Materials TodayPub Date : 2025-06-28DOI: 10.1016/j.mattod.2025.06.026
Zixiong Shi , Dong Guo , Georgian Melinte , Christian G. Canlas , Xianrong Guo , Nimer Wehbe , Jehad K. El-Demellawi , Zhiming Zhao , Yongjiu Lei , Yunpei Zhu , Manuel A. Quevedo-Lopez , Husam N. Alshareef
{"title":"Modulating electrolyte solvation structure and ion dynamics for thermotolerant Li–S batteries","authors":"Zixiong Shi , Dong Guo , Georgian Melinte , Christian G. Canlas , Xianrong Guo , Nimer Wehbe , Jehad K. El-Demellawi , Zhiming Zhao , Yongjiu Lei , Yunpei Zhu , Manuel A. Quevedo-Lopez , Husam N. Alshareef","doi":"10.1016/j.mattod.2025.06.026","DOIUrl":"10.1016/j.mattod.2025.06.026","url":null,"abstract":"<div><div><span>Traditional electrolytes impose tremendous limitation on the effective operation of lithium–sulfur (Li–S) batteries at elevated temperatures due to insufficient thermal stability and aggravated side reactions, wherein battery<span> failure mechanism and electrolyte design principle remain elusive. Herein, we developed a varied-temperature multimodal nuclear magnetic resonance (VT-mNMR) methodology to elucidate temperature-dependent electrolyte </span></span>solvation<span> structure and ion dynamics, whereby a thermotolerant bistratal solvation<span><span><span><span><span> structure electrolyte (BSSE) was formulated to concurrently maintain compact inner solvation sheath and restrict polysulfide shuttling at high temperatures. Cryogenic </span>transmission electron microscopy combined with X-ray photoelectron spectroscopy </span>depth profiling discloses rich inorganic components in the inner layer of </span>solid electrolyte interface. Consequently, Li–S batteries with BSSE can sustain stable operation with a high capacity retention of 90 % at 60 °C, which also harvest a stable cycling performance under a wide temperature range within 20–80 °C. Our study provides a reliable toolbox for studying </span>liquid electrolyte<span> chemistry in Li–S batteries and beyond, which opens a new avenue for advancing extreme-temperature electrolyte design.</span></span></span></div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"88 ","pages":"Pages 219-228"},"PeriodicalIF":22.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Materials TodayPub Date : 2025-06-27DOI: 10.1016/j.mattod.2025.06.030
Ruixue Wang , Xiaoniu Guo , Shuai Guo , Enhui Wang , Ruohan Geng , Zhengkun Xie , Weihua Chen
{"title":"Unveiling interphase and other soft matter in liquid and solid-state batteries by cryogenic electron microscopy","authors":"Ruixue Wang , Xiaoniu Guo , Shuai Guo , Enhui Wang , Ruohan Geng , Zhengkun Xie , Weihua Chen","doi":"10.1016/j.mattod.2025.06.030","DOIUrl":"10.1016/j.mattod.2025.06.030","url":null,"abstract":"<div><div>Soft matter components in rechargeable batteries, such as the electrochemically-formed solid-state interphase layer on electrodes, dendrites, electrolytes, and separators are essential for dynamic performance, cycling stability, and safety. However, their sensitivity to air, moisture, and electron-beam exposure poses challenges for accurate characterization, hindering an objective understanding and the effective design of advanced energy storage systems. Cryogenic electron microscopy (Cryo-EM), an emerging non-destructive imaging technology, offers unique capabilities to probe and analyze the pristine nanostructure and chemical composition of fragile soft matter in various battery systems. This review provides a comprehensive overview of the fundamental principles, the optimized workflows of sample preparation techniques, and key advancements of Cryo-EM in characterizing interphases and other soft matter within batteries. Additionally, the thickness and composition of the interphases captured by Cryo-EM that forms on diverse electrode materials in liquid, gel, and solid-state electrolytes of Li/Na/Zn battery systems are summarized and discussed. Finally, the challenges and the perspectives for Cryo-EM to characterize soft matter in batteries are provided.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"88 ","pages":"Pages 933-958"},"PeriodicalIF":22.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Materials TodayPub Date : 2025-06-27DOI: 10.1016/j.mattod.2025.06.027
Zhihong Yu , Huayang Zhang , Yilong Yang , Ben Wang , Zhiguang Guo
