Journal of Pharmacovigilance and Drug Research最新文献

{"title":"Peptic ulcer in nephrotic syndrome patients due to steroid therapy","authors":"Sreeja Ankireddypalli","doi":"10.53411/jpadr.2023.4.1.1","DOIUrl":"https://doi.org/10.53411/jpadr.2023.4.1.1","url":null,"abstract":"Peptic ulcers comprise gastric and duodenal ulcers. Complications of peptic ulcers include bleeding, perforation, and obstruction. Bleeding is a major problem of peptic ulcers, as it is at times fatal. Peptic ulcer bleeding is diagnosed and treated by upper gastrointestinal (GI) endoscopy. Oral glucocorticosteroids (referred to hereafter as corticosteroids) are commonly prescribed for symptom control in patients receiving palliative care. A recent study has shown that one-third of patients admitted to an inpatient hospice unit were receiving corticosteroids. This frequency in prescribing exposes a large number of patients to the potential side effects known to be associated with corticosteroids, including weight gain, impaired glucose tolerance, and proximal myopathy.H. pylori infection is a risk factor for PUD in aspirin and NSAID users.","PeriodicalId":388338,"journal":{"name":"Journal of Pharmacovigilance and Drug Research","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122156200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AICTE Sponsored National Conference","authors":"P. Patra","doi":"10.53411/jpadr.2023.4.1.7","DOIUrl":"https://doi.org/10.53411/jpadr.2023.4.1.7","url":null,"abstract":"Sovenier (ETRAPS- 2023)","PeriodicalId":388338,"journal":{"name":"Journal of Pharmacovigilance and Drug Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133532711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A factor of anti-atherosclerotic activity-fibrinolytic activity of venom of Buthus tumulus species (Indian red scorpion)","authors":"Renuka Bhoi, Sonali Nipte, M. Pandey","doi":"10.53411/jpadr.2023.4.1.4","DOIUrl":"https://doi.org/10.53411/jpadr.2023.4.1.4","url":null,"abstract":"Introduction: Atherosclerosis (AS) is an inflammatory disease of the arterial blood vessels (arteries), in which the walls of the blood vessels become thickened and hardened specifically due to atheromatous plaques. The plaques are composed of cholesterol and other lipids, inflammatory cells, and calcium deposits. There are five different types of atherosclerosis such as in the aorta, coronary, cerebral, renal, and pulmonary arteries. The scorpion species that present medical importance belonging to the family Buthidae Scorpion toxins consist of several peptides isolated from the venom of different species of scorpion and are based on their pharmacological action and also agree well with the structural properties of this peptide family. \u0000Method: The study was conducted in the Department of Pharmacology, Modern College of Pharmacy, Nigadi, Pune in the year June 2012- June-2013 by In-vitro blood clot dissolving activity of SV and artificial blood clot degradation method \u0000Results: It was observed that SV was evaluated for its fibrinolytic properties in the In-vitro blood clot dissolving method and shown to decrease the stained area of the blood-stained cloth as compared to the control. \u0000Conclusion: In the artificial blood clot degradation method, the color intensity is higher in the test tube containing SV compared to the control and hence, it can be stated that SV has fibrinolytic activity.","PeriodicalId":388338,"journal":{"name":"Journal of Pharmacovigilance and Drug Research","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122855995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Knowledge, Attitude, and Practice on Pharmacovigilance among Unani Stakeholders in India: A Cross-Sectional Study","authors":"M. Quamri, Rabia N. Malik, A. Wadud, R. Kunnavil","doi":"10.53411/jpadr.2022.3.4.4","DOIUrl":"https://doi.org/10.53411/jpadr.2022.3.4.4","url":null,"abstract":"","PeriodicalId":388338,"journal":{"name":"Journal of Pharmacovigilance and Drug Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130666915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-drug interactions presenting as Bradyarrhythmia and Hyperkalaemia: A Case Report","authors":"Hirva S. Santoki, Sapna D. Gupta, S. Sood, S. Malhotra","doi":"10.53411/jpadr.2022.3.4.6","DOIUrl":"https://doi.org/10.53411/jpadr.2022.3.4.6","url":null,"abstract":"","PeriodicalId":388338,"journal":{"name":"Journal of Pharmacovigilance and Drug Research","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132862493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of monteleukast in the treatment of covid – 19 an overview","authors":"Thurka S, Sravani Marpaka, C. T., Swati