Open Respiratory Medicine Journal最新文献

{"title":"Serum CYFRA 21-1 but not Vimentin is Associated with Poor Prognosis in Advanced Lung Cancer Patients.","authors":"Nobuhiro Kanaji,&nbsp;Kyuichi Kadota,&nbsp;Akira Tadokoro,&nbsp;Takuya Inoue,&nbsp;Naoki Watanabe,&nbsp;Reiji Haba,&nbsp;Norimitsu Kadowaki,&nbsp;Tomoya Ishii","doi":"10.2174/1874306401913010031","DOIUrl":"https://doi.org/10.2174/1874306401913010031","url":null,"abstract":"<p><strong>Background: </strong>Cytokeratins and Vimentin are intermediate filament proteins. Vimentin expression in tissue samples has been reported to be associated with a poor prognosis in non-small cell lung cancer patients who underwent surgery. CYFRA 21-1 (Cytokeratin 19 Fragment) is a well known tumor marker.</p><p><strong>Objective: </strong>This study aimed to investigate the usefulness of serum vimentin as a tumor marker and significance of CYFRA 21-1 and vimentin expression on prognosis of advanced lung cancer patients.</p><p><strong>Methods: </strong>One hundred and four advanced lung cancer patients and 19 non-lung cancer patients were included. A total of 157 clinical samples obtained from 113 patients was used for immunostaining of vimentin and measurements of CYFRA 21-1 and vimentin concentrations.</p><p><strong>Results: </strong>Compared to low concentration, high concentration of serum CYFRA 21-1 was associated with shorter overall survival in lung cancer patients. However, there was no difference in the serum vimentin concentration between the patients with lung cancer and those with non-lung cancer. No difference in vimentin concentration was observed between the malignant and non-malignant pleural effusions. Immunostaining revealed that of the 43 tumor samples, 21 were positive and 22 were negative for vimentin. No significant difference was found in overall survival between patients with positive and negative for vimentin.</p><p><strong>Conclusion: </strong>An elevated serum CYFRA 21-1 concentration was associated with shorter overall survival in advanced lung cancer patients. However, serum vimentin was not as useful as a tumor marker of lung cancer. The vimentin positivity in tumor samples might not predict patients' prognosis in patients with advanced lung cancer.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"13 ","pages":"31-37"},"PeriodicalIF":0.0,"publicationDate":"2019-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/29/3e/TORMJ-13-31.PMC6918537.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37518174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Noninvasive Ventilation with Volume-Assured Pressure Support in Neuralgic Amyotrophy with Bilateral Diaphragmatic Paralysis.","authors":"Montserrat Diaz-Abad,&nbsp;Neil Porter,&nbsp;Lindsay Zilliox,&nbsp;Nevins Todd","doi":"10.2174/1874306401913010045","DOIUrl":"https://doi.org/10.2174/1874306401913010045","url":null,"abstract":"<p><p>Neuralgic Amyotrophy (NA) is a rare, acute onset inflammatory brachial plexopathy that frequently presents with acute pain followed by shoulder girdle muscle weakness. Phrenic nerve involvement affecting the diaphragms occurs in 7-10% of cases. We present the case of a 52-year-old man with neuralgic amyotrophy with phrenic nerve involvement and bilateral diaphragmatic paralysis with marked respiratory symptoms and sleep hypoventilation, who was treated with non-invasive ventilation with volume assured pressure support mode. By 21 months post disease onset, the patient had experienced marked improvement in orthopnea, sleep quality and functional status. This is the first reported case of the use of this mode of noninvasive ventilation in neuralgic amyotrophy.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"13 ","pages":"45-47"},"PeriodicalIF":0.0,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e5/49/TORMJ-13-45.PMC6918536.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37518175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Clinical Markers During A Short-Term Transfer Program of Adult Cystic Fibrosis Patients from Pediatric to Adult Care.","authors":"Matthias Welsner,&nbsp;Sivagurunathan Sutharsan,&nbsp;Christian Taube,&nbsp;Margarete Olivier,&nbsp;Uwe Mellies,&nbsp;Florian Stehling","doi":"10.2174/1874306401913010011","DOIUrl":"https://doi.org/10.2174/1874306401913010011","url":null,"abstract":"<p><strong>Background: </strong>Transition from child-oriented to adult-oriented health care in Cystic Fibrosis (CF) has become more important over recent decades as the survival of people with this disease has increased. The transition process usually begins in adolescence, with full transfer completed in early adulthood.</p><p><strong>Objective: </strong>This study investigated the impact of a short-term transfer program on clinical markers in an adult CF cohort still being managed by pediatricians.