Neurologia Argentina最新文献

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Barreras y facilitadores en emergencias neurovasculares: reporte de caso de zona rural de Colombia 神经血管紧急情况中的障碍和促成因素:哥伦比亚农村地区的案例报告
Neurologia Argentina Pub Date : 2026-07-01 Epub Date: 2026-08-04 DOI: 10.1016/j.neuarg.2026.100749
Juan David Tascón-Romero, David Fabian Ramirez-Moreno, Julio César Mantilla-Pardo, Jose Ricardo Muñoz-Zuñiga, Natalia Llanos-Leyton, Diego Herrera, Pablo Amaya
{"title":"Barreras y facilitadores en emergencias neurovasculares: reporte de caso de zona rural de Colombia","authors":"Juan David Tascón-Romero,&nbsp;David Fabian Ramirez-Moreno,&nbsp;Julio César Mantilla-Pardo,&nbsp;Jose Ricardo Muñoz-Zuñiga,&nbsp;Natalia Llanos-Leyton,&nbsp;Diego Herrera,&nbsp;Pablo Amaya","doi":"10.1016/j.neuarg.2026.100749","DOIUrl":"10.1016/j.neuarg.2026.100749","url":null,"abstract":"<div><h3>Introduction</h3><div>Stroke is a neurologic emergency, represents the second leading cause of death and the third cause of disability worldwide. In low- and middle-income countries, multiple barriers limit access to care, conditioning clinical outcomes.</div></div><div><h3>Case presentation</h3><div>A 39-year-old woman with acute altered mental status, left-sided hemiparesis, and aphasia was transferred from a rural area of the Colombian Pacific coast to a specialized center. Neuroimaging revealed significant penumbra, and mechanical thrombectomy was performed 25 hours after symptom onset. The patient recovered language function, with persistent motor deficit.</div></div><div><h3>Conclusions</h3><div>Telemedicine and referral network models reduce healthcare inequities and make mechanical thrombectomy feasible in an ultra-extended time window.</div></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"18 3","pages":"Article 100749"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148950193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eventos neurológicos transitorios focales en pacientes con angiopatía amiloide cerebral 淀粉样脑血管病患者的局灶性短暂神经事件
Neurologia Argentina Pub Date : 2026-07-01 Epub Date: 2026-08-17 DOI: 10.1016/j.neuarg.2026.100752
Juan Pablo Tavarone, Hernan Chaves, Virginia Pujol Lereis, Sebastián Francisco Ameriso
{"title":"Eventos neurológicos transitorios focales en pacientes con angiopatía amiloide cerebral","authors":"Juan Pablo Tavarone,&nbsp;Hernan Chaves,&nbsp;Virginia Pujol Lereis,&nbsp;Sebastián Francisco Ameriso","doi":"10.1016/j.neuarg.2026.100752","DOIUrl":"10.1016/j.neuarg.2026.100752","url":null,"abstract":"<div><h3>Introduction</h3><div>Cerebral amyloid angiopathy (CAA) is an age-related small vessel disease affecting cortical and leptomeningeal vessels. Recently, focal transient neurological episodes (FTNEs) have been described as a manifestation of CAA and are frequently misdiagnosed as transient ischemic attacks (TIAs). Previous studies estimated a prevalence of 10% for CAA-related FTNEs. The aim of our study was to investigate the prevalence of CAA in patients hospitalized for FTNEs initially interpreted as TIAs at a comprehensive stroke center.</div></div><div><h3>Materials and methods</h3><div>We conducted a retrospective observational study including consecutive patients aged 55 years or older who were admitted between May 2016 and December 2018 for FTNEs with complete symptom resolution within 24<!--> <!-->hours. Continuous variables were compared using t tests, and categorical variables were analyzed using Fisher's exact test or the chi-square test, as appropriate. A p value &lt;<!--> <!-->0.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>A total of 167 patients with FTNEs initially interpreted as TIAs were included, of whom 79 were women (47%), with a mean age of 73<!--> <!-->±<!--> <!-->9 years. Applying the Boston criteria version 1.5, 44 patients (26%) met diagnostic criteria for CAA (15% possible, 11% probable). Patients with suspected CAA were older than those without CAA (mean age 76 vs. 71 years, p<!