Negi","doi":"10.53411/jpadr.2022.3.3.04","DOIUrl":"https://doi.org/10.53411/jpadr.2022.3.3.04","url":null,"abstract":"Introduction: COVID – 19 infections that has shaken the world by leading into a significant health issue. World is in the need for effective therapies in order to improve clinical outcomes of patients. We must consider new approaches in the treatment of COVID-19. In order to bring effectiveness in treatment, it is important to know the exact pathogenesis of the virus so that it will pave a path for an efficient treatment. \u0000Methods: To ensure comprehensive research and discuss the objective of the review of the study, literature collection was collected from the relevant published articles from databases such as “PubMed, Medline, and SCOPUS,” \u0000Results: COVID-19 is linked with severe inflammation. Pro-inflammatory cytokine levels are elevated in the lung and in bronchial cells. Leukotrienes [LTs] are eicosanoids and inflammatory mediators. Leukotrienes are produced by various cell types which includes, leukocytes. Cysteinyl-leukotrienes (CysLTs) are involved in respiratory pathologies such as inflammation, thrombosis and vascular damage, and fibrotic remodeling. \u0000Discussion: Hence there is a rational for LTs inhibition and montelukast usage in respiratory diseases beyond asthma. Various literatures suggest the use of LT receptor antagonist ‘Montelukast’ in COVID – 19 treatments. \u0000Conclusion: This review article will discuss various aspects of Montelukast in COVID – 19 treatments and reviews the properties of montelukast that could be beneficial in the treatment of COVID-19.","PeriodicalId":388338,"journal":{"name":"Journal of Pharmacovigilance and Drug Research","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116345634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Need for involving the pharmaceutical industry in the national pharmacovigilance program of Nepal","authors":"N. Jha, Yunima Sapkota, Prabakaran Shankar","doi":"10.53411/jpadr.2022.3.3.03","DOIUrl":"https://doi.org/10.53411/jpadr.2022.3.3.03","url":null,"abstract":"Introduction: Adverse drug reactions (ADRs) have high morbidity and mortality and can cause a significant burden on patients. Most of the data on ADRs are generated from the developed world, and these data cannot be generalized to developing nations due to the variation in prescribing patterns, regulatory policies, and varied effects of drugs. Implementing a successful pharmacovigilance program in many developing countries faces several challenges including under-reporting, human resource shortage, financial challenges as well as poor policy and legal framework. \u0000Method: In this commentary, we aim to explore the situation of Pharmacovigilance in Nepal through a close comparison with India and suggest ways to strengthen the same. \u0000Results: Nepal is still in the beginning stage of Pharmacovigilance and ADR reporting is quite low. The Pharmacovigilance System in Nepal is limited to regional centers which report ADRs to the national center. There is no involvement of pharmaceutical industries in the system which may be a major reason for underreporting and suboptimal functioning of the pharmacovigilance system. \u0000Discussion: Nepal must mandatorily involve pharmaceutical industries in pharmacovigilance. The new drug policy is under revision and addresses aspects of pharmacovigilance in terms of patient safety and the role of pharmaceutical companies.","PeriodicalId":388338,"journal":{"name":"Journal of Pharmacovigilance and Drug Research","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121305137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitude and practice of pharmacovigilance among Nepalese health professionals","authors":"S. Shrestha, K. Ghebremeskel, K. White, C. Minelli, I. Tewfik, P. Thapa, S. Tewfik","doi":"10.53411/jpadr.2022.3.3.07","DOIUrl":"https://doi.org/10.53411/jpadr.2022.3.3.07","url":null,"abstract":"Introduction: Although Nepal joined the WHO program for International Drug Monitoring in 2006, published data about Nepalese health professionals’ understanding of pharmacovigilance and spontaneous reporting of adverse drug reactions (ADRs) is limited. \u0000Objectives: The purposes of this study were to: (1) investigate awareness, knowledge, attitude, and practice (KAP) of pharmacovigilance among health professionals and (2) gain insight into the ADRs reported for statins in Nepal. \u0000Methods: 125 health professionals (doctors, pharmacists/assistant pharmacists, and nurses) were recruited from health care institutions (hospitals, clinics, pharmacies) in Kathmandu, Nepal. Electronic and paper