Materials Today最新文献_第2页

Topology and curvature effects in the photonics of ring – split ring – cuboid transitions 环形-分裂环形-立方体过渡光子学中的拓扑和曲率效应

IF 21.1 1区材料科学

Materials Today Pub Date : 2024-11-01 DOI: 10.1016/j.mattod.2024.08.015

Mikhail Bochkarev , Nikolay Solodovchenko , Kirill Samusev , Mikhail Limonov

{"title":"Topology and curvature effects in the photonics of ring – split ring – cuboid transitions","authors":"Mikhail Bochkarev , Nikolay Solodovchenko , Kirill Samusev , Mikhail Limonov","doi":"10.1016/j.mattod.2024.08.015","DOIUrl":"10.1016/j.mattod.2024.08.015","url":null,"abstract":"<div><div>Topological transitions in various materials are actively being studied, including topological quantum phase transitions, going beyond the Landau theory and the concept of the order parameter. Here we propose the concept of a transition between two structures with different topology using the example of the transition between a flat dielectric ring and a split ring and its further unbending into a rectangular Fabry-Pérot resonator. Experimentally and theoretically, we discovered the lifting of the degeneracy of the CW-CCW photonic modes of the ring and the formation of two families: topological, which acquire an additional phase <span><math><mi>π</mi></math></span>, equal to the Berry phase in a thin Möbius strip, and ordinary ones, which do not acquire an additional phase. Topological modes arise due to the gradual “cutting” of one antinode of the field by a gap into two antinodes as the angular size of the gap increases from zero to one degree. Thus, using a topological Fabry-Pérot resonator with variable curvature and fixed length, resonant modes with an arbitrary non-integer number of waves are realized and a new generation of resonators is created with the prospect of unique classical and quantum applications.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"80 ","pages":"Pages 179-186"},"PeriodicalIF":21.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-situ reconstructed surface/inner-structure synergistic design enabling 4.6 V LiCoO2 cathode for all-solid-state thin-film battery 原位重构表面/内部结构协同设计使全固态薄膜电池的钴酸锂正极电压达到 4.6 V

IF 21.1 1区材料科学

Materials Today Pub Date : 2024-11-01 DOI: 10.1016/j.mattod.2024.09.011

Jinxu Qiu , Hongliang Li , Yu Zhao , Rongrui Xu , Kaiyuan Wei , Yixiu Cui , Jie Shu , Yanhua Cui

{"title":"In-situ reconstructed surface/inner-structure synergistic design enabling 4.6 V LiCoO2 cathode for all-solid-state thin-film battery","authors":"Jinxu Qiu , Hongliang Li , Yu Zhao , Rongrui Xu , Kaiyuan Wei , Yixiu Cui , Jie Shu , Yanhua Cui","doi":"10.1016/j.mattod.2024.09.011","DOIUrl":"10.1016/j.mattod.2024.09.011","url":null,"abstract":"<div><div>Developing high-voltage LiCoO<sub>2</sub> cathode film is a promising approach to meet high-energy density demands for intelligent microdevices. However, the electrochemical performance of bare LiCoO<sub>2</sub> is compromised beyond 4.55 V due to irreversible phase transitions, cobalt dissolution, and intergranular cracking. Meanwhile, vacuum physical deposition technology and interface compatibility pose challenges to achieving higher capacity integrated into a narrow space. Herein we proposed an in-situ reconstructed surface/inner-structure synergistic modification prototype strategy to achieve a superior high-voltage LiCoO<sub>2</sub> through a facile in-situ magnetron sputtering. This sandwich structure design enables a synergistic effect of internal titanium body-doping and external LiCoPO<sub>4</sub> compact layer to strengthen stability under high voltage. Consequently, the triggered defects and strong P<img>O coordination are substantially beneficial for stabilizing Li<sup>+</sup> channels, inhibiting Co migration, as well as enhancing diffusion kinetics. Strain field analysis reveals that the mitigated lattice deformation along (104) preferential orientation is beneficial for alleviating volumetric strain even at an operating voltage of up to 4.6 V. Additionally, the induced body and surface atom rearrangement regulates the band structure and reduces oxygen redox activity. Therefore, the as-designed high-voltage LiCoO<sub>2</sub>-based all-solid-state thin-film battery achieves superior cycle stability with 75 % capacity retention after 500 cycles at 1 C under 10 °C.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"80 ","pages":"Pages 342-352"},"PeriodicalIF":21.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering defects in graphitic carbon nitride photocatalysts 氮化石墨碳光催化剂中的工程缺陷