--> <!-->=<!--> <!-->0.0285) and were more frequently male (68% vs. 47%, p<!--> <!-->=<!--> <!-->0.0165). Coronary artery disease was more frequent in patients with suspected CAA than in those without CAA (32% vs. 12%, p<!--> <!-->=<!--> <!-->0.0032).</div></div><div><h3>Conclusions</h3><div>To our knowledge, this is the first report on the prevalence of FTNEs in patients with findings compatible with CAA from a single comprehensive stroke center in the region, showing a prevalence of 26% when applying the Boston criteria version 1.5.</div></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"18 3","pages":"Article 100752"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148950194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simulation-based models for endovascular and microsurgery training in brain arteriovenous malformations: A systematic review 基于模拟的脑动静脉畸形血管内和显微外科训练模型:系统综述
Neurologia Argentina Pub Date : 2026-07-01 Epub Date: 2026-07-17 DOI: 10.1016/j.neuarg.2026.100746
Helbert de Oliveira Manduca Palmiero, Eberval Gadelha Figueiredo
{"title":"Simulation-based models for endovascular and microsurgery training in brain arteriovenous malformations: A systematic review","authors":"Helbert de Oliveira Manduca Palmiero,&nbsp;Eberval Gadelha Figueiredo","doi":"10.1016/j.neuarg.2026.100746","DOIUrl":"10.1016/j.neuarg.2026.100746","url":null,"abstract":"<div><h3>Background</h3><div>Simulation-based training has become increasingly important in cerebrovascular education; however, available arteriovenous malformation (AVM) models vary in fidelity, accessibility, and educational focus. This systematic review aims to identify, classify, and compare simulation-based and experimental AVM models used for operative neurosurgical and endovascular training.</div></div><div><h3>Methods</h3><div>A PRISMA-compliant systematic review of PubMed was conducted. English-language studies describing AVM-specific simulation or experimental models for operative/microsurgical and/or endovascular training were included. Extracted data included model type, targeted training domain, procedural tasks, anatomic and flow fidelity, feasibility, and reported educational outcomes. Results were synthesized qualitatively.</div></div><div><h3>Results</h3><div>Twenty studies met the inclusion criteria. AVM training platforms were categorized into five groups: in vivo animal models, ex vivo biological tissue models, in vitro synthetic flow models, 3D-printed physical models, and digital visualization platforms. Most models emphasized endovascular skill acquisition (<em>n</em> <!-->=<!--> <!-->13), supporting catheter navigation, embolic delivery, and hemodynamic assessment. Operative microsurgical training was addressed less frequently (<em>n</em> <!-->=<!--> <!-->3), with ex vivo placenta-based models providing the highest tactile fidelity for vessel handling, dissection, and flow assessment. Visualization and planning platforms (<em>n</em> <!-->=<!--> <!-->4), including 3D printing and VR/AR, enhanced three-dimensional anatomic understanding but lacked haptic feedback. Educational validation was heterogeneous and relied predominantly on subjective assessment.</div></div><div><h3>Conclusion</h3><div>Current AVM simulation platforms predominantly support endovascular training, whereas high-fidelity operative microsurgical simulation remains limited. A competency-driven, multimodal training strategy integrating complementary endovascular, microsurgical, and cognitive platforms is warranted. Future efforts should prioritize the development of an operation-focused model and rigorous educational validation aligned with the technical demands of contemporary operative neurosurgery.</div></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"18 3","pages":"Article 100746"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148950195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dieta mediterránea en la enfermedad de Parkinson: una revisión sistemática 地中海饮食在帕金森氏症中的作用:系统综述
