Neurologia Argentina最新文献_第10页

Presentación atípica en resonancia de cerebro de la enfermedad de Creutzfeldt-Jakob: reporte de un caso 克雅氏病的非典型脑共振表现:病例报告

Neurologia Argentina Pub Date : 2023-04-01 DOI: 10.1016/j.neuarg.2023.01.003

Rodrigo Sanjinez , Rocío Márquez , Juan Pablo Rodríguez , Otto Vega , José Zuñiga , Alejandra Heriz

引用次数: 0

Volumetría encefálica en imágenes de tomografía computarizada en adultos con funciones cognitivas normales 认知功能正常成人计算机断层扫描图像中的脑容量测量

Neurologia Argentina Pub Date : 2023-04-01 DOI: 10.1016/j.neuarg.2022.11.003

Katherine Susana Hernández-Cortés , Adrián Alberto Mesa-Pujals , Lázaro Ibrahim Romero-García , Nelsa María Sagaró-del Campo , Arquímes Montoya-Pedrón

{"title":"Volumetría encefálica en imágenes de tomografía computarizada en adultos con funciones cognitivas normales","authors":"Katherine Susana Hernández-Cortés , Adrián Alberto Mesa-Pujals , Lázaro Ibrahim Romero-García , Nelsa María Sagaró-del Campo , Arquímes Montoya-Pedrón","doi":"10.1016/j.neuarg.2022.11.003","DOIUrl":"10.1016/j.neuarg.2022.11.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Advanced neuroimaging techniques allow exploratory analyzes of structural alterations that can be used as evaluations of changes related to age and sex for the early diagnosis of cognitive decline.</p></div><div><h3>Objective</h3><p>To determine the differences in brain volume in relation to age, sex and the score of the mini mental test for the diagnosis of cognitive impairment.</p></div><div><h3>Patients and methods</h3><p>An observational analytical study was developed in 320 subjects with normal neurocognitive functions and neuropsychiatric examination, aged between 30 and 79 years, who underwent single-slice computed tomography of the skull. A segmentation method was used based on the analysis of homogeneous textures and interpolation.</p></div><div><h3>Results</h3><p>The multivariate analysis of variance showed the differences in the volume of the brain between both sexes and its decrease with respect to age. However, when taking into account the age of the individual, none of the correlations between the brain volumes and the scores obtained in the mental examination were significant, which implies that the age determines the correlation between the mini mental status exam and the volumes.</p></div><div><h3>Conclusions</h3><p>A morphometric quantification method of brain volumetric was obtained, confirming that brain volume differs significantly with sex and age, related to normal cognitive functioning associated with aging.</p></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"15 2","pages":"Pages 78-86"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49274727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marcación con ultrasonido para guiar la punción lumbar 引导腰椎穿刺的超声标记

Neurologia Argentina Pub Date : 2023-04-01 DOI: 10.1016/j.neuarg.2023.03.005

Camilo Romero , Jorge Molinares , Jesús Achury

{"title":"Marcación con ultrasonido para guiar la punción lumbar","authors":"Camilo Romero , Jorge Molinares , Jesús Achury","doi":"10.1016/j.neuarg.2023.03.005","DOIUrl":"10.1016/j.neuarg.2023.03.005","url":null,"abstract":"<div><h3>Introduction</h3><p>Lumbar puncture (LP) is an invasive procedure frequently used by neurologists as a diagnostic and therapeutic tool. However, its performance is usually based on surface anatomy that can be difficult or end up with failed attempts. The ultrasound (US)-guided LP is a bedside strategy that facilitates this procedure.</p></div><div><h3>Objective</h3><p>To present a description of the US-guided LP technique and to characterize the usefulness of its application in medical practice and different clinical contexts.</p></div><div><h3>Methods</h3><p>A non-systematic review of the literature was conducted. The description of the US-guided LP was performed based on this results and the experience of authors on the technique.</p></div><div><h3>Results</h3><p>Six articles were identified for the description. The US-guided PL is an easy, fast and very available technique. In pediatric patients and/or with a difficult spine anatomy, US-guided LP reduces the number of attempts, the number of failed procedures and the number of traumatic procedures.</p></div><div><h3>Conclusions</h3><p>US-guided LP is a strategy within the reach of neurologists with no contraindications or side effects and with clear benefits for patients who undergo to the procedure.</p></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"15 2","pages":"Pages 101-107"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49541593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluaciones económicas sobre el tratamiento específico del síndrome de Guillain-Barré: ¿Una limitación para elaborar guías de práctica clínica en Latinoamérica y el Caribe? guillain - barre综合征具体治疗的经济评估:拉丁美洲和加勒比地区临床实践指南的局限性?

