Journal of Gastrointestinal and Digestive System最新文献

Effectiveness of 14 Days Concomitant Therapy as a New Regimen in Treatment of Helicobacter Pylori Infection on a Sample of Lebanese Population 14天联合治疗作为治疗幽门螺杆菌感染的新方案在黎巴嫩人群中的有效性

Journal of Gastrointestinal and Digestive System Pub Date : 2020-11-25 DOI: 10.15761/GHE.1000212

Khalil Ali, Hallal Mahmoud, Mahfouz Rayane, Z. Moubarak, Al-Ola Abdallah, Moushira, M. Rasha

{"title":"Effectiveness of 14 Days Concomitant Therapy as a New Regimen in Treatment of Helicobacter Pylori Infection on a Sample of Lebanese Population","authors":"Khalil Ali, Hallal Mahmoud, Mahfouz Rayane, Z. Moubarak, Al-Ola Abdallah, Moushira, M. Rasha","doi":"10.15761/GHE.1000212","DOIUrl":"https://doi.org/10.15761/GHE.1000212","url":null,"abstract":"Background: Finding new efficacious regimens for H Pylori eradication remains the goal of many studies especially after the increased resistance to standard therapy, which includes clarithromycin as the main antibiotic. In the current study, the aim is to evaluate the efficacy of concomitant or non-bismuth quadruple therapy in eradication of H Pylori. \u0000Methods: 50 patients from Al-Zahraa Hospital University Medical Center (ZHUMC) receiving concomitant therapy were included in the study from August 2015 to December 2016. Patients were presented with symptoms of gastritis, peptic ulcer diseases (epigastric pain, heartburn, halitosis, nausea…) and found to have H. pylori infection through Rapid Urease Test (RUT) following endoscopy, were included in this study. Patients were assigned into the 14 days’ concomitant non-bismuth quadruple therapy, which is consisted of Lansoprazole (30mg), amoxicillin (1g), clarithromycin (500mg) and metronidazole (500mg).Our primary endpoint was H. Pylori eradication as established by a negative urease breath test at least 2 weeks after the end of treatment. \u0000Results: All were evaluated at the end of the study. The H. pylori eradication rate was 94% (47/50). The treatment was well tolerated by the participants to the study with a 96% compliance. \u0000Conclusions: A total 14-day concomitant therapy is a highly effective treatment for H. pylori infection as showed by the high tolerance, mild and non-serious side effects in our sample of patients.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125644114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aflatoxin B1 and glucose-6-phosphate dehydrogenase deficiency in neonatal jaundice 黄曲霉毒素B1和葡萄糖-6-磷酸脱氢酶缺乏症在新生儿黄疸

Journal of Gastrointestinal and Digestive System Pub Date : 2018-12-06 DOI: 10.4172/2161-069X-C7-081

pNermin Raafatp

引用次数: 0

The role of vitamin D levels in early onset sepsis development in term neonates 维生素D水平在足月新生儿早期脓毒症发展中的作用

Journal of Gastrointestinal and Digestive System Pub Date : 2018-12-06 DOI: 10.4172/2161-069X-C7-082

pAhmed Sharap

引用次数: 0

Volatile organic metabolites as novel, non-invasive diagnostic biomarkers in Inflammatory Bowel Disease 挥发性有机代谢物作为炎症性肠病的新型无创诊断生物标志物

Journal of Gastrointestinal and Digestive System Pub Date : 2018-08-31 DOI: 10.4172/2161-069x-c4-072

pIftikhar Ahmedp

{"title":"Volatile organic metabolites as novel, non-invasive diagnostic biomarkers in Inflammatory Bowel Disease","authors":"pIftikhar Ahmedp","doi":"10.4172/2161-069x-c4-072","DOIUrl":"https://doi.org/10.4172/2161-069x-c4-072","url":null,"abstract":"T Diagnosis of inflammatory bowel disease (IBD) requires extensive and often invasive investigations including colonoscopy and histology and places a heavy burden, both on healthcare resources, because of the cost, and on the individual, in times of disease-related disability and poor quality of life. Recently, there has been increasing interest in noninvasive biomarkers to diagnose IBD and to monitor the disease activity. There is growing scientific interest in the investigation of volatile metabolites and numbers of studies have focused on the utilization of non-invasive biomarkers in the diagnosis of GI disease. The development of sophisticated analytical techniques has enabled the study and interpretation of changes in the faecal and breath volatile organic metabolites (VOMs) and its correlation with the pathophysiological mechanisms in IBD. VOMs are the chemicals that are the products and intermediates of metabolism and may be altered during the diseases process. Changes in the signature of VOMs could potentially provide diagnostic information about health and disease. Multiple studies have reported the differences in VOM profiles of healthy controls vs. patients with IBD other GI disorders. VOM profiles have been used to segregate patients by disease activity and the type of disease. The correlation of VOMs with Microbiota is interesting and supports the hypothesis of gut microbial dysbiosis in the etiology of IBD. This provides an important platform to explore the role of dysbiosis in IBD and other GI disorders pathogenesis and development of novel therapeutic targets. In future, further understanding of faecal VOMs may lead to the development of a rapid and simple point of care diagnosis and monitoring of IBD.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133003819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of bile acids in the treatment of non-alcoholic steatohepatitis: A 10-year systematic review 胆汁酸治疗非酒精性脂肪性肝炎的疗效:一项10年系统评价