survey data were collected with the use of a validated questionnaire between April and December 2018. The multiple-choice questionnaire was structured to assess the KAP of pharmacovigilance, and ADRs associated with statins, and consisted of two open-ended questions for health professionals to give suggestions for the improvement of the pharmacovigilance system. Statistical Package for the Social Sciences (SPSS, version 25) was used to analyze the demographic and pharmacovigilance data. The main outcome measures were KAP of pharmacovigilance and ADRs reported for statins. \u0000Results:100 (80%) participants (44 doctors, 32 pharmacists / assistant pharmacists, 24 nurses) completed the self-administered questionnaire. Pharmacovigilance knowledge, attitude, and practice scores were 71%, 81%, and 53%, respectively. There was a significant difference between the number of knowledgeable health professionals (71 vs. 29%, p < 0.05) and had a favorable attitude (81 vs. 19%, p < 0.05) toward pharmacovigilance and ADR reporting compared with those who did not. The number of participants who did not report ADR was higher than those who did (90 vs. 10%, p < 0.05). The adverse reactions associated with statins were muscle symptoms (62%), elevated activity of liver enzymes (24%), and gastrointestinal symptoms (9%). \u0000Conclusion: Despite the knowledge and willingness of health professionals to report ADRs, the practice of pharmacovigilance remains low in Nepal. There is a need for clear and enforceable regulations for monitoring and reporting ADRs, and effective educational interventions to promote pharmacovigilance practices.","PeriodicalId":388338,"journal":{"name":"Journal of Pharmacovigilance and Drug Research","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115159273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Automation, Natural Language Processing, Artificial Intelligence, and Machine Learning in hospital settings to identify and prevent Adverse Drug Reactions","authors":"Akanksha Togra, S. Pawar","doi":"10.53411/jpadr.2022.3.3.02","DOIUrl":"https://doi.org/10.53411/jpadr.2022.3.3.02","url":null,"abstract":"Patient Safety is at the center of all pharmacovigilance activities. As several covariates can impact the safety of a medicinal product in patients, a large amount of data is required for an accurate assessment of the safety and therefore, the benefit-risk balance of a medicinal product. Natural language processing, Artificial Intelligence, and Machine Learning are being popularly used to facilitate various pharmacovigilance activities in the Pharma industry. Artificial Intelligence and Machine learning if properly used in hospital settings can also facilitate the identification of adverse events from hospital records and discharge summaries and prescription errors, thus, alerting treating physicians regarding the same. However, the potential of using these techniques needs to be fully explored in hospital settings to facilitate the collection and evaluation of safety data.","PeriodicalId":388338,"journal":{"name":"Journal of Pharmacovigilance and Drug Research","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129519402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Communication in Pharmacovigilance","authors":"Sakshi Desai","doi":"10.53411/jpadr.2022.3.3.01","DOIUrl":"https://doi.org/10.53411/jpadr.2022.3.3.01","url":null,"abstract":"Risk communication is a critical aspect of pharmacovigilance that must be considered by organizations during their Risk Management planning phase. The main challenges that hinder effective risk communication is its dependence on the perception of stakeholders, underpinned by their opinions, experiences and emotional responses to risk.  The way to address these challenges is two-fold. One is dealing with it at a strategic level which involves collaborative problem-solving providing an understanding of strengths and limitations of risk analysis along with tools for internal and external communication to ensure consistent messaging. And the second is dealing at an interpersonal level, which involves utilizing empathetic listening to understand needs of the stakeholders and then sharing expert insights, translating technical information into understandable language to ensure effective delivery of messages. Ultimately, integrating expert communication with computational methods creates a strong foundation and increases success of risk communication.","PeriodicalId":388338,"journal":{"name":"Journal of Pharmacovigilance and Drug Research","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115828199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}