Journal of Gastrointestinal and Digestive System最新文献_第9页

Characterization of Selected Metabolic and Immunologic Markers Following Exclusive Enteral Nutrition of Pediatric CrohnÃ¢Â€Â™s Disease Patients 儿童CrohnÃ¢Â€Â™疾病患者独家肠内营养后选定代谢和免疫标志物的特征

Journal of Gastrointestinal and Digestive System Pub Date : 2016-08-31 DOI: 10.4172/2161-069X.1000466

V. Brahmbhatt, Ivan Montoliu, N. Bosco, F. Martin, P. Guy, Manuel Oliveira, S. Schatz, K. Werkstetter, E. Schiffrin, B. Koletzko, J. Benyacoub, S. Koletzko

{"title":"Characterization of Selected Metabolic and Immunologic Markers Following Exclusive Enteral Nutrition of Pediatric CrohnÃ¢Â€Â™s Disease Patients","authors":"V. Brahmbhatt, Ivan Montoliu, N. Bosco, F. Martin, P. Guy, Manuel Oliveira, S. Schatz, K. Werkstetter, E. Schiffrin, B. Koletzko, J. Benyacoub, S. Koletzko","doi":"10.4172/2161-069X.1000466","DOIUrl":"https://doi.org/10.4172/2161-069X.1000466","url":null,"abstract":"Objectives: Exclusive enteral nutrition (EEN) is one of the first-line therapeutic options for pediatric patients with active Crohn’s disease (CD). However, only sparse data exist on plasma metabolic changes from patients on EEN therapy. Thus to gain mechanistic insights, we have characterized selected markers in pediatric CD patients treated with EEN for induction of disease remission. Methods: Plasma levels of 18 cytokines and chemokines and 163 metabolites in 10 pediatric CD patients receiving 8 weeks of EEN therapy were measured. Measurements were performed at three time points: a) at baseline (V0); b) during EEN intervention at week 4 (V4) and; c) at 4 weeks after completion of EEN therapy at week 12 (V12). Results: Comparisons between V0 and V4 levels identified changes in 20 different molecules, including increases in 7 metabolites of the diacyl phosphatidylcholine (PC) class and 6 metabolites of the alkylacyl PC class. However, most of these changes were not sustained after returning to a normal diet, i.e. only 7 out of the 20 molecules with significant changes between V0 and V4 still retained significance upon comparing V0 and V12. Conclusions: The changes in the plasma levels of various phospholipids at different time-points reflect the nutritional intervention and improved health status of pediatric CD patients.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115949287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Use of Biological Ã¢ÂÂInfillÃ¢ÂÂ Materials for the Treatment of Recto/Ano-vaginalFistulae-A Systematic Review 生物材料Ã¢ÂÂInfillÃ¢ÂÂ治疗直肠/肛门阴道瘘的系统综述

Journal of Gastrointestinal and Digestive System Pub Date : 2016-08-25 DOI: 10.4172/2161-069X.1000465

N. Yassin, A. Askari, J. Jenkins, A. Uraiqat, O. Faiz, A. Hart, R. Phillips

{"title":"The Use of Biological Ã¢ÂÂInfillÃ¢ÂÂ Materials for the Treatment of Recto/Ano-vaginalFistulae-A Systematic Review","authors":"N. Yassin, A. Askari, J. Jenkins, A. Uraiqat, O. Faiz, A. Hart, R. Phillips","doi":"10.4172/2161-069X.1000465","DOIUrl":"https://doi.org/10.4172/2161-069X.1000465","url":null,"abstract":"Aim: Recto-vaginal fistulae are distressing. They are most commonly caused by obstetric injury, a failed pelvic anastomosis, or Crohn’s disease. Biological infill materials have been used in their management. We assessed the efficacy of biological infill materials when recto-vaginal fistulae. Methods: We applied the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: Twenty-five articles yielded a pooled total of 105 patients; 27% had Crohn’s disease. Fifty-six percent of patients had treatment with glue, 31% with plug, 6% with permacol paste and 7% with stem-cells. For Crohn’s, 50% were treated with glue, 39% with a fistula plug and 11% with stem cells. The overall healing rate for all infill materials was 41%, with the highest reported rate amongst the stem cell group (71%) and the lowest (32%) for glue. For Crohn's, the overall healing rate was 36%, glue was the lowest (14%), followed by the anal fistula plug (55%). Stem cells had a healing rate of 67%. Conclusions: Overall, the use of infill materials to treat Crohn’s and non-Crohn’s related recto-vaginal fistulae is associated with healing in approximately 41% of cases. Crohn’s related recto-vaginal fistulae represent a more challenging group of patients to treat.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127077933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angiotensin Converting Enzyme (ACE) Inhibitor Associated Small BowelAngioedema and Ascites Presenting as Recurrent Acute Abdomen: A CaseReport 血管紧张素转换酶(ACE)抑制剂相关的小肠血管性水肿和腹水表现为复发性急腹症:一个病例报告