Neurologia Argentina Pub Date : 2023-04-01 DOI: 10.1016/j.neuarg.2022.12.002

Milagros Torres-Valerio , Alvaro Milla-Martinez , Fiorella Avila-Terrones , Victor Velásquez-Rimachi

引用次数: 0

Neuropatía sensorial como síndrome paraneoplásico del cáncer de vejiga: caso raro con revisión de literatura

Neurologia Argentina Pub Date : 2023-01-01 DOI: 10.1016/j.neuarg.2022.08.002

José Fernando Robles Díaz

引用次数: 0

Valores normativos para el Test del Hotel en adultos jóvenes de Buenos Aires 布宜诺斯艾利斯年轻人酒店测试的规范值

Neurologia Argentina Pub Date : 2023-01-01 DOI: 10.1016/j.neuarg.2022.11.002

Clara M. Pinasco , Eluney Herrera , Diana Bruno , Teresa Torralva , María Roca

{"title":"Valores normativos para el Test del Hotel en adultos jóvenes de Buenos Aires","authors":"Clara M. Pinasco , Eluney Herrera , Diana Bruno , Teresa Torralva , María Roca","doi":"10.1016/j.neuarg.2022.11.002","DOIUrl":"10.1016/j.neuarg.2022.11.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Multitasking is a key component of everyday performance. Previous research has shown that multitasking can be impaired in a number of neurological and psychiatric conditions. However, most executive tests included in neuropsychological assessment batteries are not sensible to deficits in this ability. The Hotel Task assesses multitasking abilities through an «ecological» environment that mimics the work of a hotel.</p></div><div><h3>Aim</h3><p>The aim of the study was to establish normative data for the Hotel Test in young adults of Buenos Aires.</p></div><div><h3>Methods</h3><p>Participant sample consisted of 160 healthy control subjects with an age range 19-60years. All participants had 12 or more years of education.</p></div><div><h3>Results</h3><p>Statistical analysis revealed that age and education had no influence on the performance in the amount of tasks attempted, deviation of time spent on tasks and garage door time deviations. Significant differences in sex were observed in deviation of time spent on tasks and garage door time deviations, but with small effect sizes.</p></div><div><h3>Conclusion</h3><p>Normative data was presented for the Hotel Test to be used in young adults of Buenos Aires. This study provides clinicians with an ecological tool that can be used in daily practice to assess multitasking abilities and prospective memory within a «real life» environment, thus surpassing the limitations that «classical» executive functions tests present.</p></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"15 1","pages":"Pages 8-14"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41711304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Análisis del impacto presupuestario de incorporar alemtuzumab para el tratamiento de la esclerosis múltiple a recaídas y remisiones en Argentina 阿根廷将alemtuzumab纳入多发性硬化症复发和转诊治疗的预算影响分析

Neurologia Argentina Pub Date : 2023-01-01 DOI: 10.1016/j.neuarg.2022.12.003

Constanza Silvestrini Viola , Juan I. Rojas , Liliana Patrucco , Edgardo Cristiano , Jorge F. Elgart

