Neurologia Argentina最新文献_第4页

Embolia grasa cerebral de presentación inusual: reporte de caso 表现异常的脑脂肪栓塞：病例报告

Neurologia Argentina Pub Date : 2024-04-01 DOI: 10.1016/j.neuarg.2024.02.003

Lizeth Acosta Tascón , Tomás Acosta Pérez , Jaime Andrés Gómez Jiménez , José Mauricio Cárdenas Prieto

引用次数: 0

Episodios «stroke-like» en madre e hija portadoras de enfermedad de MELAS: reporte de 2 casos y revisión de la literatura MELAS 疾病母女携带者的中风样发作：2 例病例报告和文献综述。

Neurologia Argentina Pub Date : 2024-04-01 DOI: 10.1016/j.neuarg.2024.03.001

Joselyn Miño , Rodrigo Sanjinez , Facundo Escandón , Juan Ignacio Kenny , Rosario Elena , Agustina Moroni , Alejandra Heriz

{"title":"Episodios «stroke-like» en madre e hija portadoras de enfermedad de MELAS: reporte de 2 casos y revisión de la literatura","authors":"Joselyn Miño , Rodrigo Sanjinez , Facundo Escandón , Juan Ignacio Kenny , Rosario Elena , Agustina Moroni , Alejandra Heriz","doi":"10.1016/j.neuarg.2024.03.001","DOIUrl":"10.1016/j.neuarg.2024.03.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Mitochondrial diseases are maternally inherited, and the most prevalent is MELAS syndrome. The clinical features of the disease are myopathy, encephalopathy, seizures, lactic acidosis, and stroke-like episodes (SLEs). Its typical presentation is in young adults, adolescents and children, its debut in older adults being much rarer.</p></div><div><h3>Clinical cases</h3><p>We present clinical cases of 2 female patients, daughter and mother, aged 31 and 75, respectively. Both are short of stature and had hearing loss as a previously shared symptom. The first with debut in early adulthood characterized by several episodes that resembled a stroke, lactic acidosis and seizures; and the second with encephalopathy, and a SLE. Both with brain MRI that showed extensive lesions without respecting specific vascular territories and an evolution with subsequent imaging improvement. The youngest performed a genetic test that confirmed mitochondrial disease. His mother debuted later, so the diagnostic suspicion was directed to MELAS. To assess the consequences, neuropsychological tests were performed, both with evidence of showing minor (daughter) and major (mother) neurocognitive disorder.</p></div><div><h3>Conclusion</h3><p>MELAS syndrome should be suspected in patients with recurrent SLEs and images that subsequently resolve. We emphasize the foolishness of a high diagnostic suspicion, even in late presentations after the 6th decade of life. Although there is no specific therapy, the disease can be controlled with amino acid supplementation and strict nutritional guidelines to avoid metabolic crises that exacerbate the condition. It should be considered that there is no proven treatment to stop the progression of the disease.</p></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"16 2","pages":"Pages 92-99"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140775685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

¿Podrían los aminoácidos ser un biomarcador de crisis en pacientes con epilepsia? 氨基酸可能是癫痫患者癫痫发作的生物标志物吗？

Neurologia Argentina Pub Date : 2024-04-01 DOI: 10.1016/j.neuarg.2024.04.001

María Claudia Burbano , Yandri Lorena Garcia , Martín Aran , Leonardo Pellizza , Eugenia Hesse , María del Carmen Garcia , Juan Carlos Avalos