Journal of Gastrointestinal and Digestive System Pub Date : 2016-08-19 DOI: 10.4172/2161-069X.1000464

P. Mittal, A. Agarwal, Peter A. Harri, F. Miller, C. Moreno, W. Small

引用次数: 0

A Gastrointestinal Study on Linear and Non-Linear Quantitative Structure (Chromatographic) Retention Relationships (QSRR) Models for Analysis 5- Aminosalicylates Nano Particles as Digestive System Nano Drugs under Synchrotron Radiations 同步辐射下消化系统纳米药物5-氨基水杨酸钠纳米颗粒线性和非线性定量结构(色谱)保留关系(QSRR)模型的胃肠研究

Journal of Gastrointestinal and Digestive System Pub Date : 2016-08-18 DOI: 10.4172/2161-069X.1000E119

A. Heidari

{"title":"A Gastrointestinal Study on Linear and Non-Linear Quantitative Structure (Chromatographic) Retention Relationships (QSRR) Models for Analysis 5- Aminosalicylates Nano Particles as Digestive System Nano Drugs under Synchrotron Radiations","authors":"A. Heidari","doi":"10.4172/2161-069X.1000E119","DOIUrl":"https://doi.org/10.4172/2161-069X.1000E119","url":null,"abstract":"The analysis of 5-aminosalicylates nano particles as gastrointestinal and digestive system nano drugs under synchrotron radiations is mainly carried out by Gas Chromatography (GC), making use of their specific Retention Times (RT) which is related to their medicinal, pharmaceutical, physiochemical and topological properties [1-28]. Predicting chromatographic retention is an interesting subject. Quantitative Structure (Chromatographic) Retention Relationships (QSRR) has been demonstrated to be a powerful tool in chromatography. Linear and non-linear methods, such as Multiple Linear Regression (MLR) or Partial Least Squares Regression (PLSR) and Neural Network (NN) or Multiple Non-Linear Regression (MNLR), have been widely applied in the QSAR/QSRR area based on an assumption of linearity or non–linearity between the descriptors and an investigated experimental property [29-59]. Neural Network (NN) or Multiple Non–Linear Regression (MNLR), as non–linear regression methods, have been widely used as efficient regression methods and successfully applied to diverse medicinal, pharmaceutical, physiochemical and topological chemistry problems. The aim of this editorial is to research for an efficient method to build an accurate quantitative relationship between the chemical and molecular structure and the Retention Times (RT) of the some medicinal and pharmaceutical nano compounds by stepwise Multiple Linear Regression (MLR), Multiple Non–Linear Regression (MNLR) and Artificial Neural Networks (ANN) methods under synchrotron radiations.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129156627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 130

An Orally-Bioavailable Glutathione-Based Hepatoprotective Compound inExperimental Acute Liver Injury: More Effective than Silymarin and YHK 以谷胱甘肽为基础的口服肝保护化合物治疗实验性急性肝损伤:比水飞蓟素和YHK更有效

Journal of Gastrointestinal and Digestive System Pub Date : 2016-08-09 DOI: 10.4172/2161-069X.1000462

Makoto Kantah, A. Kumari, F. He, J. Sollano, H. Alagozlu, M. Ch, A. Lorenzetti, Y. Morita, F. Marotta