{"title":"Análisis del impacto presupuestario de incorporar alemtuzumab para el tratamiento de la esclerosis múltiple a recaídas y remisiones en Argentina","authors":"Constanza Silvestrini Viola , Juan I. Rojas , Liliana Patrucco , Edgardo Cristiano , Jorge F. Elgart","doi":"10.1016/j.neuarg.2022.12.003","DOIUrl":"10.1016/j.neuarg.2022.12.003","url":null,"abstract":"<div><p>The objective of the study was to estimate the budget impact of incorporating alemtuzumab to treat adult patients with relapsing-remitting multiple sclerosis (RRMS) in Argentina, from the perspective of social security.</p></div><div><h3>Methods</h3><p>A budget impact model was used. A time horizon of 3years was considered. The target population was determined based on RRMS prevalence and incidence data published in Argentina. All treatment options for RRMS used in Argentina were considered as comparators. The costs of pharmacological treatments, administration and monitoring were used. For medicines, the laboratory starting price (PSL) was estimated based on information from the Pharmaceutical Manual (AlfaBeta). Administration and monitoring costs were obtained from national Social Security. Market shares and their evolution were prepared based on the opinion of local experts and market research. The results are reported in terms of annual, percentage and total cumulative budget impact.</p></div><div><h3>Results</h3><p>Incorporating alemtuzumab as a therapeutic option showed a budget impact of $1,393 million (2.98%), $92 million (0.19%) and −$1,858 million (−3.9%), in years 1 to 3, respectively. The result considers a retreatment rate with alemtuzumab of 98% for the second year and 26% for the third year. The cumulative budget impact over 3years showed a savings of $373 million (−0.73% compared to the scenario without alemtuzumab).</p></div><div><h3>Conclusion</h3><p>The study shows that, according to the assumptions considered, the cumulative budget impact in 3years of incorporating alemtuzumab as a therapeutic option for adult patients with RRMS in Argentina would be cost-saving.</p></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"15 1","pages":"Pages 20-27"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47613018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Síndrome de Leigh de inicio adulto, con epilepsia mioclónica progresiva, asociado a la mutación m.14487T>C: reporte de caso 成人发病利综合征，进行性肌阵挛性癫痫，与m.14487T>C突变相关:病例报告

Neurologia Argentina Pub Date : 2023-01-01 DOI: 10.1016/j.neuarg.2022.07.003

Darwin Segura-Chávez , Luis Torres-Ramírez , Sonia Emperador-Ortiz , Miriam Vélez-Rojas , Martha Flores-Mendoza , Carlos Cosentino-Esquerre , Eduardo Ruiz-Pesini , Julio Montoya-Villarroya

{"title":"Síndrome de Leigh de inicio adulto, con epilepsia mioclónica progresiva, asociado a la mutación m.14487T>C: reporte de caso","authors":"Darwin Segura-Chávez , Luis Torres-Ramírez , Sonia Emperador-Ortiz , Miriam Vélez-Rojas , Martha Flores-Mendoza , Carlos Cosentino-Esquerre , Eduardo Ruiz-Pesini , Julio Montoya-Villarroya","doi":"10.1016/j.neuarg.2022.07.003","DOIUrl":"10.1016/j.neuarg.2022.07.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Leigh's syndrome or subacute necrotizing encephalomyelopathy, is a progressive, genetically and clinically heterogeneous neurodegenerative disease that is generally associated with alteration of mitochondrial metabolism at the level of oxidative phosphorylation. It generally occurs in the neonatal period but also in adulthood, at this age it is usually expressed with a combination of various manifestations including Parkinsonism, movement disorders, neuropsychiatric disorders and others.</p></div><div><h3>Clinical case</h3><p>Thirty four-year-old male patient who began his symptoms at 18 years of age, after a few months his mother died with similar symptoms, but without a defined diagnosis. The patient presented progressive myoclonus in the right upper limb, bilateral palpebral and cervical spasms, later associated with facial myoclonus triggered by speech and dystonia in the lower right limb that restrict him from ambulation. Brain MRI showed the presence of bilateral symmetric lesions in the basal ganglia, cortical and periaqueductal lesions. The genetic study showed a m.14487T>C mutation in the ND6 gene of complex 1 of the mitochondrial oxidative phosphorylation system in leukocytes and cells of the buccal mucosa. This study was extended to the grandmother and two maternal aunts, asymptomatic at the time, who carried the same mutation.</p></div><div><h3>Conclusion</h3><p>The case corresponds to an adult patient with Leigh syndrome, a carrier of the m.14487T>C mutation, which seems to be related to a predominantly progressive myoclonic phenotype of cortical origin.</p></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"15 1","pages":"Pages 56-60"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47429549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Susceptibilidad del PTZ en ratones viejos y jóvenes. Diferencias entre un protocolo kindling convulsivo y subconvulsivo 老年和年轻小鼠对PTZ的易感性。惊厥性和亚惊厥性Kindling方案之间的差异

Neurologia Argentina Pub Date : 2023-01-01 DOI: 10.1016/j.neuarg.2022.08.005

Santiago Uriel Celi Aguilar , Rocio Beatriz Casado Sanchez , Matias Solari Ferreyra , Franco Funez , Gabriela Silas , Solano Federica , Ochoa Mariano , Alberto Musto , Facundo Latini