Neurologia Argentina Pub Date : 2026-07-01 Epub Date: 2026-08-14 DOI: 10.1016/j.neuarg.2026.100751
Juan Pablo Rodriguez, Estefania Quarteroni, Lucia Belen Varela, Samanta Díaz Menai, Camila Micaela Escobar Liquitay, Luis Garegnani
{"title":"Dieta mediterránea en la enfermedad de Parkinson: una revisión sistemática","authors":"Juan Pablo Rodriguez,&nbsp;Estefania Quarteroni,&nbsp;Lucia Belen Varela,&nbsp;Samanta Díaz Menai,&nbsp;Camila Micaela Escobar Liquitay,&nbsp;Luis Garegnani","doi":"10.1016/j.neuarg.2026.100751","DOIUrl":"10.1016/j.neuarg.2026.100751","url":null,"abstract":"<div><h3>Background</h3><div>Parkinson's disease (PD) is a rapidly growing neurodegenerative disorder. Patients increasingly seek non-pharmacological strategies, such as the Mediterranean diet (MeD), to manage symptoms. Due to its potential modulation of the gut-brain axis, evaluating the MeD's efficacy as a complementary therapy is essential for improving PD symptoms.</div></div><div><h3>Objectives</h3><div>To assess the effects of the MeD on motor and non-motor symptoms in adults with PD.</div></div><div><h3>Methods</h3><div>We conducted a systematic review (CRD420251016657). We searched major databases (CENTRAL, MEDLINE, and trial registers) up to July 2025. We included RCTs and cluster RCTs assessing the effects of MeD for adults of any gender with PD, regardless of their publication status or language. We assessed the outcomes: motor symptoms, functionality, quality of life, adverse events, cognitive and gastrointestinal function, neuropsychiatric symptoms, and adherence.</div></div><div><h3>Main results</h3><div>We included two RCTs, involving 106 participants. The results suggest the MeD likely has little to no effect on key outcomes, specifically motor symptoms (MD: 1.18; 95%<!--> <!-->CI: 0.36 to 2, one study, low certainty evidence) and quality of life (MD: −2.24: 95%<!--> <!-->CI: −3.79 to −1, one study, low certainty evidence), when compared to standard care. None of the included studies reported on adverse events.</div></div><div><h3>Authors’ conclusions</h3><div>The MeD demonstrates little to no significant clinical effect on motor neurological symptoms and health-related quality of life in PD patients compared with usual care. Future, larger-scale, and methodologically rigorous RCTs are required to definitively establish the benefits and harms of the MeD for PD management.</div></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"18 3","pages":"Article 100751"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148950196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Signo de corteza florecida en la carcinomatosis leptomeníngea 钩状脑癌的树皮开花迹象a
Neurologia Argentina Pub Date : 2026-07-01 Epub Date: 2026-07-18 DOI: 10.1016/j.neuarg.2026.100747
Juan Paulo Villamizar Villamizar, Héctor Alberto Intriago Ochoa, Alex Alejandro Cornejo, Laura Maria Andrade Angarita, Gabriela Demelli, Alejandra Baez
{"title":"Signo de corteza florecida en la carcinomatosis leptomeníngea","authors":"Juan Paulo Villamizar Villamizar,&nbsp;Héctor Alberto Intriago Ochoa,&nbsp;Alex Alejandro Cornejo,&nbsp;Laura Maria Andrade Angarita,&nbsp;Gabriela Demelli,&nbsp;Alejandra Baez","doi":"10.1016/j.neuarg.2026.100747","DOIUrl":"10.1016/j.neuarg.2026.100747","url":null,"abstract":"","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"18 3","pages":"Article 100747"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148950247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Red de Ataque Cerebral de Formosa: análisis inicial 福尔摩沙脑攻击网络:初步分析
Neurologia Argentina Pub Date : 2026-07-01 Epub Date: 2026-08-04 DOI: 10.1016/j.neuarg.2026.100750
Juan José Cirio, Valeria Gómez, Miguel Campuzano, Martín Kriebaum, Alberto Parra, Martin Puga