{"title":"Slippery liquid-infused porous surfaces (SLIPS) for anti-icing","authors":"Zhihong Yu , Huayang Zhang , Yilong Yang , Ben Wang , Zhiguang Guo","doi":"10.1016/j.mattod.2025.06.027","DOIUrl":"10.1016/j.mattod.2025.06.027","url":null,"abstract":"<div><div>Slippery liquid −infused porous surfaces (SLIPS) have received significant attention for their potential to address icing safety and deicing energy challenges. In order to overcome the bottlenecks due to inconsistencies in evaluation methods and durability issues. The mechanism research of SLIPS has been discussed from wettability until anti-icing and deicing, and the related evaluation methods are organized. Moreover, the performance characteristics, preparation processes and key research results of various SLIPS materials are summarized. Further, three SLIPS durability enhancement approaches are proposed as the focus of this paper, including structural engineering of the substrate, lubricant immobilization, and supplementation strategies. Finally, current key issues are summarized and potential application scenarios are envisioned, which are inspiring for subsequent interdisciplinary research and engineering translation of SLIPS.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"88 ","pages":"Pages 906-932"},"PeriodicalIF":22.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Materials TodayPub Date : 2025-06-27DOI: 10.1016/j.mattod.2025.06.031
Jinlong Su , Lequn Chen , Steven Van Petegem , Fulin Jiang , Qinzhi Li , Junhua Luan , Swee Leong Sing , Jian Wang , Chaolin Tan
{"title":"Additive manufacturing metallurgy guided machine learning design of versatile alloys","authors":"Jinlong Su , Lequn Chen , Steven Van Petegem , Fulin Jiang , Qinzhi Li , Junhua Luan , Swee Leong Sing , Jian Wang , Chaolin Tan","doi":"10.1016/j.mattod.2025.06.031","DOIUrl":"10.1016/j.mattod.2025.06.031","url":null,"abstract":"<div><div><span>Additive manufacturing<span><span> (AM) is distinguished by its near-net-shape fabrication capability, enabling single-step production of geometrically complex components. However, unlike conventional manufacturing processes, AM-fabricated parts generally lack post-process thermo-mechanical treatments. As a result, the performance of AM-built materials is predominantly governed by their composition and the thermal history inherent to AM. This underscores the necessity for developing materials dedicated to AM. To address this challenge, this study introduces an AM metallurgy-guided machine learning (ML) alloy design framework aimed at developing high-performance AM-specific alloys. The framework combines high-throughput thermodynamic simulations with ML </span>surrogate models to predict key AM-oriented properties, including solidification freezing range, growth restriction factor, hot </span></span>cracking susceptibility<span>, and carbide precipitation<span> speed. These AM-oriented properties are optimised through multi-objective optimisation and decision-making to design alloys with optimal AM performance. To validate this framework, pre-alloyed powders of a designed novel alloy were prepared and printed using various laser-directed energy deposition strategies. Comprehensive characterisations confirmed that the resulting microstructures and properties aligned well with the AM-oriented design objectives. Remarkably, the novel alloy exhibited superior yet highly tunable mechanical properties, with yield strength ranging from 1062 to 1769 MPa and uniform elongation varying between 2.1 % and 11.7 %, depending on the printing strategy. The superior yet tunable mechanical properties are attributed to the temperature-dependent phase transformations and rapid carbide precipitation kinetics of the novel alloy. Overall, this study establishes a robust data-driven framework for AM-specific alloy design, providing a powerful tool to reliably accelerate the development of high-performance and versatile alloys for AM.</span></span></div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"88 ","pages":"Pages 240-250"},"PeriodicalIF":22.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Materials TodayPub Date : 2025-06-26DOI: 10.1016/j.mattod.2025.06.028
Wenjun Li , Xinqin Li , Yang Gu , Bin Zhu , Yu Zheng , Jianyou Shi , Wu Tang