{"title":"¿Podrían los aminoácidos ser un biomarcador de crisis en pacientes con epilepsia?","authors":"María Claudia Burbano , Yandri Lorena Garcia , Martín Aran , Leonardo Pellizza , Eugenia Hesse , María del Carmen Garcia , Juan Carlos Avalos","doi":"10.1016/j.neuarg.2024.04.001","DOIUrl":"10.1016/j.neuarg.2024.04.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Different metabolic pathways may be altered after a seizure, including amino acids. Our study aims to analyze serum amino acid concentrations in patients with epilepsy through metabolomic evaluation using magnetic resonance spectroscopy and determine their utility as biomarkers of seizures.</p></div><div><h3>Methods</h3><p>A cross-sectional study involving patients with epilepsy and a healthy control group. Serum levels of fifteen amino acids were analyzed using magnetic resonance spectroscopy, and clinical-demographic variables were collected. Statistical analysis was conducted with SPSS21, considering a significant value of p ≤ 0.05.</p></div><div><h3>Results</h3><p>The study included fourteen patients with epilepsy and thirteen controls. Patients exhibited higher levels of glutamic acid (3.613 AUC vs. 2.861 AUC, p 0.043) and proline (4.851 AUC vs. 3.843 AUC, p 0.038), while phenylalanine (0.706 AUC vs. 0.861 AUC, p 0.016), tryptophan (2.129 AUC vs. 2.512 AUC, p 0.007), and threonine (4.424 AUC vs. 5.313 AUC, p 0.033) showed lower concentrations than the control group. Following seizures, a decrease in threonine (5.006 AUC vs. 4.424 AUC, p 0.007), isoleucine (3.974 AUC vs. 3.240 AUC, p 0.027), valine (2.783 AUC vs. 2.534 AUC, p 0.044), and leucine (1.790 AUC vs. 1.572 AUC, p 0.025) was observed in the serum.</p></div><div><h3>Conclusion</h3><p>The reduction in threonine, valine, isoleucine, and leucine after a seizure could be considered a biomarker for the disease, although further investigations are required to confirm these findings.</p></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"16 2","pages":"Pages 66-72"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141138931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parálisis periódica tirotóxica, una serie de casos 甲亢性周期性麻痹病例系列

Neurologia Argentina Pub Date : 2024-04-01 DOI: 10.1016/j.neuarg.2024.04.003

José Luis Bustos Sánchez , Luisa Ivonne Guerra Guerra , Iván Andrés Penagos Martínez , Jeisson Steven Núñez Mesa , Ledmar Jovanny Vargas Rodríguez

{"title":"Parálisis periódica tirotóxica, una serie de casos","authors":"José Luis Bustos Sánchez , Luisa Ivonne Guerra Guerra , Iván Andrés Penagos Martínez , Jeisson Steven Núñez Mesa , Ledmar Jovanny Vargas Rodríguez","doi":"10.1016/j.neuarg.2024.04.003","DOIUrl":"10.1016/j.neuarg.2024.04.003","url":null,"abstract":"<div><h3>Background</h3><p>Thyrotoxic periodic paralysis (TPP) is a rare but dangerous complication observed in thyrotoxic patients, where a clinical presentation of muscle compromise common in channelopathies occurs.</p></div><div><h3>Objective</h3><p>The objective of the study was to present 2clinical cases of patients who presented PPT.</p></div><div><h3>Clinical cases</h3><p><strong>Case 1:</strong> A 31-year-old male patient, with a progressive picture of asthenia, cramps, decreased muscle strength in the 4 extremities with greater involvement of the lower extremities, gait slower than usual, and tremor over the course of 4 days distal postural position in all 4 extremities, not triggered by any physical activity or stressful situation. <strong>Case 2:</strong> A 25-year-old male patient, with a 3-day progression of weakness in the 4 extremities, with a greater predominance in the lower extremities associated with myalgia in the thighs and calves, not triggered by any physical activity or stressful situation.</p></div><div><h3>Conclusion</h3><p>In the cases presented, the patients reported hypokalemia and uncontrolled hyperthyroidism in the paraclinical tests, so it was decided to perform management with K<sup>+</sup> replacement to prevent rebound hyperkalemia and β blockers, with which an adequate evolution was obtained, concluding that it presented with PPT. This pathological entity should be suspected in patients with thyrotoxicosis, hypokalemia, and sudden proximal symmetric muscle weakness of the lower extremities.</p></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"16 2","pages":"Pages 109-112"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141039614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epilepsia de ausencias infantil y juvenil y comorbilidades asociadas 儿童和青少年失神癫痫及相关并发症

Neurologia Argentina Pub Date : 2024-04-01 DOI: 10.1016/j.neuarg.2024.02.005

Luisa Fernanda Ortiz Velásquez , Stephanie Sánchez Villa , Angélica Arteaga Arteaga , Laura Fernanda Niño-Serna

