Journal of Gastrointestinal and Digestive System最新文献

{"title":"The Role of Second-look Endoscopy in Severe Esophageal Caustic Injury","authors":"Le Puo-Hsien, Seak Chen-June, Chiu Cheng-Tang, Chen Tsung-Hsing, Kang Shih-Ching, Cheng Hao-Tsai","doi":"10.4172/2161-069X.1000518","DOIUrl":"https://doi.org/10.4172/2161-069X.1000518","url":null,"abstract":"Severe caustic ingestion often leads to multiple complications and high mortality rate. Esophagogastroduodenoscopy is recommended during the first 24 hours for severity and extent evaluation, but it seems insufficient to guide further managements in severe caustic injury patients due to rapid progression and variable clinical conditions. Therefore, we tried to evaluate the safety and role of second-look endoscopy in these patients in 1-2 weeks later. \u0000We retrospectively collected severe esophageal caustic injury (grade 2b, 3a, 3b) adults with and without secondlook endoscopy in subacute stage (6th-14th days after caustic injury) in Linkou Change Gung Memorial Hospital during 2011/1-2014/11. They were divided in to once endoscopy group and second-look endoscopic group according to the patients with second-look endoscopy or not. They were further matched with the same cause of caustic injury, corrosive properties, injury grading, and then selected with Excel RAND function. There were 26 patients in both groups. \u0000The average timing of second-look endoscopy was 10.23 ± 3.166 (mean ± SD) days after caustic ingestion. The hospital stay was significantly shorter in the second-look endoscopy group (24.92 ± 17.50 days, 54.38 ± 43.73 days, P=0.002). However, the complication rate was not statistically significant between these two groups. \u0000In conclusion, second-look endoscopy is safe and might shorten the hospital stay. However, prospective, randomized and larger sample size studies are needed to support the finding.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128337860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis C and Neurological Disorders: A Patient’s Case Report","authors":"A. Aomari, M. Firwana, I. Benelbarhdadi, F. Ajana","doi":"10.4172/2161-069X.1000517","DOIUrl":"https://doi.org/10.4172/2161-069X.1000517","url":null,"abstract":"Introduction: Neurological disorders associated with hepatitis C is most often related to mixed cryoglobulinemia. \u0000 The aim of this study is to show the severity of neurological disorders during hepatitis C infection. \u0000Observation: Mrs. S A, 60 years old, who had been in purpuric rash for six months, associated with physical and \u0000 psychic asthenia and weight loss at 16 kg in 8 months. The evolution was marked by an alteration of the \u0000 neurological state of the patient with an installation of motor deficit affecting the 04 limbs, abolition of the osteotendinous \u0000 reflexes, and a hypoesthesia of the upper and lower limbs. The electromyogram (EMG) showed a sensorimotor \u0000 polyradiculoneuropathy, and the etiological diagnosis was in favor of a peripheral neuropathy secondary to a \u0000 cryoglobulinemia, related to hepatitis C. In addition, the patient presented after a few days of headaches, a sharp \u0000 drop in visual acuity and high blood pressure, this is complicated by two episodes of convulsive seizures. A cranial \u0000 CT scan is performed in an emergency without abnormalities, with no sign in relation to thrombophlebitis after \u0000 injection of contrast agent. The diagnosis retained is a central neurological disease secondary to infection with the \u0000 virus c associated with peripheral neurological disease. \u0000Conclusion: Neurological disorders associated with hepatitis C are rare but poor prognosis threatening the \u0000 functional and vital prognosis of patients.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123437764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Accuracy of Computer Automated Analysis of Esophageal 24-hour Impedance pH Studies","authors":"Mouhamed Amr Sabouni, M. Ghalayini, Sayf Bala, S. Petty, N. Hajar, Alon Yarkoni, A. Hila","doi":"10.4172/2161-069X.1000516","DOIUrl":"https://doi.org/10.4172/2161-069X.1000516","url":null,"abstract":"Background: Esophageal pH monitoring in conjunction with multichannel intraluminal impedance (MII-pH) is now \u0000 considered the most accurate method for detection and characterization of gastro-esophageal reflux (GER), with \u0000 higher sensitivity and specificity in detecting reflux than esophageal pH monitoring alone. \u0000Aims: One possibly limiting factor for using MII-pH testing is the time required to analyze the results. Automatic \u0000 interpretation softwares have been produced to reduce this, in this study, we assessed the reliability of two 24 hour \u0000 MII-pH analysis softwares compared to the interpretation provided by an expert. \u0000Methods: We performed a retrospective review of 200 MII-pH studies done on patients with reflux symptoms \u0000 between September 2009 and September 2014. The studies were split into two groups of 100 patients: one group’s \u0000 testing was performed using MMS equipment and software, and the other group used Sandhill Scientific equipment \u0000 and software. All tracings were additionally analyzed by an expert and the interpretations were compared. \u0000Results: Our data indicated a strong correlation between the expert’s analysis and both automatic softwares in \u0000 all positions, Demeester score, reflux episodes and symptoms index (p<0.0001). For studies interpreted as either \u0000 normal or abnormal, there was concordance between the expert analysis and the software 95% of the time for the \u0000 MMS software, and 93% of the instances for the Sandhill software. \u0000Conclusions: The MII-pH data analysis software provide reliable diagnostic utility and are time-efficient at the \u0000 present time, but it is advisable to seek interpretation from an experienced interpreting physician, prior to signing off \u0000 the report in order to avert any possible troubles such as probe malfunctioning.