{"title":"Unveiling high-voltage organic cathodes via carbazole-dihydrophenazine conjugation for next-generation lithium dual-ion batteries","authors":"Wenjun Li , Xinqin Li , Yang Gu , Bin Zhu , Yu Zheng , Jianyou Shi , Wu Tang","doi":"10.1016/j.mattod.2025.06.028","DOIUrl":"10.1016/j.mattod.2025.06.028","url":null,"abstract":"<div><div><span><span>Organic redox-active compounds have shown immense potential in advancing battery technology, yet conventional organic cathodes still struggle with low capacities and insufficient output voltages. Here, we design a p-type </span>organic polymer<span> cathode based on poly[5-(3-(9H-carbazol-9-yl)phenyl)-5,10-dihydrophenazine] (p-CZPDPZ), in which the conjugation of carbazole (CZ) and dihydrophenazine (DPZ) units through Buchwald-Hartwig C-N cross-coupling reaction leads to a remarkable average potential of 3.45 V, a peak specific capacity of 197mAh g</span></span><sup>−1</sup><span>, and an impressive energy density of 680 Wh kg</span><sup>−1</sup><span>. The expanded π-conjugated architecture in p-CZPDPZ enables efficient electron density dilution and single-electron stabilization through whole-skeleton delocalization during redox processes, contributing to an exceptional lifespan of 4.8 months with a long-term cycling stability exceeding 1600 cycles. Characterizations and theoretical calculations confirm that p-CZPDPZ can stably and reversibly store BF</span><sub>4</sub><sup>-</sup> for charge compensation. The constructed Li-based dual-ion full batteries (LDIBs) assembled with graphite anode and p-CZPDPZ cathode exhibit a peak discharge capacity of 185 mAh g<sup>−1</sup> and an energy density of up to 596 Wh kg<sup>−1</sup><span> with over 1400 cycles. This study provides a novel framework for designing high-performance organic cathode materials through molecular conjugation strategy, offering substantial potential for</span> <!-->advancing next-generation lithium dual-ion batteries.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"88 ","pages":"Pages 229-239"},"PeriodicalIF":22.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Challenges and strategies for constructing stable aluminum metal anodes in rechargeable aluminum-ion batteries","authors":"Jiaqiang Yu , Dengke Wang , Danyang Zhao , Wenming Zhang , Qiancheng Zhu","doi":"10.1016/j.mattod.2025.06.023","DOIUrl":"10.1016/j.mattod.2025.06.023","url":null,"abstract":"<div><div><span><span>With the growing market for electric vehicles and the development of renewable energy storage technologies, rechargeable aluminum-ion batteries (RAIBs) have garnered significant interests because of the abundant </span>natural resources<span><span>, impressive theoretical capacity and inherent safety advantages. Nevertheless, the poor stability of metallic Al anode poses a formidable challenge, stemming from issues such as self-corrosion and dendritic growth in ionic liquid electrolyte, as well as self-corrosion, surface </span>passivation and </span></span>hydrogen evolution reaction<span> in aqueous electrolyte. This comprehensive review delves into the key scientific challenges faced of Al anode both in non-aqueous and aqueous electrolytes, and subsequently outlines innovative strategies and recent progresses that aimed at stabilizing aluminum metal anodes. In summary and outlook part, we present insightful suggestions and future perspectives for constructing stable aluminum metal anodes, which could propel the development of high-performance RAIBs. Specially, we also concern the controversy about aqueous aluminum-ion batteries and propose some reasonable standards for proving the reversibility of aqueous RAIBs.</span></div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"88 ","pages":"Pages 888-905"},"PeriodicalIF":22.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Materials TodayPub Date : 2025-06-26DOI: 10.1016/j.mattod.2025.06.029
Zhendong Li , Xinxin Wang , Zhonggang Wang , Xinwei Li , Xiang Yu , Seeram Ramakrishna , Yang Lu , Li Cheng