</p><p><strong>Methods: </strong>Clinically relevant data from the year before (T-1), the time of Transfer (T) and the year after the transfer (T+1) were analysed retrospectively.</p><p><strong>Results: </strong>39 patients (median age 29.0 years; 64% male) were transferred between February and December 2016. Lung function had declined significantly in the year before transfer (in % predicted: Forced Expiratory Volume in 1 second (FEV), 62.8 <i>vs.</i> 57.7, <i>p</i> <0.05; Forced Vital Capacity (FVC), 79.9 <i>vs.</i> 71.1, <i>p</i><0.05), but remained stable in the year after transfer (in % predicted: FEV: 56.3; FVC 68.2). BMI was stable over the whole observational period. There was no relevant change in chronic lung infection with <i>P. aeruginosa</i>, Methicillin-Resistant Staphylococcus aureus (MRSA) and <i>Burkholderia</i> sp. during the observation period. The number of patient contacts increased significantly in the year after versus the year before transfer (inpatient: 1.51 <i>vs.</i> 2.51, <i>p</i><0.05; outpatient: 2.67 <i>vs.</i> 3.41, <i>p</i><0.05).</p><p><strong>Conclusions: </strong>Our data show that, within the framework of a structured transfer process, it is possible to transfer a large number of adult CF patients, outside a classic transition program, from a pediatric to an adult CF center in a short period of time, without any relevant changes in clinical markers and, stability.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"13 ","pages":"11-18"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ea/44/TORMJ-13-11.PMC6918541.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37518248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonographically Measured Improvement in Diaphragmatic Mobility and Outcomes Among Patients Requiring Prolonged Weaning from the Ventilator.","authors":"N Gibis,&nbsp;A Schulz,&nbsp;S Vonderbank,&nbsp;M Boyko,&nbsp;H Gürleyen,&nbsp;X Schulz,&nbsp;A Bastian","doi":"10.2174/1874306401913010038","DOIUrl":"https://doi.org/10.2174/1874306401913010038","url":null,"abstract":"<p><strong>Background: </strong>The need of prolonged weaning from the ventilator is a well-known predictor of an unfavorable patients` outcome. Diaphragmatic dysfunction is a serious problem for these patients. We wanted to determine the survival in patients who were already intubated for more than 4 weeks before they were admitted to our weaning unit. In this prospective study, we wanted to investigate if the diaphragmatic function could improve or was related to survival over an 18 months follow up period.</p><p><strong>Methods: </strong>84 patients were included when they were able to breathe at least 10 minutes over a t-piece and sit upright for at least 5 minutes. The diaphragmatic function was estimated sonographically using the up and downward movement of the lung silhouette. Sonographic follow-ups were performed for over 18 months. The survival rate, outcome and changes in diaphragm mobility were investigated.</p><p><strong>Results: </strong>a) Survival: 49 patients (58%) survived the 18 months follow up period - 30 had a good outcome; 19 needed assistance. b) Survival in relation to diaphragm mobility: If diaphragmatic mobility improved ≥ 15.5 mm on the left side, the probability of survival was 94% with a probability of 76% to have a satisfying outcome.</p><p><strong>Conclusion: </strong>Survival and outcome of prolonged weaning were significantly better when sonographically measured the mobility of left hemidiaphragm improved.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"13 ","pages":"38-44"},"PeriodicalIF":0.0,"publicationDate":"2019-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c2/fe/TORMJ-13-38.PMC6935944.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37535279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asbestos Bodies Burden in the Autopsy Lung Tissue from General Thai Population.","authors":"Pimpin Incharoen,&nbsp;Tuanseeta Hama,&nbsp;Lalida Arsa,&nbsp;Kaettipong Kamprerasart,&nbsp;Sompong Wongwichai,&nbsp;Somchai Bovornkitti","doi":"10.2174/1874306401913010005","DOIUrl":"https://doi.org/10.2174/1874306401913010005","url":null,"abstract":"<p><strong>Background: </strong>Chrysotile asbestos has been used in Thailand for over 30 years mainly in asbestos-cement wall and roof tiles. In non-exposed subject, asbestos fiber can contaminate in ambient indoor and outdoor environments.</p><p><strong>Objective: </strong>The aim of the present study is to evaluate the current prevalence and volume of AB load in general Thai population.</p><p><strong>Methods: </strong>Lung tissues were obtained from 200 autopsy cases. Asbestos Bodies (AB) were identified with light microscopy using the tissue digestion and membrane filtration method. Results are reported as AB/g wet lung tissue.