{"title":"Epilepsia de ausencias infantil y juvenil y comorbilidades asociadas","authors":"Luisa Fernanda Ortiz Velásquez , Stephanie Sánchez Villa , Angélica Arteaga Arteaga , Laura Fernanda Niño-Serna","doi":"10.1016/j.neuarg.2024.02.005","DOIUrl":"10.1016/j.neuarg.2024.02.005","url":null,"abstract":"<div><h3>Introduction</h3><p>Among the idiopathic generalized epilepsies, absence epilepsy is the most prevalent type. They can be associated with cognitive, behavioral, or psychiatric disorders.</p></div><div><h3>Objective</h3><p>To describe the clinical and electroencephalographic characteristics, as well as the comorbidities, in children under 18 years old who had childhood and juvenile absences epilepsy.</p></div><div><h3>Patients and methods</h3><p>Retrospective, single-center, observational study in a referral center for 8 years.</p></div><div><h3>Results</h3><p>Of the 103 patients, 67 were female (65%). The median age of the first crisis was 7 years. Forty-four percent of patients had a personal history of seizures, and half had a family history of epilepsy. Learning disorders were present in 21% of the patients; 14% had associated attention-deficit hyperactivity disorders, and 11% had both. Anxiety and depression were found in 10% of children. The electroencephalogram, in most cases (68%), presented abnormal activity. The most used drug was valproic acid.</p></div><div><h3>Conclusion</h3><p>Behavioral, cognitive, and psychiatric comorbidities are common in children with childhood and juvenile absence epilepsy, so an active search for these disorders is required in order to achieve timely treatment and reduce the impact on the school life of children and adolescents.</p></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"16 2","pages":"Pages 59-65"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140786968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disautonomía cardíaca parasimpática en pacientes con esclerosis lateral amiotrófica 肌萎缩性脊髓侧索硬化症患者的副交感神经性心脏自主神经功能障碍

Neurologia Argentina Pub Date : 2024-04-01 DOI: 10.1016/j.neuarg.2024.03.003

Cecilia Quarracino , Natalia Bohórquez Morera , Francisco Capani , Santiago Pérez-Lloret , Gabriel Eduardo Rodríguez

{"title":"Disautonomía cardíaca parasimpática en pacientes con esclerosis lateral amiotrófica","authors":"Cecilia Quarracino , Natalia Bohórquez Morera , Francisco Capani , Santiago Pérez-Lloret , Gabriel Eduardo Rodríguez","doi":"10.1016/j.neuarg.2024.03.003","DOIUrl":"10.1016/j.neuarg.2024.03.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Although some studies have shown the presence of cardiac dysautonomia in amyotrophic lateral sclerosis (ALS) patients, its relationship with the disease is still controversial.</p></div><div><h3>Objective</h3><p>To explore cardiac dysautonomia in ALS and its possible association with disease evolution and patient's quality of life.</p></div><div><h3>Materials and methods</h3><p>We evaluated demographics and disease-related variables, comorbidities and quality of life in 20 ALS patients. We performed the autonomic symptoms profile and SF-36 (quality of life) scales. Patients were also evaluated with dynamometry, orthostatic testing and RR interval variability (RRIV) in resting and deep breathing electrocardiograms. Twenty age- and gender- matched healthy individuals served as controls for autonomic cardiovascular measurements.</p></div><div><h3>Results</h3><p>The mean age of ALS patients was 52±14 years, 75% were male and 85% had spinal disease onset. The mean score as per the ALS-FRS and FVC were 25.65±10.55 and 67%±21, respectively. Cardiac parasympathetic dysautonomia was found in 4 out of 17 (25%) ALS patients vs. none of the controls (<em>P</em>    <!-->0.18).</p></div><div><h3>Conclusion</h3><p>Parasympathetic cardiac dysautonomia was observed in 25% of the ALS patients. Lack of association with epidemiological or ALS-related variables suggests a different pathological process.</p></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"16 2","pages":"Pages 73-79"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141029217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacto de una intervención breve y online de mindfulness para mejorar el rendimiento cognitivo y bienestar emocional en adultos 简短的在线正念干预对提高成人认知能力和情绪健康的影响。

Neurologia Argentina Pub Date : 2024-01-01 DOI: 10.1016/j.neuarg.2024.02.002

María Emilia Gobbo , Leonardo Adrian Medrano , María de la Paz Scribano Parada , Fátima González Palau