{"title":"Emerging acousto-mechanical metamaterials: From physics-guided design to coupling-driven performance","authors":"Zhendong Li , Xinxin Wang , Zhonggang Wang , Xinwei Li , Xiang Yu , Seeram Ramakrishna , Yang Lu , Li Cheng","doi":"10.1016/j.mattod.2025.06.029","DOIUrl":"10.1016/j.mattod.2025.06.029","url":null,"abstract":"<div><div><span><span><span>The growing demand for materials that simultaneously absorb airborne sound and sustain mechanical loads has catalyzed the rise of acousto-mechanical metamaterials (AMMs)—architected systems that embed </span>acoustic resonances<span> within mechanically efficient architectures, enabling multifunctionality beyond the reach of conventional materials. This review provides in-depth insights into the structural and physical principles that govern acoustic absorption—the central challenge in advancing AMMs. We classify existing architectures and reveal how tailored topologies can achieve superior resonant responses and dissipative pathways. To overcome causality-governed efficiency–thickness trade-offs, we consolidate three physics-informed enhancement strategies: coherent weak </span></span>resonator coupling, geometry-driven impedance tuning, and intrinsic loss engineering—offering viable paths toward optimal absorption. Critically, we elucidate the structural origins of acousto-mechanical coupling by analyzing synergistic trends and mismatches arising from parent material, unit-cell scale, and topological interdependence. We introduce a three-tier coupling framework based on geometry-sharing levels, clarifying when acoustic and mechanical functions can be decoupled and when they demand co-optimization. Finally, we outline key challenges and propose future directions in functional integration, AI-driven development, and real-world deployment. Positioned at the intersection of geometry, </span>physics, and multifunctionality, AMMs are poised to serve as a versatile platform for next-generation engineered systems.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"89 ","pages":"Pages 151-171"},"PeriodicalIF":22.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Materials TodayPub Date : 2025-06-23DOI: 10.1016/j.mattod.2025.06.016
Hamid Ali , Basem Al Alwan , Amal Abdulrahman , Dewu Yue , Asif Hayat
{"title":"Novel breakthrough in the synthesis, functionalization, morphology, properties, and applications of hydrogen-bonded organic frameworks","authors":"Hamid Ali , Basem Al Alwan , Amal Abdulrahman , Dewu Yue , Asif Hayat","doi":"10.1016/j.mattod.2025.06.016","DOIUrl":"10.1016/j.mattod.2025.06.016","url":null,"abstract":"<div><div>Hydrogen-bonded organic frameworks (HOFs) are porous crystalline materials due to their excellent crystallinity, solution processability, and ease of regeneration, making them well-suited for multifunctional applications. Despite these advantages, some HOFs become unstable after desolvation, presenting challenges related to stability, porosity, and functionalization. Recent advancements have enhanced HOFs stability through strategies like stronger charge-assisted hydrogen bonds and coordination bonds, leading to more robust composite HOFs, including ionic and metal types. The present study examines the fundamental design concepts and chemical synthons necessary for the development of HOFs, focussing on their structural variety from one-dimensional (1D) to three-dimensional (3D) designs. It provides a detailed exploration of HOFs properties, including luminescence, magnetism, mechanical strength, dielectric characteristics, guest exchange, adsorption, and electronic and optical features. The review also covers a range of synthesis methodologies, each offering unique benefits for tailoring HOFs structures and functionalities. The role of π-π interactions, structural integration, electrostatic interactions, and covalent bonding in enhancing structural integrity, resilience, and stability is highlighted in the detailed discussion of key strategies for increasing the stability of HOFs. Additionally, diverse functionalization strategies incorporating various chemical groups are explored for the first time, showing how they can modify and expand HOFs properties. Finally, the review addresses different HOFs morphologies, including thin films, nanosheets, nanospheres, and nanotubes, and their broad applications in fields such as batteries, membranes, sensors, separation technologies, supercapacitors, carbon dioxide capture, electrocatalysts, photocatalysts, proton conductivity, and biological applications. In this review, we aim to provide a comprehensive platform that covers all aspects of HOFs, especially highlighting a wide range of different functionality units and dimensionality. This detailed examination provides readers with an in-depth comprehension of the characteristics and possible uses of HOFs, setting our review distinct via its wide-ranging breadth and thorough analysis. This comprehensive overview illustrates the significant potential of HOFs to advance various technological and scientific domains.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"88 ","pages":"Pages 783-813"},"PeriodicalIF":22.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Materials TodayPub Date : 2025-06-19DOI: 10.1016/j.mattod.2025.06.012
