A. Romano, M. Grassia, G. Esposito, M. Petrillo, M. Pezzella, F. Romano, F. Torelli, A. Volpicelli, F. Ferraraccio, G. Nardone, N. Martino
{"title":"Total Esophagectomy and Endoscopic Radiofrequency Ablation for a Case of Diffuse Esophageal Papillomatosis: Case Report","authors":"A. Romano, M. Grassia, G. Esposito, M. Petrillo, M. Pezzella, F. Romano, F. Torelli, A. Volpicelli, F. Ferraraccio, G. Nardone, N. Martino","doi":"10.4172/2161-069X.1000478","DOIUrl":"https://doi.org/10.4172/2161-069X.1000478","url":null,"abstract":"Esophageal squamous papilloma (ESP) is a benign epithelial lesion. ESP is extremely rare and it has been described in few cases in literature. The etiology of ESP may be associated to chronic mucosal irritation and HPV infection. It is usually asymptomatic and mostly discovered as an incidental finding during upper gastrointestinal endoscopy. It is considered a benign neoplasia but recent reports have stressed the potential malignant evolution of these lesions. A 53 year old caucasian woman presented with a four years history of disphagia not responsive to medical therapy. At upper endoscopy, esophageal mucosa appeared hyperemic and completely covered by numerous (>100) sessile peduncolate papules. Biopsies demostrating atypical epithelial proliferation confirmed the diagnosis of esophageal squamal papillomatosis with low grade and focal high grade dysplasia; in situ hybridization studies for HPV were perfomed and it was positive for the type 16. We report a case of diffuse esophageal papillomatosis with histologic and microbiologic findings of genotype 16 HPV and Lichen Planus infection successfully treated with an Ivor Lewis Esophagectomy and a second look endoscopy by radiofrequency ablation.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130917579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea S. Porpiglia, D. Nguyen, J. Farma, S. Reddy
{"title":"The Role of Heated Intraperitoneal Chemotherapy (HIPEC) in Low-Grade Appendiceal Neoplasm: Friend or Foe?","authors":"Andrea S. Porpiglia, D. Nguyen, J. Farma, S. Reddy","doi":"10.4172/2161-069X.1000477","DOIUrl":"https://doi.org/10.4172/2161-069X.1000477","url":null,"abstract":"Low-grade mucinous appendiceal neoplasms are rare tumors. There is limited data on the treatment for pseudomyxoma peritonei with low-grade appendiceal histology. Classifications of appendiceal neoplasms include low-grade appendiceal mucinous neoplasm (LAMN), diffuse peritoneal adenomucinosis (DPAM), and peritoneal mucinous carcinomatosis (PMCA). Studies have demonstrated patients with low-grade appendiceal neoplasms have improved overall survival compared to patients with high-grade appendiceal neoplasms. Since low-grade tumors have better prognosis some retrospective trials have suggested observation in patients with these types of tumors. Another option includes cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). We have done an extensive literature search exploring the various methods in which to treat patients with this disease.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115229011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anal Canal Electrosensitivity Test on Child Patients after Total Colectomy,Mucosal Protectomy and Ileal J Pouch-Anal-Anastomosis","authors":"R. Tomita","doi":"10.4172/2161-069X.1000476","DOIUrl":"https://doi.org/10.4172/2161-069X.1000476","url":null,"abstract":"Objectives: To clarify the role of anal canal sensitivity in soiling (minor incontinence; the seepage of mucus and/or stool during nighttime and/or daytime) in child patients after ileal J pouch-anal-anastomosis (IPAA), the author studied the sensory function of the anal canal. Twelve patients one year after IPAA for ulcerative colitis were studied (8 males, 4 females; aged 10.5 to 14.5 years, average 13.0 years). Setting: Nihon University Hospital at Itabashi/Department of Pediatric Surgery Methods: Four patients showed soiling (group A) and 8 patients showed continence (group B). Group C serving as controls consisted of 12 children with normal defecation (9 males, 3 females; aged 6 to 15 years, average 11.7 years). The anal canal sensitivity thresholds (ACST) on the oral side of the dentate line (ODL) and the anal side of the dentate line (ADL) were measured by anal canal electrosensitivity test. Results: No patients in group A could discriminate between flatus and feces, but all those in group B could discriminate between them. In terms of ACST at the ODL, sensitivity levels of groups A and B were significantly lower than that of group C (P=0.0249, P=0.0004, respectively). In terms of ACST at the ADL, significantly lower sensitivity was found in patients of group A than in groups B and C (P=0.0039, P=0.0021, respectively). Conclusion: The anal transitional zone may not contribute to discrimination between flatus and feces and not influence soiling following IPAA. Soiling after IAPP may be caused by damage to the sensory nerves in the ADL","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122981483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gastrointestinal endoscopic innovation from China","authors":"Bingrong Liu","doi":"10.4172/2161-069X.C1.040","DOIUrl":"https://doi.org/10.4172/2161-069X.C1.040","url":null,"abstract":"","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132043713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Dell’Edera, F. Nicoletti, M. D’Apice, A. Allegretti, A. Epifania