</p><p><strong>Results: </strong>AB was identified in 97(48.5%) out of 200 cases. The AB level ranged from 0.19-14.4 AB/g wet lung. Most of the positive cases (99%) have less than 10 AB/g wet lung. Only one case exhibited a high value at 14.4 AB/g wet lung. Age, gender, occupation and hometown were found to have no effect on AB burden in autopsy lung tissue from this study.</p><p><strong>Conclusion: </strong>The prevalence of AB in autopsy lung tissue from general Thai population is 48.5% and the AB level ranges from 0-14.4 AB/g wet lung in consistent with non-occupational asbestos exposure level regarding several reference reports.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"13 ","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"2019-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/19/TORMJ-13-5.PMC6935945.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37536453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Risk Factors for Latent Tuberculosis Infection among Healthcare Workers in a Low Incidence Country.","authors":"Luca Coppeta,&nbsp;Antonio Pietroiusti,&nbsp;Anna Neri,&nbsp;Aurelio Janni,&nbsp;Savino Baldi,&nbsp;Francesca Papa,&nbsp;Andrea Magrini","doi":"10.2174/1874306401913010001","DOIUrl":"https://doi.org/10.2174/1874306401913010001","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis prevention is a major goal in the hospital setting. Because of the possible progression or reactivation of latent disease, the screening of healthcare workers is an important issue in the TB control program. The aim of the study was to assess the prevalence of LTBI (latent tuberculosis infection) and to evaluate the main risk factors related to this condition in a teaching hospital in Italy.</p><p><strong>Methods: </strong>We reviewed the data of a tuberculosis screening conducted on 3622 healthcare professionals in a teaching hospital in Rome. All subjects were evaluated by QuantiFERON test which if positive, was followed by appropriate clinical and diagnostic procedures.</p><p><strong>Results: </strong>Latent Tuberculosis Infection LTBI condition was detected in 2.1% of the cases, most commonly in men. Male gender, higher age class, country of birth and nurse job were statistically related with the positivity to QuantiFERON test.</p><p><strong>Conclusion: </strong>LTBI was relatively uncommon in our population, however, given the potential risk of reactivation and progression to overt disease, the screening of healthcare workers and students is recommended in the hospital of low-incidence countries.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"13 ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e7/c3/TORMJ-13-1.PMC6918539.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37518247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric Aspiration and Its Role in Airway Inflammation.","authors":"E B Hunt,&nbsp;A Sullivan,&nbsp;J Galvin,&nbsp;J MacSharry,&nbsp;D M Murphy","doi":"10.2174/1874306401812010083","DOIUrl":"https://doi.org/10.2174/1874306401812010083","url":null,"abstract":"","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"12 ","pages":"83"},"PeriodicalIF":0.0,"publicationDate":"2018-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37154782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a Clinical Instrument for Measuring the Severity of Acute Bronchitis in Children - The BSS-ped.","authors":"Siegfried Lehrl,&nbsp;Peter Kardos,&nbsp;Heinrich Matthys,&nbsp;Wolfgang Kamin","doi":"10.2174/1874306401812010081","DOIUrl":"https://doi.org/10.2174/1874306401812010081","url":null,"abstract":"RESEARCH ARTICLE Validation of a Clinical Instrument for Measuring the Severity of Acute Bronchitis in Children – The BSS-ped Siegfried Lehrl, Peter Kardos, Heinrich Matthys and Wolfgang Kamin Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany Group Practice and Centre for Pneumology, Center for Respiratory, Allergy and Sleep Medicine at Red Cross Maingau Hospital, Frankfurt am Main, Germany Department of Pneumology, University Hospital Freiburg, Freiburg, Germany Clinic for Paediatrics, Evangelic Hospital Hamm, Hamm, Germany","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"12 ","pages":"81-82"},"PeriodicalIF":0.0,"publicationDate":"2018-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37154781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging In Acute Bronchiolitis: Evaluation of The Current Practice In a Kuwaiti Governmental Hospital and Its Possible Impact on Hospitalization Period.","authors":"Alaa Abdel-Kader,&nbsp;May Fouad Nassar,&nbsp;Zahra Qabazard,&nbsp;Mohamed Disawi","doi":"10.2174/1874306401812010075","DOIUrl":"https://doi.org/10.2174/1874306401812010075","url":null,"abstract":"<p><strong>Background and objectives: </strong>Guidelines for acute bronchiolitis recommend primarily supportive care, but unnecessary treatment measures remain well documented. This study was designed to assess the Al-Adan Hospital pediatricians` attitude towards imaging of inpatients with bronchiolitis aiming to evaluate its utilization and possible impact on patients` management and length of hospital stay.