{"title":"Red de Ataque Cerebral de Formosa: análisis inicial","authors":"Juan José Cirio,&nbsp;Valeria Gómez,&nbsp;Miguel Campuzano,&nbsp;Martín Kriebaum,&nbsp;Alberto Parra,&nbsp;Martin Puga","doi":"10.1016/j.neuarg.2026.100750","DOIUrl":"10.1016/j.neuarg.2026.100750","url":null,"abstract":"<div><h3>Introduction</h3><div>The Formosa Stroke Network (RAC-F) was created in March 2023 to systematize stroke care with a structured, multidisciplinary approach throughout the province.</div></div><div><h3>Objective</h3><div>To analyze the implementation and safety of the RAC-F in its first 16 months of operation.</div></div><div><h3>Materials and methods</h3><div>Data collected between March 2023 and July 2024 were analyzed, including demographic characteristics, risk factors, metrics, and clinical safety outcomes such as symptomatic intracranial hemorrhage (SIH) and death.</div></div><div><h3>Results</h3><div>A total of 237 consultations were received. Of these, 56 (23.62%) corresponded to stroke mimics and 181 (76.4%) were strokes, of which 116 were ischemic (64.08%) and 65 were hemorrhagic (35.91%). The age of stroke patients was 63.6 years (SD 12.2), and 35.9% were women.</div><div>Thrombolytic treatment was administered to 34 patients (29.3%). In terms of safety, ICH was observed in 1 patient (2.9%), and 30-day mortality occurred in 3 cases (8.8%).</div></div><div><h3>Discussion</h3><div>Stroke care within networks optimizes the treatment of time-dependent pathologies. The implementation of RAC-Formosa is a fundamental tool for understanding the epidemiology of the disease, allowing access to intravenous reperfusion treatments, and evaluating the safety variables associated with its operation.</div></div><div><h3>Conclusions</h3><div>The implementation of RAC-F has been effective and safe, achieving a significant proportion of patients treated with intravenous thrombolysis with a low complication rate, improving equity in access to treatment in the province of Formosa, regardless of geographic location.</div></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"18 3","pages":"Article 100750"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148961534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Síndrome POEMS sin enfermedad clonal o proteína M identificable: un diagnóstico a considerar 无可识别的克隆病或M蛋白的POEMS综合征:需要考虑的诊断
Neurologia Argentina Pub Date : 2026-07-01 Epub Date: 2026-07-11 DOI: 10.1016/j.neuarg.2026.100748
Esteban Leonardo Calabrese
{"title":"Síndrome POEMS sin enfermedad clonal o proteína M identificable: un diagnóstico a considerar","authors":"Esteban Leonardo Calabrese","doi":"10.1016/j.neuarg.2026.100748","DOIUrl":"10.1016/j.neuarg.2026.100748","url":null,"abstract":"<div><div>POEMS syndrome is a paraneoplastic disorder associated with clonal proliferation of plasma cells. Diagnosis requires two mandatory criteria (polyneuropathy, plasma cell dyscrasia [M protein]) and a major criterion (Castleman disease, osteosclerotic lesions, elevated VEGF levels) and a minor criterion (organomegaly, volume overload, endocrinopathy, skin changes, papilledema, thrombocytosis/polycythemia). While polyneuropathy is a constant finding, sometimes «M protein» or plasma cell dyscrasia cannot be defined by standard methods. Our objective is to report a case of POEMS without «M protein» and without an identifiable plasma cell disorder. A 36-year-old woman presented with occipital headache, demonstrating ischemic stroke. Physical examination revealed hypopalesthesia, negative deep tendon reflexes, distal paraparesis, and bimalleolar edema. A history of inflammatory polyneuropathy (CIDP) associated with dysesthesia was diagnosed. Treatment was given with prednisone and immunoglobulin. EMG showed demyelinating involvement. CSF, 1<!--> <!-->g/dL protein/2<!--> <!