{"title":"Genetic Aspects of Adult-Type Hypolactasia","authors":"D. Dell’Edera, F. Nicoletti, M. D’Apice, A. Allegretti, A. Epifania","doi":"10.4172/2161-069X.1000475","DOIUrl":"https://doi.org/10.4172/2161-069X.1000475","url":null,"abstract":"Background and Objective: Lactose is a disaccharide sugar and is found in mammals milk and derivatives. Lactose intolerance is the inability to metabolize lactose, because of a lack of the required enzyme lactase in the digestive system. Genetically the physiological hypolactasia (primary LM) is associated with the LCT-13910 C/T and LCT-22018 G/A polymorphisms. The aim of this study focused on the diagnosis and treatment intolerance or malabsorption of lactose in a cohort of 983 patients for the appearance of non-specific symptoms suggestive of a lactose intolerance. Methods: The work was divided into the following phases: diagnosis of lactose intolerance or malabsorption; Check the incidence of primary lactase deficiency in the population Lucana (Italy); Evaluate the improvement of post-diagnosis symptoms and impact on quality of life (Q.O.L: Quality Of Life) as a result of enzymatic and/or food therapy in intolerant subjects. Evaluate the correlation genotype/phenotype studying variants -13910 C>T and -22018 A>G in LPH gene. Results: Of the 983 participants, 668 subjects (67.95%) had a positive homozygous mutation (associated to-13910CC hypolactasic phenotype), 314 subjects (31.94%) had a positive heterozygous mutation (associated to -13910CT lactase persistent phenotype) and only in 1 subject (0,1%) the 2 alleles were not mutated (-13910TT dominant homozygous). The present work reveals a 67.95% of participant with a positive homozygous mutation (-13910CC). Conclusions: The lactose malabsorption is a condition widespread in Italy, but much less frequently is the syndrome of intolerance. Embarking on a diet that a priori excludes milk and derivatives, in the absence of a definitive diagnosis, it can have a negative impact on the welfare of the organism The genetic test is really simple and noninvasive, confirms or excludes a malabsorption and in particular circumstances provides a predictive test to detect primary hypolactasia long before of her clinical manifestation.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123520005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Debbie R. Walley, R. Greer, M. González, C. Subramony
{"title":"Melanosis “Coli” in Anal Heterotopic Gastric Mucosa: A Case Report and Review of the Literature","authors":"Debbie R. Walley, R. Greer, M. González, C. Subramony","doi":"10.4172/2161-069X.1000471","DOIUrl":"https://doi.org/10.4172/2161-069X.1000471","url":null,"abstract":"Background: Gastric heterotopia is the presence of gastric mucosa in a foreign anatomic location. It can occur anywhere in the gastrointestinal tract and has been well documented in the esophagus. Gastric heterotopia of the anorectum is a rare occurrence. Case Report: We present a case of an asymptomatic adult male who underwent a colonoscopy during which an anal nodule was biopsied. Microscopic examination revealed oxyntic gastric mucosa with chronic active gastritis and melanosis coli. During a subsequent colonoscopy six years later, an abnormally pigmented area of anus was biopsied. Microscopic examination revealed antral gastric mucosa with chronic active gastritis. A literature review showed that there have been 72 reported cases of gastric heterotopia of the anorectum. Only four of those case occurred in the anus. Conclusion: To our knowledge, this is the first report of melanosis coli associated with gastric heterotopia of the anorectum as well as a shift in gastric mucosal type on repeat biopsy. We propose the term \"outlet patch\" for gastric heterotopia of the anorectum.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134426830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel Diagnostic Tool CISH to Demonstrate CMV DNA by Light Microscopy-A Case Report of CMV Colitis","authors":"Barodawala Sm, Majethia Nk, K. Chadha","doi":"10.4172/2161-069X.1000472","DOIUrl":"https://doi.org/10.4172/2161-069X.1000472","url":null,"abstract":"Cytomegalovirus (CMV) infections are generally thought to be opportunistic especially in the setting of an immunosuppressed host. We present an unusual case of CMV colitis with liver abscess observed in an immunocompetent patient. The right diagnosis was made after implementation of Chromogenic In Situ Hybridization (CISH) on colonic biopsy tissue. Our purpose is therefore to familiarize fellow colleagues and clinicians with possible role of CISH in the diagnosis of this entity.