Dabin Kim , Sera Jeon , Cheol Hyoun Ahn , Minki Kang , Jin Young Choi , Xiangchun Meng , Byung-Joon Park , Hyun Mo , SeongMin Kim , Byung-Ok Choi , Hyung Koun Cho , Sang-Woo Kim
{"title":"Sono-responsive Bio-MOF-11 as a triboelectric material for powering transient implants","authors":"Dabin Kim , Sera Jeon , Cheol Hyoun Ahn , Minki Kang , Jin Young Choi , Xiangchun Meng , Byung-Joon Park , Hyun Mo , SeongMin Kim , Byung-Ok Choi , Hyung Koun Cho , Sang-Woo Kim","doi":"10.1016/j.mattod.2025.06.012","DOIUrl":"10.1016/j.mattod.2025.06.012","url":null,"abstract":"<div><div>Recent progress in transient implantable medical devices (IMDs) has drawn attention to the necessity for biodegradable power sources, which can eliminate the need for secondary removal surgeries after implantation. However, relying solely on the material’s intrinsic biodegradation rate or device dimensions for biodegradation presents limitations. In this study, we propose an acoustically-mediated degradable-triboelectric nanogenerator (AMD-TENG) and its operating system as a transient implantable power source. We introduce the incorporation of Bio-MOF-11 into poly(lactic-co-glycolic) acid (PLGA) as a durable, high-performance triboelectric layer. Our findings demonstrate that the Bio-MOF-11/PLGA film, when exposed to low-intensity ultrasound, generates a stable electrical output of 12.5 V and 87.5 μA/cm<sup>2</sup>, confirming its viability as a power source for IMDs. Additionally, the integration of surface pores allows for controlled biodegradation under high-intensity ultrasound, enabling on-demand dissolution and subsequent generation of reactive oxygen species (ROS) to accelerate degradation. These results highlight the efficiency of the Bio-MOF-11/PLGA as a tribo-layer in electricity generation and controlled degradation, offering a sustainable and safe solution for powering and disposing of transient IMDs.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"88 ","pages":"Pages 178-185"},"PeriodicalIF":22.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Materials TodayPub Date : 2025-06-19DOI: 10.1016/j.mattod.2025.06.011
Yuan-Yuan Zhao , Sungkyu Lee , Yeju Lee , Bokyeong Hwang , Hwapyung Jung , Qiongzheng Hu , Guosheng Song , Heemin Kang , Juyoung Yoon
{"title":"Sustainable cancer therapy","authors":"Yuan-Yuan Zhao , Sungkyu Lee , Yeju Lee , Bokyeong Hwang , Hwapyung Jung , Qiongzheng Hu , Guosheng Song , Heemin Kang , Juyoung Yoon","doi":"10.1016/j.mattod.2025.06.011","DOIUrl":"10.1016/j.mattod.2025.06.011","url":null,"abstract":"<div><div>Sustainable cancer therapy, achieved through the activation of molecules or nanoparticles that initiate long-term cancer-therapeutic actions, has attracted increasing attention in recent years. Numerous pre-clinical and clinical investigations have shown that sustainable cancer treatments can effectively trigger tumor regression. Currently, near-infrared light, X-rays, and ultrasound stimuli are extensively employed to trigger long-term therapeutic effects. In particular, X-rays and ultrasound possess significant potential for deep tumor therapy due to their excellent tissue penetration capabilities, which can boost treatment efficacy. Notably, long-term photonic and ultrasound activation can be synergistically combined with various therapies, such as sonodynamic therapy, photothermal therapy, photodynamic therapy, and immunotherapy, to further enhance therapeutic efficacy. Additionally, chemodynamic therapy enables synergistic dual activation, including cyclic and switchable reactions, to elicit a sustained therapeutic effect. This review encapsulates recent methodologies and benefits of sustainable cancer treatment, particularly for intractable tumors, and underscores that sustained cancer treatment can incorporate long-term self-powering, autonomous control, and self-replenishing functions. Crucially, the challenges and future outlooks of stimuli-responsive sustainable cancer therapy are examined to foster its advancement and clinical applications.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"88 ","pages":"Pages 705-729"},"PeriodicalIF":22.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}