocyte ratio. In the validation cohort, the area under the receiver operating characteristic curve (AUROCC) was 0.907 (95% CI, 0.892-0.922) and the Brier Score was 0.098. The decision curve analysis showed good clinical utility in hypothetical scenarios where admission of patients was decided according to the prognostic index. When the prognostic index was used to predict mortality in the validation cohort, the AUROCC was 0.947 (95% CI, 0.925-0.97) and the Brier score was 0.0188. If our results are validated in other settings, the RCOS prognostic index could help improve the decision making in the current COVID-19 pandemic, especially in resource limited-settings.","PeriodicalId":39128,"journal":{"name":"Interdisciplinary Perspectives on Infectious Diseases","volume":"2022 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49023925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1