{"title":"An Orally-Bioavailable Glutathione-Based Hepatoprotective Compound inExperimental Acute Liver Injury: More Effective than Silymarin and YHK","authors":"Makoto Kantah, A. Kumari, F. He, J. Sollano, H. Alagozlu, M. Ch, A. Lorenzetti, Y. Morita, F. Marotta","doi":"10.4172/2161-069X.1000462","DOIUrl":"https://doi.org/10.4172/2161-069X.1000462","url":null,"abstract":"Many hepatoprotective non-chemical preparations have been recommended as complementary medicine for the treatment of liver disorders. We have utilized a well-defined model of liver injury to study the efficacy of GLU-9599 (a oral bioavailable glutathione-based compound added with selenium, L-cysteine and vitamin C) designed to support liver detox function. Wistar albino rats were divided into five groups. Group I represented the healthy control group; Groups II-IV were given carbon tetrachloride (CCl4) intragastrically. Rats were exposed to CCl4 after they had been pretreated for five days with either saline, silymarin extract, YHK (am herbal Japanese compound with putative hepatoprotective effects) or GLU-9599. After inducing hepatic damage, Group II served as control CCl4; Group III and IV were given silymarin (reference hepatoprotective) and YHK whereas Groups V was administered GLU-9599. Animals were sacrificed 24 hours after receiving CCl4. Liver enzymes and hepatic histology formed the basis for evaluating the efficacy of the treatments. Samples of livers were observed under microscope and electron microscopy (TEM) for the histopathological changes. Levels of marker enzymes such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) significantly increased in CCl4 treated rats (Group II). Groups III, IV and V intoxicated with CCl4 and treated with the above hepatoprotective agents showed a significant decrease of the activities of these two enzymes (p<0.05). However, GLU-9599 provided a significantly stronger effect than YHK (p<0.05) and a trend improvement as compared to sylimarin. This was confirmed at histology and TEM whereas the others hepatoprotective compounds had only limited benefits on morphological abnormalities. In conclusion GLU-9599 could be a promising hepatoprotective compound of safe profile although extensive clinical studies are warranted.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130535468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Chediak-Higashi Syndrome with Novel Gene Mutation 新基因突变的Chediak-Higashi综合征

Journal of Gastrointestinal and Digestive System Pub Date : 2016-08-05 DOI: 10.4172/2161-069X.1000463

M. Abdulaziz

引用次数: 2

HyGIeaCareÃÂ® Preparation for Colonoscopy-A Technical Update for Success HyGIeaCareÃÂ®结肠镜检查准备-成功的技术更新

Journal of Gastrointestinal and Digestive System Pub Date : 2016-08-03 DOI: 10.4172/2161-069X.1000458

H. Gagneja, P. Parekh, D. Burleson, D. Johnson

引用次数: 9

Is the Routine Insertion of a Gastric Tube Necessary for Full Term or LatePreterm Infants Admitted with Mild Respiratory Distress in NICU NICU收治轻度呼吸窘迫的足月或晚早产儿是否有必要常规插入胃管

Journal of Gastrointestinal and Digestive System Pub Date : 2016-08-03 DOI: 10.4172/2161-069X.1000460

Ji Hee Kim, Homin Jang, H. Jo, J. Heo, J. Jeon, K. Lee

{"title":"Is the Routine Insertion of a Gastric Tube Necessary for Full Term or LatePreterm Infants Admitted with Mild Respiratory Distress in NICU","authors":"Ji Hee Kim, Homin Jang, H. Jo, J. Heo, J. Jeon, K. Lee","doi":"10.4172/2161-069X.1000460","DOIUrl":"https://doi.org/10.4172/2161-069X.1000460","url":null,"abstract":"Objectives: Gastric tubes are routinely in infants with transient tachypnea of newborn and mild respiratory distress. This study was conducted to investigate the need for routine insertion of gastric tube in full term and late preterm infants with mild respiratory distress admitted to the neonatal intensive care unit. Methods: This study was conducted on full term and late preterm infants who were admitted with mild respiratory distress to the Gangnam Cha Hospital NICU. From January to June 2014, a retrospective chart review was done 62 infants in the control group for whom an orogastric or nasogastric tube was routinely inserted and whose feedings were increased before gastric tubes were removed. In the experimental group infants, from July to September 2014, no gastric tube was inserted or was inserted for the identification of choanal atresia and for gastric contents aspiration and then removed rapidly. Results: The mean gestational age and birth weight of the infants in the experimental group were 37.2 ± 3.6 weeks and 2866 ± 337 gm, respectively, and those in the control group, 37.2 ± 3.2 weeks and 2849 ± 677 gm. There were no infants who needed intubation and CPAP or mandatory ventilator support. Most of the subjects in the experimental and control group were diagnosed with transient tachypnea of the newborn. The mean achieving age at full enteral feeding of experimental group infants was 4.76 days that for the control group infants, 4.67 day. The duration of hospital stay was 7.15 days for the experimental group infants and 7.23 days control group infants. Conclusion: We concluded that the routine use of a gastric tube for term and late preterm infants admitted with mild respiratory distress in NICU may be unnecessary, and that either a gastric tube should not be used at all for such infants or the period of its use should be minimized.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114993833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Are Double-Layer Stents Better than Plastic Stents and Self-Expandable MetalStents in Palliating Malignant Biliary Obstruction? Meta-Analysis andSystematic Review 双层支架在缓解恶性胆道梗阻方面是否优于塑料支架和自膨胀金属支架?荟萃分析和系统评价