IF 21.1 1区材料科学

Materials Today Pub Date : 2024-11-01 DOI: 10.1016/j.mattod.2024.09.019

Qi Li , Siyu Zhao , Baojiang Jiang , Mietek Jaroniec , Liping Zhang

{"title":"Engineering defects in graphitic carbon nitride photocatalysts","authors":"Qi Li , Siyu Zhao , Baojiang Jiang , Mietek Jaroniec , Liping Zhang","doi":"10.1016/j.mattod.2024.09.019","DOIUrl":"10.1016/j.mattod.2024.09.019","url":null,"abstract":"<div><div>Graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>) has emerged as a promising metal-free photocatalyst. However, it continues to face significant challenges in achieving competitive activities both in laboratories and practical applications. Defect engineering is a versatile strategy to refine the intrinsic properties of semiconductor photocatalysts, modulating their electronic structure, charge dynamics and active surface sites. Given rapid advancements in this field, there is an urgent need to overview the progress in engineering of defects in g-C<sub>3</sub>N<sub>4</sub>, which is essential for a deeper understanding of the activity of this photocatalyst. This review focuses on the synthesis, characterization, and physiochemical properties of defect-engineered g-C<sub>3</sub>N<sub>4</sub>, including g-C<sub>3</sub>N<sub>4</sub> with substitutional dopants, interstitial dopants, vacancies, functional groups and/or structural disorder. It also explores various applications of g-C<sub>3</sub>N<sub>4</sub> materials with introduced defects for photocatalytic H<sub>2</sub> evolution, CO<sub>2</sub> reduction, N<sub>2</sub> fixation and organic transformations, along with the mechanisms underlying their performance at the molecular level. Finally, this review article presents a perspective on the design, synthesis and properties of defect-modified g-C<sub>3</sub>N<sub>4</sub> photocatalysts.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"80 ","pages":"Pages 886-904"},"PeriodicalIF":21.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing solid-state sodium batteries: Status quo of sulfide-based solid electrolytes 推进固态钠电池：硫化物固态电解质的现状

IF 21.1 1区材料科学

Materials Today Pub Date : 2024-11-01 DOI: 10.1016/j.mattod.2024.08.011

Zhendong Yang , Bin Tang , Dehang Ren , Xinyu Yu , Yirong Gao , Yifan Wu , Yongan Yang , Zhongfang Chen , Zhen Zhou

{"title":"Advancing solid-state sodium batteries: Status quo of sulfide-based solid electrolytes","authors":"Zhendong Yang , Bin Tang , Dehang Ren , Xinyu Yu , Yirong Gao , Yifan Wu , Yongan Yang , Zhongfang Chen , Zhen Zhou","doi":"10.1016/j.mattod.2024.08.011","DOIUrl":"10.1016/j.mattod.2024.08.011","url":null,"abstract":"<div><div>Solid-state sodium batteries are among the most promising candidates for replacing conventional lithium-ion batteries for next-generation electrochemical energy storage systems. Their advantages include abundant Na resources, lower cost, enhanced safety, and high energy density. Central to the development of these batteries is the use of all-solid-state sodium electrolytes, with sulfide-based solid electrolytes emerging as particularly viable due to their high ionic conductivity (on par with liquid electrolytes), favorable interfacial contact with electrodes, and mild preparation conditions. Despite these benefits, several crucial challenges limit the development of sulfide-based solid electrolytes, including a narrow electrochemical stability window, unstable interface between sulfide-based solid electrolytes and electrodes, and the growth of detrimental sodium dendrites. This review examines the fundamental ion transport mechanism in sulfide-based solid electrolytes, discusses the primary challenges and strategic solutions, and separately addresses the critical interfacial issues at the cathode and anode. It also highlights the importance of scaling up these techniques for industrial applications. Finally, this review offers key recommendations for advancing the industrialization and enhancing the energy density of sulfide-based solid-state sodium batteries. Hopefully, solid-state sodium batteries based on sulfide-based solid electrolytes will achieve significant breakthroughs in energy density and industrial scalability in the very near future.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"80 ","pages":"Pages 429-449"},"PeriodicalIF":21.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metals beyond tomorrow: Balancing supply, demand, sustainability, substitution, and innovations 未来的金属：平衡供应、需求、可持续性、替代和创新