</p><p><strong>Subjects and methods: </strong>This study included 194 cases of acute bronchiolitis admitted to Al-Adan Hospital. Number of X-Rays done following admission and reasons stated in the files were recorded. Bronchiolitis severity was estimated from the data obtained.</p><p><strong>Results: </strong>Chest X-Rays were ordered in 52.1% of our inpatients with acute bronchiolitis. In nearly half of those cases, the reason for X-Ray request is a clinical severity factor, namely desaturations and apneas, and in rest of the cases, no specific reason for ordering X-Rays was documented. Significantly more patients who had two or more X-Rays were prescribed antibiotics and had statistically longer hospital stay. The number of X-Rays performed during admission was not a significant contributor to the need for PICU care, however, it was a significant factor affecting the length of hospital stay.</p><p><strong>Conclusion: </strong>The implementation of acute bronchiolitis guidelines regarding imaging in admitted cases with acute bronchiolitis is highly recommended in Al-Adan hospital. Clear documentation for the reasons behind ordering X-Rays is needed for those cases. A decrease in the X-Ray utilization and subsequent unnecessary antibiotic use can help in decreasing the costs and hazards of hospitalization for patients with acute bronchiolitis.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"12 ","pages":"75-80"},"PeriodicalIF":0.0,"publicationDate":"2018-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37154780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Montelukast 10 mg in Elderly Patients with Mild and Moderate Asthma Compared with Young Adults. Results of a Cohort Study.","authors":"Guillermo Sánchez,&nbsp;Diana Buitrago","doi":"10.2174/1874306401812010067","DOIUrl":"https://doi.org/10.2174/1874306401812010067","url":null,"abstract":"<p><strong>Background: </strong>The clinical characteristics and physio-pathogenic mechanisms of asthma in patients older than 60 years appear to differ from the behavior described for other age groups. Therefore, the effectiveness of medications for elderly patients with asthma should not be extrapolated from studies conducted on teenagers or young adults.</p><p><strong>Objective: </strong>The study aimed to establish the clinical effect of montelukast 10 mg in elderly patients with mild and moderate asthma compared to its effect on young adults.</p><p><strong>Method: </strong>A prospective cohort study was conducted during 12 weeks of follow-up, which consecutively included the total population of adult patients attended by a group of 21 general practitioners, between July and December 2016. Young adults (18-59 years) and older adults were included (60 years or older) with mild or moderate asthma, which, according to the criteria of his treating physician, had been prescribed montelukast 10 mg/day. The variables of interest were: use of inhaled corticosteroids during the last month, use of inhaled beta-2 adrenergic agonists as a rescue in the last month, having attended the emergency service during the last month due to an asthma attack, presence of wheezing in the physical examination, the number of attacks in the last month and the number of days without symptoms in the last month.</p><p><strong>Results: </strong>A total of 126 patients entered the cohort and 104 completed the follow-up, of which 29% were older adults. On admission, 65.4% of patients (68/104) had used rescue inhaled beta2 in the last month and had been using schemes with corticosteroids. After 12 weeks of follow-up, 58.1% (43/74) of the young adults required treatment schedules with corticosteroids, while in the elderly, only 36.7% of the patients (11/30) required this treatment scheme (<i>p</i>-value: 0.047). Regarding the use of rescue inhaled beta-2 at 12 weeks, 55% of young adults reported using them, compared to 33.3% of older adults (<i>p</i>-value: 0.041).</p><p><strong>Conclusion: </strong>In this cohort of patients, treated with montelukast 10 mg/day for 12 weeks, there was a reduction of broncho-obstructive symptoms and exacerbations of the disease. In older adults compared to young adults, a greater reduction in the use of beta2 agonists rescue medications and in the concomitant use of inhaled corticosteroid schemes was documented.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"12 ","pages":"67-74"},"PeriodicalIF":0.0,"publicationDate":"2018-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874306401812010067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37154779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}