Journal of Gastrointestinal and Digestive System Pub Date : 2016-08-03 DOI: 10.4172/2161-069X.1000459

Harsha Moole, Matthew L Bechtold, Micheal D Cashman, Fritz-Henry Volmar, S. Dhillon, D. Forcione, S. Puli

{"title":"Are Double-Layer Stents Better than Plastic Stents and Self-Expandable MetalStents in Palliating Malignant Biliary Obstruction? Meta-Analysis andSystematic Review","authors":"Harsha Moole, Matthew L Bechtold, Micheal D Cashman, Fritz-Henry Volmar, S. Dhillon, D. Forcione, S. Puli","doi":"10.4172/2161-069X.1000459","DOIUrl":"https://doi.org/10.4172/2161-069X.1000459","url":null,"abstract":"Background: Double layer stents (DLS) were designed to overcome the limitations of plastic stents (PS) and self-expandable metal stents (SEMS) in palliating inoperable malignant biliary obstructions (MBO). Aims: Primary outcomes are stent patency period, occlusion rates and adverse events. Methods: Study Selection Criteria: Studies using DLS, SEMS and PS for palliation of patients with inoperable MBO. Data collection and extraction: Articles were searched in Pubmed and Ovid. Statistical method: Pooled proportions were calculated using both fixed and random effects model. Results: Initial search identified 374 reference articles, of which 41 were selected and reviewed. Five studies (N=460) for DLS, SEMS and PS which met the inclusion criteria were included in this analysis. Pooled analysis by fixed effects showed DLS patency to be 118.9 days (95% CI=110.4 to 127.4) compared to 77.4 days (95% CI=70.2 to 84.6) in PS and 170.7 days (95% CI=154.4 to 187.0) in SEMS. Stent occlusion rates in DLS, PS and SEMS group were 8.1% (95% CI=7.1 to 9.0), 37.5% (95% CI=33.8 to 41.1) and 19.9% (95% CI=18.1 to 21.7) respectively. Conclusions: In palliating inoperable MBO patients, DLS seem to be superior to PS. SEMS tend to have higher occlusion rates compared to DLS.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131032045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Single Anastomosis Gastro Ileal Bypass with Pyloric and Gastric Plication(SAGI PGP): A New Innovative Bariatric Operation 单吻合术胃回肠分流术(SAGI PGP):一种创新的减肥手术

Journal of Gastrointestinal and Digestive System Pub Date : 2016-07-25 DOI: 10.4172/2161-069X.1000455

Ferman Faris Mohammed, Rafil Abdel Alwahab Aldaaod

{"title":"Single Anastomosis Gastro Ileal Bypass with Pyloric and Gastric Plication(SAGI PGP): A New Innovative Bariatric Operation","authors":"Ferman Faris Mohammed, Rafil Abdel Alwahab Aldaaod","doi":"10.4172/2161-069X.1000455","DOIUrl":"https://doi.org/10.4172/2161-069X.1000455","url":null,"abstract":"Objectives: Objective is to analyze the operation results of 270 patients in 2013, 2014 and 2015. Setting: Soran Private Hospital/Department of general &laparoscopic surgery/ErbilIraq. Methods: The mean BMI of patients is 43.5 kg/m2 with female patient were 165 and male patients were 115. Type 2 DM was presenting in 68 patients. Hypertension in 48 Hypercholesterolemia in 104, Hypertriglyceridemia in 178 and sleep apnea in 20, polycystic ovarian syndrome in 34 patients. Case study was possible for 240 patients in the 1st year post operation and 200 patients for the 2nd year and 130 in the 3rd year. Results: EWL is above 90% at first year, 85% at year 2. All diabetic patients return to normal blood sugar level usually at the first month with no need for any kind of anti-diabetic medication. Conclusion: SAGI PGP is a novel operation with the least complication that can happen in any other type of bariatric surgeries and the best EWL that can be expected. This technique is combination of single anastmosis gastroileostomy with gastric and pyloric placation. It is a simplified version of biliopancreatic diversion duodenal switch. SAGI PGP is a new combination of bariatric techniques which introduce gastric placation the new simple but yet very effective diversion component which is replacing the duodenal switch and other difficult diversion modalities. Gastric placation is also considered a new territory in bariatric operations and it combination with malasorbative component is rarely done so we try to explore this area and to reach the best results for our patients.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125145123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1