IF 21.1 1区材料科学

Materials Today Pub Date : 2024-11-01 DOI: 10.1016/j.mattod.2024.09.007

T. DebRoy , J.W. Elmer

{"title":"Metals beyond tomorrow: Balancing supply, demand, sustainability, substitution, and innovations","authors":"T. DebRoy , J.W. Elmer","doi":"10.1016/j.mattod.2024.09.007","DOIUrl":"10.1016/j.mattod.2024.09.007","url":null,"abstract":"<div><div>Finite or scarce metal supplies, rising demand, declining ore grades, and prospects of creating a climate-friendly metallurgical industry pose both a challenge and an opportunity to revitalize metals production through sustainable technology, innovations, and informed public policies. The rapid rise in metal consumption, faster than the population growth, challenges both the supply-demand balance and international environmental goals. Depletion of green technology critical metals, with known metal reserves unlikely to last more than half a century, emphasizes the need for increased substitutions, recycling, and reuse efforts. In the past, organized research and serendipity empowered us to innovate manufacturing processes and develop new alloys that fulfilled important societal needs. However, a renewed emphasis on metals research and development is required to meet new and future challenges where the use of critical metals is optimized, and metal sustainability is taken into account. While green technologies offer hope for a cleaner future, scale-up concerns and higher costs of these metals inhibit their widespread use. Current mitigation strategies fall short of Paris Agreement goals, but using advanced high-strength steels could significantly cut total steel usage and greenhouse gas emissions. Ensuring long-term reliance on metals necessitates finding a delicate balance between the challenges facing the metals industry and the multitude of technical and political factors important for their resolution. Engaging and educating the younger generation, particularly Generation Z, policymakers, and industry leaders, is necessary to effectively map out a path forward to revitalize the metals industry.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"80 ","pages":"Pages 737-757"},"PeriodicalIF":21.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Droplet nanogenerators: Mechanisms, performance, and applications 液滴纳米发电机：机理、性能和应用

IF 21.1 1区材料科学

Materials Today Pub Date : 2024-11-01 DOI: 10.1016/j.mattod.2024.08.017

Pawantree Promsuwan , Md Al Mahadi Hasan , Suwen Xu , Ya Yang

{"title":"Droplet nanogenerators: Mechanisms, performance, and applications","authors":"Pawantree Promsuwan , Md Al Mahadi Hasan , Suwen Xu , Ya Yang","doi":"10.1016/j.mattod.2024.08.017","DOIUrl":"10.1016/j.mattod.2024.08.017","url":null,"abstract":"<div><div>The need for power technology that improves human life and convenience is driving the demand for increased energy consumption. At present, fossil fuels are the primary source of energy that meets the energy demand of mankind. However, they are also the main cause of environmental pollution. Therefore, it is imperative to develop technology that can harness energy from renewable sources to replace fossil fuels. One promising technology that has gained significant attention is the droplet nanogenerators, which harvest energy from various forms of water. This technology has grown in popularity due to its straightforward design, low fabrication cost, and high output power, which is sufficient to power small electronic devices sustainably. With innovative structures and various fundamental materials, droplet nanogenerators’ performance can be improved, which leads to the expansion of their application areas. This review summarizes recent advancements in droplet nanogenerators, including mechanisms, output performance, and applications. Finally, the challenges and opportunities associated with droplet nanogenerators are briefly discussed.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"80 ","pages":"Pages 497-528"},"PeriodicalIF":21.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulating interfacial behavior via reintegration the Helmholtz layer structure towards ultra-stable and wide-temperature-range aqueous zinc ion batteries 通过重新整合赫尔姆霍兹层结构调节界面行为，实现超稳定、宽温程锌离子水电池

IF 21.1 1区材料科学

Materials Today Pub Date : 2024-11-01 DOI: 10.1016/j.mattod.2024.08.003

Shijia Li , Jingwen Zhao , Xieyu Xu , Jiasen Shen , Kai Zhang , Xue Chen , Kai Wang , Xingxing Jiao , Ziyang Wang , Dinghao Xu , Qianyu Zhang , Yangyang Liu , Ying Bai