Journal of Gastrointestinal and Digestive System Pub Date : 2018-08-06 DOI: 10.4172/2161-069x-c2-066

Higinio T. Mappala

引用次数: 0

Comparative Study between Use of Endoscopic Ultrasound before Endoscopic Retrograde Cholangio Pancreatography vs. Endoscopic Retrograde Cholangio Pancreatography Alone 内镜下逆行胆管造影前超声与单独内镜下逆行胆管造影的比较研究

Journal of Gastrointestinal and Digestive System Pub Date : 2018-05-14 DOI: 10.4172/2161-069X.1000565

Mohamed A Allam

引用次数: 0

Magnetic compression anastomosis for obstructed choledocho-jejunostomy 磁压吻合术治疗胆总管-空肠吻合术梗阻

Journal of Gastrointestinal and Digestive System Pub Date : 2018-03-20 DOI: 10.4172/2161-069X-C1-063

H. Kawabata

引用次数: 0

Bile reflux of the remnant stomach following Roux-en-Y gastric bypass: An etiology of chronic abdominal pain treated with remnant gastrectomy Roux-en-Y胃旁路术后残胃胆汁反流:残胃切除术治疗慢性腹痛的病因学

Journal of Gastrointestinal and Digestive System Pub Date : 2018-03-20 DOI: 10.4172/2161-069X-C1-064

Erika La Vella

引用次数: 1

Late Complications of Colon Interposition for Esophageal Reconstruction 结肠介入食管重建术的晚期并发症

Journal of Gastrointestinal and Digestive System Pub Date : 2018-03-12 DOI: 10.4172/2161-069X.1000555

A. Boukerrouche

{"title":"Late Complications of Colon Interposition for Esophageal Reconstruction","authors":"A. Boukerrouche","doi":"10.4172/2161-069X.1000555","DOIUrl":"https://doi.org/10.4172/2161-069X.1000555","url":null,"abstract":"Introduction: Successful restoration of digestive continuity following esophagectomy is a challenge. Gastric graft remains is the first option to reconstruct diseased esophagus. However, colon graft is preferable in some instances. Colon interposition is a complex and more demanding surgical procedure. The long-term functional results of colon interposition were satisfactory and can be subsequently affected by late complications. We reported in this retrospective study, the late complications occurred after left colon interposition performed for esophageal caustic stricture from 2000 to 2016. Patients and Methods: Sixteen of 107 patients who received left colon interposition for esophageal caustic stricture developed a late complication. There were 15 women and one man with median age of 20 years. Three patients had a previous cervical leak and thoracic inlet was widened in 2 cases. Results: The late post-operative morbidity rate was 14.9%. Cervical anastomotic stricture occurred in 8 patients. Dilations were successful in 6 patients and surgical revision was required in 2 patients. Symptomatic mild gastrocolic reflux occurred in 5 patients and Symptoms improvement had been obtained after medical treatment and lifestyle modification. Two patients developed graft redundancy and surgery was required after failure of life-style modification measures. It consisted of resecting the redundant colon and performing an end-to-end anastomosis. Conclusion: Late complication after colon interposition can greatly affect swallowing function and quality of life. Surgery is required in some conditions to improve symptoms and life-quality. Identification of predisposing factors and improvement in technique remain the best way to reduce the risk of late complications.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114905895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Role of Zinc in Shaping the Gut Microbiome; Proposed Mechanisms and Evidence from the Literature 锌在肠道微生物群形成中的作用提出的机制和文献证据

Journal of Gastrointestinal and Digestive System Pub Date : 2018-01-23 DOI: 10.4172/2161-069X.1000548

Usama Usama, Muhammad Jaffar Khan, S. Fatima

引用次数: 12