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115962242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Calretinin Stain in Work-up of Inadequate Biopies in Patient’s with Hirschsprung’s Disease.","authors":"M. Sikandar, Nagi Ah, N. Naseem","doi":"10.4172/2161-069X.1000515","DOIUrl":"https://doi.org/10.4172/2161-069X.1000515","url":null,"abstract":"Background and Objective: A thorough study was designed with an objective of observing utility of calretinin as immune-histochemical marker for aganglionosis and for detection of ganglion cells in the inadequate biopies of affected areas for more accurate and better diagnosis of the disease. \u0000Study Design: It was observational, descriptive study. \u0000Setting: It was carried out at the Department of Morbid Anatomy and Histopathology in University of Health Sciences (UHS) Lahore. \u0000Period: The study commenced in March 2016 after approval of the synopsis by the Advance Studies and Research Board of UHS and was successfully completed in December 2016. \u0000Methodology: Biopsy specimens of colon which were considered for the study were collected from 73 patients from Mayo Hospital and Jinnah Hospital, Lahore with established histopathologically diagnosed HSCR on H&E staining. \u0000Results: The mean age was 12.52 ± 9.21 months. On the basis of Calretinin staining Ganglion cells were present in 42/73 (57.53%) and absent in 31/73 (42.47%) respectively. \u0000Conclusion: It was consummated that Calretinin provides a reliable and very cost effective adjunctive test to be used routinely with H&E in diagnosing HSCR and consequently waiving off the need for unnecessary surgeries and repeated biopsies.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123170818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-angiogenic Agents in Resectable Colorectal Cancer Metastases: A Lebanese Experience","authors":"A. A. Abboud, Evelyne G Helou, R. Ismail, Layale Olaywan","doi":"10.4172/2161-069X.1000513","DOIUrl":"https://doi.org/10.4172/2161-069X.1000513","url":null,"abstract":"Background: Certain studies demonstrated that the addition of anti-VEGF and anti-EGFR drugs improves the overall survival, progression free survival, and response rate in colorectal cancer patients after resection of their liver metastases in a curative intent. We aimed to assess the benefit of addition of cetuximab to standard chemotherapy in patients with resectable colorectal liver metastases. \u0000Methods: In this research, 11 patients with colorectal cancer and potentially curative liver metastases, who underwent metastasectomy from different Lebanese hospitals were analyzed. Patients received 5-FU, irinotecan, oxaliplatin with either cetuximab or bevacizumab pre and post operation. Response rate was compared between patients retrospectively, whether complete, partial, stable, or no response. \u0000Results: Out of 11 patients, 5 patients had progression free survival for 3 months after surgery, out of which 1 (9%) had a complete response, 2 had partial response, and 2 had a stable disease. No increase in the major side effects or mortality was noted. \u0000Discussion: Our results agree with other studies from different geographic regions. We recommend the addition of a biological agent to the standard systemic chemotherapy, because it is associated with improved overall survival and disease control rate, but further studies are still needed to investigate the influence of KRAS and BRAF mutation status on prognosis and treatment outcome.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115718267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interest of Corticosteroid Injection in Refractory Benign Stenosis of the Esophagus","authors":"A. Aomari, H. Seddik, Benkirane","doi":"10.4172/2161-069X.1000514","DOIUrl":"https://doi.org/10.4172/2161-069X.1000514","url":null,"abstract":"The post-surgical anastomotic oesophageal stenosis is usually benign, which may recur rapidly after several endoscopic dilations (refractory stenosis). The purpose of this work is to show, through an observation, the interest \u0000of the injection of the corticoids during the endoscopic treatment of refractory oesophageal stenosis. It was a patient who benefited from an esophagectomy of 2/3 inferior+oeso-gastric anastomosis after ingestion of hydrochloric acid (spirit of salt). \u0000The evolution was marked by the installation of a post-anastomotic stenosis recurring after several sessions of endoscopic dilations. The local injection of the corticosteroids (Triamcinolone) at the time of the dilation sessions, allowed a decrease in the frequency of the dilatations, a disappearance of the dysphagia, an improvement of the general state with a weight gain. The injection of corticosteroids was a good solution for this patient, to avoid endoscopic treatment failures, and to improve her quality of life.