-->elements. Immunological and endocrinological laboratory results, immunoglobulin dosage, and protein electrophoresis were normal. CT scan of the abdomen showed Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporationhepato-splenomegaly and sacral osteolytic/osteocalcic lesions. Lumbar MRI showed bilateral thickening of the lumbosacral plexuses. PET-CT showed uptake of the sacral lesion. Bone marrow puncture of the lesion and normal bone marrow. Ophthalmological and dermatological studies were normal. VEGF value was 211<!--> <!-->pg/ml. A course of bortezomib plus dexamethasone was started, with disappearance of bone uptake on PET-CT and a decrease in VEGF. Although the diagnosis of POEMS is not met, polyneuropathy is a mandatory criterion. The associated clinical findings and response to plasma cell therapies support a diagnosis of POEMS with undetectable M<!--> <!-->protein. If the diagnosis depends on the detection of M<!--> <!-->proteins by electrophoresis, up to 25% of reported cases are excluded.</div></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"18 3","pages":"Article 100748"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148950192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serie de casos de parkinsonismo atípico en Lima, Perú: características clínicas, evolución funcional y hallazgos de imagen 秘鲁利马非典型帕金森病系列:临床特征、功能演变和影像发现
Neurologia Argentina Pub Date : 2026-07-01 Epub Date: 2026-07-13 DOI: 10.1016/j.neuarg.2026.100745
Víctor V. Saquisela-Albuquerque, Luis Angel Díaz-Tejada, Lucero Brigitte Diaz-Capcha, Cesar A. Lupaca-Bailon, Jhonatan M. Zumaeta-Pérez, Edward S. Ramos-Maguiña
{"title":"Serie de casos de parkinsonismo atípico en Lima, Perú: características clínicas, evolución funcional y hallazgos de imagen","authors":"Víctor V. Saquisela-Albuquerque,&nbsp;Luis Angel Díaz-Tejada,&nbsp;Lucero Brigitte Diaz-Capcha,&nbsp;Cesar A. Lupaca-Bailon,&nbsp;Jhonatan M. Zumaeta-Pérez,&nbsp;Edward S. Ramos-Maguiña","doi":"10.1016/j.neuarg.2026.100745","DOIUrl":"10.1016/j.neuarg.2026.100745","url":null,"abstract":"<div><h3>Introduction</h3><div>Atypical parkinsonian syndromes (APS) are neurodegenerative disorders marked by rapid progression and a poor response to levodopa. Evidence describing their features in Latin American populations is scarce. This study describes clinical manifestations, functional course, and neuroimaging findings in a cohort of patients with APS at a referral center in Lima, Peru.</div></div><div><h3>Methods</h3><div>We conducted an observational, descriptive, retrospective study of patients diagnosed with APS seen between January 2020 and December 2024. Sociodemographic, clinical, neuroimaging (MRI/CT), and functional progression data were abstracted from medical records. Diagnoses were based on Movement Disorder Society criteria for Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP), and the Armstrong criteria for Corticobasal Degeneration (CBD).</div></div><div><h3>Results</h3><div>Thirteen patients were included (9 male), with a mean age at diagnosis of 60.46<!--> <!-->±<!--> <!-->11.24 years. The most frequent initial symptoms were gait impairment (13/13) and dysarthria (12/13). The most common final diagnosis was MSA (7/13), predominantly the cerebellar subtype (MSA-C), followed by PSP (4/13) and CBD (2/13). Characteristic neuroimaging signs such as the “hot cross bun” sign and the “hummingbird” sign were observed in MSA and PSP, respectively. During follow-up, eight required a wheelchair, and four patients died.</div></div><div><h3>Conclusion</h3><div>This case series underscores the clinical heterogeneity of APS and the substantial functional burden they impose. The findings reinforce the importance of clinical red flags and structural neuroimaging for differential diagnosis in resource-limited settings, contributing valuable data to characterize these disorders in Latin America.</div></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"18 3","pages":"Article 100745"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148950191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revisión de aspectos claves en el abordaje terapéutico de la miastenia gravis ACRA. Parte 1 重症肌无力治疗ACRA的关键方面综述。第1部分