{"title":"Regulating interfacial behavior via reintegration the Helmholtz layer structure towards ultra-stable and wide-temperature-range aqueous zinc ion batteries","authors":"Shijia Li , Jingwen Zhao , Xieyu Xu , Jiasen Shen , Kai Zhang , Xue Chen , Kai Wang , Xingxing Jiao , Ziyang Wang , Dinghao Xu , Qianyu Zhang , Yangyang Liu , Ying Bai","doi":"10.1016/j.mattod.2024.08.003","DOIUrl":"10.1016/j.mattod.2024.08.003","url":null,"abstract":"<div><div>Aqueous zinc-ion batteries are recognized as a potential candidate in large-scale energy storage devices. However, parasitic reactions on interfaces have severely limited their further development due to sticky de-solvation process of Zn(H<sub>2</sub>O)<sub>6</sub><sup>2+</sup>. Acetylacetone (Hacac) is proposed as a tri-functional additive by altering the solvation structure to address detrimental interface issues. Specifically, the acetyl groups induced by decomposition of Hacac inhibit dendrite growth, by-product aggregation on anode via guiding ordered deposition of zinc ions and suppressing water decomposition in internal Helmholtz plane (IHP). Meanwhile, the acetyl groups remarkably alleviate by-product aggregation and maintain the cathode structure by accelerating zinc ion transfer and inhibiting disintegration of water in IHP. With the addition of 0.5 wt% Hacac, Zn metal maintains a high coulombic efficiency of 99.9 % after 2000 cycles at 10 mA cm<sup>−2</sup> and 1 mAh cm<sup>−2</sup>, with superior longevity of 5200 h at 1 mA cm<sup>−2</sup> with 0.5 mAh cm<sup>−2</sup> for Zn|Zn cells. As expected, the assembled Zn|NH<sub>4</sub>V<sub>4</sub>O<sub>10</sub> batteries exhibit an outstanding capacity retention of 90 % up to 22,000 cycles at 10 A/g. As a highly efficient strategy, the reframing of Helmholtz layer structure via electrolyte additive could be broadened to address general interfacial issues in advanced energy storage systems.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"80 ","pages":"Pages 50-60"},"PeriodicalIF":21.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in conducting gels for flexible and stretchable smart electronic devices: A comprehensive review 用于柔性和可拉伸智能电子设备的导电凝胶的最新进展：全面回顾

IF 21.1 1区材料科学

Materials Today Pub Date : 2024-11-01 DOI: 10.1016/j.mattod.2024.09.001

Bablesh Gupta , Suman Kalyan Samanta , Ranbir Singh

{"title":"Recent advances in conducting gels for flexible and stretchable smart electronic devices: A comprehensive review","authors":"Bablesh Gupta , Suman Kalyan Samanta , Ranbir Singh","doi":"10.1016/j.mattod.2024.09.001","DOIUrl":"10.1016/j.mattod.2024.09.001","url":null,"abstract":"<div><div>Conducting gels have garnered significant attention due to their distinctive properties, such as unique electrical/thermal conductivity, biocompatibility, flexibility, stretchability, and transparency. These gels adeptly combine the viscoelastic features with the combination of organic, metal, and semiconductor components. Consequently, these gels have become the subject of extensive exploration across various fields, encompassing tactile sensors, power generation systems, actuators, wearable electronics, and biomedical devices. Their potential applications extend beyond these fields to encompass human–machine interfaces, artificial intelligence, and other implementations. This review provides a comprehensive examination of the synthesis methods for various electrically conducting gels, such as hydrogels, organogels, metal–organic gels, and perovskite gels. Furthermore, this study investigates the promising applications of these gels across various fields, focusing on their potential use in energy storage, energy harvesting devices, and advanced sensors. Resolutely, the review outlines both the prospects and challenges in further research endeavors concerning the development and utilization of these remarkable gels for boosting the evolution of cutting-edge mechanically versatile intelligent stretchable skin-like devices.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"80 ","pages":"Pages 681-709"},"PeriodicalIF":21.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic intervention mitochondria nanomotors breakdown redox homeostasis for boosting oxidative stress-dependent antitumor therapy 代谢干预线粒体纳米马达打破氧化还原平衡，促进氧化应激依赖性抗肿瘤治疗

IF 21.1 1区材料科学

Materials Today Pub Date : 2024-11-01 DOI: 10.1016/j.mattod.2024.08.019

Xinping Luo , Xincong Li , Shiyu Li , Chenxi Zhou , Jing Li , Zhanwei Zhou , Minjie Sun