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132051843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pneumatosis Intestinalis in Patient with Relapsing Polychondritis","authors":"SI Kim, So Ree Kim, Ji-young Kim, H. Kim, Sung Won Park, Jinmyeong Oh, H. Jeong","doi":"10.4172/2161-069X.1000511","DOIUrl":"https://doi.org/10.4172/2161-069X.1000511","url":null,"abstract":"Relapsing polychondritis (RP) predominantly involves cartilaginous structures, but systemic vasculitis is also associated with RP. A 44-year-old man with RP visited the emergency department for incidentally detected free air in a chest X-ray. He was diagnosed with pneumotosis intestinalis (PI). PI is rare disease in which gas forms between the bowel walls. He was successfully treated with bowel rest and empirical antibiotics. This paper reports a case of PI in a RP patient.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128575430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Finding of Gallbladder Cholesterolosis in an Infant with Rotavirus Infection and Transaminitis","authors":"Upma Suneja, A. Donaire, Franscene E. Oulds","doi":"10.4172/2161-069X.1000510","DOIUrl":"https://doi.org/10.4172/2161-069X.1000510","url":null,"abstract":"Gall bladder diseases are relatively less prevalent in pediatrics compared to the adult population. With the use of ultrasound, more and more pediatric cases of gall bladder diseases are being reported. This is a case of an infant with Rotavirus gastroenteritis who was incidentally found to have cholesterolosis of gall bladder on abdominal ultrasound.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124180454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Stromal Tumor: A CytologistâÂÂs Perspective","authors":"T. Santosh, Kanchan S. Kothari, P. Sathe, Prachi Gholap","doi":"10.4172/2161-069X.1000509","DOIUrl":"https://doi.org/10.4172/2161-069X.1000509","url":null,"abstract":"Introduction: Gastro-intestinal stromal tumors are mesenchymal tumors they have a unique immunophenotype, \u0000 expressing c-KIT (CD117), DOG-1 and CD34 in most cases. Most commonly occurring in small intestine and \u0000 stomach. \u0000Case report: We report a case of EUS guided FNA from gastric mass in a 60 year old patient. Cytology showed \u0000 cellular smears with palisade of tumor cells and blunt end spindle cells. \u0000Discussion: GIST is very difficult to differentiate from other benign tumors i.e. leiomyoma and schwannoma. \u0000 EUS guided FNA can be a very useful tool in approaching deep seated intra-abdominal lesion with ease. It also \u0000 helps in diagnosis and treatment of the disease in a better way.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115207820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Helicobacter pylori Infection among Symptomatic Patients, Correlation with Endoscopic Findings and itâÂÂs Association with Type II Diabetes Mellitus","authors":"A. A. Abboud, W. Khalek","doi":"10.4172/2161-069X.1000508","DOIUrl":"https://doi.org/10.4172/2161-069X.1000508","url":null,"abstract":"Background: Helicobacter pylori (H. pylori) is an important global pathogen infecting approximately 50% of the world’s population. This study was undertaken in order to estimate the prevalence of Helicobacter pylori infections among symptomatic patients in Lebanese Hospital Geitaoui University Medical Center (HLG-CHU) and Middle East Institute of Health (MEIH), to investigate the associated risk factors, the endoscopic findings and its association with type 2 diabetes. \u0000Method: This is an observational analytic case-control study, carried out over a period of 6 months, from January 2016 till June 2016, including all patients complaining of upper gastrointestinal (GI) symptoms. The patients (n=226) were enrolled following same protocol in both the hospitals. All subjects completed a validated questionnaire and underwent upper GI endoscopy. The histo-pathological diagnosis of H. pylori infection in biopsy specimen was done using the modified Giemsa stain. H. Pylori prevalence and associated factors were analysed by Students t-test, Chisquare test and Fisher exact test. Statistical analysis was performed using the statistical program SPSS version 22. \u0000Results: The overall prevalence was 38.9% with no difference between sexes. There was no association with age, residential region, alcohol and caffeine use and smoking. Low level of education and non-steroidal anti-inflammatory (NSAIDs) use were the only significant factors. Bloating, nausea and early satiety were significant predictors of H. pylori infection. The most commonly identified endoscopic finding was gastritis (78.3%), only duodenitis and oesophagitis were significantly associated with H. pylori. Prevalence of H. pylori was 38.8% and 39%, respectively, in patients with diabetes and having no diabetes. \u0000Conclusion: H. Pylori prevalence was found to be high. Individuals who had low educational level and NSAIDs consumers, were under higher risk of infection than others. H. pylori infection appears not to be associated with diabetes.","PeriodicalId":388922,"journal":{"name":"Journal of Gastrointestinal and Digestive System","volume":"546 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133944612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}