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130118805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Percutaneous Endoscopic Gastrostomy and Buried Bumper Syndrome","authors":"E. Makhoul, Ralph Kamel, N. Hanna, A. Zaarour","doi":"10.4172/2161-069X.1000469","DOIUrl":"https://doi.org/10.4172/2161-069X.1000469","url":null,"abstract":"Percutaneous Endoscopic Gastrostomy (PEG) is a method of placing percutaneously a tube into the stomach by endoscopy. This technique is a relatively safe and effective method indicated in the treatment of neurologic diseases with irreversible swallowing problem or proximal esophageal pathology. Complications can occur including pain at the site, leakage of stomach contents and malfunction of the tube. Possible complications include infections of the PEG site, aspiration, bleeding and perforation. In this article we would like to bring to attention a rare complication of PEG, the Buried Bumper Syndrome (BBS) that presented in an 86-year-old female with gradual migration of the internal bumper alongside the stoma tract outside the stomach.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126852141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fitz-Hugh-Curtis Syndrome as Finding during Open Cholecystectomy andUnknown Pregnancy: Clinical Case","authors":"G. Arredondo","doi":"10.4172/2161-069X.1000468","DOIUrl":"https://doi.org/10.4172/2161-069X.1000468","url":null,"abstract":"Introduction: The Fitz-Hugh-Curtis syndrome is a perihepatitis produced by secondary peritonitis the rise of bacteria, as a result of pelvic inflammatory disease. In the chronic stage can be observed adhesions between abdominal wall and the liver surface characterized by the similarity to \"violin strings\". This image is considered diagnostic criterion. Clinical case: Female 37 years-old, Gesta 7, Births 5, Abortion 1, Cesarean Section 0, who intervenes surgically open to present intermittent pain for gallstone cholecystitis two years of evolution. Normal vital signs; Laboratory test preoperative: erythrocytes 3.40 × 106, hemoglobin 9.9 g/dl, hematocrit 33.8%, lymphocytes 19%, leukocytes 11.86 × 103/mm3, total neutrophil 86%. Glucose 139 mg/dl, BUN 4.35 mg/dl, urea 9.3 mg/dl, SGOT (AST) 80 U/I, SGPT (ALT) 66 U/I, Proteins 6.0 g/dl, serum albumin 3.4 mg/dl. VDRL Neg. Urinalysis: Urobilinogen 2 mg/dl; Leukocyte 15-20 x field and postoperatory pregnancy test (+). It proceeds to open cholecystectomy and during exposure of the gallbladder is located in hepatic parenchyma multiple adhesions and congestive liver. Discussion: The combination of a painful liver without biochemical evidence of hepatitis or biliary obstruction, and menorrhagia raised the suspicion of perihepatitis Fitz-Hugh-Curtis, an inflammatory process of the liver capsule due to pelvic inflammatory disease mostly caused by Chlamydia trachomatis or Neisseria gonorrhoeae. The pathophysiology of perihepatitis FHC is unclear, but direct infection of the liver capsule, hematologic or lymphatic spread as well as an exaggerated immune response has been suggested.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130031997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Analysis of a New Diagnostic Test for Children with Acute Appendicitis:Plasma Leptin Level","authors":"Harun Resit Ayangil, M. E. Dörterler, C. Turan","doi":"10.4172/2161-069X.1000470","DOIUrl":"https://doi.org/10.4172/2161-069X.1000470","url":null,"abstract":"Aim: In the diagnosis of acute appendicitis, the most frequently-applied laboratory tests are blood leukocyte level (WBC) and serum C-reactive protein (CRP). In recent years, it has been thought that the leptin hormone level, which has been proven to be raised in acute inflammation, could be used diagnostically in patients with acute appendicitis. In this study, we aimed to determine the relationship between WBC, CRP, and leptin levels with inflammation in acute appendicitis and to define the role of leptin in the mechanism underlying loss of appetite, which is the most frequently observed symptom. Materials and method: The study comprised 40 patients diagnosed with acute appendicitis (AA) in the Pediatric Surgery Department and a control group of 20 age-matched patients. Blood samples were taken from all subjects in both groups and the levels of WBC, CRP and leptin were measured. Body mass index was calculated and all findings were compared. Results: In the AA group, the median leptin value was measured as 1.24 ng/ml preoperatively, 1.37 ng/ml perioperatively, and 0.81 ng/ml 2 days postoperatively. The leptin value in the control group was 1.90 ng/ml. No statistically significant difference was found between the two groups with respect to the preoperative and perioperative leptin values (p>0.05). The postoperative 2nd day leptin values of the AA group were statistically significantly lower than those of the control group (p<0.05). Conclusions: In cases of suspected acute appendicitis, leptin can be a useful diagnostic parameter since its levels increase during the early stages of inflammation.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129196598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}