{"title":"Impacto de una intervención breve y online de mindfulness para mejorar el rendimiento cognitivo y bienestar emocional en adultos","authors":"María Emilia Gobbo , Leonardo Adrian Medrano , María de la Paz Scribano Parada , Fátima González Palau","doi":"10.1016/j.neuarg.2024.02.002","DOIUrl":"10.1016/j.neuarg.2024.02.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Mindfulness is defined as a form of conscious and deliberate attention to the present moment without judgment. The objective of this research was to evaluate the impact of the application of a brief online group program based on mindfulness on the cognitive functions, emotional and mindfulness variables of an adult community population.</p></div><div><h3>Method</h3><p>58 people participated, to whom a battery of neuropsychological and psychological tests were administered pre and post intervention. A 6-week training program in mindfulness skills was applied in order to evaluate its impact on emotional variables, as well as performance in episodic memory, attentional processes and executive functions.</p></div><div><h3>Results</h3><p>For most of the emotional variables, a statistically significant interaction effect was verified, observing in the experimental group an improvement in the variables anxiety and depression, state and trait well-being, in the post-test compared to the pre-test except in the perceived stress variable. where there were no changes after the intervention. In the cognitive functions of verbal episodic memory, sustained, selective and alternating attention, attentional span, cognitive flexibility, inhibitory control and information processing speed, no statistically significant interaction differences were observed after training.</p></div><div><h3>Conclusion</h3><p>The study results provide more evidence in favor of the benefits of programs based on mindfulness, online and brief modality, for the emotional well-being of the general population.</p></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"16 1","pages":"Pages 22-30"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140084907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Síndrome de Miller Fisher: un caso desafiante para el diagnóstico diferencial 米勒-费希尔综合征：鉴别诊断的难题

Neurologia Argentina Pub Date : 2024-01-01 DOI: 10.1016/j.neuarg.2023.12.002

Vileth Johana Franco Torres , Jair Alexander Montenegro Pérez , Melani Saray Caballero Alonso , Daniela Jireth Merlano Betin , Nohemí Meza Cely

引用次数: 0

Omaveloxolone para la ataxia de Friedreich: un primer paso innovador hacia futuros avances en el tratamiento de esta enfermedad 治疗弗里德里希共济失调症的奥马韦洛酮：迈向未来疾病治疗进展的突破性第一步

Neurologia Argentina Pub Date : 2024-01-01 DOI: 10.1016/j.neuarg.2023.12.003

Dolores Gonzalez Moron, Carolina Azcona, Sergio Rodriguez Quiroga, Patricia Vega, Marcelo Andres Kauffman

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Relevamiento de residencias y concurrencias de neurología en Argentina 阿根廷神经病学住院医师和主治医师调查

Neurologia Argentina Pub Date : 2024-01-01 DOI: 10.1016/j.neuarg.2023.12.001

Josefina Seguí , Agustina Piedrabuena , Matías Alet

{"title":"Relevamiento de residencias y concurrencias de neurología en Argentina","authors":"Josefina Seguí , Agustina Piedrabuena , Matías Alet","doi":"10.1016/j.neuarg.2023.12.001","DOIUrl":"10.1016/j.neuarg.2023.12.001","url":null,"abstract":"<div><h3>Introduction</h3><p>In Argentina, physicians can obtain specialization certification through a university postgraduate program, courses provided by recognized medical associations or through a residency or concurrence. Neurologists constitute a small percentage of specialists, with only 0.67% of the available slots in the unique exam allocated to neurology. Accurate data regarding the current situation of training centers in this specialty is lacking. The objective of this study is to assess the current status of neurology residencies and concurrencies in our country.</p></div><div><h3>Materials and methods</h3><p>Descriptive observational study. Data were collected on institutions offering neurology services and training in the country. A representative from each institution was contacted and administered a questionnaire regarding the presence and number of residents, concurrents, chief resident, resident instructor, with a breakdown by year of training. Information on membership in the Argentine Neurological Society was also obtained.</p></div><div><h3>Results</h3><p>A total of 52 centers with neurology residency and/or concurrence programs were surveyed. 61.5% (<em>n</em>  =146) and PBA (<em>n</em>  =37), encompassing 69.4% of neurologists in training. Only 37.5% of professionals (<em>n</em>  <!-->116) were members of the Argentine Neurological Society.</p></div><div><h3>Conclusion</h3><p>We observed a significant disparity in the geographical distribution of neurology training programs in Argentina, contributing to the shortage of neurologists in less populated areas. A collaborative and periodic survey is needed to improve the distribution of future neurologists in the country.</p></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"16 1","pages":"Pages 9-14"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139456960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0