Neurologia Argentina Pub Date : 2026-07-01 Epub Date: 2026-06-23 DOI: 10.1016/j.neuarg.2026.100736
Valeria L. Salutto, Mayra Aldecoa, María Florencia Sica, Carolina L. Azcona, Mariana Bendersky, Mariela Bettini, Francisco Caiza-Zambrano, Esteban Calabrese, Marcelo Chaves, Sofia Garcia Martín, Gisella Gargiulo-Monachelli, Cintia L. Marchesoni, Marta Medina, Gonzalo Nieto, Marisol Pazos, Fatima Paintu, María Gabriela Peretti Ratto, Laura Pirra, Cecilia Quarracino, Luciano Recchia, Florencia Aguirre
{"title":"Revisión de aspectos claves en el abordaje terapéutico de la miastenia gravis ACRA. Parte 1","authors":"Valeria L. Salutto,&nbsp;Mayra Aldecoa,&nbsp;María Florencia Sica,&nbsp;Carolina L. Azcona,&nbsp;Mariana Bendersky,&nbsp;Mariela Bettini,&nbsp;Francisco Caiza-Zambrano,&nbsp;Esteban Calabrese,&nbsp;Marcelo Chaves,&nbsp;Sofia Garcia Martín,&nbsp;Gisella Gargiulo-Monachelli,&nbsp;Cintia L. Marchesoni,&nbsp;Marta Medina,&nbsp;Gonzalo Nieto,&nbsp;Marisol Pazos,&nbsp;Fatima Paintu,&nbsp;María Gabriela Peretti Ratto,&nbsp;Laura Pirra,&nbsp;Cecilia Quarracino,&nbsp;Luciano Recchia,&nbsp;Florencia Aguirre","doi":"10.1016/j.neuarg.2026.100736","DOIUrl":"10.1016/j.neuarg.2026.100736","url":null,"abstract":"<div><h3>Introduction</h3><div>Myasthenia gravis (MG) is a common disease of the neuromuscular junction. The variant with antibodies directed against the acetylcholine receptor (AChR-Ab) is the most typical. There is no unanimous local consensus regarding the management of this condition.</div></div><div><h3>Objective</h3><div>This study aims to summarize the available evidence on the conventional therapeutic management of AChR-Ab positive MG based on a literature review and expert opinion and consensus.</div></div><div><h3>Materials and methods</h3><div>A database review was conducted (PubMed, MEDLINE, EMBASE, Cochrane). Data extraction focused on addressing clinical questions and controversial topics in routine practice, using an expert consensus approach.</div></div><div><h3>Results</h3><div>Symptomatic treatment with pyridostigmine is insufficient in approximately 80% of cases. Thymectomy is effective in patients with AChR-Ab positive MG younger than 50 years with a short disease duration. Steroids are used in various regimens; their effect appears in the medium term, they prevent generalization of ocular MG, and adverse effects may limit their use. Non-steroidal immunosuppressants have a broad mechanism of action, a latency of several months, and know adverse effects; however, all can be administered orally. Azathioprine is safe during pregnancy and is considered a first-line treatment. Rituximab shows divergent evidence regarding dosage and efficacy. The mentioned drugs act on immune autoreactivity, whereas short-term immunomodulatory therapies (immunoglobulins and plasmapheresis) primarily reduce circulating antibodies with similar efficacy.</div></div><div><h3>Conclusions</h3><div>Management of AChR-Ab positive MG requires the neurologist to have knowledge regarding the efficacy and safety of available therapies. The conventional approach includes treatments aimed at eliminating immune autoreactivity and reducing circulating antibodies. Treatment election must be individualized.</div></div>","PeriodicalId":39051,"journal":{"name":"Neurologia Argentina","volume":"18 3","pages":"Article 100736"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148950248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enfermedades neuromusculares pediátricas: impacto del diagnóstico en el estilo de crianza y sus implicancias para los profesionales de la salud 儿科神经肌肉疾病:诊断对育儿方式的影响及其对卫生专业人员的影响
Neurologia Argentina Pub Date : 2026-04-01 Epub Date: 2026-02-23 DOI: 10.1016/j.neuarg.2026.100714
María de Guadalupe Pérez Cano , Javiera Ortega , Laura Oros , Veronica Ramenzoni
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