{"title":"Metabolic intervention mitochondria nanomotors breakdown redox homeostasis for boosting oxidative stress-dependent antitumor therapy","authors":"Xinping Luo , Xincong Li , Shiyu Li , Chenxi Zhou , Jing Li , Zhanwei Zhou , Minjie Sun","doi":"10.1016/j.mattod.2024.08.019","DOIUrl":"10.1016/j.mattod.2024.08.019","url":null,"abstract":"<div><div>Aberrant metabolic balance in malignant tumors shapes defensive redox homeostasis and protected tumor cells from oxidative stress damage, consequently impeding clinical transformation process of oxidative stress-dependent anti-tumor therapies represented by chemodynamic therapy and immunotherapy. Herein, a rational designed mitochondria nanomotor was developed by coating a GSH-responsive functional Pt(IV) prodrug layer DP on magnetic iron oxide nanoparticles (MN), which can thoroughly breakdown redox homeostasis by metabolic intervention strategy. Specifically, DP loading two dichloroacetic acid (DCA) axial ligands was stimuli-responsively reduced into Pt(II) and DCA molecules in highly reductive tumor cells, accompanied with glutathione elimination and oxidative stress counteraction weakening. Subsequently, DCA increased pyruvate influx into the mitochondria by pyruvate dehydrogenase activation and enduringly elevated oxidative phosphorylation level, breaking the tumor redox homeostasis thoroughly, contributing to 7.5-fold amplifying hydrogen peroxide production and sensitizing chemodynamic therapy mediated by MN, finally resulting in inspiring 89.5% tumor suppression rate on triple negative breast cancer model. In short, this work realized comprehensive and sustainable oxidative stress elevation of the intracellular environment by metabolic intervention strategy and provided an ingenious perspective of augmenting oxidative stress-dependent anti-tumor therapies.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"80 ","pages":"Pages 187-200"},"PeriodicalIF":21.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-activated polymeric crosslinked nanocarriers as a checkpoint blockade immunoregulatory platform for synergistic tumor therapy 光活化聚合物交联纳米载体作为检查点阻断免疫调节平台用于肿瘤协同治疗

IF 21.1 1区材料科学

Materials Today Pub Date : 2024-11-01 DOI: 10.1016/j.mattod.2024.07.012

Yao Yang , Xiaotong Liang , Qimanguli Saiding , Jiachan Lin , Jinyuan Li , Wenyan Wang , Ping Huang , Li Huang , Wenfeng Zeng , Jinhai Huang , Hongzhong Chen , Wei Tao , Xiaowei Zeng

{"title":"Light-activated polymeric crosslinked nanocarriers as a checkpoint blockade immunoregulatory platform for synergistic tumor therapy","authors":"Yao Yang , Xiaotong Liang , Qimanguli Saiding , Jiachan Lin , Jinyuan Li , Wenyan Wang , Ping Huang , Li Huang , Wenfeng Zeng , Jinhai Huang , Hongzhong Chen , Wei Tao , Xiaowei Zeng","doi":"10.1016/j.mattod.2024.07.012","DOIUrl":"10.1016/j.mattod.2024.07.012","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) can enhance immune checkpoint blockade (ICB) antitumor immunity. However, PDT can significantly exacerbate the hypoxic tumor microenvironment and stimulate tumor neovascularization, promoting tumor invasion and metastasis. Camptothecin can inhibit angiogenesis by down-regulating hypoxia-inducible factor 1α (HIF-1α). Therefore, this study proposed to combine camptothecin with PDT for the first time to alleviate the disadvantage of PDT, and play its dual role of chemotherapy and antiangiogenesis. Here, a light-activated nanocarrier crosslinked the anti-PD-L1, photosensitizer, and camptothecin prodrug mildly with a thioketal bond for checkpoint blockade immunoregulation was designed. Firstly, photosensitizer-induced PDT and immunogenic cell death effect significantly increase T cell infiltration (33.3 % CD8<sup>+</sup> increase), enhancing ICB antitumor immunity. Secondly, the antiangiogenic effect of camptothecin was beneficial for alleviating hypoxic tumor microenvironment exacerbated by PDT (HIF-1α expression decreased in tumor cells). Thirdly, light-activated release facilitates tumor accumulation (3.22 times) and controlled drug release. Thus, the immune checkpoint blockade combined with PDT and an antiangiogenic therapy of camptothecin creates a positive feedback co-delivery platform that exemplifies cascaded synergistic tumor therapy by checkpoint blockade immunoregulation. Besides, it also introduces a new strategy for combining small molecule drugs with macromolecules like proteins to treat various diseases.</div></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":"80 ","pages":"Pages 1-22"},"PeriodicalIF":21.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0