{"title":"Susceptibilidad del PTZ en ratones viejos y jóvenes. Diferencias entre un protocolo kindling convulsivo y subconvulsivo","authors":"Santiago Uriel Celi Aguilar , Rocio Beatriz Casado Sanchez , Matias Solari Ferreyra , Franco Funez , Gabriela Silas , Solano Federica , Ochoa Mariano , Alberto Musto , Facundo Latini","doi":"10.1016/j.neuarg.2022.08.005","DOIUrl":"10.1016/j.neuarg.2022.08.005","url":null,"abstract":"<div><h3>Introduction</h3><p>Kindling Model consist sequential injections of a dose Pentylenetetrazole causing spontaneous seizures. (ES)</p></div><div><h3>Objectives</h3><p>Compare convulsive and subconvulsive effect in old and young mice, to evaluate the differences between ichthyogenesis and epileptogenesis.</p></div><div><h3>Methods</h3><p>Rapid kindling model was performed using pentylenetetrazole in C57BL/6 mice. Using convulsive doses (C) (75 mg/kg in one injection) and sub-convulsive (SC) (10 mg/kg every 5 minutes for 30 minutes, for a total of 5 injections). Four groups were formed, young mouse (<32 weeks; C = 8; SC = 9) and 16 Old mouse (>32 weeks; C = 8; SC = 8). Using Racine Score. Descriptive statistics.</p></div><div><h3>Results</h3><p>Has been made 16 C protocols and 17 SC protocols. The latency time to phase 1 in sec. it is lower in old C (50.5 sec) than in young C (170.3). In SC, it was higher in the old group 170.3 vs young 105.5 (P = 0.001). Young C group presented longer time during Phase 1 to 3, and old C group during phase 4 and 5. Young SC presented longer duration in phase 2, unlike old SC with linear duration in different SR phases (P = 0.001). There were no differences in spontaneous death in all groups.</p></div><div><h3>Conclusion</h3><p>Latency time to Phase 1 was shorter in old convulsives and longer than young SC, indicative greater ichthyogenesis and less epileptogenesis in the old population. Tendency in the elderly to stay longer in phases 4 and 5 in convulsive doses suggests a greater tendency to ichthyogenesis and greater severity of spontaneous seizures.</p></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"15 1","pages":"Pages 1-7"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46634868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MoCA-T como herramienta de evaluación remota para precisar deterioro cognitivo en pacientes con SAHOS moderado a severo MoCA-T作为一种远程评估工具，用于确定中度至重度osahs患者的认知障碍

Neurologia Argentina Pub Date : 2023-01-01 DOI: 10.1016/j.neuarg.2022.12.001

Maria Isabel Correa-Naranjo , Loida Camargo-Camargo , Laura Acosta-Camargo , Enrique Carlos Ramos-Clason , Norman López-Velásquez

{"title":"MoCA-T como herramienta de evaluación remota para precisar deterioro cognitivo en pacientes con SAHOS moderado a severo","authors":"Maria Isabel Correa-Naranjo , Loida Camargo-Camargo , Laura Acosta-Camargo , Enrique Carlos Ramos-Clason , Norman López-Velásquez","doi":"10.1016/j.neuarg.2022.12.001","DOIUrl":"https://doi.org/10.1016/j.neuarg.2022.12.001","url":null,"abstract":"<div><p>The COVID-19 pandemic has led to the emergence of technological tools that allow remote assessment on patients. The Montreal Cognitive Assessment Test Telephone Version (MoCA-T) is one of them. Considered as a telemedicine resource that allows remote cognitive screening in pandemic era and in the population with difficulties in accessing health centers. Mild cognitive impairment (MCI) is a common finding in patients with Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS). However, the application of telephone tests for cognitive screening has not been studied. To determine the frequency of cognitive deterioration through the application of MoCA-T as a remote screening test in patients with moderate and severe OSAHS is the main objective of this work. To do this, the MoCA-T test was applied to 104 patients with polysomnographic diagnostic capabilities for moderate and severe OSAHS between ages 18 and 65, excluding patients with comorbidities that affect cognitive ones. Abnormal MoCA-T results were obtained in 43% of patients, with the cognitive domains of memory and attention being the most affected. Finally, abnormal MoCA-T results correlated with self-perception of memory difficulties, being more frequently altered in those who manifest cognitive complaints. The MoCA-T test could be a brief, validated and feasible technological tool for cognitive screening of patients with OSAHS in times of pandemic and in patients with care barriers.</p></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"15 1","pages":"Pages 15-19"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49864291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0